Nitric oxide (NO)-releasing aspirin exhibits a potent esophagoprotection in experimental model of acute reflux esophagitis. Role of nitric oxide and proinflammatory cytokines

Journal of Physiology and Pharmacology

Volumn 62, Issue 1, 2011, Pages 75-86

  Pawlik, M ^a   Pajdo, R ^a   Kwiecien, S ^a   Ptak Belowska, A ^a   Sliwowski, Z ^a   Mazurkiewicz Janik, M ^a   Konturek, S J ^a   Pawlik, W W ^a   Brzozowski, T ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Aspirin; Celecoxib; Esophageal blood flow; Glyceryl trinitrate; Interleukin 1 ; Nitric oxide releasing aspirin; Reflux esophagitis; Tumor necrosis factor

Indexed keywords

5 (4 CHLOROPHENYL) 1 (4 METHOXYPHENYL) 3 TRIFLUOROMETHYL 1H PYRAZOLE; ACETYLSALICYLIC ACID; CELECOXIB; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYTOKINE; GLYCERYL TRINITRATE; INDOMETACIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; NITRIC OXDIDE RELEASING ASPIRIN; NONSTEROID ANTIINFLAMMATORY AGENT; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE RESPONSE; DRUG EFFICACY; DRUG MECHANISM; DRUG SAFETY; ENZYME LINKED IMMUNOSORBENT ASSAY; ESOPHAGUS INJURY; ESOPHAGUS MUCOSA; HISTOLOGY; MALE; MICROCIRCULATION; NONHUMAN; ORGAN BLOOD FLOW; PROTEIN EXPRESSION; RAT; REFLUX ESOPHAGITIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; STOMACH JUICE;

ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ASPIRIN; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE INHIBITORS; CYTOKINES; DINOPROSTONE; ESOPHAGITIS, PEPTIC; ESOPHAGUS; GASTRIC ACID; HUMANS; INDOMETHACIN; MALE; NITRIC OXIDE; NITRIC OXIDE DONORS; NITROGLYCERIN; PYRAZOLES; RATS; RATS, WISTAR; RNA, MESSENGER; SULFONAMIDES;

EID: 79954552106     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (50)

1. Dent J, El-Serag HB, Wallander MA, Johansson S. Epidemiology of gastro-oesophageal reflux disease: a systemic review. Gut 2005; 54: 710-717.
2. Fox M, Forgacs I. Gastro-oesophageal reflux disease. Br Med J 2006; 332: 88-93.
3. El-Searag HB. Time trends of gastroesophageal reflux disease: a systemic review. Clin Gastroenterol Hepatol 2007; 5: 17-26.
4. Kahrilas PJ, Lee TJ. Pathophysiology of gastroesophageal reflux disease. Thorac Surg Clin 2005; 15: 323-333.
5. Sifrim D, Mittal R, Fass R, et al. Acidity and volume of the refluxate in the genesis of gastro-oesophageal reflux disease symptoms. Aliment Pharmacol Ther 2007; 25: 1003-1015.
6. Lanas A, Royo Y, Ortego J, Molina M, Sainz R. Experimental esophagitis induced by acid and pepsin in rabbits mimicking human reflux esophagitis. Gastroenterology 1999; 116: 997-1107.
7. Vaezi MF, Richter JE. Role of acid and duodenogastroesophageal reflux in gastroesophageal reflux disease. Gastroenterology 1996; 111: 1192-1199.
8. Oh DS, Hagen JA, Fein M. The impact of reflux composition on mucosal injury and esophageal function. J Gastrointest Surg 2006; 10: 787-797.
9. Orlando RC, Bryson JC, Powell DW. Mechanisms of H+ injury in rabbit esophageal epithelium. Am J Physiol 1984; 246: G718-G724.
10. Tobey NA, Carson JL, Alkiek RA, Orlando RC. Dilated intercellular spaces: a morphological feature of acid refluxdamaged human esophageal epithelium. Gastroenterology 1996; 111: 1200-1205.
11. Szentpali K, Kaszaki J, Eros G, et al. Changes in microcirculation of esophageal mucosa during acute experimental reflux. Pathogenic role of the biliary component. Magy Seb 2003; 56: 61-67.
12. Abdulnour-Nakhoul S, Nakhoul NL, Wang P, Swenson ER, Orlando RC. HCO3 secretion in the esophageal submucosal glands. Am J Physiol Gastrointest Liver Physiol 2006; 288: G736-G744.
13. Nagahama K, Yamoto M, Nishio H, Takeuchi K. Essential role of pepsin in pathogenesis of acid reflux esophagitis in rats. Dig Dis Sci 2006; 51: 303-309.
14. Tobey NA, Hossein SS, Argote CM., et al. Dilated intercellular spaces and shunt permeability in nonerosive acid-damaged esophageal epithelium. Am J Gastroenterol 2004; 9: 13-22.
15. Fujiwara Y, Higuchi K, Takashima, et al. Roles of epidermal growth factor and Na+/H+ exchanger-1 in esophageal epitheial defense against acid-induced injury. Am J Physiol 2006; 290: G665-G673.
16. Naito Y, Uchiyama K, Kuroda M, et al. Role of pancreatic trypsin in chronic esophagitis induced by gastroduodenal reflux in rats. J Gastroenterol 2006; 41: 198-208.
17. Lillemoe KD, Johnson LF, Harmon JW. Alkaline esophagitis: a comparison of the ability of components of the gastroduodenal contents to injure the rabbit esophagus. Gastroenterology 1983; 85: 621-628.
18. Poplawski C, Sosnowski D, Szaflarska-Poplawska A, Sarosiek J, McCallum R, Bartuzi Z. Role of bile acids, prostaglandins and COX inhibitors in chronic esophagitis in a mouse model. World J Gastroenterol 2006; 12: 1739-1742.
19. Konturek SJ, Zayachkivska O, Havryluk XO, et al. Protective influence of melatonin against acute esophageal lesions involves prostaglandins, nitric oxide and sensory nerves. J Physiol Pharmacol 2007; 58: 371-387.
20. Armstrong HP, Blower AL. Non-steroidal anti-inflammatory drugs and life-threatening complications of peptic ulceration. Gut 1987; 28: 527-532.
21. Kikendall JW, Friedman AC, Oyewole MA, Fleischer D, Johnson LF. Pill-induced esophageal injury: case reports and review of the medical literature. Dig Dis Sci 1983; 28: 174-181.
22. Heller SR, Fellows IW, Ogilvie AL, Atkinson M. Nonsteroidal antiinflammatory drugs and benign oesophageal stricture. Br Med J 1982; 285: 167-168.
23. Safaie-Shirazi S, Zike WL, Brubacher M, DenBensten L. Effect of aspirin, alcohol, and pepsin on mucosal permeability of esophageal mucosa. Surg Forum 1974; 25: 335-337.
24. Carlsby B, Densert O. Esophageal lesions caused by orally administered drugs: an experimental study in the cat. Eur Surg Res 1980; 12: 270-282.
25. Lanas A, Hirschowitz BI. Significant role of aspirin use in patients with esophagitis. J Clin Gastroenterol 1991; 13: 622-627.
26. Konturek PC, Konturek SJ, Brzozowski T. Helicobacter pylori infection in gastric cancerogensesis. J Physiol Pharmacol 2009; 60: 3-21.
27. Wallace JL, Reuter B, Cicala C, McKnight W, Grishman M, Cirino G. A diclofenac derivative without ulcerogenic properties. Eur J Pharmacol 1994; 257: 249-255.
28. Elliott SN, McKnight W, Cirino G, Wallace JL. A nitric oxide-releasing non steroidal anti-inflammatory drug accelerates gastric ulcer healing in rats. Gastroenterology 1995; 109: 524-530.
29. Davies NM, Rosenth AG, Appleyard CB, et al. NO-naproxen vs. naproxen: ulcerogeniic, analgesic and anti-inflammatory effects. Aliment Pharmacol Ther 1997; 11: 69-79.
30. Tashima K, Fujita A, Umeda M, Takeuchi K. Lack of gastric toxicity of nitric oxide-releasing aspirin, NCX-4026, in the stomach of diabetic rats. Life Sci 2000; 67: 1639-1652.
31. Brzozowski T, Konturek PC, Konturek SJ, Sliwowski Z, Drozdowicz D., Kwiecien S. Gastroprotective and ulcer healing effects of nitric oxide-releasing non-steroidal antiinflammatory drugs. Dig Liver Dis 2000; 32: 583-594.
32. Fiorucci S, Santucci C, Gresele P, Del Soldato P, Morelli A. Gastrointestinal safety of NO-aspirin (NCX-4016) in healthy human volunteers; a proof of concept endoscopic study. Gastroenterology 2003; 124: 600-607.
33. Burgaud JL, Ongini E, Del Soldato P. Nitric oxide-releasing drugs: a novel class of effective and safe therapeutic agents. Ann NY Acad Sci 2002; 962: 360-371.
34. Brzozowski T, Konturek PC, Konturek SJ. Nitric oxidereleasing agents-a new generation of drugs for gastrointestinal diseases. Front Gastrointest Res 2002; 25: 158-165.
35. Brzozowska I, Targosz A, Sliwowski Z, et al. Healing of chronic gastric ulcers in diabetic rats treated with native aspirin, nitric oxide (NO)-derivative of aspirin and cyclooxygenase (COX)-2 inhibitor. J Physiol Pharmacol 2004; 55: 773-790.
36. Lee M, Aldred K, Lee E, Feldman M. Aspirin-induced acute gastric mucosal injury is a neutrophil-dependent process in rats. Am J Physiol 1992; 263: G920-G926.
37. Elliott SN, McKnight W, Cirino G, Wallace JL. A nitric oxide-releasing non steroidal anti-inflammatory drug accelerates gastric ulcer healing in rats. Gastroenterology 1995; 109: 524-530.
38. Omura N, Kashiwagi H, Chen G, Suzuki Y, Yano F, Aoki T. Establishment of surgically induced chronic acid reflux esophagitis in rats. Scand J Gastroenterol 1999; 34: 948-953.
39. Brzozowski T, Konturek PC, Konturek SJ, et al. Role of prostaglandins generated by cyclooxygenase-1 and cyclooxygenase-2 in healing of ischemia-reperfusioninduced gastric lesions. Eur J Pharmacol 1999; 385: 47-61.
40. Konturek SJ, Konturek PC, Brzozowski T. Role of prostaglandins in ulcer healing. J Physiol Pharmacol 2005; 56: 33-56.
41. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinum thiocyanate-phenolcholroform extraction. Anal Biochem 1987; 162: 156-159.
42. Essen G. The epidemiology of gastroesophageal reflux disease: what we know and what we need to know. Am J Gastroenterol 2001; 96 (Suppl. 8): S16-S18.
43. El-Searag HB. Time trends of gastroesophageal reflux disease: a systemic review. Clin Gastroenterol Hepatol 2007; 5: 17-26.
44. Wallace JL, McKnight W, Miyasaka M, et al. Role of endothelial adhesion molecules in NSAID-induced gastric mucosal injury. Am J Physiol 1993; 265: G993-G998.
45. Hamaguchi M, Fujiwara Y, Takashima T, et al. Increased expression of cytokines and adhesion molecules in rat chronic esophagitis. Digestion 2003; 68: 189-197.
46. Yamaguchi T, Yoshida N, Tomatsuri N, et al. Cytokineinduced neutrophil accumulation in the pathogenesis of acute reflux esophagitis in rats. Int J Mol Med 2005; 16: 71-77.
47. Wallace JL, McKnight W, Reuter B, Vergnolle N. NSAIDinduced gastric damage in rats: Requirement for inhibition of both cyclooxygenase 1 and 2. Gastroenterology 2000; 119: 706-714.
48. Hayakawa T, Fujiwara Y, Hamaguchi M, et al. Roles of cyclooxygenase 2 and microsomal prostaglandin E synthase 1 in rat acid reflux oesophagitis. Gut 2006; 55: 450-456.
49. Majka J, Rembiasz K, Migaczewski M, et al. Cyclooxygenase- 2 (COX-2) is the key event in pathophysiology of Barrett's esophagus. Lesson from experimental animal model and human subjects. J Physiol Pharmacol 2010; 61: 409-418.
50. Brzozowski T, Konturek PC, Konturek SJ, et al. Implications of reactive oxygen species and cytokines in gastroprotection against stress-induced gastric damage by nitric oxide releasing aspirin. Int J Colorectal Dis 2003; 18: 320-329.