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Volumn 37, Issue 6, 2012, Pages 729-732

Thrombopoietin receptor agonists in refractory immune thrombocytopenia: Differential responses to eltrombopag and romiplostim: A case report and possible explanations

Author keywords

eltrombopag; immune thrombocytopenia; romiplostim

Indexed keywords

ASPARTATE AMINOTRANSFERASE; AZATHIOPRINE; CORTICOSTEROID; ELTROMBOPAG; IMMUNOGLOBULIN; PREDNISOLONE; ROMIPLOSTIM;

EID: 84868358231     PISSN: 02694727     EISSN: 13652710     Source Type: Journal    
DOI: 10.1111/j.1365-2710.2012.01353.x     Document Type: Article
Times cited : (21)

References (30)
  • 1
    • 75649104701 scopus 로고    scopus 로고
    • International consensus report on the investigation and management of primary immune thrombocytopenia
    • Provan D, Stasi R, Newland AC, et al. International consensus report on the investigation and management of primary immune thrombocytopenia. Blood, 2010; 115: 168-186.
    • (2010) Blood , vol.115 , pp. 168-186
    • Provan, D.1    Stasi, R.2    Newland, A.C.3
  • 2
    • 33746642069 scopus 로고    scopus 로고
    • Management of patients with refractory immune thrombocytopenic purpura
    • George JN,. Management of patients with refractory immune thrombocytopenic purpura. J Thromb Haemost, 2006; 4: 1664-1672.
    • (2006) J Thromb Haemost , vol.4 , pp. 1664-1672
    • George, J.N.1
  • 3
    • 0029090437 scopus 로고
    • Thrombopoietin: The primary regulator of megakaryocyte and platelet production
    • Kaushansky K,. Thrombopoietin: the primary regulator of megakaryocyte and platelet production. Thromb Haemost, 1995; 74: 521-525.
    • (1995) Thromb Haemost , vol.74 , pp. 521-525
    • Kaushansky, K.1
  • 4
    • 34249733156 scopus 로고    scopus 로고
    • New thrombopoietic growth factors
    • Kuter DJ,. New thrombopoietic growth factors. Blood, 2007; 109: 4607-4616.
    • (2007) Blood , vol.109 , pp. 4607-4616
    • Kuter, D.J.1
  • 5
    • 0036530040 scopus 로고    scopus 로고
    • Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor
    • Basser RL, O'Flaherty E, Green M, Edmonds M, Nichol J, Menchaca DM, et al. Development of pancytopenia with neutralizing antibodies to thrombopoietin after multicycle chemotherapy supported by megakaryocyte growth and development factor. Blood, 2002; 99: 2599-2602.
    • (2002) Blood , vol.99 , pp. 2599-2602
    • Basser, R.L.1    O'Flaherty, E.2    Green, M.3    Edmonds, M.4    Nichol, J.5    Menchaca, D.M.6
  • 6
    • 0035760892 scopus 로고    scopus 로고
    • Thrombocytopenia caused by the development of antibodies to thrombopoietin
    • Li J, Yang C, Xia Y, Bertino A, Glaspy J, Roberts M, Kuter DJ,. Thrombocytopenia caused by the development of antibodies to thrombopoietin. Blood, 2001; 98: 3241-3248.
    • (2001) Blood , vol.98 , pp. 3241-3248
    • Li, J.1    Yang, C.2    Xia, Y.3    Bertino, A.4    Glaspy, J.5    Roberts, M.6    Kuter, D.J.7
  • 7
    • 66749122752 scopus 로고    scopus 로고
    • Thrombopoietin and thrombopoietin mimetics in the treatment of thrombocytopenia
    • Kuter DJ,. Thrombopoietin and thrombopoietin mimetics in the treatment of thrombocytopenia. Annu Rev Med, 2009; 60: 193-206.
    • (2009) Annu Rev Med , vol.60 , pp. 193-206
    • Kuter, D.J.1
  • 8
    • 79251583872 scopus 로고    scopus 로고
    • Eltrombopag for management of chronic immune thrombocytopenia (RAISE): A 6-month, randomised, phase 3 study
    • Cheng G, Saleh MN, Marcher C, et al. Eltrombopag for management of chronic immune thrombocytopenia (RAISE): a 6-month, randomised, phase 3 study. Lancet, 2011; 377: 393-402.
    • (2011) Lancet , vol.377 , pp. 393-402
    • Cheng, G.1    Saleh, M.N.2    Marcher, C.3
  • 9
    • 38649120593 scopus 로고    scopus 로고
    • Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: A double-blind randomised controlled trial
    • Kuter DJ, Bussel JB, Lyons RM, et al. Efficacy of romiplostim in patients with chronic immune thrombocytopenic purpura: a double-blind randomised controlled trial. Lancet, 2008; 371: 395-403.
    • (2008) Lancet , vol.371 , pp. 395-403
    • Kuter, D.J.1    Bussel, J.B.2    Lyons, R.M.3
  • 10
    • 79955984501 scopus 로고    scopus 로고
    • The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia
    • Neunert C, Lim W, Crowther M, Cohen A, Solberg L Jr, Crowther MA,. The American Society of Hematology 2011 evidence-based practice guideline for immune thrombocytopenia. Blood, 2011; 117: 4190-4207.
    • (2011) Blood , vol.117 , pp. 4190-4207
    • Neunert, C.1    Lim, W.2    Crowther, M.3    Cohen, A.4    Solberg, Jr.L.5    Crowther, M.A.6
  • 11
    • 36549001698 scopus 로고    scopus 로고
    • Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura
    • Bussel JB, Cheng G, Saleh MN, et al. Eltrombopag for the treatment of chronic idiopathic thrombocytopenic purpura. N Engl J Med, 2007; 357: 2237-2247.
    • (2007) N Engl J Med , vol.357 , pp. 2237-2247
    • Bussel, J.B.1    Cheng, G.2    Saleh, M.N.3
  • 12
    • 33750035507 scopus 로고    scopus 로고
    • AMG 531, a thrombopoiesis-stimulating protein, for chronic ITP
    • Bussel JB, Kuter DJ, George JN, et al. AMG 531, a thrombopoiesis- stimulating protein, for chronic ITP. N Engl J Med, 2006; 355: 1672-1681.
    • (2006) N Engl J Med , vol.355 , pp. 1672-1681
    • Bussel, J.B.1    Kuter, D.J.2    George, J.N.3
  • 13
    • 63849111465 scopus 로고    scopus 로고
    • Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP
    • Bussel JB, Kuter DJ, Pullarkat V, Lyons RM, Guo M, Nichol JL,. Safety and efficacy of long-term treatment with romiplostim in thrombocytopenic patients with chronic ITP. Blood, 2009; 113: 2161-2171.
    • (2009) Blood , vol.113 , pp. 2161-2171
    • Bussel, J.B.1    Kuter, D.J.2    Pullarkat, V.3    Lyons, R.M.4    Guo, M.5    Nichol, J.L.6
  • 14
    • 60249099882 scopus 로고    scopus 로고
    • Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: A randomised, double-blind, placebo-controlled trial
    • Bussel JB, Provan D, Shamsi T, et al. Effect of eltrombopag on platelet counts and bleeding during treatment of chronic idiopathic thrombocytopenic purpura: a randomised, double-blind, placebo-controlled trial. Lancet, 2009; 373: 641-648.
    • (2009) Lancet , vol.373 , pp. 641-648
    • Bussel, J.B.1    Provan, D.2    Shamsi, T.3
  • 16
    • 36148972012 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of AMG 531, a thrombopoiesis- stimulating peptibody, in healthy Japanese subjects: A randomized, placebo-controlled study
    • Kumagai Y, Fujita T, Ozaki M, et al. Pharmacodynamics and pharmacokinetics of AMG 531, a thrombopoiesis-stimulating peptibody, in healthy Japanese subjects: a randomized, placebo-controlled study. J Clin Pharmacol, 2007; 47: 1489-1497.
    • (2007) J Clin Pharmacol , vol.47 , pp. 1489-1497
    • Kumagai, Y.1    Fujita, T.2    Ozaki, M.3
  • 17
    • 33750051618 scopus 로고    scopus 로고
    • An open-label, unit dose-finding study of AMG 531, a novel thrombopoiesis-stimulating peptibody, in patients with immune thrombocytopenic purpura
    • Newland A, Caulier MT, Kappers-Klunne M, et al. An open-label, unit dose-finding study of AMG 531, a novel thrombopoiesis-stimulating peptibody, in patients with immune thrombocytopenic purpura. Br J Haematol, 2006; 135: 547-553.
    • (2006) Br J Haematol , vol.135 , pp. 547-553
    • Newland, A.1    Caulier, M.T.2    Kappers-Klunne, M.3
  • 18
    • 0030773876 scopus 로고    scopus 로고
    • Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine
    • Cwirla SE, Balasubramanian P, Duffin DJ, et al. Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine. Science, 1997; 276: 1696-1699.
    • (1997) Science , vol.276 , pp. 1696-1699
    • Cwirla, S.E.1    Balasubramanian, P.2    Duffin, D.J.3
  • 19
    • 10044296968 scopus 로고    scopus 로고
    • Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand
    • Wang B, Nichol JL, Sullivan JT,. Pharmacodynamics and pharmacokinetics of AMG 531, a novel thrombopoietin receptor ligand. Clin Pharmacol Ther, 2004; 76: 628-638.
    • (2004) Clin Pharmacol Ther , vol.76 , pp. 628-638
    • Wang, B.1    Nichol, J.L.2    Sullivan, J.T.3
  • 20
    • 0028820319 scopus 로고
    • Regulation of platelet activation in vitro by the c-Mpl ligand, thrombopoietin
    • Chen J, Herceg-Harjacek L, Groopman JE, Grabarek J,. Regulation of platelet activation in vitro by the c-Mpl ligand, thrombopoietin. Blood, 1995; 86: 4054-4062.
    • (1995) Blood , vol.86 , pp. 4054-4062
    • Chen, J.1    Herceg-Harjacek, L.2    Groopman, J.E.3    Grabarek, J.4
  • 21
    • 0036325620 scopus 로고    scopus 로고
    • Thrombopoietin, but not cytokines binding to gp130 protein-coupled receptors, activates MAPKp42/44, AKT, and STAT proteins in normal human CD34+ cells, megakaryocytes, and platelets
    • Majka M, Ratajczak J, Villaire G, Kubiczek K, Marquez LA, Janowska-Wieczorek A, Ratajczak MZ, et al. Thrombopoietin, but not cytokines binding to gp130 protein-coupled receptors, activates MAPKp42/44, AKT, and STAT proteins in normal human CD34+ cells, megakaryocytes, and platelets. Exp Hematol, 2002; 30: 751-760.
    • (2002) Exp Hematol , vol.30 , pp. 751-760
    • Majka, M.1    Ratajczak, J.2    Villaire, G.3    Kubiczek, K.4    Marquez, L.A.5    Janowska-Wieczorek, A.6    Ratajczak, M.Z.7
  • 22
    • 0033532069 scopus 로고    scopus 로고
    • Thrombopoietin signal transduction requires functional JAK2, not TYK2
    • Drachman JG, Millett KM, Kaushansky K,. Thrombopoietin signal transduction requires functional JAK2, not TYK2. J Biol Chem, 1999; 274: 13480-13484.
    • (1999) J Biol Chem , vol.274 , pp. 13480-13484
    • Drachman, J.G.1    Millett, K.M.2    Kaushansky, K.3
  • 23
    • 0028827190 scopus 로고
    • Thrombopoietin, c-Mpl ligand, induces tyrosine phosphorylation of Tyk2, JAK2, and STAT3, and enhances agonists-induced aggregation in platelets in vitro
    • Ezumi Y, Takayama H, Okuma M,. Thrombopoietin, c-Mpl ligand, induces tyrosine phosphorylation of Tyk2, JAK2, and STAT3, and enhances agonists-induced aggregation in platelets in vitro. FEBS Lett, 1995; 374: 48-52.
    • (1995) FEBS Lett , vol.374 , pp. 48-52
    • Ezumi, Y.1    Takayama, H.2    Okuma, M.3
  • 24
    • 0033566712 scopus 로고    scopus 로고
    • Thrombopoietin-induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: Role in endomitosis
    • Rojnuckarin P, Drachman JG, Kaushansky K,. Thrombopoietin-induced activation of the mitogen-activated protein kinase (MAPK) pathway in normal megakaryocytes: role in endomitosis. Blood, 1999; 94: 1273-1282.
    • (1999) Blood , vol.94 , pp. 1273-1282
    • Rojnuckarin, P.1    Drachman, J.G.2    Kaushansky, K.3
  • 25
    • 0346881171 scopus 로고    scopus 로고
    • AMG531 stimulates megakaryopoiesis in vitro by binding to Mpl
    • Broudy VC, Lin NL,. AMG531 stimulates megakaryopoiesis in vitro by binding to Mpl. Cytokine, 2004; 25: 52-60.
    • (2004) Cytokine , vol.25 , pp. 52-60
    • Broudy, V.C.1    Lin, N.L.2
  • 26
    • 4444269330 scopus 로고    scopus 로고
    • Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice
    • Chen J, De S, Damron DS, Chen WS, Hay N, Byzova TV,. Impaired platelet responses to thrombin and collagen in AKT-1-deficient mice. Blood, 2004; 104: 1703-1710.
    • (2004) Blood , vol.104 , pp. 1703-1710
    • Chen, J.1    De, S.2    Damron, D.S.3    Chen, W.S.4    Hay, N.5    Byzova, T.V.6
  • 27
    • 1542317617 scopus 로고    scopus 로고
    • Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2
    • Woulfe D, Jiang H, Morgans A, Monks R, Birnbaum M, Brass LF,. Defects in secretion, aggregation, and thrombus formation in platelets from mice lacking Akt2. J Clin Invest, 2004; 11: 441-450.
    • (2004) J Clin Invest , vol.11 , pp. 441-450
    • Woulfe, D.1    Jiang, H.2    Morgans, A.3    Monks, R.4    Birnbaum, M.5    Brass, L.F.6
  • 28
    • 79955820299 scopus 로고    scopus 로고
    • Population pharmacokinetics of eltrombopag in healthy subjects and patients with chronic idiopathic thrombocytopenic purpura
    • Gibiansky E, Zhang J, Williams D, Wang Z, Ouellet D,. Population pharmacokinetics of eltrombopag in healthy subjects and patients with chronic idiopathic thrombocytopenic purpura. J Clin Pharmacol, 2011; 51: 842-856.
    • (2011) J Clin Pharmacol , vol.51 , pp. 842-856
    • Gibiansky, E.1    Zhang, J.2    Williams, D.3    Wang, Z.4    Ouellet, D.5
  • 29
    • 80053235106 scopus 로고    scopus 로고
    • Population PK/PD modeling of eltrombopag in healthy volunteers and patients with immune thrombocytopenic purpura and optimization of response-guided dosing
    • Hayes S, Ouellet D, Zhang J, Wire MB, Gibiansky E,. Population PK/PD modeling of eltrombopag in healthy volunteers and patients with immune thrombocytopenic purpura and optimization of response-guided dosing. J Clin Pharmacol, 2011; 51: 1403-1417.
    • (2011) J Clin Pharmacol , vol.51 , pp. 1403-1417
    • Hayes, S.1    Ouellet, D.2    Zhang, J.3    Wire, M.B.4    Gibiansky, E.5
  • 30
    • 70449704426 scopus 로고    scopus 로고
    • Evaluation of bone marrow reticulin formation in chronic immune thrombocytopenia patients treated with romiplostim
    • Kuter DJ, Mufti GJ, Bain BJ, Hasserjian RP, Davis W, Rutstein M,. Evaluation of bone marrow reticulin formation in chronic immune thrombocytopenia patients treated with romiplostim. Blood, 2009; 114: 3748-3756.
    • (2009) Blood , vol.114 , pp. 3748-3756
    • Kuter, D.J.1    Mufti, G.J.2    Bain, B.J.3    Hasserjian, R.P.4    Davis, W.5    Rutstein, M.6


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