Gastric secretion

Current Opinion in Gastroenterology

Volumn 28, Issue 6, 2012, Pages 587-593

  Chu, Shijian ^a   Schubert, Mitchell L ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

acid secretion; gastrin; histamine; proton pump; review

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM); ADENYLATE CYCLASE; APELIN; CALCIUM; CHROMOGRANIN A; CYANOCOBALAMIN; EPIDERMAL GROWTH FACTOR RECEPTOR; GASTRIN; GHRELIN; GLUTAMIC ACID; HEPCIDIN; HISTAMINE; HYDROCHLORIC ACID; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; IRON; METHIONINE; MITOGEN ACTIVATED PROTEIN KINASE; PEPSINOGEN I; PEPSINOGEN II; POTASSIUM CHANNEL;

ACHLORHYDRIA; ACID SECRETION; APICAL MEMBRANE; ATROPHIC GASTRITIS; ATROPHY; BACTERIAL ARTIFICIAL CHROMOSOME; BACTERIAL OVERGROWTH; BACTERIAL PERITONITIS; BONE DENSITY; BONE MINERAL; COMMUNITY ACQUIRED PNEUMONIA; FALSE POSITIVE RESULT; HELICOBACTER PYLORI; HUMAN; INTESTINE INFECTION; IRON ABSORPTION; NEUROENDOCRINE SYSTEM; NEUROENDOCRINE TUMOR; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PATHOGENICITY ISLAND; PERNICIOUS ANEMIA; PROTEIN EXPRESSION; PROTEIN PROCESSING; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STOMACH ACID SECRETION; STOMACH EMPTYING; STOMACH PH; STOMACH SECRETION; TYPE IV SECRETION SYSTEM;

GASTRIC ACID; GASTRIC MUCOSA; HUMANS; NEUROSECRETORY SYSTEMS; STOMACH;

EID: 84868346385     PISSN: 02671379     EISSN: 15317056     Source Type: Journal    
DOI: 10.1097/MOG.0b013e328358e5cc     Document Type: Review

References (108)

1. Choi EJ, Lee HJ, Kim KO, et al. Association between acid suppressive therapy and spontaneous bacterial peritonitis in cirrhotic patients with ascites. Scand J Gastroenterol 2011; 46:616-620.
2. Pali-Scholl I, Jensen-Jarolim E. Antiacid medication as a risk factor for food allergy. Allergy 2011; 66:469-477.
3. Maloum F, Allaire JM, Gagne-Sansfacon J, et al. Epithelial BMP signaling is required for proper specification of epithelial cell lineages and gastric endocrine cells. Am J Physiol Gastrointest Liver Physiol 2011; 300:G1065-G1079.
4. Goebel M, Stengel A, Lambrecht NWG, Sachs G. Selective gene expression by rat gastric corpus epithelium. Physiol Genomics 2011; 43:237-254.
5. Gustafsson BI, Bakke I, Hauso O, et al. Parietal cell activation by arborization of ECL cell cytoplasmic projections is likely the mechanism of histamine induced secretion of hydrochloric acid. Scand J Gastroenterol 2011; 46: 531-537.
6. Liu C, Chen J, Guo Y, et al. The expression of PTHLH in human gastric mucosa enterochromaffin-like cells. Digest Dis Sci 2011; 56:993-998.
7. Fourmy D, Gigoux V, Reubi JC. Gastrin in gastrointestinal diseases. Gastroenterology 2011; 141:814-818.
8. Calatayud S, Alvarez A, Victor VM. Gastrin: an acid-releasing, proliferative and immunomodulatory peptide? Min Rev Med Chem 2010; 10:8-19.
9. De DD, Bhattacharjya S, Maitra M, et al. IL1B induced Smad 7 negatively regulates gastrin expression. PLoS One 2011; 6:e14775.
10. Takahashi H, Nakanuma Y, Matsuoka T, et al. Role of indigenous lactobacilli in gastrin-mediated acid production in the mouse stomach. Appl Environ Microbiol 2011; 77:6964-6971.
11. Takaishi S, Shibata W, Tomita H, et al. In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice. Am J Physiol Gastrointest Liver Physiol 2011; 300:G334-G344.
12. Buchan AMJ, Squires PE, Ring M, Meloche RM. Mechanism of action of the calcium-sensing receptor in human antral gastrin cells. Gastroenterology 2001; 120:1128-1139.
13. Feng J, Petersen CD, Coy DH, et al. Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion. Proc Nat Acad Sci U S A 2010; 107:17791-17796.
14. Haid D, Widmayer P, Breer H. Nutrient sensing receptors in gastric endocrine cells. J Mol Histol 2011; 42:355-364.
15. Mensah-Osman EJ, Veniaminova NA, Merchant JL. Menin and JunD regulate gastrin gene expression through proximal DNA elements. Am J Physiol Gastrointest Liver Physiol 2011; 301:G783-G790.
16. Kovac S, Anderson GJ, Baldwin GS. Gastrins, iron homeostasis and colorectal cancer. Biochem Biophys Acta 2011; 1813:889-895.
17. Schwarz P, Kubler JAM, Strnad P, et al. Hepcidin is localized in gastric parietal cells, regulates acid secretion, and is induced by Helicobacter pylori infection. Gut 2012; 61:193-201.
18. Kovac S, Anderson GJ, Alexander WS, et al. Gastrin-deficient mice have disturbed hematopoiesis in response to iron deficiency. Endocrinology 2011; 152:3062-3073.
19. Kovac S, Smith K, Anderson GJ, et al. Interrelationships between circulating gastrin and iron status in mice and humans. Am J Physiol Gastrointest Liver Physiol 2008; 295:G855-G861.
20. Jeffery P, McDonald V, Tippett E, McGuckin M. Ghrelin in gastrointestinal disease. Mol Cell Endocrinol 2011; 340:35-43.
21. Sahin I, Aydin S, Ozkan Y, et al. Diet-induced obesity suppresses ghrelin in rat gastrointestinal tract and serum. Mol Cell Biochem 2011; 355:299-308.
22. Stengel A, Tache Y. Interaction between gastric and upper small intestinal hormones in the regulation of hunger and satiety: ghrelin and cholecystokinin take the central stage. Curr Protein Peptide Sci 2011; 12:293-304.
23. Garner AL, Janda KD. Shedding light on the ghrelin/GOAT metabolism saga. Chembiochem 2011; 12:523-525.
24. Sakurada T, Ro S, Onouchi T, et al. Comparison of the actions of acylated and deacylated ghrelin on acid secretion in the rat stomach. J Gastroenterol 2010; 45:1111-1120.
25. Yakabi K, Noguchi M, Ohno S, et al. Urocortin 1 reduces food intake and ghrelin secretion via CRF2 receptors. Am J Physiol Endocrinol Metab 2011; 301:E72-E82.
26. Strickertsson JAB, Kossing KBV, Aabakke AJM, et al. Interferon-g inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism. World J Gastroenterol 2011; 17:3117-3125.
27. Maksud FAN, Alves JS, Diniz MTC, Barbosa AJA. Density of ghrelin-producing cells is higher in the gastric mucosa of morbidly obese patients. Eur J Endocrinol 2011; 165:57-62.
28. Ohno S, Yakabi K, Ro S, et al. Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs. Regul Pept 2012; 174:71-78.
29. Lu YX, Germano P, Ohning GV, et al. PAC1 deficiency in a murine model induces gastric mucosa hypertrophy and higher basal gastric acid output. J Mol Neurosci 2011; 43:76-84.
30. Nakamura E, Hasumura M, Uneyama H, Torii K. Luminal amino acid-sensing cells in gastric mucosa. Digestion 2011; 83:13-18.
31. Zolotarev V, Khropycheva R, Uneyama H, Torii K. Effect of free dietary glutamate on gastric acid secretion in dogs. Ann NY Acad Sci 2009; 1170:87-90.
32. Malfertheiner P. The intriguing relationship of Helicobacter pylori infection and acid secretion in peptic ulcer disease and gastric cancer. Dig Dis 2011; 29:459-464.
33. Wiedemann T, Hofbaur S, Tegtmeyer N, et al. Helicobacter pylori CagL dependent induction of gastrin expression via a novel avb5-integrin-integrin linked kinase signalling complex. Gut 2012; 61:986-996.
34. Cover TL. Role of Helicobacter pylori CagL in modulating gastrin secretion. Gut 2012; 1:965-966.
35. 2+. PLoS One 2011; 6:e19638.
36. Jones MK, Zhu E, Sarino EV, et al. Loss of parietal cell superoxide dismutase leads to gastric oxidative stress and increased injury susceptibility in mice. Am J Physiol Gastrointest Liver Physiol 2011; 301:G537-G546.
37. Aoyama F, Sawaguchi A. Functional transformation of gastric parietal cells and intracellular trafficking of ion channels/transporters in the apical canalicular membrane associated with acid secretion. Biol Pharm Bull 2011; 34:813-816.
38. Suda J, Zhu LX, Okamoto CT, Karvar S. Rab27b localizes to the tubulovesicle membranes of gastric parietal cells and regulates acid secretion. Gastroenterology 2011; 140:868-878.
39. +-ATPase beta-subunit deficient mice. J Cell Biochem 2012; 113:141-147.
40. +-ATPasemediated proton transport in the rat parietal cell. Pflugers Arch Eur J Physiol 2012; 463:419-427.
41. He W, Liu W, Chew CS, et al. Acid secretion-associated translocation of KCNJ15 in gastric parietal cells. Am J Physiol Gastrointest Liver Physiol 2011; 301:G591-G600.
42. Song P, Groos S, Riederer B, et al. Kir4.1 channel expression is essential for parietal cell control of acid secretion. J Biol Chem 2012; 286:14120-14128.
43. +-Cl- cotransporters in the acid secretory mechanism of gastric parietal cells. Biol Pharm Bull 2011; 34:810-812.
44. + channel Kca3.1 as a determinant of gastric acid secretion. Cell Physiol Biochem 2011; 27:597-604.
45. Metz DC. The diagnosis of ZollingerYEllison syndrome. Clin Gastroenterol Hepatol 2012; 10:126-130.
46. Rehfeld JF, Gingras MH, Bardram L, et al. The ZollingerYEllison syndrome and mismeasurement of gastrin. Gastroenterology 2011; 140:1444-1453.
47. Pritchard DM. ZollingerYEllison syndrome: still a diagnostic challenge in the 21st century? Gastroenterology 2011; 140:1380-1383.
48. Johnson AH, Assaad FN, Rehfeld JF. Competitive solid-phase immunoassay of gastrin in serum using time-resolved fluorometry. Scand J Clin Lab Invest 2011; 71:216-220.
49. Ojeaburu JV, Ito T, Crafa P, et al. Mechanism of acid hypersecretion post curative gastrinoma resection. Digest Dis Sci 2011; 56:139-154.
50. Pregun I, Herszenyi L, Juhasz M, et al. Effect of proton-pump inhibitor therapy on serum chromogranin A level. Digestion 2011; 84:22-28.
51. Agreus L, Kuipers EJ, Kupcinskas L, et al. Rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma markers. Scand J Gastroenterol 2012; 47:136-147.
52. Kikuchi R, Abe Y, Iijima K, et al. Low serum levels of pepsinogen and gastrin 17 are predictive of extensive gastric atrophy with high-risk of early gastric cancer. Tohoku J Exp Med 2011; 223:35-44.
53. He CY, Sun LP, Gong YH, et al. Serum pepsinogen II: a neglected but useful biomarker to differentiate between diseased and normal stomachs. J Gastroenterol Hepatol 2011; 26:1039-1046.
54. Gatta L, Di Mario F, Vaira D, et al. Quantification of serum levels of pepsinogens and gastrin to assess eradication of Helicobacter pylori. Clin Gastroenterol Hepatol 2011; 9:440-442.
55. Choi EJ, Lee HJ, Kim KO, et al. Association between acid suppressive therapy and spontaneous bacterial peritonitis in cirrhotic patients with ascites. Scand J Gastroenterol 2011; 46:616-620.
56. Pali-Scholl I, Jensen-Jarolim E. Antiacid medication as a risk factor for food allergy. Allergy 2011; 66:469-477.
57. Maloum F, Allaire JM, Gagne-Sansfacon J, et al. Epithelial BMP signaling is required for proper specification of epithelial cell lineages and gastric endocrine cells. Am J Physiol Gastrointest Liver Physiol 2011; 300:G1065-G1079.
58. Goebel M, Stengel A, Lambrecht NWG, Sachs G. Selective gene expression by rat gastric corpus epithelium. Physiol Genomics 2011; 43:237-254.
59. Gustafsson BI, Bakke I, Hauso O, et al. Parietal cell activation by arborization of ECL cell cytoplasmic projections is likely the mechanism of histamine induced secretion of hydrochloric acid. Scand J Gastroenterol 2011; 46: 531-537.
60. Liu C, Chen J, Guo Y, et al. The expression of PTHLH in human gastric mucosa enterochromaffin-like cells. Digest Dis Sci 2011; 56:993-998.
61. Fourmy D, Gigoux V, Reubi JC. Gastrin in gastrointestinal diseases. Gastroenterology 2011; 141:814-818.
62. Calatayud S, Alvarez A, Victor VM. Gastrin: an acid-releasing, proliferative and immunomodulatory peptide? Min Rev Med Chem 2010; 10:8-19.
63. De DD, Bhattacharjya S, Maitra M, et al. IL1B induced Smad 7 negatively regulates gastrin expression. PLoS One 2011; 6:e14775.
64. Takahashi H, Nakanuma Y, Matsuoka T, et al. Role of indigenous lactobacilli in gastrin-mediated acid production in the mouse stomach. Appl Environ Microbiol 2011; 77:6964-6971.
65. Takaishi S, Shibata W, Tomita H, et al. In vivo analysis of mouse gastrin gene regulation in enhanced GFP-BAC transgenic mice. Am J Physiol Gastrointest Liver Physiol 2011; 300:G334-G344.
66. Buchan AMJ, Squires PE, Ring M, Meloche RM. Mechanism of action of the calcium-sensing receptor in human antral gastrin cells. Gastroenterology 2001; 120:1128-1139.
67. Feng J, Petersen CD, Coy DH, et al. Calcium-sensing receptor is a physiologic multimodal chemosensor regulating gastric G-cell growth and gastrin secretion. Proc Nat Acad Sci U S A 2010; 107:17791-17796.
68. Haid D, Widmayer P, Breer H. Nutrient sensing receptors in gastric endocrine cells. J Mol Histol 2011; 42:355-364.
69. Mensah-Osman EJ, Veniaminova NA, Merchant JL. Menin and JunD regulate gastrin gene expression through proximal DNA elements. Am J Physiol Gastrointest Liver Physiol 2011; 301:G783-G790.
70. Kovac S, Anderson GJ, Baldwin GS. Gastrins, iron homeostasis and colorectal cancer. Biochem Biophys Acta 2011; 1813:889-895.
71. Schwarz P, Kubler JAM, Strnad P, et al. Hepcidin is localized in gastric parietal cells, regulates acid secretion, and is induced by Helicobacter pylori infection. Gut 2012; 61:193-201.
72. Kovac S, Anderson GJ, Alexander WS, et al. Gastrin-deficient mice have disturbed hematopoiesis in response to iron deficiency. Endocrinology 2011; 152:3062-3073.
73. Kovac S, Smith K, Anderson GJ, et al. Interrelationships between circulating gastrin and iron status in mice and humans. Am J Physiol Gastrointest Liver Physiol 2008; 295:G855-G861.
74. Jeffery P, McDonald V, Tippett E, McGuckin M. Ghrelin in gastrointestinal disease. Mol Cell Endocrinol 2011; 340:35-43.
75. Sahin I, Aydin S, Ozkan Y, et al. Diet-induced obesity suppresses ghrelin in rat gastrointestinal tract and serum. Mol Cell Biochem 2011; 355:299-308.
76. Stengel A, Tache Y. Interaction between gastric and upper small intestinal hormones in the regulation of hunger and satiety: ghrelin and cholecystokinin take the central stage. Curr Protein Peptide Sci 2011; 12:293-304.
77. Garner AL, Janda KD. Shedding light on the ghrelin/GOAT metabolism saga. Chembiochem 2011; 12:523-525.
78. Sakurada T, Ro S, Onouchi T, et al. Comparison of the actions of acylated and deacylated ghrelin on acid secretion in the rat stomach. J Gastroenterol 2010; 45:1111-1120.
79. Yakabi K, Noguchi M, Ohno S, et al. Urocortin 1 reduces food intake and ghrelin secretion via CRF2 receptors. Am J Physiol Endocrinol Metab 2011; 301:E72-E82.
80. Strickertsson JAB, Kossing KBV, Aabakke AJM, et al. Interferon-g inhibits ghrelin expression and secretion via a somatostatin-mediated mechanism. World J Gastroenterol 2011; 17:3117-3125.
81. Maksud FAN, Alves JS, Diniz MTC, Barbosa AJA. Density of ghrelin-producing cells is higher in the gastric mucosa of morbidly obese patients. Eur J Endocrinol 2011; 165:57-62.
82. Ohno S, Yakabi K, Ro S, et al. Apelin-12 stimulates acid secretion through an increase of histamine release in rat stomachs. Regul Pept 2012; 174:71-78.
83. Lu YX, Germano P, Ohning GV, et al. PAC1 deficiency in a murine model induces gastric mucosa hypertrophy and higher basal gastric acid output. J Mol Neurosci 2011; 43:76-84.
84. Nakamura E, Hasumura M, Uneyama H, Torii K. Luminal amino acid-sensing cells in gastric mucosa. Digestion 2011; 83:13-18.
85. Zolotarev V, Khropycheva R, Uneyama H, Torii K. Effect of free dietary glutamate on gastric acid secretion in dogs. Ann NY Acad Sci 2009; 1170:87-90.
86. Malfertheiner P. The intriguing relationship of Helicobacter pylori infection and acid secretion in peptic ulcer disease and gastric cancer. Dig Dis 2011; 29:459-464.
87. Wiedemann T, Hofbaur S, Tegtmeyer N, et al. Helicobacter pylori CagL dependent induction of gastrin expression via a novel avb5-integrin-integrin linked kinase signalling complex. Gut 2012; 61:986-996.
88. Cover TL. Role of Helicobacter pylori CagL in modulating gastrin secretion. Gut 2012; 1:965-966.
89. 2+. PLoS One 2011; 6:e19638.
90. Jones MK, Zhu E, Sarino EV, et al. Loss of parietal cell superoxide dismutase leads to gastric oxidative stress and increased injury susceptibility in mice. Am J Physiol Gastrointest Liver Physiol 2011; 301:G537-G546.
91. Aoyama F, Sawaguchi A. Functional transformation of gastric parietal cells and intracellular trafficking of ion channels/transporters in the apical canalicular membrane associated with acid secretion. Biol Pharm Bull 2011; 34:813-816.
92. Suda J, Zhu LX, Okamoto CT, Karvar S. Rab27b localizes to the tubulovesicle membranes of gastric parietal cells and regulates acid secretion. Gastroenterology 2011; 140:868-878.
93. +-ATPase beta-subunit deficient mice. J Cell Biochem 2012; 113:141-147.
94. +-ATPasemediated proton transport in the rat parietal cell. Pflugers Arch Eur J Physiol 2012; 463:419-427.
95. He W, Liu W, Chew CS, et al. Acid secretion-associated translocation of KCNJ15 in gastric parietal cells. Am J Physiol Gastrointest Liver Physiol 2011; 301:G591-G600.
96. Song P, Groos S, Riederer B, et al. Kir4.1 channel expression is essential for parietal cell control of acid secretion. J Biol Chem 2012; 286:14120-14128.
97. +-Cl- cotransporters in the acid secretory mechanism of gastric parietal cells. Biol Pharm Bull 2011; 34:810-812.
98. + channel Kca3.1 as a determinant of gastric acid secretion. Cell Physiol Biochem 2011; 27:597-604.
99. Metz DC. The diagnosis of ZollingerYEllison syndrome. Clin Gastroenterol Hepatol 2012; 10:126-130.
100. Rehfeld JF, Gingras MH, Bardram L, et al. The ZollingerYEllison syndrome and mismeasurement of gastrin. Gastroenterology 2011; 140:1444-1453.
101. Pritchard DM. ZollingerYEllison syndrome: still a diagnostic challenge in the 21st century? Gastroenterology 2011; 140:1380-1383.
102. Johnson AH, Assaad FN, Rehfeld JF. Competitive solid-phase immunoassay of gastrin in serum using time-resolved fluorometry. Scand J Clin Lab Invest 2011; 71:216-220.
103. Ojeaburu JV, Ito T, Crafa P, et al. Mechanism of acid hypersecretion post curative gastrinoma resection. Digest Dis Sci 2011; 56:139-154.
104. Pregun I, Herszenyi L, Juhasz M, et al. Effect of proton-pump inhibitor therapy on serum chromogranin A level. Digestion 2011; 84:22-28.
105. Agreus L, Kuipers EJ, Kupcinskas L, et al. Rationale in diagnosis and screening of atrophic gastritis with stomach-specific plasma markers. Scand J Gastroenterol 2012; 47:136-147.
106. Kikuchi R, Abe Y, Iijima K, et al. Low serum levels of pepsinogen and gastrin 17 are predictive of extensive gastric atrophy with high-risk of early gastric cancer. Tohoku J Exp Med 2011; 223:35-44.
107. He CY, Sun LP, Gong YH, et al. Serum pepsinogen II: a neglected but useful biomarker to differentiate between diseased and normal stomachs. J Gastroenterol Hepatol 2011; 26:1039-1046.
108. Gatta L, Di Mario F, Vaira D, et al. Quantification of serum levels of pepsinogens and gastrin to assess eradication of Helicobacter pylori. Clin Gastroenterol Hepatol 2011; 9:440-442.