PAC1 deficiency in a murine model induces gastric mucosa hypertrophy and higher basal gastric acid output

Journal of Molecular Neuroscience

Volumn 43, Issue 1, 2011, Pages 76-84

  Lu, Yuxin ^a,b   Germano, Patrizia ^a,b   Ohning, Gordon V ^a,b   Vu, John P ^a,b   Pisegna, Joseph R ^a,b  

^a VA GREATER LOS ANGELES HEALTHCARE SYSTEM   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Gastric acid secretion; PAC1 deficient; PACAP

Indexed keywords

DUAL SPECIFICITY PHOSPHATASE 2; GASTRIN; HYPOPHYSIS ADENYLATE CYCLASE ACTIVATING POLYPEPTIDE; VASOACTIVE INTESTINAL POLYPEPTIDE RECEPTOR 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL COUNT; CONTROLLED STUDY; GASTRIN BLOOD LEVEL; HUMAN; HYPERTROPHY; MALE; MORPHOLOGY; MOUSE; NONHUMAN; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; STIMULATION; STOMACH ACID SECRETION; STOMACH MUCOSA; STOMACH PARIETAL CELL; STOMACH SECRETION;

ANIMALS; BIOLOGICAL MARKERS; GASTRIC ACID; GASTRIC MUCOSA; GASTRINS; HYPERTROPHY; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; RATS; RECEPTORS, PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE, TYPE I;

MURINAE; MUS; RATTUS;

EID: 79951576724     PISSN: 08958696     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12031-010-9440-z     Document Type: Article

References (19)

1. EA Fradinger JA Tello JE Rivier NM Sherwood 2005 Characterization of four receptor cDNAs: PAC1, VPAC1, a novel PAC1 and a partial GHRH in zebrafish Mol Cell Endocrinol 231 1-2 49 63 1:CAS:528:DC%2BD2MXhtlOlsbs%3D 10.1016/j.mce.2004.12.002 15713535 (Pubitemid 40248816)
2. F Jamen K Persson G Bertrand, et al. 2000 PAC1 receptor-deficient mice display impaired insulinotropic response to glucose and reduced glucose tolerance J Clin Invest 105 9 1307 1315 1:CAS:528:DC%2BD3cXivFKgt78%3D 10.1172/JCI9387 10792006 (Pubitemid 30266084)
3. TJ Koh JR Goldenring S Ito, et al. 1997 Gastrin deficiency results in altered gastric differentiation and decreased colonic proliferation in mice Gastroenterology 113 3 1015 1025 1:CAS:528:DyaK2sXmt1Wjsb4%3D 10.1016/S0016-5085(97)70199-9 9287997 (Pubitemid 27381165)
4. NW Lambrecht I Yakubov D Scott G Sachs 2005 Identification of the K efflux channel coupled to the gastric H-K-ATPase during acid secretion Physiol Genomics 21 1 81 91 1:CAS:528:DC%2BD2MXjtFyhs74%3D 10.1152/physiolgenomics. 00212.2004 15613615 (Pubitemid 40898467)
5. JM Läuffer IM Modlin T Hinoue, et al. 1999 Pituitary adenylate cyclase-activating polypeptide modulates gastric enterochromaffin-like cell proliferation in rats Gastroenterology 116 3 623 635 10.1016/S0016-5085(99) 70184-8 10029621 (Pubitemid 29106770)
6. V Lelievre G Favrais C Abad, et al. 2007 Gastrointestinal dysfunction in mice with a targeted mutation in the gene encoding vasoactive intestinal polypeptide: a model for the study of intestinal ileus and Hirschsprung's disease Peptides 28 9 1688 1699 1:CAS:528:DC%2BD2sXhtVWms7nK 10.1016/j.peptides.2007.05.006 17606312 (Pubitemid 47361426)
7. SN Lieu DS Oh JR Pisegna PM Germano 2006 Neuroendocrine tumors express PAC1 receptors Ann NY Acad Sci 1070 399 404 1:CAS:528:DC%2BD28XpvVehur4%3D 10.1196/annals.1317.052 16888199 (Pubitemid 44126676)
8. E Lindström L Eliasson M Björkqvist R Håkanson 2001 Gastrin and the neuropeptide PACAP evoke secretion from rat stomach histamine-containing (ECL) cells by stimulating influx of Ca2+ through different Ca2+ channels J Physiol 535 Pt 3 663 677 10.1111/j.1469-7793.2001.00663.x 11559765 (Pubitemid 32894479)
9. JT McLaughlin W Ai NF Sinclair, et al. 2004 PACAP and gastrin regulate the histidine decarboxylase promoter via distinct mechanisms Am J Physiol Gastrointest Liver Physiol 286 1 G51 G59 1:CAS:528:DC%2BD2cXot1Wksw%3D%3D 10.1152/ajpgi.00169.2002 12816760
10. M Miampamba PM Germano S Arli HH Wong D Scott Y Taché JR Pisegna 2002 Expression of pituitary adenylate cyclase-activating polypeptide and PACAP type 1 receptor in the rat gastric and colonic myenteric neurons Regul Pept 105 3 145 154 1:CAS:528:DC%2BD38XivVShtb8%3D 11959368 (Pubitemid 34311862)
11. A Miyata A Arimura RR Dahl, et al. 1989 Isolation of a novel 38 residue-hypothalamic polypeptide which stimulates adenylate cyclase in pituitary cells Biochem Biophys Res Commun 164 1 567 574 1:CAS:528:DyaK3cXps1Y%3D 10.1016/0006-291X(89)91757-9 2803320 (Pubitemid 19269770)
12. DS Oh SN Lieu DJ Yamaguchi, et al. 2005 PACAP regulation of secretion and proliferation of pure populations of gastric ECL cells J Mol Neurosci 26 1 85 97 1:CAS:528:DC%2BD2MXmsVaku7o%3D 10.1385/JMN:26:1:085 15968088 (Pubitemid 41003429)
13. L Piqueras Y Taché V Martínez 2004 Peripheral PACAP inhibits gastric acid secretion through somatostatin release in mice Br J Pharmacol 142 1 67 78 1:CAS:528:DC%2BD2cXktFyqtLY%3D 10.1038/sj.bjp.0705739 15023860 (Pubitemid 38698195)
14. AK Sandvik G Cui I Bakke B Munkvold HL Waldum 2001 PACAP stimulates gastric acid secretion in the rat by inducing histamine release Am J Physiol Gastrointest Liver Physiol 281 4 G997 G1003 1:CAS:528:DC%2BD3MXnsFSksbg%3D 11557520
15. BA Schurizek LH Willacy K Kraglund F Andreasen B Juhl 1989 Effects of general anaesthesia with enflurane on antroduodenal motility, pH and gastric emptying rate in man Eur J Anaesthesiol 6 4 265 279 1:STN:280: DyaL1MzjvVeltQ%3D%3D 2759065 (Pubitemid 19183803)
16. F Sundler E Ekblad A Absood R Håkanson K Köves A Arimura 1992 Pituitary adenylate cyclase activating peptide: a novel vasoactive intestinal peptide-like neuropeptide in the gut Neuroscience 46 2 439 454 1:CAS:528:DyaK38Xht1Wht70%3D 10.1016/0306-4522(92)90064-9 1542417
17. N Zeng T Kang RM Lyu, et al. 1998 The pituitary adenylate cyclase activating polypeptide type 1 receptor (PAC1-R) is expressed on gastric ECL cells: evidence by immunocytochemistry and RT-PCR Ann NY Acad Sci 865 147 156 1:CAS:528:DyaK1MXmvFWmtw%3D%3D 10.1111/j.1749-6632.1998.tb11173.x 9928007 (Pubitemid 29047822)
18. N Zeng C Athmann T Kang, et al. 1999 PACAP type I receptor activation regulates ECL cells and gastric acid secretion J Clin Invest 104 10 1383 1391 1:CAS:528:DyaK1MXntlyru7c%3D 10.1172/JCI7537 10562300
19. CM Zhao V Martinez L Piqueras L Wang Y Taché D Chen 2008 Control of gastric acid secretion in somatostatin receptor 2 deficient mice: shift from endocrine/paracrine to neurocrine pathways Endocrinology 149 2 498 505 1:CAS:528:DC%2BD1cXht1yqsbg%3D 10.1210/en.2007-0238 17974627 (Pubitemid 351159345)