Interrelationships between circulating gastrin and iron status in mice and humans

American Journal of Physiology - Gastrointestinal and Liver Physiology

Volumn 295, Issue 4, 2008, Pages

  Kovac, Suzana ^a   Smith, Kelly ^a   Anderson, Gregory J ^b   Burgess, John R ^c   Shulkes, Arthur ^a   Baldwin, Graham S ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b QIMR BERGHOFER MEDICAL RESEARCH INSTITUTE   (Australia)

^c ROYAL HOBART HOSPITAL   (Australia)

Author keywords

Anemia; Ferric; Hemochromatosis

Indexed keywords

CHOLECYSTOKININ B RECEPTOR; GASTRIN; HEPCIDIN; IRON; MESSENGER RNA; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; TRANSFERRIN;

ADULT; ARTICLE; BAGG ALBINO MOUSE; C57BL 6 MOUSE; CONCENTRATION (PARAMETERS); DUODENUM; FEEDING; FEMALE; GASTRIN BLOOD LEVEL; HOMEOSTASIS; HORMONE TRANSPORT; HUMAN; HUMAN TISSUE; HYPERGASTRINEMIA; INTESTINE ABSORPTION; IRON BLOOD LEVEL; IRON TRANSPORT; MALE; MOUSE; MOUSE STRAIN; MULTIPLE ENDOCRINE NEOPLASIA; NEWBORN; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN FUNCTION; REAL TIME POLYMERASE CHAIN REACTION; WILD TYPE;

ANIMALS; ANTIMICROBIAL CATIONIC PEPTIDES; CATION TRANSPORT PROTEINS; DUODENUM; FEMALE; FERRITINS; GASTRINS; HOMEOSTASIS; HUMANS; IRON; LIVER; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED; MULTIPLE ENDOCRINE NEOPLASIA TYPE 1; RECEPTOR, CHOLECYSTOKININ B; RNA, MESSENGER;

EID: 57349127252     PISSN: 01931857     EISSN: 15221547     Source Type: Journal    
DOI: 10.1152/ajpgi.90359.2008     Document Type: Article

References (40)

1. Allen KJ, Gurrin LC, Constantine CC, Osborne NJ, Delatycki MB, Nicoll AJ, McLaren CE, Bahlo M, Nisselle AE, Vulpe CD, Anderson GJ, Southey MC, Giles GG, English DR, Hopper JL, Olynyk JK, Powell LW, Gertig DM. Iron-overload-related disease in HFE hereditary hemochromatosis. N Engl J Med 358: 221-230, 2008.
2. Aly A, Shulkes A, Baldwin GS. Gastrins, cholecystokinins and gastrointestinal cancer. Biochim Biophys Acta 1704: 1-10, 2004.
3. Aly A, Shulkes A, Baldwin GS. Short term infusion of glycine-extended gastrin(17) stimulates both proliferation and formation of aberrant crypt foci in rat colonic mucosa. Int J Cancer 94: 307-313, 2001.
4. Anderson GJ, Frazer DM, McKie AT, Vulpe CD, Smith A. Mechanisms of haem and non-haem iron absorption: lessons from inherited disorders of iron metabolism. Biometals 18: 339-348, 2005.
5. Baird IM, Blackburn EK, Wilson GM. The pathogenesis of anaemia after partial gastrectomy. I. Development of anaemia in relation to time after operation, blood loss, and diet. Q J Med 28: 21-34, 1959.
6. Baldwin GS, Chandler R, Weinstock J. Binding of gastrin to gastric transferrin. FEBS Lett 205: 147-149, 1986.
7. Baldwin GS, Curtain CC, Sawyer WH. Selective, high-affinity binding of ferric ions by glycine-extended gastrin(17). Biochemistry 40: 10741-10746, 2001.
8. Brandi ML, Gagel RF, Angeli A, Bilezikian JP, Beck-Peccoz P, Bordi C, Conte-Devolx B, Falchetti A, Gheri RG, Libroia A, Lips CJ, Lombardi G, Mannelli M, Pacini F, Ponder BA, Raue F, Skogseid B, Tamburrano G, Thakker RV, Thompson NW, Tomassetti P, Tonelli F, Wells SA Jr, Marx SJ. Guidelines for diagnosis and therapy of MEN type 1 and type 2. J Clin Endocrinol Metab 86: 5658-5671, 2001.
9. Brookes MJ, Hughes S, Turner FE, Reynolds G, Sharma N, Ismail T, Berx G, McKie AT, Hotchin N, Anderson GJ, Iqbal T, Tselepis C. Modulation of iron transport proteins in human colorectal carcinogenesis. Gut 55: 1449-1460, 2006.
10. Burgess JR, Nord B, David R, Greenaway TM, Parameswaran V, Larsson C, Shepherd JJ, Teh BT. Phenotype and phenocopy: the relationship between genotype and clinical phenotype in a single large family with multiple endocrine neoplasia type 1 (MEN 1). Clin Endocrinol (Oxf) 53: 205-211, 2000.
11. Butterworth JR. Another important function for an old friend! The role of iron in colorectal carcinogenesis. Gut 55: 1384-1386, 2006.
12. Ciccotosto GD, McLeish A, Hardy KJ, Shulkes A. Expression, processing, and secretion of gastrin in patients with colorectal carcinoma. Gastroenterology 109: 1142-1153, 1995.
13. Collins JF, Franck CA, Kowdley KV, Ghishan FK. Identification of differentially expressed genes in response to dietary iron deprivation in rat duodenum. Am J Physiol Gastrointest Liver Physiol 288: G964-G971, 2005.
14. Dockray GJ, Varro A, Dimaline R, Wang T. The gastrins: their production and biological activities. Annu Rev Physiol 63: 119-139, 2001.
15. Frazer DM, Anderson GJ. The orchestration of body iron intake: how and where do enterocytes receive their cues? Blood Cells Mol Dis 30: 288-297, 2003.
16. Frazer DM, Wilkins SJ, Becker EM, Vulpe CD, McKie AT, Trinder D, Anderson GJ. Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats. Gastroenterology 123: 835-844, 2002.
17. Friis-Hansen L, Rieneck K, Nilsson HO, Wadstrom T, Rehfeld JF. Gastric inflammation, metaplasia, and tumor development in gastrin-deficient mice. Gastroenterology 131: 246-258, 2006.
18. Friis-Hansen L, Sundler F, Li Y, Gillespie PJ, Saunders TL, Greenson JK, Owyang C, Rehfeld JF, Samuelson LC. Impaired gastric acid secretion in gastrin-deficient mice. Am J Physiol Gastrointest Liver Physiol 274: G561-G568, 1998.
19. Golubov J, Flanagan P, Adams P. Inhibition of iron absorption by omeprazole in rat model. Dig Dis Sci 36: 405-408, 1991.
20. Hollande F, Imdahl A, Mantamadiotis T, Ciccotosto GD, Shulkes A, Baldwin GS. Glycine-extended gastrin acts as an autocrine growth factor in a nontransformed colon cell line. Gastroenterology 113: 1576-1588, 1997.
21. Leong WI, Bowlus CL, Tallkvist J, Lonnerdal B. DMT1 and FPN1 expression during infancy: developmental regulation of iron absorption. Am J Physiol Gastrointest Liver Physiol 285: G1153-G1161, 2003.
22. Longano SC, Knesel J, Howlett GJ, Baldwin GS. Interaction of gastrin with transferrin: effects of ferric ions. Arch Biochem Biophys 263: 410-417, 1988.
23. Magnusson B, Solvell L, Rehnberg O. Iron absorption from ferrous ascorbate in normal male subjects and in patients 3-6 years after antrectomy with gastroduodenostomy. Scand J Haematol Suppl 26: 53-67, 1976.
24. Mainous AG 3rd, Gill JM, Everett CJ. Transferrin saturation, dietary iron intake, and risk of cancer. Ann Fam Med 3: 131-137, 2005.
25. Miret S, Simpson RJ, McKie AT. Physiology and molecular biology of dietary iron absorption. Annu Rev Nutr 23: 283-301, 2003.
26. Nagata A, Ito M, Iwata N, Kuno J, Takano H, Minowa O, Chihara K, Matsui T, Noda T. G protein-coupled cholecystokinin-B/gastrin receptors are responsible for physiological cell growth of the stomach mucosa in vivo. Proc Natl Acad Sci USA 93: 11825-11830, 1996.
27. Nelson RL. Iron and colorectal cancer risk: human studies. Nutr Rev 59: 140-148, 2001.
28. Nemeth E, Tuttle MS, Powelson J, Vaughn MB, Donovan A, Ward DM, Ganz T, Kaplan J. Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science 306: 2090-2093, 2004.
29. Pannequin J, Barnham KJ, Hollande F, Shulkes A, Norton RS, Baldwin GS. Ferric ions are essential for the biological activity of the hormone glycine-extended gastrin. J Biol Chem 277: 48602-48609, 2002.
30. Pannequin J, Delaunay N, Buchert M, Surrel F, Bourgaux JF, Ryan J, Boireau S, Coelho J, Pelegrin A, Singh P, Shulkes A, Yim M, Baldwin GS, Pignodel C, Lambeau G, Jay P, Joubert D, Hollande F. Beta-catenin/Tcf-4 inhibition after progastrin targeting reduces growth and drives differentiation of intestinal tumors. Gastroenterology 133: 1554-1568, 2007.
31. Pannequin J, Tantiongco JP, Kovac S, Shulkes A, Baldwin GS. Divergent roles for ferric ions in the biological activity of amidated and non-amidated gastrins. J Endocrinol 181: 315-325, 2004.
32. Shaheen NJ, Silverman LM, Keku T, Lawrence LB, Rohlfs EM, Martin CF, Galanko J, Sandler RS. Association between hemochromatosis (HFE) gene mutation carrier status and the risk of colon cancer. J Natl Cancer Inst 95: 154-159, 2003.
33. Singh P, Velasco M, Given R, Varro A, Wang TC. Progastrin expression predisposes mice to colon carcinomas and adenomas in response to a chemical carcinogen. Gastroenterology 119: 162-171, 2000.
34. Skikne BS, Lynch SR, Cook JD. Role of gastric acid in food iron absorption. Gastroenterology 81: 1068-1071, 1981.
35. Smith KA, Kovac S, Anderson GJ, Shulkes A, Baldwin GS. Circulating gastrin is increased in hemochromatosis. FEBS Lett 580: 6195-6198, 2006.
36. Smith KA, Patel O, Lachal S, Jennings I, Kemp B, Burgess J, Baldwin GS, Shulkes A. Production, secretion, and biological activity of the C-terminal flanking peptide of human progastrin. Gastroenterology 131: 1463-1474, 2006.
37. Stewart CA, Termanini B, Sutliff VE, Serrano J, Yu F, Gibril F, Jensen RT. Iron absorption in patients with Zollinger-Ellison syndrome treated with long-term gastric acid antisecretory therapy. Aliment Pharmacol Ther 12: 83-98, 1998.
38. Stuart KA, Anderson GJ, Frazer DM, Powell LW, McCullen M, Fletcher LM, Crawford DH. Duodenal expression of iron transport molecules in untreated haemochromatosis subjects. Gut 52: 953-959, 2003.
39. Thorburn CM, Friedman GD, Dickinson CJ, Vogelman JH, Orentreich N, Parsonnet J. Gastrin and colorectal cancer: a prospective study. Gastroenterology 115: 275-280, 1998.
40. Wang TC, Koh TJ, Varro A, Cahill RJ, Dangler CA, Fox JG, Dockray GJ. Processing and proliferative effects of human progastrin in transgenic mice. J Clin Invest 98: 1918-1929, 1996.