A sequential mechanism for exosite-mediated factor IX activation by factor XIa

Journal of Biological Chemistry

Volumn 287, Issue 45, 2012, Pages 38200-38209

  Geng, Yipeng ^a   Verhamme, Ingrid M ^a   Messer, Amanda ^b   Sun, Mao Fu ^a   Smith, Stephen B ^a   Bajaj, S Paul ^b   Gailani, David ^a  

^a VANDERBILT UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DATA SUPPORT; SEQUENTIAL MECHANISM; SUBSTRATE BINDING;

BIOCHEMISTRY;

BIOLOGY;

BLOOD CLOTTING FACTOR 11A; BLOOD CLOTTING FACTOR 9; BLOOD CLOTTING FACTOR 9A;

ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME BINDING; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME RELEASE; ENZYME SUBSTRATE COMPLEX; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN DOMAIN;

ARGININE; BINDING SITES; BINDING, COMPETITIVE; BIOCATALYSIS; CALCIUM; CATALYTIC DOMAIN; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FACTOR IX; FACTOR IXA; FACTOR XIA; HEK293 CELLS; HUMANS; KINETICS; MUTATION; OLIGOPEPTIDES; PROTEIN MULTIMERIZATION; PROTEOLYSIS; PYRROLIDONECARBOXYLIC ACID; RECOMBINANT PROTEINS; SUBSTRATE SPECIFICITY;

EID: 84868325413     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.376343     Document Type: Article

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