Identification and characterization of subtype selective somatostatin receptor agonists

Journal of Physiology Paris

Volumn 94, Issue 3-4, 2000, Pages 211-215

  Rohrer, Susan P ^a   Schaeffer, James M ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Adenylate cyclase; Glucagon secretion; Growth hormone secretion; Insulin secretion; Somatostatin receptors

Indexed keywords

ADENYLATE CYCLASE; GROWTH HORMONE; INSULIN; RECEPTOR SUBTYPE; SOMATOSTATIN RECEPTOR; SOMATOSTATIN RECEPTOR 2; UNCLASSIFIED DRUG;

ADENOHYPOPHYSIS; BINDING AFFINITY; CHEMICAL ANALYSIS; GLUCOSE BLOOD LEVEL; GROWTH HORMONE RELEASE; IN VITRO STUDY; INSULIN RELEASE; MOLECULAR CLONING; MOUSE; NONHUMAN; RECEPTOR BINDING; RECEPTOR INTRINSIC ACTIVITY; REVIEW;

EID: 0033747981     PISSN: 09284257     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-4257(00)00215-1     Document Type: Review

References (11)

1. A combinatorial approach toward the discovery of non-peptide, subtype-selective somatostatin receptor ligands
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4. Flexibases - A way to enhance the use of molecular docking methods
5. New lead discovery in drug development
6. Cloned somatostatin receptors: Identification of subtype-selective peptides and demonstration of high affinity binding of linear peptides
7. Development of somatostatin receptor subtype selective agonists through combinatorial chemistry
8. Rapid identification of subtype-selective agonists of the somatostatin receptor through combinatorial chemistry
9. Specific inhibition of rat pancreatic insulin or glucagon release by receptor selective somatostatin analogs
10. A super active cyclic hexapeptide analog of somatostatin
11. The design and biological activities of potent peptidomimetics selective for somatostatin receptor subtype-2