Pathophysiology, clinics, diagnosis and treatment of heart involvement in carbon monoxide poisoning

Clinical Biochemistry

Volumn 45, Issue 16-17, 2012, Pages 1278-1285

  Lippi, Giuseppe ^a   Rastelli, Gianni ^b   Meschi, Tiziana ^a   Borghi, Loris ^a   Cervellin, Gianfranco ^a  

^a UNIVERSITY HOSPITAL OF PARMA   (Italy)

^b U O Pronto Soccorso e Medicina d'Urgenza   (Italy)

Author keywords

Carbon monoxide; Carboxyhemoglobin; Cardiac injury; Heart; Poisoning

Indexed keywords

CARBON MONOXIDE; CARBOXYHEMOGLOBIN; HEMOGLOBIN; TROPONIN;

AGE; AIR CONDITIONING; ANGINA PECTORIS; BLOOD CARBON DIOXIDE TENSION; BRAIN DAMAGE; CARBON MONOXIDE INTOXICATION; CARDIOGENIC SHOCK; CARDIOMYOPATHY; CARDIOTOXICITY; CARDIOVASCULAR RISK; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL FEATURE; CORONARY ARTERY BLOOD FLOW; DISEASE SEVERITY; ELECTROCARDIOGRAM; ENDOTHELIAL DYSFUNCTION; ENVIRONMENTAL FACTOR; FATALITY; HEART ARRHYTHMIA; HEART FAILURE; HEART INFARCTION; HEART INJURY; HEART MUSCLE ISCHEMIA; HEART MUSCLE OXYGEN CONSUMPTION; HUMAN; HYPERBARIC OXYGEN; IMMUNOASSAY; INCIDENCE; ISCHEMIC HEART DISEASE; LACTIC ACIDOSIS; MORTALITY; OXYGEN SATURATION; OXYGEN THERAPY; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PULSE OXIMETRY; RADIOCARDIOGRAPHY; REVIEW; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SUDDEN DEATH;

ANIMALS; ANOXIA; CARBON MONOXIDE; CARBON MONOXIDE POISONING; HEART DISEASES; HUMANS; HYPERBARIC OXYGENATION;

EID: 84868302588     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2012.06.004     Document Type: Review

References (96)

1. Wu L., Wang R. Carbon monoxide: endogenous production, physiological functions, and pharmacological applications. Pharmacol Rev 2005, 57:585-630.
2. Blumenthal I. Carbon monoxide poisoning. J R Soc Med 2001, 94:270-272.
3. Ryter S.W., Otterbein L.E. Carbon monoxide in biology and medicine. Bioessays 2004, 26:270-280.
4. Maines M.D. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol 1997, 37:517-554.
5. Leffler C.W., Parfenova H., Jaggar J.H. Carbon monoxide as an endogenous vascular modulator. Am J Physiol Heart Circ Physiol 2011, 301:H1-H11.
6. Siow R.C., Sato H., Mann G.E. Heme oxygenase-carbon monoxide signalling pathway in atherosclerosis: anti-atherogenic actions of bilirubin and carbon monoxide?. Cardiovasc Res 1999, 41:385-394.
7. Marks G.S., Brien J.F., Nakatsu K., McLaughlin B.E. Does carbon monoxide have a physiological function?. Trends Pharmacol Sci 1991, 12:185-188.
8. Tarquini R., Masini E., La Villa G., Mazzoccoli G., Mastroianni R., Romanelli R.G., et al. Hepato-systemic gradient of carbon monoxide in cirrhosis. Eur J Intern Med 2012, 23:e14-e18.
9. Johnson R.A., Johnson F.K. The effects of carbon monoxide as a neurotransmitter. Curr Opin Neurol 2000, 13:709-713.
10. Brugger J., Schick M.A., Brock R.W., Baumann A., Muellenbach R.M., Roewer N., et al. Carbon monoxide has antioxidative properties in the liver involving p38 MAP kinase pathway in a murine model of systemic inflammation. Microcirculation 2010, 17:504-513.
11. Song H., Zhao H., Qu Y., Sun Q., Zhang F., Du Z., et al. Carbon monoxide releasing molecule-3 inhibits concurrent tumor necrosis factor-α- and interleukin-1β-induced expression of adhesion molecules on human gingival fibroblasts. J Periodontal Res 2011, 46:48-57.
12. Christova T., Diankova Z., Setchenska M. Heme oxygenase-carbon monoxide signalling pathway as a physiological regulator of vascular smooth muscle cells. Acta Physiol Pharmacol Bulg 2000, 25:9-17.
13. Csongradi E., Juncos L.A., Drummond H.A., Vera T., Stec D.E. Role of carbon monoxide in kidney function: is a little carbon monoxide good for the kidney?. Curr Pharm Biotechnol 2012, 13:819-826.
14. Prockop L.D., Chichkova R.I. Carbon monoxide intoxication: an updated review. J Neurol Sci 2007, 262:122-130.
15. Lascaratos J.G., Marketos S.G. The carbon monoxide poisoning of two Byzantine emperors. J Toxicol Clin Toxicol 1998, 36:103-107.
16. Guy K.M., Pimlott J.K., Rogers M., Cross M. The new CO and smoke inhalation advisory service in the UK. Treatment of poisoning. Indoor Built Environ 1999, 8:199-202.
17. Raub J.A., Mathieu-Nolf M., Hampson N.B., Thom S.R. Carbon monoxide poisoning-a public health perspective. Toxicology 2000, 145:1-14.
18. Centers for Disease Control, Prevention (CDC) Carbon monoxide exposures--United States, 2000-2009. MMWR Morb Mortal Wkly Rep 2011, 60:1014-1017.
19. Alarie Y. Toxicity of fire smoke. Crit Rev Toxicol 2002, 32:259-289.
20. Centers for Disease Control, Prevention (CDC) Unintentional non-fire-related carbon monoxide exposures-United States, 2001-2003. MMWR Morb Mortal Wkly Rep 2005, 54:36-39.
21. Kim H. A case of acute toxic hepatitis after suicidal chloroform and dichloromethane ingestion. Am J Emerg Med 2008, 26:1073.e3-1073.e6.
22. Banjoko S.O., Sridhar Mynapelli K.C., Ogunkola I.O., Masheyi O.O. Methylene chloride exposure and carboxyhemoglobin levels in cabinetmakers. Indian. J Occup Environ Med 2007, 11:56-60.
23. Piantadosi C.A. Carbon monoxide poisoning. N Engl J Med 2002, 347:1053-1055.
24. Gabrielli A., Layon A.J. Carbon monoxide intoxication during pregnancy: a case presentation and pathophysiologic discussion, with emphasis on molecular mechanisms. J Clin Anesth 1995, 7:82-87.
25. Tikuisis P., Kane D.M., McLellan T.M., Buick F., Fairburn S.M. Rate of formation of carboxyhemoglobin in exercising humans exposed to carbon monoxide. J Appl Physiol 1992, 72:1311-1319.
26. Klebs E. Über die Wirkung des kohlenoxyds auf den thierische organisms. Virchows Arch Path Anat 1865, 32:450-517.
27. Fracasso T., Pfeiffer H., Michaud K., Köhler H., Sauerland C., Schmeling A. Immunohistochemical expression of fibronectin and C5b-9 in the myocardium in cases of carbon monoxide poisoning. Int J Legal Med 2011, 125:377-384.
28. Alonso J.R., Cardellach F., López S., Casademont J., Miró O. Carbon monoxide specifically inhibits cytochrome c oxidase of human mitochondrial respiratory chain. Pharmacol Toxicol 2003, 93:142-146.
29. Taskiran D., Nesil T., Alkan K. Mitochondrial oxidative stress in female and male rat brain after ex vivo carbon monoxide treatment. Hum Exp Toxicol 2007, 26:645-651.
30. Thom S.R., Fisher D., Xu Y.A., Notarfrancesco K., Ischiropoulos H. Adaptive responses and apoptosis in endothelial cells exposed to carbon monoxide. Proc Natl Acad Sci U S A 2000, 97:1305-1310.
31. Thom S.R., Fisher D., Xu Y.A., Garner S., Ischiropoulos H. Role of nitric oxide-derived oxidants in vascular injury from carbon monoxide in the rat. Am J Physiol 1999, 276:H984-H992.
32. Wattel F., Favory R., Lancel S., Neviere R., Mathieu D. Carbon monoxide and the heart: unequivocal effects?. Bull Acad Natl Med 2006, 190:1961-1974.
33. Franchini M., Mannucci P.M. Short-term effects of air pollution on cardiovascular diseases: outcomes and mechanisms. J Thromb Haemost 2007, 5:2169-2174.
34. Baccarelli A., Martinelli I., Zanobetti A., Grillo P., Hou L.F., Bertazzi P.A., et al. Exposure to particulate air pollution and risk of deep vein thrombosis. Arch Intern Med 2008, 168:920-927.
35. Lippi G., Favaloro E.J., Franchini M., Guidi G.C. Air pollution and coagulation testing: a new source of biological variability?. Thromb Res 2008, 123:50-54.
36. Baccarelli A., Martinelli I., Pegoraro V., Melly S., Grillo P., Zanobetti A., et al. Living near major traffic roads and risk of deep vein thrombosis. Circulation 2009, 119:3118-3124.
37. Franchini M., Mannucci P.M. Particulate air pollution and cardiovascular risk: short-term and long-term effects. Semin Thromb Hemost 2009, 35:665-670.
38. Lippi G., Franchini M., Montagnana M., Filippozzi L., Favaloro E.J., Guidi G.C. Relationship between 24-h air pollution, emergency department admission and diagnosis of acute coronary syndrome. J Thromb Thrombolysis 2010, 29:381-386.
39. Franchini M., Mannucci P.M. Thrombogenicity and cardiovascular effects of ambient air pollution. Blood 2011, 118:2405-2412.
40. Franchini M., Mannucci P.M. Air pollution and cardiovascular disease. Thromb Res 2012, 129:230-234.
41. Dileo P.A., Tucciarone M., Castro E.R., Guerrero M. Late stent thrombosis secondary to carbon monoxide poisoning. Cardiovasc Revasc Med 2011, 12:56-58.
42. Kalay N., Ozdogru I., Cetinkaya Y., Eryol N.K., Dogan A., Gul I., et al. Cardiovascular effects of carbon monoxide poisoning. Am J Cardiol 2007, 99:322-324.
43. Henry T.D., Lesser J.R., Satran D. Myocardial fibrosis from severe carbon monoxide poisoning detected by cardiac magnetic resonance imaging. Circulation 2008, 118:792.
44. Andre L., Boissière J., Reboul C., Perrier R., Zalvidea S., Meyer G., et al. Carbon monoxide pollution promotes cardiac remodeling and ventricular arrhythmia in healthy rats. Am J Respir Crit Care Med 2010, 181:587-595.
45. Suner S., Jay G. Carbon monoxide has direct toxicity on the myocardium distinct from effects of hypoxia in an ex vivo rat heart model. Acad Emerg Med 2008, 15:59-65.
46. Anderson R.F., Allensworth D.C., DeGroot W.J. Myocardial toxicity from carbon monoxide poisoning. Ann Intern Med 1967, 67:1172-1182.
47. Henz S., Maeder M. Prospective study of accidental carbon monoxide poisoning in 38 Swiss soldiers. Swiss Med Wkly 2005, 135:398-408.
48. Smith J.S., Brandon S. Acute carbon monoxide poisoning-3years experience in a defined population. Postgrad Med J 1970, 46:65-70.
49. Sam-Laï N.F., Saviuc P., Danel V. Carbon monoxide poisoning monitoring network: a five-year experience of household poisonings in two French regions. J Toxicol Clin Toxicol 2003, 41:349-353.
50. Dueñas-Laita A., Ruiz-Mambrilla M., Gandía F., Cerdá R., Martín-Escudero J.C., Pérez-Castrillón J.L., et al. Epidemiology of acute carbon monoxide poisoning in a Spanish region. J Toxicol Clin Toxicol 2001, 39:53-57.
51. Rastelli G., Callegari S., Locatelli C., Vezzani G. Myocardial injury in carbon monoxide poisoning. G Ital Cardiol (Rome) 2009, 10:227-233.
52. Yanir Y., Shupak A., Abramovich A., Reisner S.A., Lorber A. Cardiogenic shock complicating acute carbon monoxide poisoning despite neurologic and metabolic recovery. Ann Emerg Med 2002, 40:420-424.
53. Gandini C., Castoldi A.F., Candura S.M., Locatelli C., Butera R., Priori S., et al. Carbon monoxide cardiotoxicity. J Toxicol Clin Toxicol 2001, 39:35-44.
54. Lippi G., Plebani M., Cervellin G. Cocaine in acute myocardial infarction. Adv Clin Chem 2010, 51:53-70.
55. Tucciarone M., Dileo P.A., Castro E.R., Guerrero M. Myocardial infarction secondary to carbon monoxide poisoning: an uncommon presentation of a common condition. Case report and review of the literature. Am J Ther 2009, 16:462-465.
56. Lee S.J., Kang J.H., Kim N.Y., Baek I.W., Park M.Y., Shim B.J., et al. A case report of carbon monoxide poisoning induced cardiomyopathy complicated with left ventricular thrombus. J Cardiovasc Ultrasound 2011, 19:83-86.
57. Koskela R.S., Mutanen P., Sorsa J.A., Klockars M. Factors predictive of ischemic heart disease mortality in foundry workers exposed to carbon monoxide. Am J Epidemiol 2000, 152:628-632.
58. Balzan M.V., Cacciottolo J.M., Mifsud S. Unstable angina and exposure to carbon monoxide. Postgrad Med J 1994, 70:699-702.
59. Hubalewska-Hoła A., Pach D., Pach J., Sowa-Staszczak A., Winnik L., Huszno B. Clinical and scintigraphic (99mTc-MIBI SPECT) heart evaluation in young acutely carbon monoxide. Przegl Lek 2003, 60:226-232.
60. Satran D., Henry C.R., Adkinson C., Nicholson C.I., Bracha Y., Henry T.D. Cardiovascular manifestations of moderate to severe carbon monoxide poisoning. J Am Coll Cardiol 2005, 45:1513-1516.
61. Aslan S., Erol M.K., Karcioglu O., Meral M., Cakir Z., Katirci Y. The investigation of ischemic myocardial damage in patients with carbon monoxide poisoning. Anadolu Kardiyol Derg 2005, 5:189-193.
62. Aslan S., Uzkeser M., Seven B., Gundogdu F., Acemoglu H., Aksakal E., et al. The evaluation of myocardial damage in 83 young adults with carbon monoxide poisoning in the East Anatolia region in Turkey. Hum Exp Toxicol 2006, 25:439-446.
63. Henry C.R., Satran D., Lindgren B., Adkinson C., Nicholson C.I., Henry T.D. Myocardial injury and long-term mortality following moderate to severe carbon monoxide poisoning. JAMA 2006, 295:398-402.
64. Teksam O., Gumus P., Bayrakci B., Erdogan I., Kale G. Acute cardiac effects of carbon monoxide poisoning in children. Eur J Emerg Med 2010, 17:192-196.
65. Zhu B.L., Ishikawa T., Michiue T., Tanaka S., Li D.R., Zhao D., et al. Influence of inhaling carbon monoxide-containing gas in fire fatalities-an investigation of forensic autopsy cases. Chudoku Kenkyu 2007, 20:37-44.
66. Lane T.R., Williamson W.J., Brostoff J.M. Carbon monoxide poisoning in a patient with carbon dioxide retention: a therapeutic challenge. Cases J 2008, 1:102-104.
67. Suner S., Partridge R., Sucov A., Valente J., Chee K., Hughes A., et al. Non-invasive pulse CO-oximetry screening in the emergency department identifies occult carbon monoxide toxicity. J Emerg Med 2008, 34:441-450.
68. Bronstein A.C., Spyker D.A., Cantilena L.R., Green J.L., Rumack B.H., Giffin S.L. 2008 annual report of the American Association of Poison Control Centers' National Poison Data System (NPDS): 26th annual report. Clin Toxicol (Phila) 2009, 47:911-1084.
69. Kao H.K., Lien T.C., Kou Y.R., Wang J.H. Assessment of myocardial injury in the emergency department independently predicts the short-term poor outcome in patients with severe carbon monoxide poisoning receiving mechanical ventilation and hyperbaric oxygen therapy. Pulm Pharmacol Ther 2009, 22:473-477.
70. Grieb G., Simons D., Piatkowski A., Altiok E., Eppstein R.J., Bernhagen J., et al. Carbon monoxide intoxication versus myocardial infarction: an easy diagnosis?. Burns 2011, 37:e29-e31.
71. Cetin M., Ornek E., Murat S.N., Cetin Z.G., Oksuz F., Gokcen E. A case of carbon monoxide poisoning presenting with supraventricular tachycardia. Intern Med 2011, 50:2607-2609.
72. Carnevali R., Omboni E., Rossati M., Villa A., Checchini M. Electrocardiographic changes in acute carbon monoxide poisoning. Minerva Med 1987, 78:175-178.
73. Yelken B., Tanriverdi B., Cetinbaş F., Memiş D., Süt N. The assessment of QT intervals in acute carbon monoxide poisoning. Anadolu Kardiyol Derg 2009, 9:397-400.
74. Hantson P., Duprez T. The value of morphological neuroimaging after acute exposure to toxic substances. Toxicol Rev 2006, 25:87-98.
75. Lippi G., Montagnana M., Salvagno G.L., Guidi G.C. Potential value for new diagnostic markers in the early recognition of acute coronary syndromes. CJEM 2006, 8:27-31.
76. Lippi G., Cervellin G. The clinical role of high-sensitive troponin assays: update, interpretation, and perspectives. Recenti Prog Med 2010, 101:423-428.
77. Lichtarska D., Feldman R. Troponin positive acute coronary syndromes in the course of acute carbon monoxide poisoning as the factor exposing primary coronary heart disease previously undiagnosed. Przegl Lek 2011, 68:510-514.
78. Szponar J., Majewska M., Drelich G., Kostek H., Tchórz M., Górska A. Myocardial infarction secondary to carbon monoxide poisoning-a study of two cases. Przegl Lek 2011, 68:527-529.
79. Unal E., Yazar A., Oran B. The importance of troponin-I as a predictor of cardiac injury caused by carbon monoxide poisoning. Inhal Toxicol 2007, 19:587.
80. Guidi G.C., Lippi G. Molar expression: interconverting results of highly sensitive troponin I and T while preserving clinical significance. Clin Biochem 2012, 45:183.
81. Lippi G., Cervellin G., Plebani M. Sensitive cardiac troponin T assay. N Engl J Med 2010, 362:1242.
82. Zhu B.L., Ishikawa T., Michiue T., Li D.R., Zhao D., Bessho Y., et al. Postmortem cardiac troponin I and creatine kinase MB levels in the blood and pericardial fluid as markers of myocardial damage in medicolegal autopsy. Leg Med (Tokyo) 2007, 9:241-250.
83. Açikalin A., Satar S., Sebe A., Köse A., Akpinar O. H-FABP in cases of carbon monoxide intoxication admitted to the emergency room. Hum Exp Toxicol 2011, 30:443-447.
84. Davutoglu V., Gunay N., Kocoglu H., Gunay N.E., Yildirim C., Cavdar M., et al. Serum levels of NT-ProBNP as an early cardiac marker of carbon monoxide poisoning. Inhal Toxicol 2006, 18:155-158.
85. Ernst A., Zibrak J.D. Carbon monoxide poisoning. N Engl J Med 1998, 339:1603-1608.
86. Weaver L.K., Valentine K.J., Hopkins R.O. Carbon monoxide poisoning: risk factors for cognitive sequelae and the role of hyperbaric oxygen. Am J Respir Crit Care Med 2007, 176:491-497.
87. Weaver L.K., Hopkins R.O., Chan K.J., Churchill S., Elliott C.G., Clemmer T.P., et al. Hyperbaric oxygen for acute carbon monoxide poisoning. N Engl J Med 2002, 347:1057-1067.
88. Thom S.R., Taber R.L., Mendiguren I.I., Clark J.M., Hardy K.R., Fisher A.B. Delayed neuropsychologic sequelae following carbon monoxide poisoning: prevention by treatment with hyperbaric oxygen. Ann Emerg Med 1995, 25:474-480.
89. Ducassé J.L., Celsis P., Marc-Vergnes J.P. Non-comatose patients with acute carbon monoxide poisoning: hyperbaric or normobaric oxygenation?. Undersea Hyperb Med 1995, 22:9-15.
90. Hyperbaric oxygen 2009: indications and results: the Hyperbaric Oxygen Therapy Committee report 2008, Undersea and Hyperbaric Medical Society, Durham, NC. L.B. Gesell (Ed.).
91. Scheinkestel C.D., Bailey M., Myles P.S., Jones K., Cooper D.J., Millar I.L., et al. Hyperbaric or normobaric oxygen for acute carbon monoxide poisoning: a randomised controlled clinical trial. Med J Aust 1999, 170:203-210.
92. Moher D., Schulz K.F., Altman D. The CONSORT statement: revised recommendations for improving the quality of reports of parallel-group randomized trials. JAMA 2001, 285:1987-1991.
93. Juurlink D.N., Buckley N.A., Stanbrook M.B., Isbister G.K., Bennett M., McGuigan M.A. Hyperbaric oxygen for carbon monoxide poisoning. Cochrane Database Syst Rev 2005, 1:CD002041.
94. Leach R.M., Rees P.J., Wilmshurst P. Hyperbaric oxygen therapy. BMJ 1998, 317:1140-1143.
95. Wolf S.J., Lavonas E.J., Sloan E.P., Jagoda A.S. American College of Emergency Physicians. Critical issues in the management of adult patients presenting to the emergency department with acute carbon monoxide poisoning. Ann Emerg Med 2008, 51:138-152.
96. Weston C. Oxygen therapy in acute myocardial infarction - too much of a good thing?. Cochrane Database Syst Rev 2010, 8:ED000006.