Blood flow in endogenous and transplanted pancreatic islets in anesthetized rats: Effects of lactate and pyruvate

Pancreas

Volumn 41, Issue 8, 2012, Pages 1263-1271

  Barbu, Andreea ^a   Johansson, Åsa ^a   Bodin, Birgitta ^a   Källskog, Örjan ^a   Carlsson, Per Ola ^a   Sandberg, Monica ^a   Börjesson, Joey Lau ^a   Jansson, Leif ^a  

^a UPPSALA UNIVERSITY   (Sweden)

Author keywords

blood flow; lactate; pancreatic islets; pyruvate

Indexed keywords

GLUCOSE; INSULIN; LACTATE DEHYDROGENASE; LACTIC ACID; MICROSPHERE; MONOCARBOXYLATE TRANSPORTER 1; PYRUVIC ACID;

ADRENAL BLOOD FLOW; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD FLOWMETRY; COLON BLOOD FLOW; CONTROLLED STUDY; GLUCOSE BLOOD LEVEL; GRAFT PERFUSION; IMMUNOHISTOCHEMISTRY; INSULIN BLOOD LEVEL; INTESTINE BLOOD FLOW; LACTATE BLOOD LEVEL; LASER DOPPLER FLOWMETRY; MALE; MEAN ARTERIAL PRESSURE; MESENTERY BLOOD FLOW; NONHUMAN; PANCREAS BLOOD FLOW; PANCREAS ISLET; PANCREAS ISLET TRANSPLANTATION; PORTAL VEIN BLOOD FLOW; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT;

ANIMALS; BLOOD GLUCOSE; INSULIN; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; ISOENZYMES; L-LACTATE DEHYDROGENASE; LACTIC ACID; MALE; MESENTERY; MICROSPHERES; MONOCARBOXYLIC ACID TRANSPORTERS; PYRUVIC ACID; RATS; RATS, INBRED WF; REGIONAL BLOOD FLOW; SYMPORTERS; UP-REGULATION;

EID: 84868301419     PISSN: 08853177     EISSN: 15364828     Source Type: Journal    
DOI: 10.1097/MPA.0b013e31824bd97c     Document Type: Article

References (46)

1. Clanton TL, Klawitter PF. Invited review: adaptive responses of skeletal muscle to intermittent hypoxia: the known and the unknown. J Appl Physiol. 2001;90(6):2476-2487.
2. Juel C. Regulation of pH in human skeletal muscle: adaptations to physical activity. Acta Physiol (Oxf) . 2008;193(1):17-24.
3. Gladden LB. 200th Anniversary of lactate research in muscle. Exerc Sport Sci Rev. 2008;36(3):109-115.
4. Brooks GA. Cell-cell and intracellular lactate shuttles. J Physiol. 2009;587(Pt 23):5591-5600.
5. Matschinsky FM. Banting lecture 1995. A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm. Diabetes. 1996;45(2):223-241.
6. Henquin JC, Dufrane D, Nenquin M. Nutrient control of insulin secretion in isolated normal human islets. Diabetes. 2006;55(12):3470-3477.
7. Eto K, Tsubamoto Y, Terauchi Y, et al. Role of NADH shuttle system in glucose-induced activation of mitochondrial metabolism and insulin secretion. Science. 1999;283(5404):981-985.
8. Ishihara H, Wang H, Drewes LR, et al. Overexpression of monocarboxylate transporter and lactate dehydrogenase alters insulin secretory responses to pyruvate and lactate in beta cells. J Clin Invest. 1999;104(11):1621-1629.
9. Ronnebaum SM, Ilkayeva O, Burgess SC, et al. A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase regulates glucose-stimulated insulin secretion. J Biol Chem. 2006;281(41):30593-30602.
10. Miyake K, Ogawa W, Matsumoto M, et al. Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver. J Clin Invest. 2002;110(10):1483-1491.
11. Yao XH, Chen L, Nyomba BL. Adult rats prenatally exposed to ethanol have increased gluconeogenesis and impaired insulin response of hepatic gluconeogenic genes. J Appl Physiol. 2006;100(2):642-648.
12. Malaisse WJ, Sener A, Herchuelz A, et al. Insulin release: the fuel hypothesis. Metabolism. 1979;28(4):373-386.
13. Jijakli H, Rasschaert J, Nadi AB, et al. Relevance of lactate dehydrogenase activity to the control of oxidative glycolysis in pancreatic islet B-cells. Arch Biochem Biophys. 1996;327(2):260-264.
14. Zawalich WS, Zawalich KC. Influence of pyruvic acid methyl ester on rat pancreatic islets. Effects on insulin secretion, phosphoinositide hydrolysis, and sensitization of the beta cell. J Biol Chem. 1997;272(6):3527-3531.
15. Tamarit-Rodriguez J, Idahl LA, Gine E, et al. Lactate production in pancreatic islets. Diabetes. 1998;47(8):1219-1223.
16. Merezhinskaya N, Fishbein WN. Monocarboxylate transporters: past, present, and future. Histol Histopathol. 2009;24(2):243-264.
17. Poole RC, Halestrap AP. Transport of lactate and other monocarboxylates across mammalian plasma membranes. Am J Physiol. 1993;264(4 Pt 1):C761-C782.
18. Schuit F, De Vos A, Farfari S, et al. Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells. J Biol Chem. 1997;272(30):18572-18579.
19. Sekine N, Cirulli V, Regazzi R, et al. Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic beta-cells. Potential role in nutrient sensing. J Biol Chem. 1994;269(7):4895-4902.
20. Carlsson PO, Kiuru A, Nordin A, et al. Microdialysis measurements demonstrate a shift to nonoxidative glucose metabolism in rat pancreatic islets transplanted beneath the renal capsule. Surgery. 2002;132(3):487-494.
21. Lau J, Kampf C, Mattsson G, et al. Beneficial role of pancreatic microenvironment for angiogenesis in transplanted pancreatic islets. Cell Transplant. 2009;18(1):23-30.
22. Laybutt DR, Hawkins YC, Lock J, et al. Influence of diabetes on the loss of beta cell differentiation after islet transplantation in rats. Diabetologia. 2007;50(10):2117-2125.
23. Omer A, Duvivier-Kali VF, Aschenbach W, et al. Exercise induces hypoglycemia in rats with islet transplantation. Diabetes. 2004;53(2):360-365.
24. Gladden LB. Current trends in lactate metabolism: introduction. Med Sci Sports Exerc. 2008;40(3):475-476.
25. Carlsson PO, Kalskog O?, Bodin B, et al. Multiple injections of coloured microspheres for islet blood flow measurements in anaesthetised rats: influence of microsphere size. Ups J Med Sci. 2002;107(2):111-120.
26. Jansson L, Hellerstro C. Stimulation by glucose of the blood flow to the pancreatic islets of the rat. Diabetologia. 1983;25(1):45-50.
27. Sandler S, Andersson A, Hellerstro C. Inhibitory effects of interleukin 1 on insulin secretion, insulin biosynthesis, and oxidative metabolism of isolated rat pancreatic islets. Endocrinology. 1987;121(4):1424-1431.
28. Carlsson PO, Liss P, Andersson A, et al. Measurements of oxygen tension in native and transplanted rat pancreatic islets. Diabetes. 1998;47(7):1027- 1032.
29. Rajan V, Varghese B, van Leeuwen TG, et al. Review of methodological developments in laser Doppler flowmetry. Lasers Med Sci. 2009;24(2):269-283.
30. Barbu A, Hedlund GP, Lind J, et al. Pref-1 and adipokine expression in adipose tissues of GK and Zucker rats. Mol Cell Endocrinol. 2009;299(2):163-171.
31. Jansson L, Carlsson PO. Graft vascular function after transplantation of pancreatic islets. Diabetologia. 2002;45(6):749-763.
32. Menger MD, Yamauchi J, Vollmar B. Revascularization and microcirculation of freely grafted islets of Langerhans. World J Surg. 2001;25(4):509-515.
33. Brazitikos PD, Pournaras CJ, Munoz JL, et al. Microinjection of L-lactate in the preretinal vitreous induces segmental vasodilation in the inner retina of miniature pigs. Invest Ophthalmol Vis Sci. 1993;34(5):1744-1752.
34. Laties AM. Central retinal artery innervation. Absence of adrenergic innervation to the intraocular branches. Arch Ophthalmol. 1967;77(3):405-409.
35. McKinnon W, Aaronson PI, Knock G, et al. Mechanism of lactate-induced relaxation of isolated rat mesenteric resistance arteries. J Physiol. 1996;490(Pt 3):783-792.
36. Omar HA, Mohazzab KM, Mortelliti MP, et al. O2-dependent modulation of calf pulmonary artery tone by lactate: potential role of H2O2 and cGMP. Am J Physiol. 1993;264(2 Pt 1):L141-L145.
37. Omar HA, Figueroa R, Tejani N, et al. Properties of a lactate-induced relaxation in human placental arteries and veins. Am J Obstet Gynecol. 1993;169(4):912-918.
38. Frobert O, Mikkelsen EO, Bagger JP, et al. Measurement of interstitial lactate during hypoxia-induced dilatation in isolated pressurised porcine coronary arteries. J Physiol. 2002;539(Pt 1):277-284.
39. Chen YL, Wolin MS, Messina EJ. Evidence for cGMP mediation of skeletal muscle arteriolar dilation to lactate. J Appl Physiol. 1996;81(1):349-354.
40. Lau J, Mattsson G, Carlsson C, et al. Implantation siteYdependent dysfunction of transplanted pancreatic islets. Diabetes. 2007;56(6):1544-1550.
41. Jansson L. Glucose stimulation of pancreatic islet blood flow by redistribution of the blood flow within the whole pancreatic gland. Pancreas. 1988;3(4):409-412.
42. Jansson L, Hellerstro C. Glucose-induced changes in pancreatic islet blood flow mediated by central nervous system. Am J Physiol. 1986;251(6 Pt 1):E644-E647.
43. Carlsson PO, Iwase M, Jansson L. Intraportal glucose infusion and pancreatic islet blood flow in anesthetized rats. Am J Physiol Regul Integr Comp Physiol. 2000;279(4): R1224-R1229.
44. Ahre B. Autonomic regulation of islet hormone secretionVimplications for health and disease. Diabetologia. 2000;43(4):393-410.
45. Niijima A. Neural mechanisms in the control of blood glucose concentration. J Nutr. 1989;119(6):833-840.
46. Lam TK, Pocai A, Gutierrez-Juarez R, et al. Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis. Nat Med. 2005;11(3):320-327.