메뉴 건너뛰기




Volumn 1, Issue 7, 2012, Pages

PEA-15 unphosphorylated at both serine 104 and serine 116 inhibits ovarian cancer cell tumorigenicity and progression through blocking β-catenin

Author keywords

b catenin; growth inhibition; ovarian cancer; PEA 15; three dimensional Matrigel cultures; tumorigenicity

Indexed keywords

ALANINE; ANTINEOPLASTIC AGENT; BETA CATENIN; PEA 15; SERINE; SERINE 104; UNCLASSIFIED DRUG;

EID: 84868282628     PISSN: None     EISSN: 21579024     Source Type: Journal    
DOI: 10.1038/oncsis.2012.22     Document Type: Article
Times cited : (22)

References (51)
  • 1
    • 80051580618 scopus 로고    scopus 로고
    • Cancer statistics, 2011: The impact of eliminating socioeconomic and racial disparities on premature cancer deaths
    • Siegel R, Ward E, Brawley O, Jemal A. Cancer statistics, 2011: the impact of eliminating socioeconomic and racial disparities on premature cancer deaths. CA Cancer J Clin 2011; 61: 212-236.
    • (2011) CA Cancer J Clin , vol.61 , pp. 212-236
    • Siegel, R.1    Ward, E.2    Brawley, O.3    Jemal, A.4
  • 2
    • 0642314376 scopus 로고    scopus 로고
    • The multifunctional protein PEA-15 is involved in the control of apoptosis and cell cycle in astrocytes
    • DOI 10.1016/S0006-2952(03)00514-8, PII S0006295203005148
    • Renault F, Formstecher E, Callebaut I, Junier MP, Chneiweiss H. The multifunctional protein PEA-15 is involved in the control of apoptosis and cell cycle in astrocytes. Biochem Pharmacol 2003; 66: 1581-1588. (Pubitemid 38373349)
    • (2003) Biochemical Pharmacology , vol.66 , Issue.8 , pp. 1581-1588
    • Renault, F.1    Formstecher, E.2    Callebaut, I.3    Junier, M.-P.4    Chneiweiss, H.5
  • 3
    • 33847759815 scopus 로고    scopus 로고
    • PEA-15 inhibits tumor cell invasion by binding to extracellular signal-regulated kinase 1/2
    • DOI 10.1158/0008-5472.CAN-06-1378
    • Glading A, Koziol JA, Krueger J, Ginsberg MH. PEA-15 inhibits tumor cell invasion by binding to extracellular signal-regulated kinase 1/2. Cancer Res 2007; 67: 1536-1544. (Pubitemid 46383377)
    • (2007) Cancer Research , vol.67 , Issue.4 , pp. 1536-1544
    • Glading, A.1    Koziol, J.A.2    Krueger, J.3    Ginsberg, M.H.4
  • 4
    • 30044450499 scopus 로고    scopus 로고
    • Antitumor effect of E1A in ovarian cancer by cytoplasmic sequestration of activated ERK by PEA15
    • DOI 10.1038/sj.onc.1209014
    • Bartholomeusz C, Itamochi H, Nitta M, Saya H, Ginsberg MH, Ueno NT. Antitumor effect of E1A in ovarian cancer by cytoplasmic sequestration of activated ERK by PEA15. Oncogene 2006; 25: 79-90. (Pubitemid 43050006)
    • (2006) Oncogene , vol.25 , Issue.1 , pp. 79-90
    • Bartholomeusz, C.1    Itamochi, H.2    Nitta, M.3    Saya, H.4    Ginsberg, M.H.5    Ueno, N.T.6
  • 5
    • 56449116341 scopus 로고    scopus 로고
    • PEA-15 induces autophagy in human ovarian cancer cells and is associated with prolonged overall survival
    • Bartholomeusz C, Rosen D, Wei C, Kazansky A, Yamasaki F, Takahashi T et al. PEA-15 induces autophagy in human ovarian cancer cells and is associated with prolonged overall survival. Cancer Res 2008; 68: 9302-9310.
    • (2008) Cancer Res , vol.68 , pp. 9302-9310
    • Bartholomeusz, C.1    Rosen, D.2    Wei, C.3    Kazansky, A.4    Yamasaki, F.5    Takahashi, T.6
  • 6
    • 77949748262 scopus 로고    scopus 로고
    • PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase
    • Bartholomeusz C, Gonzalez-Angulo AM, Kazansky A, Krishnamurthy S, Liu P, Yuan LX et al. PEA-15 inhibits tumorigenesis in an MDA-MB-468 triple-negative breast cancer xenograft model through increased cytoplasmic localization of activated extracellular signal-regulated kinase. Clin Cancer Res 2010; 16: 1802-1811.
    • (2010) Clin Cancer Res , vol.16 , pp. 1802-1811
    • Bartholomeusz, C.1    Gonzalez-Angulo, A.M.2    Kazansky, A.3    Krishnamurthy, S.4    Liu, P.5    Yuan, L.X.6
  • 7
    • 0031456158 scopus 로고    scopus 로고
    • Wnt signaling: A common theme in animal development
    • Cadigan KM, Nusse R. Wnt signaling: a common theme in animal development. Genes Dev 1997; 11: 3286-3305. (Pubitemid 28023954)
    • (1997) Genes and Development , vol.11 , Issue.24 , pp. 3286-3305
    • Cadigan, K.M.1    Nusse, R.2
  • 8
    • 0030949463 scopus 로고    scopus 로고
    • Activation of β-catenin-Tcf signaling in colon cancer by mutations in β-catenin or APC
    • DOI 10.1126/science.275.5307.1787
    • Morin PJ, Sparks AB, Korinek V, Barker N, Clevers H, Vogelstein B et al. Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science 1997; 275: 1787-1790. (Pubitemid 27136715)
    • (1997) Science , vol.275 , Issue.5307 , pp. 1787-1790
    • Morin, P.J.1    Sparks, A.B.2    Korinek, V.3    Barker, N.4    Clevers, H.5    Vogelstein, B.6    Kinzler, K.W.7
  • 10
    • 0033486152 scopus 로고    scopus 로고
    • Beta-catenin signaling and cancer
    • Morin PJ. beta-catenin signaling and cancer. Bioessays 1999; 21: 1021-1030.
    • (1999) Bioessays , vol.21 , pp. 1021-1030
    • Morin, P.J.1
  • 11
    • 49549108896 scopus 로고    scopus 로고
    • Wnt and beyond Wnt: Multiple mechanisms control the transcriptional property of beta-catenin
    • Jin T, George Fantus I, Sun J. Wnt and beyond Wnt: multiple mechanisms control the transcriptional property of beta-catenin. Cell Signal 2008; 20: 1697-1704.
    • (2008) Cell Signal , vol.20 , pp. 1697-1704
    • Jin, T.1    George Fantus, I.2    Sun, J.3
  • 12
    • 42449134942 scopus 로고    scopus 로고
    • Cross talk between the insulin and Wnt signaling pathways: Evidence from intestinal endocrine L cells
    • DOI 10.1210/en.2007-1142
    • Yi F, Sun J, Lim GE, Fantus IG, Brubaker PL, Jin T. Cross talk between the insulin and Wnt signaling pathways: evidence from intestinal endocrine L cells. Endocrinology 2008; 149: 2341-2351. (Pubitemid 351574509)
    • (2008) Endocrinology , vol.149 , Issue.5 , pp. 2341-2351
    • Yi, F.1    Sun, J.2    Lim, G.E.3    Fantus, I.G.4    Brubaker, P.L.5    Jin, T.6
  • 14
    • 33748168778 scopus 로고    scopus 로고
    • Mind the GAP: Wnt Steps onto the mTORC1 Train
    • DOI 10.1016/j.cell.2006.08.025, PII S0092867406010944
    • Choo AY, Roux PP, Blenis J. Mind the GAP: Wnt steps onto the mTORC1 train. Cell 2006; 126: 834-836. (Pubitemid 44310790)
    • (2006) Cell , vol.126 , Issue.5 , pp. 834-836
    • Choo, A.Y.1    Roux, P.P.2    Blenis, J.3
  • 15
    • 69049103284 scopus 로고    scopus 로고
    • Frontiers: PED/PEA-15, a multifunctional protein controlling cell survival and glucose metabolism
    • Fiory F, Formisano P, Perruolo G, Beguinot F. Frontiers: PED/PEA-15, a multifunctional protein controlling cell survival and glucose metabolism. Am J Physiol Endocrinol Metab 2009; 297: E592-E601.
    • (2009) Am J Physiol Endocrinol Metab , vol.297
    • Fiory, F.1    Formisano, P.2    Perruolo, G.3    Beguinot, F.4
  • 16
    • 23044493865 scopus 로고    scopus 로고
    • Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signal-regulated kinase-dependent transcription and cell proliferation
    • DOI 10.1091/mbc.E04-11-1007
    • Krueger J, Chou FL, Glading A, Schaefer E, Ginsberg MH. Phosphorylation of phosphoprotein enriched in astrocytes (PEA-15) regulates extracellular signalregulated kinase-dependent transcription and cell proliferation. Mol Biol Cell 2005; 16: 3552-3561. (Pubitemid 41077069)
    • (2005) Molecular Biology of the Cell , vol.16 , Issue.8 , pp. 3552-3561
    • Krueger, J.1    Chou, F.-L.2    Glading, A.3    Schaefer, E.4    Ginsberg, M.H.5
  • 17
    • 0027409399 scopus 로고
    • Enhanced c-erbB-2/neu expression in human ovarian cancer cells correlates with more severe malignancy that can be suppressed by E1A
    • Yu D, Wolf JK, Scanlon M, Price JE, Hung MC. Enhanced c-erbB-2/neu expression in human ovarian cancer cells correlates with more severe malignancy that can be suppressed by E1A. Cancer Res 1993; 53: 891-898. (Pubitemid 23077880)
    • (1993) Cancer Research , vol.53 , Issue.4 , pp. 891-898
    • Yu, D.1    Wolf, J.K.2    Scanlon, M.3    Price, J.E.4    Hung, M.-C.5
  • 19
    • 33645302628 scopus 로고    scopus 로고
    • The epithelial-mesenchymal transition: New insights in signaling, development, and disease
    • Lee JM, Dedhar S, Kalluri R, Thompson EW. The epithelial-mesenchymal transition: new insights in signaling, development, and disease. J Cell Biol 2006; 172: 973-981.
    • (2006) J Cell Biol , vol.172 , pp. 973-981
    • Lee, J.M.1    Dedhar, S.2    Kalluri, R.3    Thompson, E.W.4
  • 21
    • 0033119801 scopus 로고    scopus 로고
    • β-catenin regulates expression of cyclin D1 in colon carcinoma cells
    • DOI 10.1038/18884
    • Tetsu O, McCormick F. Beta-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999; 398: 422-426. (Pubitemid 29180374)
    • (1999) Nature , vol.398 , Issue.6726 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 27
    • 0037011120 scopus 로고    scopus 로고
    • Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain
    • DOI 10.1093/emboj/cdf641
    • Hill JM, Vaidyanathan H, Ramos JW, Ginsberg MH, Werner MH. Recognition of ERK MAP kinase by PEA-15 reveals a common docking site within the death domain and death effector domain. EMBO J 2002; 21: 6494-6504. (Pubitemid 35448427)
    • (2002) EMBO Journal , vol.21 , Issue.23 , pp. 6494-6504
    • Hill, J.M.1    Vaidyanathan, H.2    Ramos, J.W.3    Ginsberg, M.H.4    Werner, M.H.5
  • 28
    • 1842581898 scopus 로고    scopus 로고
    • The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions
    • DOI 10.1074/jbc.M310031200
    • Whitehurst AW, Robinson FL, Moore MS, Cobb MH. The death effector domain protein PEA-15 prevents nuclear entry of ERK2 by inhibiting required interactions. J Biol Chem 2004; 279: 12840-12847. (Pubitemid 38445857)
    • (2004) Journal of Biological Chemistry , vol.279 , Issue.13 , pp. 12840-12847
    • Whitehurst, A.W.1    Robinson, F.L.2    Moore, M.S.3    Cobb, M.H.4
  • 29
    • 25844522837 scopus 로고    scopus 로고
    • Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD
    • DOI 10.1042/BJ20050378
    • Renganathan H, Vaidyanathan H, Knapinska A, Ramos JW. Phosphorylation of PEA-15 switches its binding specificity from ERK/MAPK to FADD. Biochem J 2005; 390: 729-735. (Pubitemid 41395356)
    • (2005) Biochemical Journal , vol.390 , Issue.3 , pp. 729-735
    • Renganathan, H.1    Vaidyanathan, H.2    Knapinska, A.3    Ramos, J.W.4
  • 31
    • 0035941075 scopus 로고    scopus 로고
    • Taking cell-matrix adhesions to the third dimension
    • DOI 10.1126/science.1064829
    • Cukierman E, Pankov R, Stevens DR, Yamada KM. Taking cell-matrix adhesions to the third dimension. Science 2001; 294: 1708-1712. (Pubitemid 33104840)
    • (2001) Science , vol.294 , Issue.5547 , pp. 1708-1712
    • Cukierman, E.1    Pankov, R.2    Stevens, D.R.3    Yamada, K.M.4
  • 32
    • 84863092269 scopus 로고    scopus 로고
    • PED/PEA-15 interacts with the 67 kDa laminin receptor and regulates cell adhesion, migration, proliferation and apoptosis
    • Formisano P, Ragno P, Pesapane A, Alfano D, Alberobello AT, Rea VE et al. PED/PEA-15 interacts with the 67 kDa laminin receptor and regulates cell adhesion, migration, proliferation and apoptosis. J Cell Mol Med 2012; 16: 1435-1446.
    • (2012) J Cell Mol Med , vol.16 , pp. 1435-1446
    • Formisano, P.1    Ragno, P.2    Pesapane, A.3    Alfano, D.4    Alberobello, A.T.5    Rea, V.E.6
  • 33
    • 0037155691 scopus 로고    scopus 로고
    • Control of β-catenin phosphorylation/degradation by a dual-kinase mechanism
    • DOI 10.1016/S0092-8674(02)00685-2
    • Liu C, Li Y, Semenov M, Han C, Baeg GH, Tan Y et al. Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell 2002; 108: 837-847. (Pubitemid 34327534)
    • (2002) Cell , vol.108 , Issue.6 , pp. 837-847
    • Liu, C.1    Li, Y.2    Semenov, M.3    Han, C.4    Baeg, G.-H.5    Tan, Y.6    Zhang, Z.7    Lin, X.8    He, X.9
  • 34
    • 12544252343 scopus 로고    scopus 로고
    • Beta-Catenin: A pivot between cell adhesion and Wnt signalling
    • Bienz M. beta-Catenin: a pivot between cell adhesion and Wnt signalling. Curr Biol 2005; 15: R64-R67.
    • (2005) Curr Biol , vol.15
    • Bienz, M.1
  • 35
    • 0029683606 scopus 로고    scopus 로고
    • The axis-inducing activity, stability, and subcellular distribution of β-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3
    • Yost C, Torres M, Miller JR, Huang E, Kimelman D, Moon RT. The axis-inducing activity, stability, and subcellular distribution of beta-catenin is regulated in Xenopus embryos by glycogen synthase kinase 3. Genes Dev 1996; 10: 1443-1454. (Pubitemid 26260702)
    • (1996) Genes and Development , vol.10 , Issue.12 , pp. 1443-1454
    • Yost, C.1    Torres, M.2    Miller, J.R.3    Huang, E.4    Kimelman, D.5    Moon, R.T.6
  • 36
    • 0029587224 scopus 로고
    • Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
    • DOI 10.1038/378785a0
    • Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995; 378: 785-789. (Pubitemid 26004411)
    • (1995) Nature , vol.378 , Issue.6559 , pp. 785-789
    • Cross, D.A.E.1    Alessi, D.R.2    Cohen, P.3    Andjelkovich, M.4    Hemmings, B.A.5
  • 37
    • 26444486391 scopus 로고    scopus 로고
    • Phosphorylation of β-catenin by cyclic AMP-dependent protein kinase stabilizes β-catenin through inhibition of its ubiquitination
    • DOI 10.1128/MCB.25.20.9063-9072.2005
    • Hino S, Tanji C, Nakayama KI, Kikuchi A. Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination. Mol Cell Biol 2005; 25: 9063-9072. (Pubitemid 41429094)
    • (2005) Molecular and Cellular Biology , vol.25 , Issue.20 , pp. 9063-9072
    • Hino, S.-I.1    Tanji, C.2    Nakayama, K.I.3    Kikuchi, A.4
  • 38
    • 33744519452 scopus 로고    scopus 로고
    • Phosphorylation of β-catenin by cyclic AMP-dependent protein kinase
    • DOI 10.1074/jbc.M508778200
    • Taurin S, Sandbo N, Qin Y, Browning D, Dulin NO. Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase. J Biol Chem 2006; 281: 9971-9976. (Pubitemid 43864529)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.15 , pp. 9971-9976
    • Taurin, S.1    Sandbo, N.2    Qin, Y.3    Browning, D.4    Dulin, N.O.5
  • 41
    • 72049096217 scopus 로고    scopus 로고
    • Regulatory subunits of PKA define an axis of cellular proliferation/differentiation in ovarian cancer cells
    • Cheadle C, Nesterova M, Watkins T, Barnes KC, Hall JC, Rosen A et al. Regulatory subunits of PKA define an axis of cellular proliferation/ differentiation in ovarian cancer cells. BMC Med Genomics 2008; 1: 43.
    • (2008) BMC Med Genomics , vol.1 , pp. 43
    • Cheadle, C.1    Nesterova, M.2    Watkins, T.3    Barnes, K.C.4    Hall, J.C.5    Rosen, A.6
  • 44
    • 70349254048 scopus 로고    scopus 로고
    • Expression profiles of genes involved in poor prognosis of epithelial ovarian carcinoma: A review
    • Yoshida S, Furukawa N, Haruta S, Tanase Y, Kanayama S, Noguchi T et al. Expression profiles of genes involved in poor prognosis of epithelial ovarian carcinoma: a review. Int J Gynecol Cancer 2009; 19: 992-997.
    • (2009) Int J Gynecol Cancer , vol.19 , pp. 992-997
    • Yoshida, S.1    Furukawa, N.2    Haruta, S.3    Tanase, Y.4    Kanayama, S.5    Noguchi, T.6
  • 45
    • 14044278776 scopus 로고    scopus 로고
    • Glycogen-synthase kinase3β/β-catenin axis promotes angiogenesis through activation of vascular endothelial growth factor signaling in endothelial cells
    • DOI 10.1161/01.RES.0000156273.30274.f7
    • Skurk C, Maatz H, Rocnik E, Bialik A, Force T, Walsh K. Glycogen-synthase kinase3beta/beta-catenin axis promotes angiogenesis through activation of vascular endothelial growth factor signaling in endothelial cells. Circ Res 2005; 96: 308-318. (Pubitemid 40279905)
    • (2005) Circulation Research , vol.96 , Issue.3 , pp. 308-318
    • Skurk, C.1    Maatz, H.2    Rocnik, E.3    Bialik, A.4    Force, T.5    Walsh, K.6
  • 46
    • 79951772974 scopus 로고    scopus 로고
    • Clinical utility of circulating matrix metalloproteinase-7 (MMP-7), CC chemokine ligand 18 (CCL18) and CC chemokine ligand 11 (CCL11) as markers for diagnosis of epithelial ovarian cancer
    • Zohny SF, Fayed ST. Clinical utility of circulating matrix metalloproteinase-7 (MMP-7), CC chemokine ligand 18 (CCL18) and CC chemokine ligand 11 (CCL11) as markers for diagnosis of epithelial ovarian cancer. Med Oncol 2010; 27: 1246-1253.
    • (2010) Med Oncol , vol.27 , pp. 1246-1253
    • Zohny, S.F.1    Fayed, S.T.2
  • 47
    • 30344480772 scopus 로고    scopus 로고
    • Role of matrix metalloproteinase-7 (matrilysin) in human cancer invasion, apoptosis, growth, and angiogenesis
    • Ii M, Yamamoto H, Adachi Y, Maruyama Y, Shinomura Y. Role of matrix metalloproteinase-in human cancer invasion, apoptosis, growth, and angiogenesis. Exp Biol Med (Maywood) 2006; 231: 20-27. (Pubitemid 43063974)
    • (2006) Experimental Biology and Medicine , vol.231 , Issue.1 , pp. 20-27
    • Ii, M.1    Yamamoto, H.2    Adachi, Y.3    Maruyama, Y.4    Shinomura, Y.5
  • 48
    • 0032545497 scopus 로고    scopus 로고
    • The death effector domain of PEA-15 is involved in its regulation of integrin activation
    • DOI 10.1074/jbc.273.51.33897
    • Ramos JW, Kojima TK, Hughes PE, Fenczik CA, Ginsberg MH. The death effector domain of PEA-15 is involved in its regulation of integrin activation. J Biol Chem 1998; 273: 33897-33900. (Pubitemid 29008850)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.51 , pp. 33897-33900
    • Ramos, J.W.1    Kojima, T.K.2    Hughes, P.E.3    Fenczik, C.A.4    Ginsberg, M.H.5
  • 49
    • 0034492451 scopus 로고    scopus 로고
    • Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism
    • Ramos JW, Hughes PE, Renshaw MW, Schwartz MA, Formstecher E, Chneiweiss H et al. Death effector domain protein PEA-15 potentiates Ras activation of extracellular signal receptor-activated kinase by an adhesion-independent mechanism. Mol Biol Cell 2000; 11: 2863-2872. (Pubitemid 32107070)
    • (2000) Molecular Biology of the Cell , vol.11 , Issue.9 , pp. 2863-2872
    • Ramos, J.W.1    Hughes, P.E.2    Renshaw, M.W.3    Schwartz, M.A.4    Formstecher, E.5    Chneiweiss, H.6    Ginsberg, M.H.7
  • 51
    • 34247864012 scopus 로고    scopus 로고
    • Three-dimensional culture models of normal and malignant breast epithelial cells
    • DOI 10.1038/nmeth1015, PII NMETH1015
    • Lee GY, Kenny PA, Lee EH, Bissell MJ. Three-dimensional culture models of normal and malignant breast epithelial cells. Nat Methods 2007; 4: 359-365. (Pubitemid 46766981)
    • (2007) Nature Methods , vol.4 , Issue.4 , pp. 359-365
    • Lee, G.Y.1    Kenny, P.A.2    Lee, E.H.3    Bissell, M.J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.