In vitro metabolism of diphenyl diselenide in rat liver fractions. Conjugation with GSH and binding to thiol groups

Chemico-Biological Interactions

Volumn 200, Issue 2-3, 2012, Pages 65-72

  Prigol, Marina ^a   Nogueira, Cristina W ^a   Zeni, Gilson ^a   Bronze, Maria Rosário ^b,c   Constantino, Luís ^b  

^a FEDERAL UNIVERSITY OF SANTA MARIA   (Brazil)

^b RESEARCH INSTITUTE FOR MEDICINES IMED ULISBOA   (Portugal)

^c INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

Author keywords

Diphenyl diselenide; GSH conjugate; Metabolism; Rat liver fractions; Selenium

Indexed keywords

ACETYLCYSTEINE; CYTOCHROME P450; DIPHENYL DISELENIDE; GLUTATHIONE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; UNSPECIFIC MONOOXYGENASE;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOSOL; ELECTROSPRAY; ENZYME ACTIVITY; ENZYME METABOLISM; FRAGMENTATION REACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; LIQUID CHROMATOGRAPHY; LIVER MICROSOME; MASS SPECTROMETRY; NONHUMAN; NUCLEOPHILICITY; PROTEIN BINDING; RAT; TANDEM MASS SPECTROMETRY;

ANIMALS; BENZENE DERIVATIVES; BIOTRANSFORMATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOCHROME P-450 ENZYME SYSTEM; GLUTATHIONE; LIVER; ORGANOSELENIUM COMPOUNDS; RATS; SULFHYDRYL COMPOUNDS; TANDEM MASS SPECTROMETRY;

RATTUS;

EID: 84868261138     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.09.007     Document Type: Article

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