The metabolism of 9-chloro-β-lapachone and its effects in isolated hepatocytes. the involvement of NAD(P)H:quinone oxidoreductase 1 (NQO1)

Chemico-Biological Interactions

Volumn 200, Issue 2-3, 2012, Pages 84-91

  Fernandez Villamil, Silvia H ^b   Carrizo, Patricia H ^a   Di Rosso, Maria E ^a   Molina Portela, Maria P ^a   Dubin, Marta ^a  

^a Centre de Estudios Farmacologicos y Botanicos   (Argentina)

^b INSTITUTO DE INVESTIGACIONES EN INGENIERÍA GENÉTICA Y BIOLOGÍA MOLECULAR   (Argentina)

Author keywords

NQO1; o Naphthoquinones; Oxidative stress

Indexed keywords

(3,4 DIHYDRO 2,2 DIMETHYL 9 CHLORO 2H NAPHTHO[1,2B]PYRAN 5,6 DIONE) (9 CHLORO BETA LAPACHONE); ADENINE NUCLEOTIDE; BETA LAPACHONE; CATALASE; GLUTATHIONE; GLUTATHIONE DISULFIDE; HYDROGEN PEROXIDE; PYRIDINE NUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE) 1; UNCLASSIFIED DRUG;

ACETYLATION; ANALYSIS OF VARIANCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELL ISOLATION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG ACTIVITY; DRUG METABOLISM; DRUG STRUCTURE; ENZYME ASSAY; LIPID PEROXIDATION; LIVER CELL; MALE; NONHUMAN; OXIDATION REDUCTION REACTION; OXYGEN CONSUMPTION; PROTEIN CONTENT; PROTEIN DEPLETION; RAT;

ANIMALS; HEPATOCYTES; HYDROGEN PEROXIDE; LIPID PEROXIDATION; MALE; NAD(P)H DEHYDROGENASE (QUINONE); NAPHTHOQUINONES; RATS; RATS, WISTAR;

RATTUS;

EID: 84868245054     PISSN: 00092797     EISSN: 18727786     Source Type: Journal    
DOI: 10.1016/j.cbi.2012.09.011     Document Type: Article

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