Antigen vehiculization particles based on the Z protein of Junin virus

BMC Biotechnology

Volumn 12, Issue , 2012, Pages

  Borio, Cristina S ^a   Bilen, Marcos F ^a   Argüelles, Marcelo H ^a   Goñi, Sandra E ^a   Iserte, Javier A ^a   Glikmann, Graciela ^a   Lozano, Mario E ^a  

^a UNIVERSIDAD NACIONAL DE QUILMES   (Argentina)

Author keywords

Antigen delivery; Arenavirus; Virus like particles; Z protein

Indexed keywords

A-SPOTS; ANTIGEN DELIVERY; ARENAVIRUS; GREEN FLUORESCENT PROTEIN; INNER SURFACES; JUNIN VIRUS; MATRIX PROTEINS; MEMBRANE BENDING; PROTECTION ASSAY; SUBUNIT VACCINE; TEM (TRANSMISSION ELECTRON MICROSCOPY); VESICLE FORMATION; VIRAL PROTEINS; VIRUS BUDDING; VIRUS-LIKE PARTICLES;

ANTIGENS; CELL MEMBRANES; CONFOCAL MICROSCOPY; CYTOLOGY; NUCLEIC ACIDS; PURIFICATION; TRANSMISSION ELECTRON MICROSCOPY; VIRUSES;

PROTEINS;

ENHANCED GREEN FLUORESCENT PROTEIN; FATTY ACID BINDING PROTEIN; IMMUNOGLOBULIN G;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ANTIBODY TITER; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; IMMUNE RESPONSE; IMMUNIZATION; JUNIN VIRUS; MALE; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PURIFICATION; TRANSMISSION ELECTRON MICROSCOPY; VIRUS PARTICLE;

ANIMALS; ANTIGENS; GREEN FLUORESCENT PROTEINS; HEK293 CELLS; HUMANS; JUNIN VIRUS; MICE; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; RECOMBINANT FUSION PROTEINS; TRANSFECTION; VIRAL PROTEINS; VIRION;

ARENAVIRUS; JUNIN VIRUS; MUS;

EID: 84868236525     PISSN: None     EISSN: 14726750     Source Type: Journal    
DOI: 10.1186/1472-6750-12-80     Document Type: Article

References (42)

1. Perez M, Craven RC, de la Torre JC. The small RING finger protein Z drives arenavirus budding: implications for antiviral strategies. Proc Natl Acad Sci USA 2003, 100(22):12978-12983. 10.1073/pnas.2133782100, 240730, 14563923.
2. Goni SE, Borio CS, Romano FB, Rota RP, Pilloff MG, Iserte JA, Tortorici MA, Stephan BI, Bilen MF, Ghiringhelli PD, et al. Expression and purification of Z protein from Junin virus. J Biomed Biotechnol 2010, 2010:970491. 2896916, 20652066.
3. Wilda M, Lopez N, Casabona JC, Franze-Fernandez MT. Mapping of the tacaribe arenavirus Z-protein binding sites on the L protein identified both amino acids within the putative polymerase domain and a region at the N terminus of L that are critically involved in binding. J Virol 2008, 82(22):11454-11460. 10.1128/JVI.01533-08, 2573253, 18799569.
4. Lopez N, Jacamo R, Franze-Fernandez MT. Transcription and RNA replication of tacaribe virus genome and antigenome analogs require N and L proteins: Z protein is an inhibitor of these processes. J Virol 2001, 75(24):12241-12251. 10.1128/JVI.75.24.12241-12251.2001, 116121, 11711615.
5. Neuman BW, Adair BD, Burns JW, Milligan RA, Buchmeier MJ, Yeager M. Complementarity in the supramolecular design of arenaviruses and retroviruses revealed by electron cryomicroscopy and image analysis. J Virol 2005, 79(6):3822-3830. 10.1128/JVI.79.6.3822-3830.2005, 1075687, 15731275.
6. Shtanko O, Imai M, Goto H, Lukashevich IS, Neumann G, Watanabe T, Kawaoka Y. A role for the C terminus of Mopeia virus nucleoprotein in its incorporation into Z protein-induced virus-like particles. J Virol 2010, 84(10):5415-5422. 10.1128/JVI.02417-09, 2863806, 20200234.
7. Borden KL, Campbell Dwyer EJ, Salvato MS. An arenavirus RING (zinc-binding) protein binds the oncoprotein promyelocyte leukemia protein (PML) and relocates PML nuclear bodies to the cytoplasm. J Virol 1998, 72(1):758-766. 109432, 9420283.
8. Kentsis A, Dwyer EC, Perez JM, Sharma M, Chen A, Pan ZQ, Borden KL. The RING domains of the promyelocytic leukemia protein PML and the arenaviral protein Z repress translation by directly inhibiting translation initiation factor eIF4E. Journal Of Molecular Biology 2001, 312(4):609-623. 10.1006/jmbi.2001.5003, 11575918.
9. Urata S, de la Torre JC. Arenavirus budding. Adv Virol 2011, 2011:180326. 3265294, 22312335.
10. Strecker T, Eichler R, Meulen J, Weissenhorn W, Dieter Klenk H, Garten W, Lenz O. Lassa virus Z protein is a matrix protein and sufficient for the release of virus-like particles [corrected]. J Virol 2003, 77(19):10700-10705. 10.1128/JVI.77.19.10700-10705.2003, 228511, 12970458.
11. Urata S, Noda T, Kawaoka Y, Yokosawa H, Yasuda J. Cellular factors required for Lassa virus budding. J Virol 2006, 80(8):4191-4195. 10.1128/JVI.80.8.4191-4195.2006, 1440458, 16571837.
12. Eichler R, Strecker T, Kolesnikova L, ter Meulen J, Weissenhorn W, Becker S, Klenk HD, Garten W, Lenz O. Characterization of the Lassa virus matrix protein Z: electron microscopic study of virus-like particles and interaction with the nucleoprotein (NP). Virus Res 2004, 100(2):249-255. 10.1016/j.virusres.2003.11.017, 15019244.
13. Casabona JC, Levingston Macleod JM, Loureiro ME, Gomez GA, Lopez N. The RING domain and the L79 residue of Z protein are involved in both the rescue of nucleocapsids and the incorporation of glycoproteins into infectious chimeric arenavirus-like particles. J Virol 2009, 83(14):7029-7039. 10.1128/JVI.00329-09, 2704760, 19420075.
14. Urata S, Yasuda J, de la Torre JC. The z protein of the new world arenavirus tacaribe virus has bona fide budding activity that does not depend on known late domain motifs. J Virol 2009, 83(23):12651-12655. 10.1128/JVI.01012-09, 2786714, 19759156.
15. Strecker T, Maisa A, Daffis S, Eichler R, Lenz O, Garten W. The role of myristoylation in the membrane association of the Lassa virus matrix protein Z. Virol J 2006, 3:93. 10.1186/1743-422X-3-93, 1647273, 17083745.
16. Perez M, Greenwald DL, de la Torre JC. Myristoylation of the RING finger Z protein is essential for arenavirus budding. J Virol 2004, 78(20):11443-11448. 10.1128/JVI.78.20.11443-11448.2004, 521847, 15452271.
17. Chackerian B. Virus-like particles: flexible platforms for vaccine development. Expert Rev Vaccines 2007, 6(3):381-390. 10.1586/14760584.6.3.381, 17542753.
18. Roy P, Noad R. Virus-like particles as a vaccine delivery system: myths and facts. Hum Vaccin 2008, 4(1):5-12. 10.4161/hv.4.1.5559, 18438104.
19. McDonald B, Martin-Serrano J. No strings attached: the ESCRT machinery in viral budding and cytokinesis. J Cell Sci 2009, 122(Pt 13):2167-2177. 2723143, 19535732.
20. Zhou W, Parent LJ, Wills JW, Resh MD. Identification of a membrane-binding domain within the amino-terminal region of human immunodeficiency virus type 1 Gag protein which interacts with acidic phospholipids. J Virol 1994, 68(4):2556-2569. 236733, 8139035.
21. Kentsis A, Gordon RE, Borden KL. Self-assembly properties of a model RING domain. Proc Natl Acad Sci USA 2002, 99(2):667-672. 10.1073/pnas.012317299, 117363, 11792829.
22. Ohkawa T, Volkman LE, Welch MD. Actin-based motility drives baculovirus transit to the nucleus and cell surface. J Cell Biol 2010, 190(2):187-195. 10.1083/jcb.201001162, 2930276, 20660627.
23. Gladnikoff M, Shimoni E, Gov NS, Rousso I. Retroviral assembly and budding occur through an actin-driven mechanism. Biophys J 2009, 97(9):2419-2428. 10.1016/j.bpj.2009.08.016, 2770610, 19883584.
24. Capul AA, de la Torre JC. A cell-based luciferase assay amenable to high-throughput screening of inhibitors of arenavirus budding. Virology 2008, 382(1):107-114. 10.1016/j.virol.2008.09.008, 18929379.
25. Murphy FA, Webb PA, Johnson KM, Whitfield SG, Chappell WA. Arenoviruses in Vero cells: ultrastructural studies. J Virol 1970, 6(4):507-518. 376150, 5497898.
26. Branco LM, Grove JN, Geske FJ, Boisen ML, Muncy IJ, Magliato SA, Henderson LA, Schoepp RJ, Cashman KA, Hensley LE, et al. Lassa virus-like particles displaying all major immunological determinants as a vaccine candidate for Lassa hemorrhagic fever. Virol J 2010, 7:279. 10.1186/1743-422X-7-279, 2984592, 20961433.
27. Ramqvist T, Andreasson K, Dalianis T. Vaccination, immune and gene therapy based on virus-like particles against viral infections and cancer. Expert Opin Biol Ther 2007, 7(7):997-1007. 10.1517/14712598.7.7.997, 17665989.
28. Bachmann MF, Jennings GT. Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns. Nat Rev Immunol 2010, 10(11):787-796. 10.1038/nri2868, 20948547.
29. Bachmann MF, Rohrer UH, Kundig TM, Burki K, Hengartner H, Zinkernagel RM. The influence of antigen organization on B cell responsiveness. Science 1993, 262(5138):1448-1451. 10.1126/science.8248784, 8248784.
30. Singh M, Chakrapani A, O'Hagan D. Nanoparticles and microparticles as vaccine-delivery systems. Expert Rev Vaccines 2007, 6(5):797-808. 10.1586/14760584.6.5.797, 17931159.
31. Szakal AK, Holmes KL, Tew JG. Transport of immune complexes from the subcapsular sinus to lymph node follicles on the surface of nonphagocytic cells, including cells with dendritic morphology. J Immunol 1983, 131(4):1714-1727.
32. Carrasco YR, Batista FD. B cells acquire particulate antigen in a macrophage-rich area at the boundary between the follicle and the subcapsular sinus of the lymph node. Immunity 2007, 27(1):160-171. 10.1016/j.immuni.2007.06.007, 17658276.
33. Junt T, Moseman EA, Iannacone M, Massberg S, Lang PA, Boes M, Fink K, Henrickson SE, Shayakhmetov DM, Di Paolo NC, et al. Subcapsular sinus macrophages in lymph nodes clear lymph-borne viruses and present them to antiviral B cells. Nature 2007, 450(7166):110-114. 10.1038/nature06287, 17934446.
34. Qi H, Egen JG, Huang AY, Germain RN. Extrafollicular activation of lymph node B cells by antigen-bearing dendritic cells. Science 2006, 312(5780):1672-1676. 10.1126/science.1125703, 16778060.
35. Batista FD, Harwood NE. The who, how and where of antigen presentation to B cells. Nat Rev Immunol 2009, 9(1):15-27. 10.1038/nri2454, 19079135.
36. Huang NN, Han SB, Hwang IY, Kehrl JH. B cells productively engage soluble antigen-pulsed dendritic cells: visualization of live-cell dynamics of B cell-dendritic cell interactions. J Immunol 2005, 175(11):7125-7134.
37. Link A, Zabel F, Schnetzler Y, Titz A, Brombacher F, Bachmann MF. Innate immunity mediates follicular transport of particulate but not soluble protein antigen. J Immunol 2012, 188(8):3724-3733. 10.4049/jimmunol.1103312, 22427639.
38. Bergtold A, Desai DD, Gavhane A, Clynes R. Cell surface recycling of internalized antigen permits dendritic cell priming of B cells. Immunity 2005, 23(5):503-514. 10.1016/j.immuni.2005.09.013, 16286018.
39. Le Roux D, Le Bon A, Dumas A, Taleb K, Sachse M, Sikora R, Julithe M, Benmerah A, Bismuth G, Niedergang F. Antigen stored in dendritic cells after macropinocytosis is released unprocessed from late endosomes to target B cells. Blood 2012, 119(1):95-105. 10.1182/blood-2011-02-336123, 22049514.
40. Cubas R, Zhang S, Kwon S, Sevick-Muraca EM, Li M, Chen C, Yao Q. Virus-like particle (VLP) lymphatic trafficking and immune response generation after immunization by different routes. J Immunother 2009, 32(2):118-128. 10.1097/CJI.0b013e31818f13c4, 2717166, 19238010.
41. Graham FL, Smiley J, Russell WC, Nairn R. Characteristics of a human cell line transformed by DNA from human adenovirus type 5. J Gen Virol 1977, 36(1):59-74. 10.1099/0022-1317-36-1-59, 886304.
42. Arguelles MH, Orellana ML, Castello AA, Villegas GA, Masini M, Belizan AL, Gonzalez Ayala S, Vera OD, Glikmann G. Measles virus-specific antibody levels in individuals in Argentina who received a one-dose vaccine. J Clin Microbiol 2006, 44(8):2733-2738. 10.1128/JCM.00980-05, 1594608, 16891485.