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Volumn 17, Issue 4, 2012, Pages 266-274

GPCR assay automation for leveraging lead optimization

Author keywords

High throughput screening (HTS); Robotics and instrumentation; Screening data analysis

Indexed keywords

DATA TRANSFER; DRUG PRODUCTS; INFORMATION MANAGEMENT; ROBOTICS;

EID: 84868228367     PISSN: 22110682     EISSN: 22110690     Source Type: Journal    
DOI: 10.1177/2211068212442502     Document Type: Article
Times cited : (5)

References (29)
  • 1
    • 84878342212 scopus 로고    scopus 로고
    • Library Design: Ligand and Structure-Based Principles for Parallel and Combinatorial Libraries
    • In Elsevier: Oxford, UK
    • Schnur, D. M.; Tebben, A. J.; Cavallaro, C. L. Library Design: Ligand and Structure-Based Principles for Parallel and Combinatorial Libraries. In Comprehensive Medicinal Chemistry II, Elsevier: Oxford, UK, 2007, 1-30.
    • (2007) Comprehensive Medicinal Chemistry II , pp. 1-30
    • Schnur, D.M.1    Tebben, A.J.2    Cavallaro, C.L.3
  • 3
    • 23844449940 scopus 로고    scopus 로고
    • Computer-Based De Novo Design of Drug-like Molecules
    • Schneider, G.; Fechner, U. Computer-Based De Novo Design of Drug-like Molecules. Nat. Rev. Drug Dis. 2005, 4, 649-663.
    • (2005) Nat. Rev. Drug Dis. , vol.4 , pp. 649-663
    • Schneider, G.1    Fechner, U.2
  • 4
    • 80052858265 scopus 로고    scopus 로고
    • Structure-Based Drug Design to Augment Hit Discovery
    • Kalyaanamoorthy, S.; Chen, Y. P. Structure-Based Drug Design to Augment Hit Discovery. Drug Discov. Today 2011, 16, 831-839.
    • (2011) Drug Discov. Today , vol.16 , pp. 831-839
    • Kalyaanamoorthy, S.1    Chen, Y.P.2
  • 6
    • 37749025511 scopus 로고    scopus 로고
    • High-Throughput Screening: Evolution of Technology and Methods
    • In Gad, S. C., Ed.; John Wiley & Sons: New York
    • Banks, M. N.; Cacace, A.; O'Connell, J.; Houston, J. G. High-Throughput Screening: Evolution of Technology and Methods. In Drug Discovery Handbook, Gad, S. C., Ed.; John Wiley & Sons: New York, 2005, 559-602.
    • (2005) Drug Discovery Handbook , pp. 559-602
    • Banks, M.N.1    Cacace, A.2    O'Connell, J.3    Houston, J.G.4
  • 7
    • 84878334198 scopus 로고    scopus 로고
    • Screening Strategy for Lead Optimization
    • Zhang, L.; Banks, M. Screening Strategy for Lead Optimization. Am. Drug Discov. 2006, 1, 6-11.
    • (2006) Am. Drug Discov. , vol.1 , pp. 6-11
    • Zhang, L.1    Banks, M.2
  • 8
    • 0030666868 scopus 로고    scopus 로고
    • The Chemical-Biochemical Interface: Developments in Automated and Miniaturized Screening Technology
    • Houston, J. G.; Banks, M. The Chemical-Biochemical Interface: Developments in Automated and Miniaturized Screening Technology. Curr. Opin. Biotechnol. 1997, 8, 734-740.
    • (1997) Curr. Opin. Biotechnol. , vol.8 , pp. 734-740
    • Houston, J.G.1    Banks, M.2
  • 9
    • 67650361711 scopus 로고    scopus 로고
    • An Overview on GPCRs and Drug Discovery: Structure-Based Drug Design and Structural Biology on GPCRs
    • Lundstrom, K. An Overview on GPCRs and Drug Discovery: Structure-Based Drug Design and Structural Biology on GPCRs. Methods Mol. Biol. 2009, 552, 51-66.
    • (2009) Methods Mol. Biol. , vol.552 , pp. 51-66
    • Lundstrom, K.1
  • 10
    • 61649096359 scopus 로고    scopus 로고
    • G-Protein-Coupled Receptor-Focused Drug Discovery Using a Target Class Platform Approach
    • Heilker, R. G-Protein-Coupled Receptor-Focused Drug Discovery Using a Target Class Platform Approach. Drug Discov. Today 2009, 14, 231-240.
    • (2009) Drug Discov. Today , vol.14 , pp. 231-240
    • Heilker, R.1
  • 11
    • 34447513030 scopus 로고    scopus 로고
    • Emerging Concepts of Guanine Nucleotide Binding Protein-Coupled Receptor (GPCR) Function and Implications for High Throughput Screening
    • Eglen, R. M.; Bosse, R.; Reisine, T. Emerging Concepts of Guanine Nucleotide Binding Protein-Coupled Receptor (GPCR) Function and Implications for High Throughput Screening. Assay Drug Dev. Technol. 2007, 5, 425-452.
    • (2007) Assay Drug Dev. Technol. , vol.5 , pp. 425-452
    • Eglen, R.M.1    Bosse, R.2    Reisine, T.3
  • 12
    • 84878273919 scopus 로고    scopus 로고
    • Screening and Characterization of G-Protein-Coupled Receptor Ligands for Drug Discovery
    • 2nd Ed.; Informa Healthcare USA: London
    • Zhang, G; Cvijic, M. E. Screening and Characterization of G-Protein-Coupled Receptor Ligands for Drug Discovery. Handbook of Drug Screening, 2nd Ed.; Informa Healthcare USA: London, 2009; 139-188.
    • (2009) Handbook of Drug Screening , pp. 139-188
    • Zhang, G.1    Cvijic, M.E.2
  • 13
    • 42149181885 scopus 로고    scopus 로고
    • Structural Diversity of G Protein-Coupled Receptors and Significance for Drug Discovery
    • Lagerstrom, M. C.; Schioth, H. B. Structural Diversity of G Protein-Coupled Receptors and Significance for Drug Discovery. Nat. Rev. Drug Discov. 2008, 7, 339-357.
    • (2008) Nat. Rev. Drug Discov. , vol.7 , pp. 339-357
    • Lagerstrom, M.C.1    Schioth, H.B.2
  • 15
    • 0036142140 scopus 로고    scopus 로고
    • G Protein-Coupled Receptors: Dominant Players in Cell-Cell Communication
    • Bockaert, J.; Claeysen, S.; Becamel, C.; Pinloche, S.; Dumuis, A. G Protein-Coupled Receptors: Dominant Players in Cell-Cell Communication. Int. Rev. Cytol. 2002, 212, 63-132.
    • (2002) Int. Rev. Cytol. , vol.212 , pp. 63-132
    • Bockaert, J.1    Claeysen, S.2    Becamel, C.3    Pinloche, S.4    Dumuis, A.5
  • 16
    • 33947527882 scopus 로고    scopus 로고
    • Cardiac GPCRs: GPCR Signaling in Healthy and Failing Hearts
    • Salazar, N. C.; Chen, J.; Rockman, H. A. Cardiac GPCRs: GPCR Signaling in Healthy and Failing Hearts. Biochim. Biophys. Acta 2007, 1768, 1006-1018.
    • (2007) Biochim. Biophys. Acta , vol.1768 , pp. 1006-1018
    • Salazar, N.C.1    Chen, J.2    Rockman, H.A.3
  • 17
    • 47749128507 scopus 로고    scopus 로고
    • Seven Transmembrane-Spanning Receptors for Free Fatty Acids as Therapeutic Targets for Diabetes Mellitus: Pharmacological, Phylogenetic, and Drug Discovery Aspects
    • Costanzi, S.; Neumann, S.; Gershengorn, M. C. Seven Transmembrane-Spanning Receptors for Free Fatty Acids as Therapeutic Targets for Diabetes Mellitus: Pharmacological, Phylogenetic, and Drug Discovery Aspects. J. Biol. Chem. 2008, 283, 16269-16273.
    • (2008) J. Biol. Chem. , vol.283 , pp. 16269-16273
    • Costanzi, S.1    Neumann, S.2    Gershengorn, M.C.3
  • 18
    • 33947537441 scopus 로고    scopus 로고
    • G-Protein Coupled Receptors in Major Psychiatric Disorders
    • Catapano, L. A.; Manji, H. K. G-Protein Coupled Receptors in Major Psychiatric Disorders. Biochim. Biophys. Acta 2007, 1748, 976-993.
    • (2007) Biochim. Biophys. Acta , vol.1748 , pp. 976-993
    • Catapano, L.A.1    Manji, H.K.2
  • 19
    • 9144233659 scopus 로고    scopus 로고
    • Central G-Protein Coupled Receptors (GPCR)s as Molecular Targets for the Treatment of Obesity: Assets, Liabilities and Development Status
    • Miller, K. J.; Murphy, B. J.; Pellymounter, M. A. Central G-Protein Coupled Receptors (GPCR)s as Molecular Targets for the Treatment of Obesity: Assets, Liabilities and Development Status. Curr. Drug Targets CNS Neurol. Disord. 2004, 3, 357-377.
    • (2004) Curr. Drug Targets CNS Neurol. Disord. , vol.3 , pp. 357-377
    • Miller, K.J.1    Murphy, B.J.2    Pellymounter, M.A.3
  • 20
    • 0036679740 scopus 로고    scopus 로고
    • Chemokine Receptor Antagonism as an Approach to Anti-inflammatory Therapy: "Just Right" or Plain Wrong?
    • Carter, P. H. Chemokine Receptor Antagonism as an Approach to Anti-inflammatory Therapy: "Just Right" or Plain Wrong? Curr. Opin. Chem. Biol. 2002, 6, 510-525.
    • (2002) Curr. Opin. Chem. Biol. , vol.6 , pp. 510-525
    • Carter, P.H.1
  • 21
    • 78650845707 scopus 로고    scopus 로고
    • G Protein-Coupled Receptors: Novel Targets for Drug Discovery in Cancer
    • Lappano, R. G.; Maggiolini, M. G Protein-Coupled Receptors: Novel Targets for Drug Discovery in Cancer. Nat. Rev. Drug Discov. 2011, 10, 47-60.
    • (2011) Nat. Rev. Drug Discov. , vol.10 , pp. 47-60
    • Lappano, R.G.1    Maggiolini, M.2
  • 22
    • 0037867964 scopus 로고    scopus 로고
    • Virally Encoded G Protein-Coupled Receptors: Targets for Potentially Innovative Anti-viral Drug Development
    • Smit, M. J.; Vink, C.; Verzijl, D.; Casarosa, P.; Bruggeman, C. A.; Leurs, R. Virally Encoded G Protein-Coupled Receptors: Targets for Potentially Innovative Anti-viral Drug Development. Curr. Drug Targets 2003, 4, 431-441.
    • (2003) Curr. Drug Targets , vol.4 , pp. 431-441
    • Smit, M.J.1    Vink, C.2    Verzijl, D.3    Casarosa, P.4    Bruggeman, C.A.5    Leurs, R.6
  • 23
    • 50449111098 scopus 로고    scopus 로고
    • Screen/Counter Screen: Early Assessment of Selectivity
    • In Bartlett, P.A., Entzeroth, M., Eds.; Royal Chemical Soc Pub: London
    • Banks, M. N.; Zhang, L.; Houston, J. G. Screen/Counter Screen: Early Assessment of Selectivity. In Exploiting Chemical Diversity for Drug Discovery, Bartlett, P.A., Entzeroth, M., Eds.; Royal Chemical Soc Pub: London, 2006, 315-335.
    • (2006) Exploiting Chemical Diversity for Drug Discovery , pp. 315-335
    • Banks, M.N.1    Zhang, L.2    Houston, J.G.3
  • 24
    • 0041932071 scopus 로고    scopus 로고
    • An Ultra-HTS Process for the Identification of Small Molecule Modulators of Orphan G-Protein-Coupled Receptors
    • Cacace, A.; Banks, M.; Spicer, T.; Civoli, F.; Watson, J. An Ultra-HTS Process for the Identification of Small Molecule Modulators of Orphan G-Protein-Coupled Receptors. Drug Discov. Today 2003, 8, 785-792.
    • (2003) Drug Discov. Today , vol.8 , pp. 785-792
    • Cacace, A.1    Banks, M.2    Spicer, T.3    Civoli, F.4    Watson, J.5
  • 26
    • 0033003760 scopus 로고    scopus 로고
    • A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays
    • Zhang, J. H.; Chung, T. D. Y.; Oldenburg, K. R. A Simple Statistical Parameter for Use in Evaluation and Validation of High Throughput Screening Assays. J. Biomol. Screen 1999, 4, 67-73.
    • (1999) J. Biomol. Screen , vol.4 , pp. 67-73
    • Zhang, J.H.1    Chung, T.D.Y.2    Oldenburg, K.R.3
  • 27
    • 30344454724 scopus 로고    scopus 로고
    • Application of Scintillation Proximity Assay in Drug Discovery
    • Wu, S.; Liu, B. Application of Scintillation Proximity Assay in Drug Discovery. BioDrugs 2005, 19, 383-392.
    • (2005) BioDrugs , vol.19 , pp. 383-392
    • Wu, S.1    Liu, B.2
  • 28
    • 0032814850 scopus 로고    scopus 로고
    • Imaging systems in assay screening
    • Ramm, P. Imaging systems in assay screening. Drug Discov. Today 1999, 4, 401-410.
    • (1999) Drug Discov. Today , vol.4 , pp. 401-410
    • Ramm, P.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.