Combination treatment of stroke with sub-therapeutic doses of Simvastatin and human umbilical cord blood cells enhances vascular remodeling and improves functional outcome

Neuroscience

Volumn 227, Issue , 2012, Pages 223-231

  Cui, X ^a   Chopp, M ^a,b   Zacharek, A ^a   Dai, J ^a   Zhang, C ^a   Yan, T ^a   Ning, R ^a   Roberts, C ^a   Shehadah, A ^a   Kuzmin Nichols, N ^c   Sanberg, C D ^c   Chen, J ^a  

^a HENRY FORD HOSPITAL   (United States)

^b OAKLAND UNIVERSITY   (United States)

^c Saneron CCEL Therapeutics Inc   (United States)

Author keywords

Angiopoietin 1 (Ang1); Human umbilical cord blood cells (HUCBCs); Simvastatin; Stroke; Vascular remodeling

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; ANGIOPOIETIN 1; ANGIOPOIETIN RECEPTOR; BROXURIDINE; OCCLUDIN; PHOSPHATE BUFFERED SALINE; SIMVASTATIN; VON WILLEBRAND FACTOR;

ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD VESSEL DIAMETER; BLOOD VESSEL WALL; BRAIN ISCHEMIA; CAPILLARY DENSITY; CAPILLARY TUBE; CELL MIGRATION; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; CORD BLOOD STEM CELL TRANSPLANTATION; ENDOTHELIUM CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MONOTHERAPY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; TREATMENT OUTCOME;

ANALYSIS OF VARIANCE; ANGIOPOIETINS; ANIMALS; ANTIBODIES; ANTICHOLESTEREMIC AGENTS; ARTERIES; BROMODEOXYURIDINE; CELL MOVEMENT; CELLS, CULTURED; DISEASE MODELS, ANIMAL; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; LECTINS; LINEAR MODELS; MALE; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; RATS; RATS, WISTAR; SIMVASTATIN; STROKE; TIME FACTORS;

EID: 84868224689     PISSN: 03064522     EISSN: 18737544     Source Type: Journal    
DOI: 10.1016/j.neuroscience.2012.09.066     Document Type: Article

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