Excessive zinc in diet induces leptin resistance in Wistar rat through increased uptake of nutrients at intestinal level

Journal of Trace Elements in Medicine and Biology

Volumn 26, Issue 4, 2012, Pages 267-272

  Taneja, Satish Kumar ^a   Jain, Mridula ^a   Mandal, Reshu ^a   Megha, Kirti ^a  

^a PANJAB UNIVERSITY   (India)

Author keywords

Insulin; Intestine; Leptin; Rat; Zinc

Indexed keywords

COPPER; GLUCOSE; HYDROCORTISONE; INSULIN; LEPTIN; MAGNESIUM; SUCROSE; ZINC;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; COPPER BLOOD LEVEL; DIETARY INTAKE; FOOD INTAKE; HAIR LEVEL; INTESTINE EPITHELIUM CELL; INTESTINE MUCOSA; LIVER LEVEL; MAGNESIUM BLOOD LEVEL; MALE; MICROVILLUS; NONHUMAN; NUTRIENT UPTAKE; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; TRANSMISSION ELECTRON MICROSCOPY; WEIGHT GAIN; WISTAR RAT; ZINC BLOOD LEVEL;

ANIMALS; DIETARY SUPPLEMENTS; EATING; INTESTINAL ABSORPTION; LEPTIN; MALE; RATS; RATS, WISTAR; ZINC;

RATTUS; RATTUS NORVEGICUS; RODENTIA;

EID: 84868213393     PISSN: 0946672X     EISSN: 18783252     Source Type: Journal    
DOI: 10.1016/j.jtemb.2012.03.002     Document Type: Article

References (45)

1. Zhang Y., Proenca R., Maffei M., Barone M., Leopold L., Friedman G.M. Positional cloning of the mouse obese gene and its human homologue. Nature 1994, 372:425-432.
2. Campfield L.A., Smith F.J., Guisez Y., Devos R., Burn P. Recombinant mouse ob protein: evidence for a peripheral signal linking adiposity and central neural network. Science 1995, 269:546-548.
3. Mohn A., Di Marzio D., Marcovecchio M., Capanna R., Verrotti A., Chiarelli F. Adipose tissue as an endocrine organ: the role of leptin, resistin and other proteins. Ital J Pediatr 2004, 30:218-225.
4. Mantzoros C.S., Qu D., Frederich R. Activation of beta 3 adrenergic receptors suppresses leptin expression and mediates a leptin independent suppression of food intake in mice. Diabetes 1996, 45:909-914.
5. Trayhurn P., Beattie J.H. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc 2001, 60:329-339.
6. Maffei M., Halaas J., Ravussin E., Pratley R.E., Lee G.H., Zang Y., Fei H., Kim S., Lallone R., Ranganathan S., Kern P.A., Friedman J.M. Leptin levels in human and rodent: measurement of plasma leptin and ob mRNA in obese and weight-reduced subjects. Nat Med 1995, 1:1155-1161.
7. Niki T., Mori H., Tarriorl Y., Kishlmoto-hashirmoto M., Ueno H., Arakl S. Human obese gene: molecular screening in Japanese and Asian Indian NIDDM patients associated with obesity. Diabetes 1996, 45:675-678.
8. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., Ohannesian J.P., Marco C.C., McKee L.J., Bauer T.L., Caro J.R. Serum immunoreactive - leptin concentrations in normal weight and obese humans. N Engl J Med 1996, 334:292-295.
9. Chen M., Lin P., Cheng V., Lin W. Zinc supplementation aggravates body fat accumulation in genetically obese mice and dietary-obese mice. Biol Trace Elem Res 1996, 34:176-185.
10. Taneja S.K., Mandal R., Girhotra S. Long term excessive Zn-supplementation promotes metabolic syndrome-X in Wistar rats fed sucrose and fat rich semi-synthetic diet. Indian J Exp Biol 2006, 44:705-718.
11. Prentice A. Does mild zinc deficiency contribute to poor growth performance?. Nutr Rev 1993, 5:268-270.
12. Taneja S.K., Mahajan M., Arya P. Excessive bioavailability of Zn may cause obesity in humans. Experientia 1996, 52:31-33.
13. Tallmana C.G., Taylor C.G. Effect of dietary fat and zinc on adiposity serum leptin and adipose fatty acid composition in C57BL/6J mice. J Nutr Biochem 2003, 14:17-23.
14. Konukoglu D., Turhan M.S., Ercan M., Serin O. Relationship between plasma leptin and effect of insulin and oxidative stress on leptin in obese diabetic patients. J Nutr Biochem 2004, 15:757-760.
15. Marreiro D.N., Geloneze B., Tambascia M.A., Lerario A.C., Halpern A., Coozzolino S.M. Effect of zinc supplementation on serum leptin levels and insulin resistance of obese women. Biol Trace Elem Res 2006, 112:109-118.
16. Kelishadi R., Hashemipour M., Adeli K., Tavakoli N., Movahedian-Atter A., Shapouri J., Poursafa P., Rouzbahani A. Effect of zinc supplementation on markers of insulin resistance, oxidative stress and inflammation among prepubescent children with metabolic syndrome. Metab Syndr Relat Disord 2010, 6:505-510.
17. Oberleas D., Harland B.F. Phytate content of food: effect on dietary Zinc bioavailability. J Am Diet Assoc 1981, 79:433-437.
18. Turnland J.R., King J.C., Keyes W.R., Gong B., Michel M.C. A stable isotope study of zinc absorption in young men: effect of phytate and alpha-cellulose. Am J Clin Nutr 1984, 40:1071-1076.
19. Orgebin-crist M.C., Freeman M., Barney G.H. Sperm formation in Zn-deficient rats. Ann Biochem Biophys 1971, 11:547-558.
20. Trinder P. Determination of glucose in blood using glucose oxidase with an alternative oxygen acceptor. Ann Clin Biochem 1969, 6:24-27.
21. Tietz N.W. Clinical guide to laboratory tests 1976, W.B. Sounders Company, Philadelphia.
22. Boehm T.M., Lobovitz H.E. Statistical analysis of glucose and insulin responses to intravenous tolbutamide: evalution of hyperglycemic and hyperinsulinemic states. Diabetes Care 1979, 52:490-497.
23. Sacks B.D. Carbohydrates. Tietz text book of Clinical Chemistry 1994, 959-970. W.B. Saunders Co., Philadelphia. 2nd ed. C.A. Burtis, A.R. Ashwood (Eds.).
24. Blum W.F. Plasma leptin levels in healthy children and adolescent: dependence on body mass index, body fat mass, gender, pubertal stage and testosterone. J Clin Endocrinol Metab 1997, 82:2904-2910.
25. Robinson C.J., Gaines-Das R., Woollacott D. The first international standard for human leptin and the first international standard for mouse leptin: comparison of candidate preparations by in vitro bioassay and immunoassay. J Mol Endocrinol 2001, 27:69-79.
26. Collect A.J. Preservation of alveolar type-II pneumocyte lamellar bodies for electron microscope studies. J Histochem Cytochem 1979, 28:989-996.
27. Pomp D., Oberbauer A.M., Murray J.D. Development of obesity following inactivation of a growth trans gene in mice. Transgenic Res 1996, 5:13-23.
28. Pomp D., Oberbauer A.M., Murray J.D. Growth and body obesity composition of OMT- la-OGH transgenic male mice with differing period of transgenic activation. J Anim Sci 1992, 70(1):198-201.
29. Moran J.C., Lyerly A. The effects of severe zinc deficiency on intestinal amino acid losses in the rats. Life Sci 1985, 36:2551-2552.
30. Koo S.I., Turk D.E. Effect of zinc deficiency on intestinal transport of triglyceride in rats. J Nutr Biochem 1977, 4:909-919.
31. [14]C-glucose uptake in intestine of zinc deficient mice. Br J Nutr 1992, 68:505-514.
32. Friedman J.M., Halas J. Leptin and the regulation of body weight in mammals. Nature 1998, 395:763-770.
33. Gu W., Chen M., Tang J. The relation between the serum leptin concentration and adiposity in cheese. Chin J Endocrionol Metab 1999, 15:15-21.
34. Morton G.J., Cummings D.E., Baskin D.G., Barsh G.S., Schwartz M.W. Central nervous system control of food intake and body weight. Nature 2006, 443:289-295.
35. Caro J.F., Kolaczynski J.W., Nyce M.R., Ohannesian J.P., Opentanova I., Goldman W.H. Decreased cerebrospinal-fluid/serum leptin ratio in obesity: a possible mechanism for leptin resistance. Lancet 1996, 348:159-161.
36. Barr V.B., Malide D., Zarnowski M.J., Taylor S.I., Cushman S.W. Insulin stimulates both leptin secretion and production by rat white tissue. Endrocrinology 1997, 138(10):530-532.
37. Remesar X., Rafecas I., Fernadez-Lopez J.A., Alemany M. Is leptin an insulin counter-regulation hormone?. FEBS Lett 1997, 402:9-11.
38. Rosmond R., Dallman M.F., Blorntorp P. Stress-related cortisol secretion in men: relationships with abdominal obesity and endocrine, metabolic and hemodynamic abnormalities. J Clin Endocrinol Metab 1998, 83:1853-1859.
39. Fraser R., Ingram M.C., Anderson N.H., Morrison C., Davier E., Connell J.M.C. Cortisol effect on body mass, blood pressure and cholesterol in the general population. Hypertension 1999, 3:1374-1378.
40. Pasquali R., Contobelli S., Casimirri F., Capelli M., Boroluzzi L., Flamia R., Labate A.M., Barbara L. The Hypothalamic-pituitary-adrenal axis in obese women with different patterns of body fat distribution. J Clin Endocrinol Metab 1993, 77:341-346.
41. Prohaska J.R. Changes in Cu, Zn, SOD, CCO, GPx and glutathione transferase activities in copper deficiency mice and rats. J Nutr 1991, 121:355-363.
42. 1-generation of metabolic syndrome-X induced Wistar rats. Indian J Exp Biol 2009, 42:104-112.
43. Tall A.C. C-Reactive protein reassessed. New Engl J Med 2004, 350:1450-1452.
44. Ur E., Grossman A., Despres J.P. Obesity results as a consequence of glucocorticoid induced leptin resistance. Horm Metab Res 1996, 28:744-747.
45. Zakrzewska K.E., Cusin I., Sainsbury A., Rohner-Jeanrenaud F., Jeanrenaud B. Glucocorticoid as counter-regulatory hormone of leptin toward an understanding of leptin resistance. Diabetes 1997, 46:717-719.