Development of obesity following inactivation of a growth hormone transgene in mice

Transgenic Research

Volumn 5, Issue 1, 1996, Pages 13-23

  Pomp, Daniel ^a   Oberbauer, Anita M ^b   Murray, James D ^b  

^a OKLAHOMA STATE UNIVERSITY   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Fat; Growth hormone; Mice; Obesity; Transgenic

Indexed keywords

MUS MUSCULUS; OVIS;

GROWTH HORMONE; METALLOTHIONEIN; RECOMBINANT PROTEIN; SULFATE; ZINC DERIVATIVE; ZINC SULFATE;

ADIPOSE TISSUE; ANIMAL; ANIMAL FOOD; ARTICLE; BODY COMPOSITION; BODY WEIGHT; CALORIC INTAKE; DIET; FEMALE; GENE EXPRESSION REGULATION; GENETICS; GROWTH, DEVELOPMENT AND AGING; INSTITUTE FOR CANCER RESEARCH MOUSE; MALE; METABOLISM; MOUSE; OBESITY; ORGAN SIZE; PATHOLOGY; TIME; TRANSGENIC MOUSE;

ADIPOSE TISSUE; ANIMAL FEED; ANIMALS; BODY COMPOSITION; BODY WEIGHT; DIET; ENERGY INTAKE; FEMALE; GENE EXPRESSION REGULATION; GROWTH HORMONE; MALE; METALLOTHIONEIN; MICE; MICE, INBRED ICR; MICE, TRANSGENIC; OBESITY; ORGAN SIZE; RECOMBINANT PROTEINS; SULFATES; TIME FACTORS; ZINC COMPOUNDS; ZINC SULFATE;

EID: 0029688676     PISSN: 09628819     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01979918     Document Type: Article

References (50)

1. Ailhaud, G.P., Grimaldi, P.A. and Négrel, R.L. (1994) Genetics and molecular biology of adipose cell characteristics. In: Bouchard C., ed. The Genetics of Obesity, pp. 199-222. Boca Raton: CRC.
2. Bartke, A., Steger, R.W., Hodges, S.L., Parkening, T.A., Collins, T.J., Yun, J.S. and Wagner, T.E. (1988) Infertility in transgenic female mice with human growth hormone expression: evidence for luteal failure. J. Exptl Zool. 248, 121-4.
3. Bauman, D.E. and Vernon, R.G. (1993) Effects of exogenous bovine somatotropin on lactation. Ann. Rev Nutr. 13, 437-61.
4. Bhuvanakumar, C.K., Lynch, C.B., Roberts, R.C. and Hill, W.G. (1985) Heterosis among lines of mice selected for body weight. I. Growth. Theor. Appl. Genet. 71, 44-51.
5. Brem, G., Wanke, R., Wolf, E., Buchmüller, T., Müller, M., Brenig, B. and Hermann, W. (1989) Multiple consequences of human growth hormone expression in transgenic mice. Mol. Biol Med. 6, 531-47.
6. Brody, S. (1945) Bioenergenetics and Growth, Chapter 17. New York: Reinhold Publishing.
7. Campbell, R.G, Steele, N C., Caperna, T.J., McMurtry, J.P., Solomon, M.B. and Mitchel, A.D. (1989) Effects of exogenous porcine growth hormone administration between 30 and 60 kilograms on the subsequent and overall performance of pigs grown to 90 kilograms. J. Anim. Sci 67, 1265-71.
8. Chow, J.C., Murray, J.D., Pomp, D., Baldwin, R.L., Calvert, C.C. and Oberbauer, A.M. (1994) Regulation of insulin-like growth factor-1 and binding protein-3 expression in oMtIa-oGH transgenic mice. Transgenic Res. 3, 127-33.
9. Colle, M. and Auzerie. J. (1993) Discontinuation of growth hormone therapy in growth-hormone-deficient patients: assessment of body fat mass using bioelectrical impedance. Horm. Res 39, 192-6.
10. Davidson, M.B. (1987) Effect of growth hormone on carbohydrate and lipid metabolism. Endocrine Rev. 8, 115-31.
11. Doglio, A., Dani, C., Grimaldi, P. and Ailhaud, G. (1986) Growth hormone regulation of the expression of differentiation-dependent genes in preadipocyte Ob1771 cells. Biochem. J. 238, 123-9.
12. Dunshea, F.R. (1993) Effect of metabolism modifiers on lipid metabolism in the pig. J. Anim. Sci. 71, 1966-77.
13. Eisen, E.J. (1987) Selection for components related to body composition in mice: direct responses. Theor. Appl. Genet 74, 793-801.
14. Eisen, E.J., Fortman, M., Chen, W.Y. and Kopchick, J.J. (1993) Effect of genetic background on growth of mice hemizygous for wild-type or dwarf mutated bovine growth hormone transgenes. Theor. Appl. Gen. 87, 161-9.
15. Eisen, E.J. and Leatherwood, J.M. (1981) Predicting percent fat in mice. Growth 45, 100-7.
16. Etherton, T.D. and Smith, S.B. (1991) Somatotropin and β-adrenergic agonists: their efficacy and mechanisms of action. J. Anim. Sci. 69(Suppl 2), 2-26.
17. Flint, D.J. and Gardner, M.J. (1993) Influence of growth hormone deficiency on growth and body composition in rats: site-specific effects upon adipose tissue development. J. Endocrinol 137, 203-11.
18. Gertner, J.M. (1993) Effects of growth hormone on body fat in adults. Horm. Res. 40, 10-15.
19. Gould, S.J. (1966) Allometry and size in ontogeny and phylogeny. Biol. Rev. 41, 587-640.
20. Green, H., Morikawa, M. and Nixon, T. (1985) A dual effector theory of growth hormone action. Differentiation 29, 195-8.
21. Hart, I.C. and Johnsson, I.D. (1986) Growth hormone and growth in meat producing animals. In: Buttery, P.J., Haynes, N.B. and Lindsay, D.B., eds, Control and Manipulation of Animal Growth, pp. 135-59. London: Butterworths.
22. Huxley, J.S. (1932) Problems of Relative Growth. London: Methuen.
23. Job, J.C. (1990) Results of long-term growth hormone replacement therapy in children: when and how to treat? Horm. Res. 33(Suppl 4), 69-76.
24. Krick, B.J., Roneker, K.R., Boyd, R.D., Beermann, D.H., David, P.J. and Meisenger, D.J. (1992) Influence of genotype and sex on the response of growing pigs to recombinant porcine somatotropin. J. Anim. Sci. 70, 3024-34.
25. Lee, K.C., Azain, M.J., Hardin, M.D. and Williams, S.E. (1994) Effect of porcine somatotropin (pST) treatment and withdrawal on performance and adipose tissue cellularity in finishing swine. J Anim Sci. 72, 1702-11.
26. Li, C.H. (1987) Human somatotropin (HGH): some aspects of recent studies on its chemistry and biology. In: Lüdecke, D.K. and Tolis, G., eds, Growth Hormone, Growth Factors, and Acromegaly, pp. 79-83. New York: Raven Press.
27. Oberbauer, A.M., Currier, T.A., Nancarrow, C.D., Ward, K.A. and Murray, J.D. (1992) Linear bone growth of oMt1a-oGH transgenic male mice. Am. J. Physiol. 262, E936-42.
28. Ogle, G.D., Rosenberg, A.R., Calligeros, D. and Kainer, G. (1994) Effects of growth hormone treatment for short stature on calcium homeostasis, bone mineralisation, and body composition. Horm. Res 41, 16-20.
29. Palmiter, R.D., Brinster, R.L., Hammer, R.E., Trumbauer, M.G., Rosenfeld, M.G., Birnberg, N.C. and Evans, R.M. (1982) Dramatic growth of mice that develop from eggs microinjected with metallothionein-growth hormone fusion genes. Nature 300, 611-5.
30. Pell, J.M. and Bates, P.C. (1990) The nutritional regulation of growth hormone action. Nutr. Res. Rev. 3, 163-92.
31. Pomp, D., Murray, J.D. and Medrano, J.F. (1991) Single day detection of transgenic mice by PCR of toe-clips. Mouse Genome 89, 279.
32. Pomp, D., Nancarrow, C.D., Ward, K.A. and Murray, J.D. (1992a) Growth, feed efficiency and body composition of transgenic mice expressing a sheep metallothionein la-sheep growth hormone fusion gene. Livest. Prod. Sci. 31, 335-50.
33. Pomp, D., Oberbauer, A.M. and Murray, J.D. (1992b) Growth and body composition of oMT1a-oGH transgenic male mice with differing periods of transgene activation. J. Anim. Sci. 70(Suppl 1), 198.
34. Pomp, D., Geisert, R.D., Durham, C.M. and Murray, J.D. (1995) Rescue of pregnancy and maintenance of corpora lutea in infertile oMt1a-oGH transgenic mice. Biol Reprod. 51, 170-8.
35. Pursel, V.G., Pinkert, C.A., Miller, K.F., Bolt, D.J., Campbell, R.G., Palmiter, R.D., Brinster, R.L. and Hammer, R.E. (1989) Genetic engineering of livestock. Science 244, 1281-8.
36. Ranke, M.B. and Bierich, J.R. (1987) Clinical experience of authentic recombinant somatotropin - German collaborative study. Acta Paediatr. Scand. (Suppl) 331, 9-17.
37. Rincón-Limas, D.E., Reséndez-Pérez, D., Ortiz-López, R., Alvídrez-Quihui, L.E., Castro-MuñozLedo, F., Kuri-Harcuch, W., Martínez-Rodríguez, H.G. and Barrera-Saldaña, H.A. (1993) HGH isoforms: cDNA expression, adipogenic activity and production in cell culture. Biochim. Biophys. Acta 1172, 49-54.
38. Rogers, P. and Webb, G.P. (1980) Estimation of body fat in normal and obese mice. Br. J. Nutr. 43, 83.
39. SAS Institute (1988) SAS/STAT User's Guide, Release 6.03. Cary, North Carolina: SAS Institute Inc.
40. Schoenle, E., Zapf, J. and Froesch, E.R. (1979) Effects of insulin on glucose metabolism and glucose transport in fat cells of hormone-treated hypophysectomized rats: evidence that growth hormone restricts glucose transport. Endocrinology 105, 1237-42.
41. Schoenle, E.J., Qiu-Ren, Q. and Zachmann, M. (1990) Growth hormone requirement for a normal human adipocyte glucose carrier function. J. Clin. Endocrinol. Metab. 70, 1674-7.
42. Searle, T.W., Murray, J.D. and Baker, P.J. (1992) Effect of increased production of growth hormone on body composition in mice: transgenic versus control. J. Endocrinol. 132, 285-91.
43. Shanahan, C.M., Rigby, N.B., Murray, J.D., Marshall, J.T., Townrow, C.A., Nancarrow, C.D. and Ward, K.A. (1989) Regulation of expression of a sheep metallothionem la-sheep growth hormone fusion gene in transgenic mice. Mol. Cell Biol. 9, 5473-9.
44. Shanahon, (1992) no details given.
45. Sharp, K.R., Rnudsen, D.E.B., Pomp, D. and Murray, J.D. (in press) Expression of an ovine growth hormone transgene in mice causes organomegaly and hepatic lesions which resolve following trangene inactivation. Lab. Animal. Sci.
46. Shea, B.T., Hammer, R.E., Brinster, R.L. and Ravosa, M.R. (1991) Relative growth of the skull and postcranium in giant transgenic mice. Gen. Res. 56, 21-34.
47. Skaggs, S.R. and Crist, D.M. (1991) Exogenous human growth hormone reduces body fat in obese women. Horm. Res. 35, 19-24.
48. Smith, V.G. and Kasson, C.W. (1990) Growth performance and carcass characteristics of pigs administered recombinant porcine somatotropin during 30 to 110 kilogram live weight. J. Anim. Sci. 68, 4109-16.
49. Squires, E.J., Adeola, O., Young, L.G. and Hacker, R.R. (1993) The role of growth hormones, β-adrenergic agents and intact males in pork production: a review. Can. J. Anim. Sci. 73, 1-23.
50. Wabitsch, M. and Heinze, E. (1993) Body fat in GH-deficient children and the effect of treatment. Horm. Res. 40, 5-9.