Nomogram for predicting positive resection margins after breast-conserving surgery

Breast Cancer Research and Treatment

Volumn 134, Issue 3, 2012, Pages 1115-1123

  Shin, Hee Chul ^a   Han, Wonshik ^b   Moon, Hyeong Gon ^b   Cho, Nariya ^b   Moon, Woo Kyung ^b   Park, In Ae ^b   Park, Sung Jun ^a   Noh, Dong Young ^b  

^a Chung Ang University   (South Korea)

^b Seoul National University   (South Korea)

Author keywords

Breast neoplasm; Breast conserving surgery; Nomogram; Resection margins

Indexed keywords

ADULT; ARTICLE; BREAST CALCIFICATION; BREAST CANCER; CANCER GRADING; CLINICAL FEATURE; CONTROLLED STUDY; ECHOGRAPHY; HUMAN; INTRADUCTAL CARCINOMA; MAJOR CLINICAL STUDY; MAMMOGRAPHY; NEEDLE BIOPSY; NOMOGRAM; NUCLEAR MAGNETIC RESONANCE IMAGING; PARTIAL MASTECTOMY; PREDICTION; PRIORITY JOURNAL; TUMOR VOLUME;

ADULT; BREAST NEOPLASMS; COHORT STUDIES; DIAGNOSTIC IMAGING; FEMALE; HUMANS; INTRAOPERATIVE CARE; MASTECTOMY, SEGMENTAL; MIDDLE AGED; NEOPLASM GRADING; NEOPLASM STAGING; NOMOGRAMS; PROGNOSIS; REPRODUCIBILITY OF RESULTS; RETROSPECTIVE STUDIES;

EID: 84868199821     PISSN: 01676806     EISSN: 15737217     Source Type: Journal    
DOI: 10.1007/s10549-012-2124-3     Document Type: Article

References (39)

1. Van Dongen JA, Voogd AC, Fentiman IS, Legrand C, Sylvester RJ, Tong D, Van der Schueren E, Helle PA, Van Zijl K, Bartelink H (2000) Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. J Natl Cancer Inst 92:1143-1150
2. Fisher B, Anderson S, Bryant J, Margolese RG, Deutsch M, Fisher ER, Jeong JH, Wolmark N (2002) Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 347:1233-1241. doi:10.1056/NEJ Moa022152
3. Kreike B, Hart AA, Van De Velde T, Borger J, Peterse H, Rutgers E, Bartelink H, Van De Vijver MJ (2008) Continuing risk of ipsilateral breast relapse after breast-conserving therapy at long-term follow-up. Int J Radiat Oncol Biol Phys 71:1014-1021. doi:10.1016/j.ijrobp. 2007.11.029
4. Mechera R, Viehl CT, Oertli D (2009) Factors predicting inbreast tumor recurrence after breast-conserving surgery. Breast Cancer Res Treat 116:171-177. doi:10.1007/s10549-008-0187-y
5. Coopey S, Smith BL, Hanson S, Buckley J, Hughes KS, Gadd M, Specht MC (2011) The safety of multiple re-excisions after lumpectomy for breast cancer. Ann Surg Oncol 18:3797-3801. doi:10.1245/s10434-011-1802-4
6. Pleijhuis RG, Graafland M, De Vries J, Bart J, De Jong JS, Van Dam GM (2009) Obtaining adequate surgical margins in breastconserving therapy for patients with early-stage breast cancer: current modalities and future directions. Ann Surg Oncol 16:2717-2730. doi:10.1245/s10434-009-0609-z
7. Weber WP, Engelberger S, Viehl CT, Zanetti-Dallenbach R, Kuster S, Dirnhofer S, Wruk D, Oertli D, Marti WR (2008) Accuracy of frozen section analysis versus specimen radiography during breast-conserving surgery for nonpalpable lesions. World J Surg 32:2599-2606. doi:10.1007/s00268-008-9757-8
8. Riedl O, Fitzal F, Mader N, Dubsky P, Rudas M, Mittlboeck M, Gnant M, Jakesz R (2009) Intraoperative frozen section analysis for breast-conserving therapy in 1016 patients with breast cancer. Eur J Surg Oncol 35:264-270. doi:10.1016/j.ejso.2008.05.007
9. Blair SL, Thompson K, Rococco J, Malcarne V, Beitsch PD, Ollila DW (2009) Attaining negative margins in breast-conservation operations: is there a consensus among breast surgeons? J Am Coll Surg 209:608-613. doi:10.1016/j.jamcollsurg.2009. 07.026
10. Lovrics PJ, Cornacchi SD, Farrokhyar F, Garnett A, Chen V, Franic S, Simunovic M (2009) The relationship between surgical factors and margin status after breast-conservation surgery for early stage breast cancer. Am J Surg 197:740-746. doi:10.1016/j.amjsurg.2008.03.007
11. Cho N, Kim SM, Park JS, Jang M, Kim SY, Chang JM, Moon WK (2011) Contralateral lesions detected by preoperative MRI in patients with recently diagnosed breast cancer: application of MR CAD in differentiation of benign and malignant lesions. Eur J Radiol. doi:10.1016/j.ejrad.2011.03.060
12. Carlson RW, Allred DC, Anderson BO, Burstein HJ, Carter WB, Edge SB, Erban JK, Farrar WB, Forero A, Giodano SH, Goldstein LJ, Gradishar WJ, Hayes DF, Hudis CA, Ljung B-M, Mankoff DA, Marcom PK, Mayer IA, McCormick B, Pierce LJ, Reed EC, Sachdev J, Smith ML, Somlo G, Ward JH, Wolff AC, Zellars R (2011) NCCN clinical practice guidelines in oncology: breast cancer version 2.2011. http://www.nccn.org. Accessed 11 Nov. 2011
13. Hosmer D, Lemeshow S (2000) Applied logistic regression. Wiley, New York
14. Iasonos A, Schrag D, Raj GV, Panageas KS (2008) How to build and interpret a nomogram for cancer prognosis. J Clin Oncol 26:1364-1370. doi:10.1200/JCO.2007.12.9791
15. Park CC, Mitsumori M, Nixon A, Recht A, Connolly J, Gelman R, Silver B, Hetelekidis S, Abner A, Harris JR, Schnitt SJ (2000) Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: influence of margin status and systemic therapy on local recurrence. J Clin Oncol 18:1668-1675
16. Groot G, Rees H, Pahwa P, Kanagaratnam S, Kinloch M (2011) Predicting local recurrence following breast-conserving therapy for early stage breast cancer: the significance of a narrow (B2 mm) surgical resection margin. J Surg Oncol 103:212-216. doi:10.1002/jso.21826
17. Galimberti V, Maisonneuve P, Rotmensz N, Viale G, Sangalli C, Sargenti M, Brenelli F, Gentilini O, Intra M, Bassi F, Luini A, Zurrida S, Veronesi P, Colleoni M, Veronesi U (2011) Influence of margin status on outcomes in lobular carcinoma: experience of the European Institute of Oncology. Ann Surg 253:580-584. doi:10.1097/SLA.0b013e31820d9a81
18. Dunne C, Burke JP, Morrow M, Kell MR (2009) Effect of margin status on local recurrence after breast conservation and radiation therapy for ductal carcinoma in situ. J Clin Oncol 27:1615-1620. doi:10.1200/JCO.2008.17.5182
19. Rudloff U, Brogi E, Reiner AS, Goldberg JI, Brockway JP, Wynveen CA, McCormick B, Patil S, Van Zee KJ (2010) The influence of margin width and volume of disease near margin on benefit of radiation therapy for women with DCIS treated with breast-conserving therapy. Ann Surg 251:583-591. doi:10.1097/SLA.0b013e3181b5931e
20. Silverstein MJ, Lagios MD, Groshen S, Waisman JR, Lewinsky BS, Martino S, Gamagami P, Colburn WJ (1999) The influence of margin width on local control of ductal carcinoma in situ of the breast. N Engl J Med 340:1455-1461. doi:10.1056/NEJM19990 5133401902
21. Turnbull L, Brown S, Harvey I, Olivier C, Drew P, Napp V, Hanby A, Brown J (2010) Comparative effectiveness of MRI in breast cancer (≥OMICE) trial: a randomised controlled trial. Lancet 375:563-571
22. Peters NH, Van Esser S, Van Den Bosch MA, Storm RK, Plaisier PW, Van Dalen T, Diepstraten SC, Weits T, Westenend PJ, Stapper G, Fernandez-Gallardo MA, Borel Rinkes IH, Van Hillegersberg R, Mali WP, Peeters PH (2011) Preoperative MRI and surgical management in patients with nonpalpable breast cancer: the MONET-randomised controlled trial. Eur J Cancer 47:879-886. doi:10.1016/j.ejca.2010.11.035
23. Olson TP, Harter J, Munoz A, Mahvi DM, Breslin T (2007) Frozen section analysis for intraoperative margin assessment during breast-conserving surgery results in low rates of re-excision and local recurrence. Ann Surg Oncol 14:2953-2960. doi:10.1245/s10434-007-9437-1
24. Fukamachi K, Ishida T, Usami S, Takeda M, Watanabe M, Sasano H, Ohuchi N (2010) Total-circumference intraoperative frozen section analysis reduces margin-positive rate in breastconservation surgery. Jpn J Clin Oncol 40:513-520. doi:10.1093/jjco/hyq006
25. Cendan JC, Coco D, Copeland EM 3rd (2005) Accuracy of intraoperative frozen-section analysis of breast cancer lumpectomy-bed margins. J Am Coll Surg 201:194-198
26. Tartter PI, Kaplan J, Bleiweiss I, Gajdos C, Kong A, Ahmed S, Zapetti D (2000) Lumpectomy margins, reexcision, and local recurrence of breast cancer. Am J Surg 179:81-85
27. Kurniawan ED, Wong MH, Windle I, Rose A, Mou A, Buchanan M, Collins JP, Miller JA, Gruen RL, Mann GB (2008) Predictors of surgical margin status in breast-conserving surgery within a breast screening program. Ann Surg Oncol 15:2542-2549. doi:10.1245/s10434-008-0054-4
28. Boyd NF, Jensen HM, Cooke G, Han HL, Lockwood GA, Miller AB (2000) Mammographic densities and the prevalence and incidence of histological types of benign breast disease. Reference Pathologists of the Canadian National Breast Screening Study. Eur J Cancer Prev 9:15-24
29. Turashvili G, McKinney S, Martin L, Gelmon KA, Watson P, Boyd N, Aparicio S (2009) Columnar cell lesions, mammographic density and breast cancer risk. Breast Cancer Res Treat 115:561-571. doi:10.1007/s10549-008-0099-x
30. Yaghjyan L, Colditz GA, Collins LC, Schnitt SJ, Rosner B, Vachon C, Tamimi RM (2011) Mammographic breast density and subsequent risk of breast cancer in postmenopausal women according to tumor characteristics. J Natl Cancer Inst 103:1179-1189
31. Hata T, Takahashi H, Watanabe K, Takahashi M, Taguchi K, Itoh T, Todo S (2004) Magnetic resonance imaging for preoperative evaluation of breast cancer: a comparative study with mammography and ultrasonography. J Am Coll Surg 198:190-197. doi:10.1016/j.jamcollsurg.2003.10.008
32. Schouten Van der Velden AP, Schlooz-Vries MS, Boetes C, Wobbes T (2009) Magnetic resonance imaging of ductal carcinoma in situ: what is its clinical application? A review. Am J Surg 198:262-269. doi:10.1016/j.amjsurg.2009.01.010
33. Liberman L, Morris EA, Dershaw DD, Abramson AF, Tan LK (2003) Ductal enhancement on MR imaging of the breast. AJR Am J Roentgenol 181:519-525
34. Tresserra F, Feu J, Grases PJ, Navarro B, Alegret X, Fernandez-Cid A (1999) Assessment of breast cancer size: sonographic and pathologic correlation. J Clin Ultrasound 27:485-491
35. Satake H, Shimamoto K, Sawaki A, Niimi R, Ando Y, Ishiguchi T, Ishigaki T, Yamakawa K, Nagasaka T, Funahashi H (2000) Role of ultrasonography in the detection of intraductal spread of breast cancer: correlation with pathologic findings, mammography and MR imaging. Eur Radiol 10:1726-1732
36. Shin HC, Han W, Moon HG, Yom CK, Ahn SK, You JM, Kim JS, Chang JM, Cho N, Moon WK, Park IA, Noh DY (2012) Limited value and utility of breast MRI in patients undergoing breast-conserving cancer surgery. Ann Surg Oncol. doi:10.1245/s10434-012-2289-3
37. Dillon MF, Maguire AA, McDermott EW, Myers C, Hill AD, O'Doherty A, Quinn CM (2008) Needle core biopsy characteristics identify patients at risk of compromised margins in breast conservation surgery. Mod Pathol 21:39-45. doi:10.1038/mod pathol.3800975
38. Saadai P, Moezzi M, Menes T (2011) Preoperative and intraoperative predictors of positive margins after breast-conserving surgery: a retrospective review. Breast Cancer 18:221-225. doi:10.1007/s12282-011-0262-9
39. Chagpar AB, Martin RC 2nd, Hagendoorn LJ, Chao C, McMasters KM (2004) Lumpectomy margins are affected by tumor size and histologic subtype but not by biopsy technique. Am J Surg 188:399-402. doi:10.1016/j.amjsurg.2004.06.020