Predicting local recurrence following breast-conserving therapy for early stage breast cancer: The significance of a narrow (≤2 mm) surgical resection margin

Journal of Surgical Oncology

Volumn 103, Issue 3, 2011, Pages 212-216

  Groot, Gary ^a   Rees, Henrike ^a   Pahwa, Punam ^a   Kanagaratnam, Sivaruban ^a   Kinloch, Mary ^a  

^a UNIVERSITY OF SASKATCHEWAN   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; BREAST CANCER; CANCER RECURRENCE; CANCER STAGING; EARLY CANCER; HUMAN; INTRADUCTAL CARCINOMA; MAJOR CLINICAL STUDY; PARTIAL MASTECTOMY; PREDICTION; PRIORITY JOURNAL; RECURRENCE RISK; SURGICAL TECHNIQUE; TREATMENT OUTCOME;

ADULT; BREAST NEOPLASMS; CARCINOMA, DUCTAL, BREAST; FEMALE; FORECASTING; HUMANS; MASTECTOMY, SEGMENTAL; MIDDLE AGED; NEOPLASM INVASIVENESS; NEOPLASM RECURRENCE, LOCAL; NEOPLASM STAGING; TREATMENT OUTCOME;

EID: 79952011387     PISSN: 00224790     EISSN: 10969098     Source Type: Journal    
DOI: 10.1002/jso.21826     Document Type: Article

References (49)

1. Fisher B, Redmond C, Fisher ER: Ten-year results of a randomized clinical trial comparing radical mastectomy and total mastectomy with or without radiation. N Engl J Med 1985;312:674-681. (Pubitemid 15134703)
2. Fisher B, Anderson S, Bryant J, et al.: Twenty-year follow-up of a randomized trial comparing total mastectomy, lumpectomy, and lumpectomy plus irradiation for the treatment of invasive breast cancer. N Engl J Med 2002;347:1233-1241. (Pubitemid 35176242)
3. Veronesi U, Cascinelli N, Mariani L, et al.: Twenty-year follow-up of a randomized study comparing breast-conserving surgery with radical mastectomy for early breast cancer. N Engl J Med 2002; 347:1227-1232. (Pubitemid 35176241)
4. Van Dongen J, Voogd AC, Fentiman IS, et al.: Long-term results of a randomized trial comparing breast-conserving therapy with mastectomy: European Organization for Research and Treatment of Cancer 10801 trial. J Natl Cancer Inst 2000;92: 1143-1150.
5. Arriagada R, Le MG, Guinebretiere JM, et al.: Late local recurrences in a randomised trial comparing conservative treatment with total mastectomy in early breast cancer patients. Ann Oncol 2003;14:1617-1622. (Pubitemid 37455809)
6. Poggi MM, Danforth DN, Sciuto LC, et al.: Eighteen-year results in the treatment of early breast carcinoma with mastectomy versus breast conservation therapy: The National Cancer Institute Randomized Trial. Cancer 2003;98:697-702. (Pubitemid 36959264)
7. Blichert-Toft M, Rose C, Andersen J, et al.: Danish randomized trial comparing breast conservation therapy with mastectomy: Six years of life-table analysis. Danish Breast Cancer Cooperative Group. J Natl Cancer Inst 1992;11:19-25.
8. Gori J, Castano R, Engel H, et al.: Conservative treatment vs. mastectomy without radiotherapy in aged women with breast cancer - A prospective and randomized trial. Zentralbl Gynakol 2000;122:311-317. (Pubitemid 30399165)
9. D'Aiuto G, Parisi V, Grasso M, editors: Conservative surgery in early breast cancer. 5th European Conference on Clinical Oncology, London, UK, 1989.
10. Hayward J: The Guy's trial of treatments of "early" breast cancer. World J Surg 1977;1:314-316.
11. Atkins H, Hayward JL, Klugman DJ, et al.: Treatment of early breast cancer: A report after ten years of a clinicl trial. BMJ 1972;2:423-429.
12. Fisher B, Redmond C: Lumpectomy for breast cancer: An update of the NSABP experience. National Surgical Adjuvant Breast and Bowel Project. J Natl Cancer Inst Monogr 1992;11:7-13.
13. Jatoi I, Proschan MA: Randomized trials of breast-conserving therapy versus mastectomy for primary breast cancer: A pooled analysis of updated results. Am J Clin Oncol 2005;28:289-294. (Pubitemid 40800482)
14. Arriagada R, Le MG, Rochard F, et al.: Conservative treatment versus mastectomy in early breast cancer: Patterns of failure with 15 years of follow-up data. Institut Gustave-Roussy Breast Cancer Group. J Clin Oncol 1996;14:1558-1564. (Pubitemid 26134214)
15. Fisher B, Anderson S, Redmond CK, et al.: Reanalysis and results after 12 years of follow-up in a randomized clinical trial comparing total mastectomy with lumpectomy with or without irradiation in the treatment of breast cancer. N Engl J Med 1995;333:1456-1461.
16. Jacobson JA, Danforth DN, Cowan KH, et al.: Ten-year results of a comparison of conservation with mastectomy in the treatment of stage I and II breast cancer. N Engl J Med 1995;332:907-911.
17. Veronesi U, Luini A, Galimberti V, et al.: Conservation approaches for the management of stage I/II carcinoma of the breast: Milan Cancer Institute trials. World J Surg 1994;18:70-75. (Pubitemid 24100695)
18. Park CC, Mitsumori M, Nixon A, et al.: Outcome at 8 years after breast-conserving surgery and radiation therapy for invasive breast cancer: Influence of margin status and systemic therapy on local recurrence. J Clin Oncol 2000;18:1668-1675. (Pubitemid 30220545)
19. Leong C, Boyages J, Jayasinghe UW, et al.: Effect of margins on ipsilateral breast tumor recurrence after breast conservation therapy for lymph node-negative breast carcinoma. Cancer 2004;100:1823-1832. (Pubitemid 38529559)
20. Bleicher R, Morrow M: Management of close margins in invasive breast cancer. Combridge University Press, breast cancer online; 2007. DOI: 10.1017/s147090307005482. ISSN 1470-9031.
21. Spivack B, Khanna MM, Tafra L, et al.: Margin status and local recurrence after breast-conserving surgery. Arch Surg 1994;129: 952-956; discussion 6-7.
22. Freedman G, Fowble B, Hanlon A: Patients with early stage invasive cancer with close or positive margins treated with conservative surgery and radiation have an increased risk of breast recurrence that is delayed by adjuvant systemic therapy. Int J Radiat Oncol Biol Phys 1999;44:1005-1015. (Pubitemid 29342901)
23. Fredriksson I, Liljegren G, Palm-Sjovall M, et al.: Risk factors for local recurrence after breast-conserving surgery. Br J Surg 2003; 90:1093-1102. (Pubitemid 37152168)
24. Schnitt S, Abner A, Gelman R, et al.: The relationship between microscopic margins of resection and the risk of local recurrence in patients with breast cancer treated breast-conserving therapy. cancer 1994;74:1746-1751.
25. Gage I, Schnitt S, Nixon A, et al.: Pathologic margin involvement and the risk of recurrence in patients treated with breast-conserving therapy. Cancer 1996;78:1921-1928. (Pubitemid 26360575)
26. Smitt MC, Nowels KW, Zdeblick MJ, et al.: The importance of the lumpectomy surgical margin status in long-term results of breast conservation. Cancer 1995;76:259-267.
27. Smitt MC, Nowels K, Carlson RW, et al.: Predictors of reexcision findings and recurrence after breast conservation. Int J Radiat Oncol Biol Phys 2003;57:979-985. (Pubitemid 37324115)
28. Schwartz GF, Veronesi UCK, Dixon JM, et al.: editors. Proceedings of the Consensus Conference on Breast Conservation, April 28 to May1, Milan, Italy. 2005 Breast Consensus Conference, 2006, Milan, Italy: Wiley Interscience.
29. Neuschatz AC, DiPetrillo T, Steinhoff M, et al.: The value of breast lumpectomy margin assessment as a predictor of residual tumor burden in ductal carcinoma in situ of the breast. Cancer 2002;94:1917-1924. (Pubitemid 34270043)
30. Kotwall C, Ranson M, Stiles A, et al.: Relationship between initial margin status for invasive breast cancer and residual carcinoma after re-excision. Am Surg 2007;73:337-343. (Pubitemid 351396674)
31. Sabel M, Rogers K, Griffith K, et al.: residual disease after reexcision lumpectomy for close margins. J Surg Oncol 2009; Feb 1; 99:99-103
32. Abd-Alla HM, Lotayef MM, Abou Bakr A, et al.: Ipsilateral inbreast tumor relapse after breast conservation therapy: True recurrence versus new primary tumor. J Egypt Natl Canc Inst 2006;18: 183-190.
33. Veronesi U, Marubini E, Del Vecchio M, et al.: Local recurrences and distant metastases after conservative breast cancer treatments: Partly independent events. J Natl Cancer Inst 1995;87:19-27.
34. Huang E, Buchholz TA, Meric F, et al.: Classifying local disease recurrences after breast conservation therapy based on location and histology: New primary tumors have more favorable outcomes than true local disease recurrences. Cancer 2002;95:2059-2067. (Pubitemid 35253366)
35. Smith TE, Lee D, Turner BC, et al.: True recurrence vs. new primary ipsilateral breast tumor relapse: An analysis of clinical and pathologic differences and their implications in natural history, prognoses, and therapeutic management. Int J Radiat Oncol Biol Phys 2000;48:1281-1289.
36. Vujovic O, Cherian A, Yu E, et al.: The effect of timing of radio-therapy after breast-conserving surgery in patients with positive or close resection margins, young age, and node-negative disease, with long term follow-up. Int J Radiat Oncol Biol Phys 2006; 66:687-690. (Pubitemid 44436701)
37. Ampil FL, Burton GV, Li BD, et al.: Radiotherapy with and without chemotherapy after breast conservation surgery for early stage breast cancer: A review of timing. Eur J Gynaecol Oncol 1999; 20:254-257. (Pubitemid 30113721)
38. Vujovic O, Perera F, Dar AR, et al.: Does delay in breast irradiation following conservative breast surgery in node-negative breast cancer patients have an impact on risk of recurrence? Int J Radiat Oncol Biol Phys 1998;40:869-874.
39. Blair S, Thompson K, Rococco J, et al.: Attaining negative margins in breast-conservation operations: Is there a consensus among breast surgeons? J Am Coll Surg 2009;209:608-613.
40. de Bock GH, van der Hage JA, Putter H, et al.: Isolated locoregional recurrence of breast cancer is more common in young patients and following breast conserving therapy: Long-term results of European Organisation for Research and Treatment of Cancer studies. Eur J Cancer 2006;42:351-356. (Pubitemid 43132890)
41. Bollet MA, Sigal-Zafrani B, Mazeau V, et al.: Age remains the first prognostic factor for loco-regional breast cancer recurrence in young (<40 years) women treated with breast conserving surgery first. Radiother Oncol 2007;82:272-280. (Pubitemid 46350796)
42. Recht A, Connolly JL, Schnitt SJ, et al.: The effect of young age on tumor recurrence in the treated breast after conservative surgery and radiotherapy. Int J Radiat Oncol Biol Phys 1988;14:3-10. (Pubitemid 18059122)
43. Fowble BL, Schultz DJ, Overmoyer B, et al.: The influence of young age on outcome in early stage breast cancer. Int J Radiat Oncol Biol Phys 1994;30:23-33. (Pubitemid 24291110)
44. Borger J, Kemperman H, Hart A, et al.: Risk factors in breast-conservation therapy. J Clin Oncol 1994;12:653-660. (Pubitemid 24110901)
45. Elkhuizen PH, Van deVijver M, Hermans J, et al.: Local recurrence after breast-conserving therapy for invasive breast cancer: High incidence in young patients and association with poor survival. Int J Radiat Oncol Biol Phys 1998;40:859-867. (Pubitemid 28150804)
46. Cowen D, Houvenaeghel G, Jacquemier J, et al.: Local recurrences after conservative treatment of breast cancer: Risk factors and influence on survival. Cancer Radiother 1998;2:460-468. (Pubitemid 29518568)
47. Voogd AC, Nielsen M, Peterse JL, et al.: Differences in risk factors for local and distant recurrence after breast-conserving therapy or mastectomy for stage I and II breast cancer: Pooled results of two large European randomized trials. J Clin Oncol 2001;19:1688-1697. (Pubitemid 32230869)
48. Hardy K, Fradette K, Gheorghe R, et al.: The impact of margin status on local rcurrence following breast conserving therapy for invasive carcinoma in Manitoba. J Surg Oncol 2008;98:399-402.
49. Bartelink H, Horiot JC, Poortmans PM, et al.: Impact of a higher radiation dose on local control and survival in breast-conserving therapy of early breast cancer: 10-year results of the randomized boost versus no boost EORTC 22881-10882 trial. J Clin Oncol 2007;25:3259-3265. (Pubitemid 47325610)