Approach to the obese adolescent with new-onset diabetes

Journal of Clinical Endocrinology and Metabolism

Volumn 95, Issue 12, 2010, Pages 5163-5170

  Zeitler, Philip ^a  

^a Children's Hospital Colorado   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

GLIMEPIRIDE; INSULIN; METFORMIN; SULFONYLUREA;

ADOLESCENT; ARTICLE; CLINICAL FEATURE; DIARRHEA; DRUG DOSE TITRATION; DRUG EFFICACY; HUMAN; HYPOGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; MORBIDITY; NAUSEA; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PRIORITY JOURNAL; SIDE EFFECT; TREATMENT RESPONSE; WEIGHT GAIN;

EID: 78650157731     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2010-0958     Document Type: Article

References (63)

1. Nadeau K, Dabelea D 2008 Epidemiology of type 2 diabetes in children and adolescents. In: Dabelea D, Klingensmith GJ, eds. Epidemiology of pediatric and adolescent diabetes. New York: Informa Healthcare; 103-124
2. Pinhas-Hamiel O, Zeitler P 2005 The global spread of type 2 diabetes in children and adolescents. J Pediatr 146:693-700 (Pubitemid 40616257)
3. Liese AD, D'Agostino Jr RB, Hamman RF, Kilgo PD, Lawrence JM, Liu LL, Loots B, Linder B, Marcovina S, Rodriguez B, Standiford D, Williams DE 2006 The burden of diabetes mellitus among US youth: prevalence estimates from the SEARCH for Diabetes in Youth Study. Pediatrics 118:1510-1518
4. Dietz WH 1998 Health consequences of obesity in youth: childhood predictors of adult disease. Pediatrics 101:518-525
5. Goran MI, Figueroa R, McGloin A, Nguyen V, Treuth MS, Nagy TR 1995 Obesity in children: recent advances in energy metabolism and body composition. Obes Res 3:277-289
6. Kimm SY, Glynn NW, Kriska AM, Fitzgerald SL, Aaron DJ, Similo SL, McMahon RP, Barton BA 2000 Longitudinal changes in physical activity in a biracial cohort during adolescence. Med Sci Sports Exerc 32:1445-1454
7. Troiano RP, Flegal KM 1998 Overweight children and adolescents: description, epidemiology, and demographics. Pediatrics 101:497-504
8. Wang Y, Beydoun MA 2007 The obesity epidemic in the United States-gender, age, socioeconomic, racial/ethnic, and geographic characteristics: a systematic review and meta-regression analysis. Epidemiol Rev 29:6-28 (Pubitemid 47229643)
9. EURODIAB ACE Study Group 2000 Variation and trends in incidence of childhood diabetes in Europe. Lancet 355:873-876 (Pubitemid 30137666)
10. American Diabetes Association 2010 Diagnosis and classification of diabetes. Diabetes Care 33(Suppl 1):S62-S69
11. Fagot-Campagna A, Pettitt DJ, Engelgau MM, Burrows NR, Geiss LS, Valdez R, Beckles GL, Saaddine J, Gregg EW, Williamson DF, Narayan KM 2000 Type 2 diabetes among North American children and adolescents: an epidemiological review and public health perspective. J Pediatr 136:664-672 (Pubitemid 30318399)
12. TODAY Study Group 20 October 2010 Characteristics of adolescents and youth with recent-onset type 2 diabetes: the TODAY cohort at baseline. J Clin Endocrinol Metab 10.1210/jc.2010-1642
13. Writing Group for the SEARCH for Diabetes in Youth Study Group, Dabelea D, Bell RA, D'Agostino Jr RB, Imperatore G, Johansen JM, Linder B, Liu LL, Loots B, Marcovina S, Mayer-Davis EJ, Pettitt DJ, Waitzfelder B 2007 Incidence of diabetes in youth in the United States. JAMA 297:2716-2724
14. American Diabetes Association 2000 Type 2 diabetes in children and adolescents. Diabetes Care 23:381-389
15. Pinhas-Hamiel O, Dolan LM, Zeitler PS 1997 Diabetic ketoacidosis among obese African-American adolescents with NIDDM. Diabetes Care 20:484-486
16. Silverstein JH, Rosenbloom AL 2000 Treatment of type 2 diabetes mellitus in children and adolescents. J Pediatr Endocrinol Metab 13:1403-1409
17. Arslanian S 2000 Type 2 diabetes mellitus in children: pathophysiology and risk factors. J Pediatr Endocrinol Metab 13(Suppl 6): 1385-1394 (Pubitemid 32061571)
18. Scott CR, Smith JM, Cradock MM, Pihoker C 1997 Characteristics of youth-onset non insulin-dependent diabetes mellitus and insulin-dependent diabetes mellitus at diagnosis. Pediatrics 100:84-91
19. Zdravkovic V, Daneman D, Hamilton J 2004 Presentation and course of type 2 diabetes in youth in a large multi-ethnic city. Diabet Med 21:1144-1148
20. Upchurch SL, Brosnan CA, Meininger JC, Wright DE, Campbell JA, McKay SV, Schreiner B 2003 Characteristics of 98 children and adolescents diagnosed with type 2 diabetes by their health care provider at initial presentation. Diabetes Care 26:2209
21. McGrath NM, Parker GN, Dawson P 1999 Early presentation of T2DM diabetes mellitus in young New Zealand Maori. Diabetes Res Clin Pract 43:205-209
22. Kershnar AK, Daniels SR, Imperatore G, Palla SL, Petitti DB, Pettitt DJ, Marcovina S, Dolan LM, Hamman RF, Liese AD, Pihoker C, Rodriguez BL 2006 Lipid abnormalities are prevalent in youth with type 1 and type 2 diabetes: the SEARCH for Diabetes in Youth Study. J Pediatr 149:314-319 (Pubitemid 44308425)
23. Newfield RS, Dewan AK, Jain S 2008 Dyslipidemia in children with type 2 diabetes vs. obesity. Pediatr Diabetes 9:115-121 (Pubitemid 351560361)
24. Sellers EA, Yung G, Dean HJ 2007 Dyslipidemia and other cardiovascular risk factors in a Canadian First Nation pediatric population with type 2 diabetes mellitus. Pediatr Diabetes 8:384-390
25. Nadeau KJ, Klingensmith G, Zeitler P 2005 Type 2 diabetes in children is frequently associated with elevated alanine aminotransferase. J Pediatr Gastroenterol Nutr 41:94-98
26. Winter WE, Nakamura M, House DV 1999 Monogenic diabetes mellitus in youth. The MODY syndromes. Endocrinol Metab Clin North Am 28:765-785
27. Hathout EH, Thomas W, El-Shahawy M, Nahab F, Mace JW 2001 Diabetic autoimmune markers in children and adolescents with type 2 diabetes. Pediatrics 107:E102
28. Umpaichitra V, Banerji MA, Castells S 2002 Autoantibodies in children with type 2 diabetes mellitus. J Pediatr Endocrinol Metab 15:525-230
29. Reinehr T, Schober E, Wiegand S, Thon A, Holl RW; on behalf of the DPV-Wiss Study Group 2006 β-Cell autoantibodies in children with type 2 diabetes mellitus: subgroup or misclassification? Arch Dis Child 91:473-477
30. Rosenbloom AL, Silverstein JH, Amemiya S, Zeitler P, Klingensmith GJ 2008 ISPAD Clinical Practice Consensus Guideline 2006-2007. Type 2 diabetes mellitus in the child and adolescent. Pediatr Diabetes 9:512-526
31. The TODAY Study Group, Zeitler P, Epstein L, Grey M, Hirst K, Kaufman F, Tamborlane W, Wilfley D 2007 Treatment options for type 2 diabetes in adolescents and youth: a study of the comparative efficacy of metformin alone or in combination with rosiglitazone or lifestyle intervention in adolescents with type 2 diabetes. Pediatr Diabetes 8:74-87
32. Tfayli H, Bacha F, Gungor N, Arslanian S 2009 Phenotypic type 2 diabetes in obese youth: insulin sensitivity and secretion in islet-cell antibody negative vs. antibody positive patients. Diabetes 58:738-744
33. Turner R, Stratton I, Horton V, Manley S, Zimmet P, Mackay IR, Shattock M, Bottazzo GF, Holman R; for the UK Prospective Diabetes Study Group 1997 Autoantibodies to islet cell cytoplasm and glutamic acid decarboxylase for prediction of insulin requirement in type 2 diabetes-UKPDS 25. Lancet 350:1288-1293
34. Klingensmith GJ, Pyle L, Arslanian S, Copeland KC, Cuttler L, Kaufman F, Laffel L, Marcovina S, Tollefsen SE, Weinstock RS, Linder B, The TODAY Study Group 2010 The presence of GAD and IA-2 antibodies in youth with a type 2 diabetes phenotype: results from the TODAY Study. Diabetes Care 33:1970-1975
35. Wang J, Miao D, Babu S, Yu J, Barker J, Klingensmith G, Rewers M, Eisenbarth GS, Yu L 2007 Prevalence of autoantibody-negative diabetes is not rare at all ages and increases with older age and obesity. J Clin Endocrinol Metab 92:88-92
36. Wenzlau JM, Moua O, Liu Y, Eisenbarth GS, Hutton JC, Davidson HW 2008 Identification of a major humoral epitope in Slc30A8 (ZnT8). Ann NY Acad Sci 1150:252-255
37. Service FJ, Rizza RA, Zimmerman BR, Dyck PJ, O'Brien PC, Melton 3rd LJ 1997 The classification of diabetes by clinical and C-peptide criteria. A prospective population-based study. Diabetes Care 20: 198-201
38. Bonora E, Targher G, Alberiche M, Bonadonna RC, Saggiani F, Zenere MB, Monauni T, Muggeo M 2000 Homeostasis model assessment closely mirrors the glucose clamp technique in the assessment of insulin sensitivity. Diabetes Care 23:57-63
39. Uwaifo GI, Fallon EM, Chin J, Elberg J, Parikh SJ, Yanovski JA 2002 Indices of insulin action, disposal, and secretion derived from fasting samples and clamps in normal glucose-tolerant black and white children. Diabetes Care 25:2081-2087
40. Hermans MP, Levy JC, Morris RJ, Turner RC 1999 Comparison of tests of β-cell function across a range of glucose tolerance from normal to diabetes. Diabetes 48:1779-1786 (Pubitemid 29415197)
41. Katz A, Nambi SS, Mather K, Baron AD, Follmann DA, Sullivan G, Quon MJ 2000 Quantitative insulin sensitivity check index: a simple, accurate, method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab 85:2402-2410 (Pubitemid 32269192)
42. Guzzaloni G, Grugni G, Mazzilli G, Moro D, Morabito F 2002 Comparison between β-cell function and insulin resistance indexes in prepubertal and pubertal obese children. Metabolism 51:1011-1016
43. Levitt Katz LE, Jawad AF, Ganesh J, Abraham M, Murphy K, Lipman TH 2007 Fasting C-peptide and insulin like growth factor binding protein-1 levels help to distinguish childhood type 1 and type 2 diabetes in diagnosis. Pediatr Diabetes 8:53-59 (Pubitemid 46629804)
44. West NA, Hamman RF, Mayer-Davis EJ, D'Agostino Jr RB, Marcovina SM, Liese AD, Zeitler PS, Daniels SR, Dabelea D 2009 Cardiovascular risk factors among youth with and without type 2 diabetes: differences and possible mechanisms. Diabetes Care 32:175-180
45. Pinhas-Hamiel O, Zeitler P 2007 Acute and chronic complications of type 2 diabetes mellitus in children and adolescents. Lancet 369: 1823-1831
46. van Vliet M, Van der Heyden JC, Diamant M, Von Rosenstiel IA, Schindhelm RK, Aanstoot HJ, Veeze HJ 2010 Overweight is highly prevalent in children with type 1 diabetes and associates with cardiometabolic risk. J Pediatr 156:923-929
47. Pinhas-Hamiel O, Standiford D, Hamiel D, Dolan LM, Cohen R, Zeitler PS 1999 The type 2 family: a setting for development and treatment of adolescent type 2 diabetes. Arch Pediatr Adolesc Med 153:1063-1067
48. Kawahara R, Amemiya T, Yoshino M, Miyamae M, Sasamoto K, Omori Y 1994 Dropout of young non-insulin-dependent diabetics from diabetic care. Diabetes Res Clin Pract 24:181-185
49. Owada M, Nitadori Y, Kitagawa T 1998 Treatment of T2DM diabetes in youth. Clin Pediatr (Phila) 37:117-121
50. Petitti DB, Klingensmith GJ, Bell RA, Andrews JS, Dabelea D, Imperatore G, Marcovina S, Pihoker C, Standiford D, Waitzfelder B, Mayer-Davis E 2009 Glycemic control in youth with diabetes: the SEARCH for Diabetes in Youth Study. J Pediatr 155:668-672.el-30
51. Pinhas-Hamiel O, Zeitler P 2007 Clinical presentation and treatment of type 2 diabetes in children. Pediatr Diabetes 8(Suppl 9):16-27 (Pubitemid 350066644)
52. Rosenbloom AL, Silverstein JH, Amemiya S, Zeitler P, Klingensmith GJ 2009 Type 2 diabetes in children and adolescents. Pediatr Diabetes 10(Suppl 12):17-32
53. Rodbard HW, Blonde L, Braithwaite SS, Brett EM, Cobin RH, Handelsman Y, Hellman R, Jellinger PS, Jovanovic LG, Levy P, Mechanick JL, Zangeneh F; AACE Diabetes Mellitus Clinical Practice Guidelines Task Force 2007 American Association of Clinical Endocrinologists medical guidelines for clinical practice for the management of diabetes mellitus. Endocr Pract 13(Suppl 1):1-68
54. Gottschalk M, Danne T, Vlajnic A, Cara JF 2007 Glimepiride versus metformin as monotherapy in pediatric patients with type 2 diabetes: a randomized, single-blind comparative study. Diabetes Care 30:790-794
55. Vella S, Buetow L, Royle P, Livingstone S, Colhoun HM, Petrie JR 2010 The use of metformin in type 1 diabetes: a systematic review of efficacy. Diabetologia 53:809-820
56. Abdelghaffar S, Attia AM 2009 Metformin added to insulin therapy for type 1 diabetes mellitus in adolescents. Cochrane Database Syst Rev 1:CD006691
57. Stone ML, Walker JL, Chisholm D, Craig ME, Donaghue KC, Crock P, Anderson D, Verge CF 2008 The addition of rosiglitazone to insulin in adolescents with type 1 diabetes and poor glycaemic control: a randomized-controlled trial. Pediatr Diabetes 9:326-334
58. Nadeau KJ, Regensteiner JG, Bauer TA, Brown MS, Dorosz JL, Hull A, Zeitler P, Draznin B, Reusch JE 2010 Insulin resistance in adolescents with type 1 diabetes and its relationship to cardiovascular function. J Clin Endocrinol Metab 95:513-521
59. Kavey RE, Allada V, Daniels SR, Hayman LL, McCrindle BW, Newburger JW, Parekh RS, Steinberger J; American Heart Association Expert Panel on Population and Prevention Science; Council on Cardiovascular Disease in the Young; Council on Epidemiology and Prevention; Council on Nutrition; Council on High Blood Pressure Research; Council on Cardiovascular Nursing; Council on the Kidney in Heart Disease; Interdisciplinary Working Group on Quality of Care and Outcomes Research 2006 Cardiovascular risk reduction in highrisk pediatric patients: a scientific statement from the American Heart Association Expert Panel on Population and Prevention Science; the Councils on Cardiovascular Disease in the Young, Epidemiology and Prevention, Nutrition, Physical Activity and Metabolism, High Blood Pressure Research, Cardiovascular Nursing, and the Kidney in Heart Disease; and the Interdisciplinary Working Group on Quality of Care and Outcomes Research: endorsed by the American Academy of Pediatrics. Circulation 114:2710-2738
60. Rothman RL, Mulvaney S, Elasy TA, VanderWoude A, Gebretsadik T, Shintani A, Potter A, Russell WE, Schlundt D 2008 Self-management behaviors, racial disparities, and glycemic control among adolescents with type 2 diabetes. Pediatrics 121:e912-e919
61. Dean H 1998 NIDDM-Y in First Nation children in Canada. Clin Pediatr (Phila) 37:89-96 (Pubitemid 28081271)
62. McNally K, Rohan J, Pendley JS, Delamater A, Drotar D 2010 Executive functioning, treatment adherence, and glycemic control in children with type 1 diabetes. Diabetes Care 33:1159-1162
63. Drotar D, Bonner MS 2009 Influences on adherence to pediatric asthma treatment: a review of correlates and predictors. J Dev Behav Pediatr 30:574-582