Cytotoxic saponins from the root of Dipsacus asper wall

Archives of Pharmacal Research

Volumn 28, Issue 9, 2005, Pages 1053-1056

  Hung, Tran Manh ^a   Wen, Yi Jin ^a   Phuong, Thien Thuong ^a   Kyung, Sik Song ^b   Yeon, Hee Seong ^c   Bae, KiHwan ^a  

^a Chungnam National University   (South Korea)

^b Kyungpook National University   (South Korea)

^c Chungbuk National University   (South Korea)

Author keywords

Cytotoxicity; Dipsacaceae; Dipsacus asper; Hederagenin saponins; MTT assay

Indexed keywords

EID: 26444568159     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02977401     Document Type: Article

References (15)

1. Bhandari, P., Gray, A. I., and Rastogi, R. P., Triterpenoid saponins from Caltha palustris. Planta Med., 53, 98-100 (1987).
2. Jung, H. J., Lee, C. O., Lee, K. T., Choi, J. W., and Park, H. J., Structure-activity relationship of oleanane disaccharides isolated from Akebia quinata versus cytotoxicity against cancer cells and NO inhibition. Biol. Pharm. Bull., 27, 744-747 (2004).
3. Jung, K. Y., Do, J. C., and Son, K. H., Triterpene glycosides from the roots of Dipsacus asper. J. Nat. Prod., 56, 1912-1916 (1993).
4. Jung, K. Y., Studies on the terpenoid constituents from the roots of Dipsacus asper Wall. Ph.D. Thesis, Yeungnam University (1995).
5. Kouno, I., Tsuboi, A., Nanri, M., and Kawano, M., Aylated triterpene glycoside from the roots of Dipsacus asper. Phytochemistry, 29, 338-339 (1990).
6. Lee, K. T., Sohn, I. C., Park, H. J., Kim, D. W., Jung, G. W., and Park, K. Y., Essential moiety antimutagenic and cytotoxic activity of hederagenin monodesmosides and bisdesmosides isolated from the stem bark of Kalopanax pictus. Planta Med., 66, 329-332 (2000).
7. Mimaki, Y., Kuroda, M., Asano, T., and Sashida, Y., Triterpene saponins and lignans from the roots of Pulsatilla chinensis and their cytotoxic activity against HL-60 cells. J. Nat. Prod., 62, 1279-1283 (1999).
8. Mosmann, T., Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J. Immunol. Methods, 65, 55-63 (1983).
9. Namba, T., The crude drugs in Japan, China and neighboring countries. Hoikusha Publishing, Osaka, (1986).
10. Oh, S. R., Jung, K. Y., Son, K. H., Park, S. H., Lee, I. S., Ahn, K. S., and Lee, H. K., In vitro anticomplementry activity of hederagenin saponins isolated from root of Dipsacus asper. Arch. Pharm. Res., 22, 317-319 (1999).
11. Park, H. J., Kwon, S. H., Lee, J. H., Lee, K. H., Miyamoto, K. I., and Lee, K. T., Kalopanaxsaponin A is a basic saponin structure for the anti-tumor activity of hederagenin monodesmosides. Planta Med., 67, 118-121 (2001).
12. Suh, H. W., Song, D. K., Son, K. H., Wie, M. B., Lee, K. H., Jung, K. Y., Do, J. C., and Kim, Y. H., Antinociceptive mechanisms of Dipsacus Saponin C administered intrecerebroventricularly in the mouse. Gen. Pharmac., 27, 1167-1172 (1996).
13. Suh, H. W., Song, D. K., Huh, S. O., Son, K. H., and Kim, Y. H., Antinociceptive mechanisms of Dipsacus Saponin C administered intrathecally in mice. J. Ethnopharmacol., 71, 211-218 (2000).
14. Tomita, H. and Mouri, Y., An iridoid glucoside from Dipsacus asperoides. Phytochemistry, 42, 239-240 (1996).
15. Zhang, Z. J., Qian, Y. H., Hu, H. T., Yang, J., and Yang, G. D., The herbal medicine Dipsacus asper Wall. extract reduces the cognitive deficits and overexpression of β-amyloid protein induced by aluminum exposure. Life Sci., 73, 2443-2454 (2003).