The novel orally active guanylhydrazone CPSI-2364 prevents postoperative ileus in mice independently of anti-inflammatory vagus nerve signaling

Langenbeck's Archives of Surgery

Volumn 397, Issue 7, 2012, Pages 1139-1147

  Wehner, S ^a   Vilz, T O ^a   Sommer, N ^a   Sielecki, T ^b   Hong, G S ^a   Lysson, M ^a   Stoffels, B ^a   Pantelis, D ^a   Kalff, J C ^a  

^a UNIVERSITY OF BONN   (Germany)

^b Cytokine PharmaSciences Inc   (United States)

Author keywords

Intestinal inflammation, surgical trauma; Muscularis externa; Postoperative ileus

Indexed keywords

ANTIINFLAMMATORY AGENT; CARBON 14; CPSI 2364; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOPEROXIDASE; NITRIC OXIDE; PLACEBO; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; DRUG DISTRIBUTION; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG EXCRETION; DRUG METABOLISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; EXTRAVASATION; GASTROINTESTINAL TRANSIT; IMMUNOBLOTTING; IN VIVO STUDY; INTESTINE MUSCLE; INTRAOPERATIVE PERIOD; ISOTOPE LABELING; LIQUID SCINTILLATION COUNTING; MALE; MOUSE; MUSCULARIS EXTERNA; NEUTROPHIL CHEMOTAXIS; NEUTROPHIL COUNT; NONHUMAN; POSTOPERATIVE ILEUS; PREOPERATIVE TREATMENT; PRIORITY JOURNAL; SINGLE DRUG DOSE; STOMACH MUSCLE; VAGOTOMY; VAGUS NERVE; VAGUS NERVE STIMULATION; WHOLE BODY AUTORADIOGRAPHY;

ADMINISTRATION, ORAL; ANALYSIS OF VARIANCE; ANIMALS; AUTORADIOGRAPHY; DISEASE MODELS, ANIMAL; GASTROINTESTINAL TRANSIT; HYDRAZONES; ILEUS; INTESTINE, SMALL; LUMINESCENCE; MALE; MICE; MICE, INBRED C57BL; NITRIC OXIDE; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEROXIDASE; PHOSPHORYLATION; POSTOPERATIVE COMPLICATIONS; RATS; RATS, SPRAGUE-DAWLEY; SCINTILLATION COUNTING; SIGNAL TRANSDUCTION;

EID: 84868193242     PISSN: 14352443     EISSN: 14352451     Source Type: Journal    
DOI: 10.1007/s00423-012-0989-6     Document Type: Article

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