Minimization of immunosuppressive therapy after islet transplantation: Combined action of heme oxygenase-1 and PEGylation to islet

American Journal of Transplantation

Volumn 6, Issue 8, 2006, Pages 1820-1828

  Lee, D Y ^a   Lee, S ^a   Nam, J H ^b   Byun, Y ^a  

^a Seoul National University   (South Korea)

^b Chonnam National University Medical School   (South Korea)

Author keywords

Cyclosporine; Heme oxygenase 1; Pancreatic islets; Polyethylene glycol; Transplantation

Indexed keywords

CYCLOSPORIN A; HEME OXYGENASE 1;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROTECTION; CELL VIABILITY; CELLULAR IMMUNITY; CONTROLLED STUDY; GENE OVEREXPRESSION; GRAFT REJECTION; GRAFT SURVIVAL; IMMUNOSUPPRESSIVE TREATMENT; LOW DRUG DOSE; MALE; NONHUMAN; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT;

ANIMALS; COBALT; CYCLOSPORINE; GRAFT SURVIVAL; HEME OXYGENASE-1; IMMUNOSUPPRESSIVE AGENTS; ISLETS OF LANGERHANS; ISLETS OF LANGERHANS TRANSPLANTATION; MALE; POLYETHYLENE GLYCOLS; RATS; SURVIVAL RATE; TRANSPLANTATION, HOMOLOGOUS;

EID: 33745768395     PISSN: 16006135     EISSN: 16006143     Source Type: Journal    
DOI: 10.1111/j.1600-6143.2006.01414.x     Document Type: Article

References (38)

1. Dibelius A, Konigsberger H, Walter P, Permanetter W, Brendel W, von Specht BU. Prolonged reversal of diabetes in the rat by transplantation of allogeneic islets from a single donor and cyclosporine treatment. Transplantation 1986; 41: 426-431.
2. Shapiro AMJ, Lakey JRT, Ryan EA et al. Islet transplantation in seven patients with type I diabetes mellitus using a glucocorticoid-free immunosuppressive regimen. N Engl J Med 2000; 343: 230-238.
3. Ryan EA, Lakey JRT, Rajotte RV et al. Clinical outcomes and insulin secretion after islet transplantation with the Edmonton protocol. Diabetes 2001; 50: 710-719.
4. Rabinovitch A, Suarez-Pinzon WL, Shapiro AMJ, Rajotte RV, Power R. Combination therapy with sirolimus and interleukin-2 prevents spontaneous and recurrent autoimmune diabetes in NOD mice. Diabetes 2002; 51: 638-645.
5. Shapiro AMJ, Suarez-Pinzon WL, Power R, Rabinovitch A. Combination therapy with low dose sirolimus and tacrolimus is synergistic in preventing spontaneous and recurrent autoimmune diabetes in non-obese diabetic mice. Diabetologia 2002; 45: 224-230.
6. Pascual M, Theruvath T, Kawai T, Tolkoff-Rubin N, Cosimi AB. Strategies to improve long-term outcomes after renal transplantation. N Engl J Med 2000; 346: 580-590.
7. EBPG Expert Group on Renal Transplantation. European best practice guidelines for renal transplantation. Nephrol Diabl Transplant 2002; 17(Suppl 4): 1-68.
8. Ayres RC, Dousset B, Wixon S, Buckels JA, McMaster P, Mayer AD. Peripheral neurotoxicity with tacrolimus. Lancet 1994; 343: 862-863.
9. Lanza RP, Hayes JL, Chick WL. Encapsulated cell technology. Nat Biotechnol 1996; 14: 1107-1111.
10. de Vos P, Hamel AF, Tatarkiewicz K. Considerations for successful transplantation of encapsulated pancreatic islets. Diabetologia 2002; 45: 159-173.
11. Orive G, Hernandez RM, Gascon AR et al. Cell encapsulation: Promise and progress. Nat Med 2003; 9: 104-107.
12. Lanza RP, Kuhtreiber WM, Ecker D, Staruk JE, Chick WL. Xenotransplantation of porcine and bovine islets without immunosuppression using uncoated alginate microspheres. Transplantation 1995; 59: 1377-1384.
13. Sun Y, Ma X, Zhou D, Vacek I, Sun AM. Normalization of diabetes in spontaneously diabetic cynomologus monkeys by xenografts of microencapsulated porcine islets without immunosuppression. J Clin Invest 1996; 98: 1417-1422.
14. Panza JL, Wagner WR, Rilo HLR, Rao RH, Beckman EJ, Russell AJ. Treatment of rat pancreatic islets with reactive PEG. Biomaterials 2000; 21: 1155-1164.
15. Lee DY, Yang K, Lee S et al. Optimization of monomethoxypolyethylene glycol grafting on the pancreatic islet capsules. J Biomed Mater Res 2002; 62: 372-377.
16. Lee DY, Jang JY, Park SJ, Byun Y. Immune reactions of lymphocytes and macrophages against PEG-grafted pancreatic islets. Biomaterials 2004; 25: 3663-3669.
17. Lee DY, Nam JH, Byun Y. Effect of polyethylene glycol grafted onto islet capsules on prevention of splenocytes and cytokine attacks. J Biomater Sci Polym Ed 2004; 15: 753-766.
18. Contreras JL, Xie D, Mays J et al. A novel approach to xenotransplantation combining surface engineering and genetic modification of isolated adult porcine islets. Surgery 2004; 136: 537-547.
19. Xie D, Smyth CA, Eckstein C et al. Cytoprotection of PEG-modified adult porcine pancreatic islets for improved xenotransplantation. Biomaterials 2005; 26: 403-412.
20. Lee DY, Park SJ, Nam JH, Byun Y. A new strategy toward improving immunoprotection in cell therapy for diabetes mellitus: Long-functioning PEGylated islets in vivo. Tissue Eng 2006; 12: 615-623.
21. Lee DY, Park SJ, Nam JH, Byun Y. A combination therapy of PEGylation and immunosuppressive agent for successful islet transplantation. J Control Release 2006; 110: 290-295.
22. Pileggi A, Molano RD, Berney T et al. Hemeoxygenase-1 induction in islet cells results in protection from apoptosis and improved in vivo function after transplantation. Diabetes 2001; 50: 1983-1991.
23. Ye J, Laychock SG. A protective role for heme oxygenase expression in pancreatic islets exposed to interleukin-1β. Endocrinology 1998; 139: 4155-4163.
24. Tobiasch E, Gunther L, Bach FH. Hemeoxygenase-1 protects pancreatic β cells from apoptosis caused by various stimuli. J Investig Med 2001; 49: 566-571.
25. Tenhunen R, Marver HS, Schmid R. The enzymatic conversion of heme to bilirubin by microsomal heme oxygenase. Proc Natl Acad Sci U S A 1968; 61: 748-755.
26. Lee TS, Chau LY. Heme oxygenase-1 mediates the anti-inflammatory effect of interleukin-10 in mice. Nat Med 2002; 8: 240-246.
27. Soare MP, Lin Y, Anrather J et al. Expression of heme oxygenase-1 can determine cardiac xenograft survival. Nat Med 1998; 4: 1073-1077.
28. Sato K, Balla J, Otterbein L et al. Carbon monoxide generated by heme oxygenase-1 suppresses the rejection of mouse-to-rat cardiac transplant. J Immunol 2001; 166: 4185-4194.
29. Bank HL. Assessment of islet cell viability using fluorescent dyes. Diabetologia 1987; 30: 812-816.
30. Nakayama M, Takahashi K, Kitamuro T et al. Repression of heme oxygenase-1 by hypoxia in vascular endothelial cells. Biochem Biophys Res Commun 2000; 271: 665-671.
31. Petrache I, Otterbein LE, Alam J, Wiegand GW, Choi AMK. Heme oxygenase-1 inhibits TNF-α-induced apoptosis in cultured fibroblasts. Am J Physiol Lung Cell Mol Physiol 2000; 278: L312-L319.
32. Tullius SG, Nieminen-Kelha M, Buelow R et al. Inhibition of ischemia/reperfusion injury and chronic graft deterioration by a single-donor treatment with cobalt-protoporphyrin for the induction of heme oxygenase-1. Transplantation 2002; 74: 591-598.
33. Christova T, Duridanova D, Braykova A, Setchenska M, Bolton T. Heme oxygenase is the main protective enzyme in rat liver up to 6-day administration of cobalt chloride. Arch Toxicol 2001; 75: 445-451.
34. Sayegh MH, Watschinger B, Carpenter CB. Mechanisms of T cell recognition of alloantigen. The role of peptides. Transplantation 1994; 57: 1295-1302.
35. Lee RS, Grusby MJ, Glimcher LH, Winn HJ, Auchincloss H. Indirect recognition by helper cells can induce donor-specific cytotoxic T lymphocytes in vivo. J Exp Med 1994; 179: 865-872.
36. Babensee JE, Anderson JM, McIntire LV, Mikos AG. Host response to tissue engineered devices. Adv Drug Deliv Rev 1998; 33: 111-139.
37. Stocker R, Yamamoto Y, McDonagh AF, Glazer AN, Ames BN. Bilirubin is an antioxidant of possible physiological importance. Science 1987; 235: 1043-1046.
38. Otterbein LE, Bach FH, Alam J et al. Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway. Nat Med 2000; 6: 422-428.