Adeno-associated virus serotype 9 administered systemically after reperfusion preferentially targets cardiomyocytes in the infarct border zone with pharmacodynamics suitable for the attenuation of left ventricular remodeling

Journal of Gene Medicine

Volumn 14, Issue 9-10, 2012, Pages 609-620

  Konkalmatt, Prasad R ^a   Wang, Feng ^b   Piras, Bryan A ^a   Xu, Yaqin ^a   O'Connor, Daniel M ^b   Beyers, Ronald J ^a   Epstein, Frederick H ^a   Annex, Brian H ^b   Hossack, John A ^a   French, Brent A ^a,b  

^a University of Virginia   (United States)

^b UNIVERSITY OF VIRGINIA   (United States)

Author keywords

AAV; Cardiac gene therapy; Ischemia and reperfusion injury; LV remodeling; Post myocardial infarction gene delivery

Indexed keywords

ADENO ASSOCIATED VIRUS SEROTYPE 9 VECTOR; ENHANCED GREEN FLUORESCENT PROTEIN; FIREFLY LUCIFERASE; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; PARVOVIRUS VECTOR; SUPEROXIDE DISMUTASE; TROPONIN T; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; CONTROLLED STUDY; DRUG EFFICACY; ECHOCARDIOGRAPHY; GENE EXPRESSION; HEART INFARCTION; HEART LEFT VENTRICLE EJECTION FRACTION; HEART LEFT VENTRICLE ENDDIASTOLIC VOLUME; HEART LEFT VENTRICLE ENDSYSTOLIC VOLUME; HEART LEFT VENTRICLE VOLUME; HEART MUSCLE CELL; HEART MUSCLE INJURY; HEART MUSCLE ISCHEMIA; HEART PROTECTION; HEART VENTRICLE REMODELING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; REPERFUSION; SYSTEMIC THERAPY; TRANSGENE; VIRAL GENE DELIVERY SYSTEM;

ANIMALS; DEPENDOVIRUS; GENE EXPRESSION; GENETIC THERAPY; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; LUCIFERASES; MICE; MICE, INBRED C57BL; MYOCARDIAL INFARCTION; MYOCARDIAL ISCHEMIA; MYOCARDIAL REPERFUSION; MYOCARDIAL REPERFUSION INJURY; MYOCYTES, CARDIAC; REFERENCE VALUES; TRANSGENES; VENTRICULAR REMODELING;

ADENO-ASSOCIATED VIRUS; ANIMALIA;

EID: 84868147722     PISSN: 1099498X     EISSN: 15212254     Source Type: Journal    
DOI: 10.1002/jgm.2673     Document Type: Article

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