The transcriptional regulator NAB2 reveals a two-step induction of TRAIL in activated plasmacytoid DCs

European Journal of Immunology

Volumn 42, Issue 11, 2012, Pages 3019-3027

  Balzarolo, Melania ^a,b   Karrich, Julien J ^a   Engels, Sander ^b   Blom, Bianca ^a   Medema, Jan Paul ^a   Wolkers, Monika C ^a  

^a UNIVERSITY OF AMSTERDAM   (Netherlands)

^b SANQUIN RESEARCH   (Netherlands)

Author keywords

NAB2; Plasmacytoid DC; TRAIL expression; Type I IFN

Indexed keywords

CPG OLIGODEOXYNUCLEOTIDE; INTERFERON RECEPTOR; NGFI-A BINDING PROTEIN 2; NUCLEIC ACID; PHOSPHATIDYLINOSITOL 3 KINASE; REGULATOR PROTEIN; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG;

ANTIGEN RECOGNITION; ARTICLE; CELL LINE; CELL STIMULATION; HUMAN; HUMAN CELL; MOLECULAR MECHANICS; NORMAL HUMAN; PLASMACYTOID DENDRITIC CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INDUCTION; SIGNAL TRANSDUCTION; TRANSCRIPTION REGULATION;

CELL LINE; DENDRITIC CELLS; HUMANS; INTERFERON-BETA; LEUKOCYTES, MONONUCLEAR; LYMPHOCYTE ACTIVATION; PHOSPHATIDYLINOSITOL 3-KINASE; REAL-TIME POLYMERASE CHAIN REACTION; REPRESSOR PROTEINS; RNA; SIGNAL TRANSDUCTION; TNF-RELATED APOPTOSIS-INDUCING LIGAND; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 9;

EID: 84868146600     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201242385     Document Type: Article

References (39)

1. Cella, M., Jarrossay, D., Facchetti, F., Alebardi, O., Nakajima, H., Lanzavecchia, A. and Colonna, M., Plasmacytoid monocytes migrate to inflamed lymph nodes and produce large amounts of type I interferon. Nat. Med. 1999. 5: 919-923.
2. Stetson, D. B. and Medzhitov, R., Type I interferons in host defence. Immunity 2006. 25: 373-381.
3. Petska, S., Krause, C. D. and Walter, M. R., Interferons, interferon-like cytokines, and their receptors. Immunol. Rev. 2004. 202: 9-32.
4. Herbeuval, J. P. and Shearer, G. M., HIV-1 immunopathogenesis: how good interferon turns bad. Clin. Immunol. 2007. 123: 121-128.
5. Chaperot, L., Blum, A., Manches, O., Lui, G., Angel, J., Molens, J.-P. and Plumas, J., Virus or TLR agonists induce TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells. J. Immunol. 2006. 176: 248-255.
6. Matsui, T., Connolly, J. E., Michnevitz, M., Chaussabel, D., Yu, C.-I., Glaser, C., Tindle, S. et al., CD2 distinguished two subsets of human plasmacytoid dendritic cells with distinct phenotype and function. J. Immunol. 2009. 182: 6815-6823.
7. Blum, A., Chaperot, L., Molens, J.-P., Foissoud, V., Plantaz, D. and Plumas, J., Mechanisms of TRAIL-induced apoptosis in leukemic plasmacytoid dendritic cells. Exp. Hemat. 2006. 34: 1655-1662.
8. Stary, G., Bangert, C., Tauber, M., Strohal, R., Kopp, T. and Stingl, G., Tumoricidal activity of TLR7/8-activated inflammatory dendritic cells. J. Exp. Med. 2007. 204: 1441-1451.
9. Stary, G., Klein, I., Kohlhofer, S., Koszik, F., Scherzer, T., Mullauer, L., Quendler, H. et al., Plasmacytoid dendritic cells express TRAIL and induce CD4+ T-cell apoptosis in HIV-1 viremic patients. Blood 2009. 114: 3854-3863.
10. Hardy, A. W., Graham, D.R., Shearer, G.M. and Herbeuval, J.-P., HIV turns plasmacytoid dendritic cells (pDC) into TRAIL-expressing killer pDC and down-regulated HIV coreceptors by toll-like receptor 7-induced IFN-alpha. Proc. Natl. Acad. Sci USA 2007. 104: 17453-17458.
11. Sato, K., Hida, H., Takayanagi, H., Yokochi, N., Kayagaki, K., Takeda, K., Yagita, H. et al., Antiviral response by natural killer cells through TRAIL gene induction by IFN-a/b. Eur. J. Immunol. 2001. 31: 3138-3146.
12. Kirshner, J. R., Karpova, A. Y., Kops, M. and Howley, P. M., Identification of TRAIL as an interferon regulatory factor 3 transcriptional target. J. Virol. 2005. 79: 9320-9324.
13. Di Domizio, J., Blum, A., Gallagher-Gambarelli, M., Molens, J.-P., Chaperot, L. and Plumas, J., TLR7 stimulation in human plasmacytoid dendritic cells leads to the induction of early IFN-inducible genes in the absence of type I IFN. Blood 2009. 114: 1794-1802.
14. Svaren, J., Sevetson, B. R., Apel, E. D., Zimonijc, D. B., Popescu, N. C. and Milbrandt, J., NAB2, a corepressor of NGFI-A (EGR-1) and Krox20, is induced by proliferative and differentiative stimuli. Mol. Cell. Biol. 1996. 16: 3545-3553.
15. Droin, N. M., Pinkoski, M. J., Dejardin, E. and Green, D. R., Egr family members regulate nonlymphoid expression of Fas ligand, TRAIL, and tumor necrosis factor during immune responses. Mol. Cell. Biol. 2003. 23: 7638-7647.
16. Baron, V., Adamson, E. D., Calogero, A., Ragona, G. and Mercola, D., The transcription factor Egr1 is a direct regulator of multiple tumor suppressors including TGFβ1, PTEN, p53 and fibronection. Cancer Gene Ther. 2008. 13: 115-124.
17. Zhu, B., Symonds, A. L., Martin, J. E., Kioussis, D., Wraith, D. C., Li, S. and Wang, P., Early growth response gene 2 (EGR-2) controls the self-tolerance of T cells and prevents the development of lupuslike autoimmune disease. J. Exp. Med. 2008. 205: 2295-2307.
18. Safford, M., Collins, S., Lutz, M. A., Allen, A., Huang, C. T., Kowalski, J., Blackford, A. et al., EGR-2 and EGR-3 are negative regulators of T-cell activation. Nat. Immunol. 2005. 6: 472-480.
19. Collins, S., Lutz, M. A., Zaker, P. E., Anders, R. A., Kersh, G. J. and Powell, J. D., Opposing regulation of T-cell function by EGR-1/NAB2 and EGR-2/EGR-3. Eur. J. Immunol. 2008. 38: 528-536.
20. Collins, S., Wolfraim, L. A., Drake, C. G., Horton, M. R. and Powell, J. D., Cutting edge: TCR induced NAB2 enhances T-cell function by coativating IL-2 trascription. J. Immunol. 2006. 177: 8301-8305.
21. Wolkers, M. C., Gerlach, C., Arens, R., Janssen, E. M., Fitzgerald, P., Schumacher, T. N., Medema, J. P. et al., Nab2 regulates secondary CD8+ T-cell responses through control of TRAIL expression. Blood 2012. 119: 798-804.
22. Hornung, V., Rothenfusser, S., Britsch, S., Krug, A., Jahnsdorfer, B., Giese, T., Endres, S. et al., Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 2002. 168: 4531-4537.
23. Maeda, T., Murata, K., Fukushima, T., Sugahara, K., Tsuruda, K., Anami, M., Onimaru, Y. et al., A novel plasmacytoid dendritic cell line, CAL-1, estabilished from a patient with blastic natural killer cell lymphoma. Int. J. Hemat. 2004. 81: 148-154.
24. Karrich, J. J., Balzarolo, M., Schmidlin, H., Libouban, M., Nagasawa, M., Gentek, R., Kamihira, S. et al., The transcription factor Spi-B regulates human plasmacytoid dendritic cell survival through direct induction of the antiapoptotic gene BCL2-A1. Blood 2012. 119: 5191-5200.
25. Kalb, M. L., Glaser, A., Stary, G., Koszik, F. and Stingl, G., TRAIL(+) human plasmacytoid dendritic cells kill tumor cells in vitro: mechanisms of imiquimod- and IFN-alpha-mediated antitumor reactivity. J Immunol. 188: 1583-1591.
26. Svaren, J., Sevetson, B. R., Golda, T., Stanton, J. J., Swirnoff, A. H. and Milbrandt, J., Novel mutants on NAB corepressors enhance activation by EGRtransactivators. EMBO J. 1998. 17: 6010-6019.
27. Kumbrink, J., Kirsch, K. H. and Johnson, J. P., EGR1, EGR2, and EGR3 activate the expression of their coregulator NAB2 establishing a negative feedback loop in cells of neuroectodermal and epithelial origin. J. Cell. Biochem. 2010. 111: 207-217.
28. Waibler, Z., Anzaghe, M., Frenz, T., Schwantes, A., Pohlmann, C., Ludwig, H., Palomo-Otero, M. et al., Vaccinia virus-mediated inhibition of type I interferon responses is a multifactorial process involving the soluble type I interferon receptor B18R and intracellular components. J. Virol. 2009. 83: 1563-1571.
29. Symons, J. A., Alcami, A. and Smith, G. L., Vaccinia virus encodes a soluble type I interferon receptor of novel structure and broad species specificity. Cell 1996. 81: 551-560.
30. Alcami, A., Symons, J. A. and Smith, G. L., The vaccinia virus soluble alpha/beta interferon (IFN) receptor binds to the cell surface and protects cell from antiviral effects of IFN. J. Virol. 2000. 74: 11230-11239.
31. Riboldi, E., Daniele, R., Cassatella, M. A., Sozzani, S. and Bosisio, D., Engagement of BDCA-2 blocks TRAIL-mediated cytotoxic activity of plasmacytoid dendritic cells. Immunobiology 2009. 214: 868-876.
32. Osawa, Y., Iho, S., Takauji, R., Takatsuka, H., Yamamoto, S., Takahashi, T., Horiguchi, S. et al., Collaborative action of NF-kB and p38 MAPK is involved in CpG DNA-induced IFN-α and chemokine production in human plasmacytoid dendritic cells. J. Immunol. 2006. 177: 4841-4852.
33. Takauji, R., Iho, S., Takatsuka, H., Yamamoto, S., Takahashi, T., Kitagawa, H., Iwasaki, H. et al., CpG-DNA-induced IFN-a production involves p38 MAPK-dependent STAT1 phosphorylation in human plasmacytoid dendritic cells precursors. J. Leukoc. Biol. 2002. 72: 1011-1019.
34. Guiducci, C., Ghirelli, C., Marloie-Provost, M.-A., Matray, T., Coffman, R.L., Liu, Y.-L., Barrat, F.J. et al., PI3K is critical for the nuclear translocation of IRF-7 and type I IFN production by human plasmacytoid predendritic cells in response to TLR activation. J. Exp. Med. 2008. 205: 315-322.
35. Sevetson, B. R., Svaren, J. and Milbrandt, J., A novel activation function for NAB proteins in EGR-dependent transcription of the luteinizing hormone beta gene. J. Biol. Chem. 2000. 275: 9749-9757.
36. Srinivasan, R., Mager, G. M., Ward, R. M., Mayer, J. and Svaren, J., NAB2 represses transcription by interacting with the CHD4 subunit of the nucleosome remodeling and deacetylase (NuRD) complex. J. Biol. Chem. 2006. 281: 15129-15137.
37. Kerkmann, M., Rothenfusser, S., Hornung, V., Towarowski, V., Wagner, M., Sarris, A., Giese, T. et al., Activation with CpG-A and CpG-B oligonucleotides reveals two distinct regulatory pathways of type I IFN synthesis in human plasmacytoid dendritic cells. J. Immunol. 2003. 170: 4465-4474.
38. Gautier, G., Humbert, M., Deauvieau, F., Scuiller, M., Hiscott, J., Bates, E. E. M., Trinchieri, G. et al., A type I interferon autocrine-paracrine loop is involved in toll-like receptor-induced interleukin-12p70 secretion by dedritic cells. J. Exp. Med. 2005. 201: 1435-1446.
39. van Lent, A. U., Dontije, W., Nagasawa, M., Siamari, R., Bakker, A. Q., Pouw, S. M., Maijoor, K. A. et al., IL-7 enhances thymic human T-cell development in "Human Immune System" Rag2-/-IL-2R {gamma} c-/- mice without affecting peripheral T-cell homeostasis. J. Immunol. 2009. 183: 7645-7655.