Bepridil decreases Aβ and calcium levels in the thalamus after middle cerebral artery occlusion in rats

Journal of Cellular and Molecular Medicine

Volumn 16, Issue 11, 2012, Pages 2754-2767

  Sarajärvi, Timo ^a   Lipsanen, Anu ^a   Mäkinen, Petra ^a   Peräniemi, Sirpa ^a   Soininen, Hilkka ^a,b   Haapasalo, Annakaisa ^a   Jolkkonen, Jukka ^a   Hiltunen, Mikko ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b KUOPIO UNIVERSITY HOSPITAL   (Finland)

Author keywords

amyloid; secretase; Alzheimer's disease; Amyloid precursor protein; Bepridil; Calcium; Seladin 1 DHCR24; Sensorimotor function; Transient middle cerebral artery occlusion

Indexed keywords

AMYLOID PRECURSOR PROTEIN; BEPRIDIL; CALCIUM; CALCIUM CHANNEL BLOCKING AGENT; CALCIUM CHANNEL L TYPE; HEME OXYGENASE 1; L TYPE CALCIUM CHANNEL ALPHA(1C); L-TYPE CALCIUM CHANNEL ALPHA(1C); NERVE PROTEIN; NQO1 PROTEIN, RAT; OXIDOREDUCTASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE); SECRETASE; SELADIN 1 PROTEIN, RAT; SELADIN-1 PROTEIN, RAT;

ANIMAL; ANIMAL BEHAVIOR; ARTICLE; CEREBRAL ARTERY DISEASE; DRUG EFFECT; GENETICS; INFLAMMATION; MALE; METABOLISM; OXIDATIVE STRESS; PATHOLOGY; RAT; THALAMUS; WISTAR RAT;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; BEHAVIOR, ANIMAL; BEPRIDIL; CALCIUM; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; HEME OXYGENASE-1; INFARCTION, MIDDLE CEREBRAL ARTERY; INFLAMMATION; MALE; NAD(P)H DEHYDROGENASE (QUINONE); NERVE TISSUE PROTEINS; OXIDATIVE STRESS; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; RATS; RATS, WISTAR; THALAMUS;

RATTUS;

EID: 84868143901     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1582-4934.2012.01599.x     Document Type: Article

References (51)

1. Abe K, Tanzi RE, Kogure K. Selective induction of Kunitz-type protease inhibitor domain-containing amyloid precursor protein mRNA after persistent focal ischemia in rat cerebral cortex. Neurosci Lett. 1991; 125: 172-4.
2. Badan I, Dinca I, Buchhold B, et al. Accelerated accumulation of N- and C-terminal beta APP fragments and delayed recovery of microtubule-associated protein 1B expression following stroke in aged rats. Eur J Neurosci. 2004; 19: 2270-80.
3. Koistinaho J, Pyykonen I, Keinanen R, et al. Expression of beta-amyloid precursor protein mRNAs following transient focal ischaemia. NeuroReport. 1996; 7: 2727-31.
4. Lin B, Schmidt-Kastner R, Busto R, et al. Progressive parenchymal deposition of beta-amyloid precursor protein in rat brain following global cerebral ischemia. Acta Neuropathol. 1999; 97: 359-68.
5. Pluta R, Kida E, Lossinsky AS, et al. Complete cerebral ischemia with short-term survival in rats induced by cardiac arrest. I. Extracellular accumulation of Alzheimer's beta-amyloid protein precursor in the brain. Brain Res. 1994; 649: 323-8.
6. Shi J, Yang SH, Stubley L, et al. Hypoperfusion induces overexpression of beta-amyloid precursor protein mRNA in a focal ischemic rodent model. Brain Res. 2000; 853: 1-4.
7. Koistinaho M, Koistinaho J. Interactions between Alzheimer's disease and cerebral ischemia - focus on inflammation. Brain Res Brain Res Rev. 2005; 48: 240-50.
8. van Groen T, Puurunen K, Maki HM, et al. Transformation of diffuse beta-amyloid precursor protein and beta-amyloid deposits to plaques in the thalamus after transient occlusion of the middle cerebral artery in rats. Stroke. 2005; 36: 1551-6.
9. Hiltunen M, Makinen P, Peraniemi S, et al. Focal cerebral ischemia in rats alters APP processing and expression of Abeta peptide degrading enzymes in the thalamus. Neurobiol Dis. 2009; 35: 103-13.
10. Tesco G, Koh YH, Kang EL, et al. Depletion of GGA3 stabilizes BACE and enhances beta-secretase activity. Neuron. 2007; 54: 721-37.
11. Iizuka H, Sakatani K, Young W. Neural damage in the rat thalamus after cortical infarcts. Stroke. 1990; 21: 790-4.
12. Ross DT, Ebner FF. Thalamic retrograde degeneration following cortical injury: an excitotoxic process? Neuroscience. 1990; 35: 525-50.
13. Wei L, Ying DJ, Cui L, et al. Necrosis, apoptosis and hybrid death in the cortex and thalamus after barrel cortex ischemia in rats. Brain Res. 2004; 1022: 54-61.
14. Demuro A, Parker I, Stutzmann GE. Calcium signaling and amyloid toxicity in Alzheimer disease. J Biol Chem. 2010; 285: 12463-8.
15. Supnet C, Bezprozvanny I. The dysregulation of intracellular calcium in Alzheimer disease. Cell Calcium. 2010; 47: 183-9.
16. Flaim SF, Ratz PH, Swigart SC, et al. Bepridil hydrochloride alters potential-dependent and receptor-operated calcium channels in vascular smooth muscle of rabbit aorta. J Pharmacol Exp Ther. 1985; 234: 63-71.
17. Hollingshead LM, Faulds D, Fitton A. Bepridil. A review of its pharmacological properties and therapeutic use in stable angina pectoris. Drugs. 1992; 44: 835-57.
18. 2+-extrusion across rat heart sarcolemma. Arch Int Pharmacodyn Ther. 1989; 298: 90-5.
19. Yatani A, Brown AM, Schwartz A. Bepridil block of cardiac calcium and sodium channels. J Pharmacol Exp Ther. 1986; 237: 9-17.
20. Mitterreiter S, Page RM, Kamp F, et al. Bepridil and amiodarone simultaneously target the Alzheimer's disease beta- and gamma-secretase via distinct mechanisms. J Neurosci. 2010; 30: 8974-83.
21. Lu X, Kambe F, Cao X, et al. 3beta-Hydroxysteroid-delta24 reductase is a hydrogen peroxide scavenger, protecting cells from oxidative stress-induced apoptosis. Endocrinology. 2008; 149: 3267-73.
22. Wu C, Miloslavskaya I, Demontis S, et al. Regulation of cellular response to oncogenic and oxidative stress by Seladin-1. Nature. 2004; 432: 640-5.
23. Greeve I, Hermans-Borgmeyer I, Brellinger C, et al. The human DIMINUTO/DWARF1 homolog seladin-1 confers resistance to Alzheimer's disease-associated neurodegeneration and oxidative stress. J Neurosci. 2000; 20: 7345-52.
24. Venugopal R, Jaiswal AK. Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase1 gene. Proc Natl Acad Sci U S A. 1996; 93: 14960-5.
25. Minelli A, Conte C, Grottelli S, et al. Cyclo(His-Pro) up-regulates heme oxygenase 1 via activation of Nrf2-ARE signalling. J Neurochem. 2009; 111: 956-66.
26. Jaiswal AK. Nrf2 signaling in coordinated activation of antioxidant gene expression. Free Radic Biol Med. 2004; 36: 1199-207.
27. Longa EZ, Weinstein PR, Carlson S, et al. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989; 20: 84-91.
28. Puurunen K, Jolkkonen J, Sirvio J, et al. An alpha(2)-adrenergic antagonist, atipamezole, facilitates behavioral recovery after focal cerebral ischemia in rats. Neuropharmacology. 2001; 40: 597-606.
29. Jolkkonen J, Puurunen K, Rantakomi S, et al. Effects-of fluoxetine on sensorimotor and spatial learning deficits following focal cerebral ischemia in rats. Restor Neurol Neurosci. 2000; 17: 211-6.
30. Karhunen H, Virtanen T, Schallert T, et al. Forelimb use after focal cerebral ischemia in rats treated with an alpha 2-adrenoceptor antagonist. Pharmacol Biochem Behav. 2003; 74: 663-9.
31. Zhao CS, Puurunen K, Schallert T, et al. Behavioral effects of photothrombotic ischemic cortical injury in aged rats treated with the sedative-hypnotic GABAergic drug zopiclone. Behav Brain Res. 2005; 160: 260-6.
32. Sarajarvi T, Tuusa JT, Haapasalo A, et al. Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking. Mol Cell Biol. 2011; 31: 2326-40.
33. Farmery MR, Tjernberg LO, Pursglove SE, et al. Partial purification and characterization of gamma-secretase from post-mortem human brain. J Biol Chem. 2003; 278: 24277-84.
34. Makinen S, van Groen T, Clarke J, et al. Coaccumulation of calcium and beta-amyloid in the thalamus after transient middle cerebral artery occlusion in rats. J Cereb Blood Flow Metab. 2008; 28: 263-8.
35. Iivonen S, Hiltunen M, Alafuzoff I, et al. Seladin-1 transcription is linked to neuronal degeneration in Alzheimer's disease. Neuroscience. 2002; 113: 301-10.
36. Kuehnle K, Crameri A, Kalin RE, et al. Prosurvival effect of DHCR24/Seladin-1 in acute and chronic responses to oxidative stress. Mol Cell Biol. 2008; 28: 539-50.
37. Nishida K, Fujiki A, Sakamoto T, et al. Bepridil reverses atrial electrical remodeling and L-type calcium channel downregulation in a canine model of persistent atrial tachycardia. J Cardiovasc Electrophysiol. 2007; 18: 765-72.
38. Miners JS, Baig S, Palmer J, et al. Abeta-degrading enzymes in Alzheimer's disease. Brain Pathol. 2008; 18: 240-52.
39. Tanzi RE, Moir RD, Wagner SL. Clearance of Alzheimer's Abeta peptide: the many roads to perdition. Neuron. 2004; 43: 605-8.
40. Fan L, Young PR, Barone FC, et al. Experimental brain injury induces differential expression of tumor necrosis factor-alpha mRNA in the CNS. Brain Res Mol Brain Res. 1996; 36: 287-91.
41. Sriram K, Matheson JM, Benkovic SA, et al. Deficiency of TNF receptors suppresses microglial activation and alters the susceptibility of brain regions to MPTP-induced neurotoxicity: role of TNF-alpha. FASEB J. 2006; 20: 670-82.
42. Kuchibhotla KV, Goldman ST, Lattarulo CR, et al. Abeta plaques lead to aberrant regulation of calcium homeostasis in vivo resulting in structural and functional disruption of neuronal networks. Neuron. 2008; 59: 214-25.
43. Pierrot N, Ghisdal P, Caumont AS, et al. Intraneuronal amyloid-beta1-42 production triggered by sustained increase of cytosolic calcium concentration induces neuronal death. J Neurochem. 2004; 88: 1140-50.
44. Yang L, Wang Z, Wang B, et al. Amyloid precursor protein regulates Cav1.2 L-type calcium channel levels and function to influence GABAergic short-term plasticity. J Neurosci. 2009; 29: 15660-8.
45. Stys PK, Lopachin RM. Mechanisms of calcium and sodium fluxes in anoxic myelinated central nervous system axons. Neuroscience. 1998; 82: 21-32.
46. Freret T, Chazalviel L, Roussel S, et al. Long-term functional outcome following transient middle cerebral artery occlusion in the rat: correlation between brain damage and behavioral impairment. Behav Neurosci. 2006; 120: 1285-98.
47. Briggs F, Usrey WM. Emerging views of corticothalamic function. Curr Opin Neurobiol. 2008; 18: 403-7.
48. Hiltunen M, Jolkkonen J. Complex pathology in the thalamus following cerebral ischemia. In: Song L, editor. Thalamus: anatomy, functions and disorders. Hauppauge, NY: Nova Publishers; 2011: p. 83-98.
49. Zhang Y, Xing S, Zhang J, et al. Reduction of β-amyloid deposits by γ-secretase inhibitor is associated with the attenuation of secondary damage in the ipsilateral thalamus and sensory functional improvement after focal cortical infarction in hypertensive rats. J Cereb Blood Flow Metab. 2011; 31: 572-9.
50. Rodríguez MJ, Bernal F, Andrés N, et al. Excitatory amino acids and neurodegeneration: a hypothetical role of calcium precipitation. Int J Dev Neurosci. 2000; 18: 299-307.
51. Loeb JA, Sohrab SA, Huq M, et al. Brain calcifications induce neurological dysfunction that can be reversed by a bone drug. J Neurol Sci. 2006; 243: 77-81.