Geldanamycin, a ligand of heat shock protein 90, inhibits herpes simplex virus type 2 replication both in vitro and in vivo

Journal of Antibiotics

Volumn 65, Issue 10, 2012, Pages 509-512

  Li, Yu Huan ^a   Lu, Qiao Ni ^a   Wang, Hui Qiang ^a   Tao, Pei Zhen ^a   Jiang, Jian Dong ^a,b  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^b INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

antiviral; geldanamycin; heat shock protein 90; herpes simplex virus type 2; in vitro; in vivo

Indexed keywords

ACICLOVIR; GELDANAMYCIN; HEAT SHOCK PROTEIN 90;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; GENITAL HERPES; HERPES SIMPLEX; HERPES SIMPLEX VIRUS 2; IN VITRO STUDY; IN VIVO STUDY; INFECTION PREVENTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; STATISTICAL SIGNIFICANCE; VAGINITIS; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS SHEDDING; WEIGHT REDUCTION;

ADMINISTRATION, INTRAVAGINAL; ANIMALS; ANTIVIRAL AGENTS; BENZOQUINONES; DISEASE MODELS, ANIMAL; FEMALE; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; LACTAMS, MACROCYCLIC; MICE; SURVIVAL ANALYSIS; TREATMENT OUTCOME; VAGINA; VIRUS REPLICATION; VIRUS SHEDDING;

HUMAN HERPESVIRUS 1; HUMAN HERPESVIRUS 2; MUS; RNA VIRUSES; SIMPLEXVIRUS;

EID: 84868139595     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2012.67     Document Type: Article

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