3-Hydroxyphthaloyl β-lactoglobulin. IV. Antiviral activity in the mouse model of genital herpesvirus infection

Antiviral Chemistry and Chemotherapy

Volumn 9, Issue 4, 1998, Pages 353-357

  Kokuba, H ^a   Aurelian, L ^a   Neurath, A R ^b  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b Lindsley F Kimball Res Inst N   (United States)

Author keywords

3 hydroxyphthaloyl lactoglobulin; Genital infection; Herpes simplex virus type 2

Indexed keywords

3 HYDROXYPHTHALOYL BETA LACTOGLOBULIN; ANTIVIRUS AGENT; UNCLASSIFIED DRUG; VIRUS GLYCOPROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; FEMALE; GENITAL HERPES; HERPES SIMPLEX VIRUS 2; HUMAN; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEXUALLY TRANSMITTED DISEASE; TOPICAL DRUG ADMINISTRATION; VIRUS SHEDDING;

ANIMALS; ANTI-INFECTIVE AGENTS; ANTIVIRAL AGENTS; DISEASE MODELS, ANIMAL; FEMALE; HERPES GENITALIS; HERPESVIRUS 2, HUMAN; LACTOGLOBULINS; MICE; MICE, INBRED STRAINS; VAGINA;

EID: 0031870658     PISSN: 09563202     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (27)

1. Arvin AM & Prober CG (1997) Herpes simplex virus type 2 - a persistent problem. New England Journal of Medicine 337:1158-1159.
2. Aurelian L (Editor) (1990) Herpesviruses, the Immune System and AIDS. Boston: Kluwer Academic.
3. Aurelian L (1992) Herpes simplex viruses. In Clinical Virology Manual, 2nd edn, pp. 473-494. Edited by S Specter & G Lancz. Oxford: Elsevier Science.
4. Aurelian L (1995) Transformation and mutagenic effects induced by herpes simplex virus types 1 and 2. In DNA Tumor Viruses: Oncogenic Mechanisms, pp. 253-280. Edited by G Barbanti-Brodano, M Bendinelli & H Friedman. New York: Plenum Press.
5. Baba M, Snoeck R, Pauwels R & De Clercq E (1988) Sulfated polysaccharides are potent selective inhibitors of various viruses, including herpes simplex virus, cytomegalovirus, vesicular stomatitis virus and human immunodeficiency virus. Antimicrobial Agents and Chemotherapy 32:1742-1745.
6. Beasley K, Cooley EG, Kao GF, Lowitt MH, Burnett JW & Aurelian L (1997) Herpes simplex vegetans: atypical genital herpes infection in a patient with common variable immunodeficiency. Journal of the American Academy of Dermatology 37:860-863.
7. DiLuca D, Caselli E & Cassai E (1995) Herpes simplex virus as a cooperating agent in human genital carcinogenesis. In DNA Tumor Viruses: Oncogenic Mechanisms, pp. 281-293. Edited by G Barbanti-Brodano, M Bendinelli & H Friedman. New York: Plenum Press.
8. Ejercito PM, Kieff ED & Roizman B (1968) Characterization of herpes simplex virus strains differing in their effect on social behaviour of infected cells. Journal of General Virology 2:357-364.
9. Feng CP, Kulka C, Smith CC & Aurelian L (1996) Herpes simplex virus-mediated activation of human immunodeficiency virus is inhibited by oligonucleotide methylphosphonates that target immediate early mRNAs 1 and 3. Antisense Research and Nucleic Acid Drug Development 6:25-35.
10. Fleming DT, McQuillan GM, Johnson RE, Nahmias AJ, Aral SO, Lee FK & St Louis ME (1997) Herpes simplex virus type 2 in the United States, 1976 to 1994. New England Journal of Medicine 337:1105-1111.
11. Jiang S, Li Y-Y, Lin K, Strick N & Neurath AR (1996) Chemically modified bovine β-lactoglobulin blocks uptake of HIV-1 by colon- and cervix-derived epithelial cell lines. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology 13:461-462.
12. Neurath AR, Debnath AK, Strick N, Li Y-Y, Lin K & Jiang S (1995) Blocking of CD4 cell receptors for the human immunodeficiency virus type 1 (HIV-1) by chemically modified bovine milk proteins: potential for AIDS prophylaxis. Journal of Molecular Recognition 8:304-316.
13. Neurath AR, Jiang S, Strick N, Lin K, Li Y-Y & Debnath AK (1996a) Bovine β-lactoglobulin modified by 3-hydroxyphthalic anhydride blocks the CD4 cell receptor for HIV. Nature Medicine 3:230-234.
14. Neurath AR, Li Y-Y, Strick N & Jiang S (1996b) A herpesvirus inhibitor prepared from bovine whey. Lancet 347:1703-1704.
15. Neurath AR, Debnath AK, Strick N, Li Y-Y, Lin K & Jiang S (1997a) 3-hydroxyphthaloyl-β-lactoglobulin. I. Optimization of production and comparison with other compounds considered for chemoprophylaxis of mucosally transmitted human immunodeficiency virus type 1. Antiviral Chemistry & Chemotherapy 8:131-139.
16. Neurath AR, Debnath AK, Strick N, Li Y-Y, Lin K & Jiang S (1997b) 3-hydroxyphthaloyl-β-lactoglobulin. II Anti-human immunodeficiency virus type 1 activity in in vitro environments relevant to prevention of sexual transmission of the virus. Antiviral Chemistry & Chemotherapy 8:141-148.
17. Neurath AR, Strick N & Li Y-Y (1998) 3-Hydroxyphthaloyl β-lactoglobulin: III. Antiviral activity against herpesviruses. Antiviral Chemistry & Chemotherapy 9:177-184.
18. Posavad CM, Koelle DM, Shaughnessy MF & Corey L (1997) Severe genital herpes infections in HIV-infected individuals with impaired herpes simplex virus-specific CD8+ cytotoxic T lymphocyte responses. Proceedings of the National Academy of Sciences, USA 94:10289-10294.
19. Richards JT, Kern ER, Overall JC & Glasgow LA (1981) Differences in neurovirulence among isolates of herpes simplex virus types 1 and 2 in mice using four routes of infection. Journal of Infectious Diseases 144:464-471.
20. Rowe PM (1997) Nonoxynol-9 fails to protect against HIV-1. Lancet 349:1074.
21. Smee DF, Martin JC, Verheyden JPH & Matthews TR (1983) Antiherpesvirus activity of the acyclic nucleoside 9-(1,3-dihydroxy-2-propoxymethyl)guanine. Antimicrobial Agents and Chemotherapy 23:676-682.
22. Strnad B & Aurelian L (1978) Proteins of herpesvirus type 2. III. Isolation and immunologic characterization of a large molecular weight viral protein. Virology 87:401-415.
23. Tong P & Mutasim DF (1996) Herpes simplex virus infection masquerading as condyloma acuminata in a patient with HIV disease. British Journal of Dermatology 134:797-800.
24. Wade A & Weller PJ (1994) Handbook of Pharmaceutical Excipients, 2nd edn, pp. 71-73. Washington, DC: American Pharmaceutical Association.
25. Walz MA, Price RW, Hayashi K, Katz BJ & Notkins AL (1977) Effect of immunization on acute and latent infections of vagino-uterine tissue with herpes simplex virus types 1 and 2. Journal of Infectious Diseases 135:744-752.
26. Whaley KJ, Barratt RA, Zeitlin L, Hoen TE & Cone RA (1993) Nonoxynol-9 protects mice against vaginal transmission of genital herpes infections. Journal of Infectious Diseases 168:1009-1111.
27. Zeitlin H, Whaley K, Hegarty TA, Moench TR & Cone RA (1997) Tests of vaginal microbicides in the mouse genital herpes model. Contraception 56:329-335.