Inhibition of herpeslex virus type 1 infection in vitro and in vivo by geldanamycin

Chinese Journal of Antibiotics

Volumn 29, Issue 5, 2004, Pages 311-315

  Li, Yu Huan ^a,c   Tao, Pei Zhen ^a   Yu, Lian ^b   Qu, You Le ^b   Liu, Yu Zhen ^a   Jiang, Jian Dong ^a,c  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

^b JIAMUSI UNIVERSITY   (China)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Antiviral; Geldanamycin; HSV 1

Indexed keywords

ACICLOVIR; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ANTIBIOTIC AGENT; ANTIVIRUS AGENT; GELDANAMYCIN; HEAT SHOCK PROTEIN 90; SOLVENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; BINDING SITE; CONTROLLED STUDY; DRUG CYTOTOXICITY; FEMALE; HERPES SIMPLEX VIRUS 1; IC 50; IN VITRO STUDY; IN VIVO STUDY; INHIBITION KINETICS; LD 50; MALE; MOUSE; NONHUMAN; VERO CELL; VIRUS ADSORPTION; VIRUS INHIBITION; VIRUS REPLICATION; VIRUS VIRULENCE;

EID: 3142686551     PISSN: 10018689     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (15)

1. Deboer C, Meulman P A, Wnuk R J, et al. A new antibiotic [J]. J Antibioti (Tokyo), 1970,23:442
2. Prodromou C, Roe S M, O'Brien R, et al. Identification and structural characterization of the ATP/ADP-binding site in the Hsp90 molecular chaperone [J]. Cell, 1997,90:65
3. Sullivan W, Stensgard B, Caucutt G, et al. Nucleotides and two functional states of hsp90 [J]. J Biol Chem, 1997,272:8007
4. Richter K, Buckner J. Hsp90: chaperoning signal transduction [J]. J Cell Physiol, 2001,188:281
5. Maki C G, Huibregtse J M, Howley P M. In vivo ubiquitination and proteosome-mediated degradation of p53 [J]. Cancer Res, 1996,56:2649
6. DeSalle LM, Pagano M. Regulation of the G1 to S transition by ubiquitin pathway [J]. FEBS Lett. 2001,490:179
7. Sainz B Jr, Halford W P. Alpha/Beta interferon and gamma interferon synergize to inhibit the replication of herpes simplex virus type 1 [J]. J Virol. 2002,76:11541
8. Andries K, Dewindt B, Snoeks J, et al. In vitro activity of pirodavir (R. 77975), a substituted phenoxy-pyridazinamine with broad-spectrum antipicornaviral activity [J]. Antimicrob Agents Chemother, 1992,36:100
9. Highlander S L, Cai W H, Person S, et al. Neutralizing monoclonal antibodies specific for herpes simplex virus glycoprotein D inhibit virus penetration [J]. J Virol, 1987,61:3356
10. Blagosklonny M V. Hsp-90-associated oncoproteins: multiple targets for geldanamycin and its analogs [J]. Leukemia, 2002, 16:455
11. Ochel H J, Eichhorn K, Gademann G. Geldanamycin: the prototype of a class of antitumor drugs targeting the heat shock protein 90 family of molecular chaperones [J]. Cell Stress Chaperones, 2001,6:105
12. Piper P W. The Hsp90 chaperone as a promising drug target [J]. Curr Opin Invest Drugs, 2001,2:1606
13. Roe S M, Prodromou C, O'Brien R, et al. Structure basis for inhibition of the Hsp90 molecular chaperone by the antitumor antibiotics radicicol and geldanamycin [J]. J Med Chem 1999,42:260
14. Kim S, Kang J, Hu W, et al. Geldanamycin decreases Raf-1 and Akt levels and induces apoptosis in neuroblastomas [J]. Int J Cancer, 2003,103:352
15. Mabjeesh N J, Post D E, Willard M T, et al. Geldanamycin induces degradation of hypoxia-inducible factor 1 alpha protein via the proteosome pathway in prostate cancer cells [J]. Cancer Res, 2002,62:2478