A novel class of geldanamycin derivatives as HCV replication inhibitors targeting on Hsp90: Synthesis, structure-activity relationships and anti-HCV activity in GS4.3 replicon cells

Journal of Antibiotics

Volumn 64, Issue 2, 2011, Pages 177-182

  Shan, Guang Zhi ^a   Peng, Zong Gen ^a   Li, Yu Huan ^a   Li, Dong ^a   Li, Yan Ping ^a   Meng, Shuai ^a   Gao, Lin Yan ^a   Jiang, Jian Dong ^a   Li, Zhuo Rong ^a  

^a INSTITUTE OF MEDICINAL BIOTECHNOLOGY   (China)

Author keywords

anti HCV agents; geldanamycin derivatives; Hsp90

Indexed keywords

17 (1' DIETHYLPHOSPHONATE METHYLAMINE) 17 DEMETHOXYGELDANAMYCIN; 17 (2' NICOTINAMIDYLETHYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (2' TETRAHYDROFURFURYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 (3',4' METHYLENEDIOXYBENZYLAMINO) 17 DEMETHOXYGELDANAMYCIN; 17 [2' (1' AZAHETEROCYCLOHEXYL 1')ETHYLAMINO] 17 DEMETHOXYGELDANAMYCIN; 17 [2' (1' OXA 4' AZA HETEROCYCLOHEXYL 1')ETHYLAMINO] 17 DEMETHOXYGELDANAMYCIN; 17 [2' (N ETHYLPYRROLIDINYL) METHYLAMINO] 17 DEMETHOXYGELDANAMYCIN; 17 [2' (THIOPHEN 2' YL)ETHANAMINE] 17 DEMETHOXYGELDANAMYCIN; 17 [3' (2' AMINO 5' NITROPYRIDIN) ETHYLAMINE] 17 DEMETHOXYGELDANAMYCIN; 17 [6',6' DIMETHYLBICYCLO[3.1.1]HEPTAN 9 YL]METHANAMINE 17; 17 TETRAHYDROFURFURYLAMINO 17 DEMETHOXYGELDANAMYCIN; 17,19 DI TETRAHYDROFURFURYLAMINO 17 DEMETHOXYGELDANAMYCIN; ANTIVIRUS AGENT; GELDANAMYCIN; HEAT SHOCK PROTEIN 90 INHIBITOR; RECOMBINANT ALPHA2B INTERFERON; RIBAVIRIN; UNCLASSIFIED DRUG; VIRUS RNA;

ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG POTENCY; DRUG POTENTIATION; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; EPIMER; HEPATITIS C VIRUS; HEPATOMA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION; VIRUS INHIBITION; VIRUS REPLICATION;

ANTIVIRAL AGENTS; BENZOQUINONES; CELL LINE; CELL SURVIVAL; HEPACIVIRUS; HUMANS; INHIBITORY CONCENTRATION 50; LACTAMS, MACROCYCLIC; MICROBIAL SENSITIVITY TESTS; STRUCTURE-ACTIVITY RELATIONSHIP; TETRAZOLIUM SALTS; THIAZOLES; VIRUS REPLICATION;

HEPATITIS C VIRUS;

EID: 79951936136     PISSN: 00218820     EISSN: 18811469     Source Type: Journal    
DOI: 10.1038/ja.2010.161     Document Type: Article

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