PI3Kγ activation is required for LPS-induced reactive oxygen species generation in respiratory epithelial cells

Inflammation Research

Volumn 61, Issue 11, 2012, Pages 1265-1272

  Kim, Hee Jung ^a   Kim, So Ri ^a   Park, Jin Kyeong ^a   Kim, Dong Im ^a   Jeong, Jae Seok ^a   Lee, Yong Chul ^a  

^a Chonbuk National University Medical School   (South Korea)

Author keywords

Airway epithelial cells; Lipopolysaccharide; PI3K ; Reactive oxygen species

Indexed keywords

5 (6 QUINOXALINYLMETHYLENE) 2,4 THIAZOLIDINEDIONE; ACETYLCYSTEINE; HYDROGEN PEROXIDE; I KAPPA B ALPHA; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIPOPOLYSACCHARIDE; PHOSPHATIDYLINOSITOL 3 KINASE GAMMA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PROTEIN KINASE B; PYRIDOXAMINE; REACTIVE OXYGEN METABOLITE; SCAVENGER; SMALL INTERFERING RNA;

ARTICLE; CANCER CELL CULTURE; CELL LEVEL; CELL STIMULATION; CELL VIABILITY; CONTROLLED STUDY; CYTOSOLIC FRACTION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; ENZYME SYNTHESIS; EPITHELIUM CELL; HUMAN; HUMAN CELL; LUNG ALVEOLUS EPITHELIUM; MOLECULAR MECHANICS; PROTEIN DEGRADATION; PROTEIN SYNTHESIS; RESPIRATORY EPITHELIUM; RNA INTERFERENCE;

CELL LINE; CELL LINE, TUMOR; CLASS IB PHOSPHATIDYLINOSITOL 3-KINASE; ENZYME INHIBITORS; EPITHELIAL CELLS; HUMANS; HYDROGEN PEROXIDE; LIPOPOLYSACCHARIDES; LUNG; NF-KAPPA B; QUINOXALINES; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; THIAZOLIDINEDIONES;

EID: 84868131799     PISSN: 10233830     EISSN: 1420908X     Source Type: Journal    
DOI: 10.1007/s00011-012-0526-7     Document Type: Article

References (11)

1. Christodoulopoulos P, Wright E, Frenkiel S, Luster A, Hamid Q. Monocyte chemotactic proteins in allergen-induced inflammation in the nasal mucosa: effect of topical corticosteroids. J Allergy Clin Immunol. 1999;103:1036-44.
2. Rahman I. Oxidative stress, chromatin remodeling and gene transcription in inflammation and chronic lung diseases. J Biochem Mol Biol. 2003;36:95-109.
3. Zhang X, Shan P, Sasidhar M, Chupp GL, Flavell RA, Choi AM, et al. Reactive oxygen species and extracellular signal-regulated kinase 1/2 mitogen-activated protein kinase mediates hyperoxia-induced cell death in lung epithelium. Am J Respir Cell Mol Biol. 2003;28:305-15.
4. Haddad JJ, Land SC. Redox signaling-mediated regulation of lipopolysaccharide-induced proinflammatory cytokine biosynthesis in alveolar epithelial cells. Antioxid Redox Signal. 2002;4:179-93.
5. Hirsch E, Katanaev VL, Garlanda C, Azzolino O, Pirola L, Silengo L, et al. Central role for G protein-coupled phosphoinositide 3-kinase gamma in inflammation. Science. 2000;287:1049-53.
6. Condliffe AM, Davidson K, Anderson KE, Ellson CD, Crabbe T, Okkenhaug K, et al. Sequential activation of class IB and class IA PI3K is important for the primed respiratory burst of human but not murine neutrophils. Blood. 2005;106:1432-40.
7. Lee KS, Lee HK, Hayflick JS, Lee YC, Puri KD. Inhibition of phosphoinositide 3-kinase delta attenuates allergic airway inflammation and hyperresponsiveness in murine asthma model. FASEB J. 2006;20:455-65.
8. Lee KS, Kim SR, Park SJ, Park HS, Min KH, Lee MH, et al. Hydrogen peroxide induces vascular permeability via regulation of vascular endothelial growth factor. Am J Respir Cell Mol Biol. 2006;35:190-7.
9. Rahman I, MacNee W. Role of oxidants/antioxidants in smoking-induced airways diseases. Free Radic Biol Med. 1999;21:669-81.
10. Kim H, Hwang JS, Woo CH, Kim EY, Kim TH, Cho KJ, et al. TNF-α-induced up-regulation of intercellular adhesion molecule-1 is regulated by a Rac-ROS-dependent cascade in human airway epithelial cells. Exp Mol Med. 2008;40:167-75.
11. Frey RS, Gao X, Javaid K, Siddiqui SS, Rahman A, Malik AB. Phosphatidylinositol 3-kinase gamma signaling through protein kinase Czeta induces NADPH oxidase-mediated oxidant generation and NF-kappaB activation in endothelial cells. J Biol Chem. 2006;281:16128-38.