Food proteins as a source of bioactive peptides with diverse functions

British Journal of Nutrition

Volumn 108, Issue SUPPL. 2, 2012, Pages

  Rutherfurd Markwick, Kay J ^a  

^a MASSEY UNIVERSITY   (New Zealand)

Author keywords

Bioactive peptides; health benefits; physiological activity

Indexed keywords

BETA CASOMORPHINE; BIOACTIVE FOOD PEPTIDE; BIOACTIVE FOOD PROTEIN; CASEINOPHOSPHOPEPTIDE; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LACTOPEROXIDASE; LOW DENSITY LIPOPROTEIN CHOLESTEROL; MILK PROTEIN; OPIATE AGONIST; OPIATE ANTAGONIST; OPIATE PEPTIDE; PEPTIDES AND PROTEINS; PHOSPHOPEPTIDE; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

AMINO ACID SEQUENCE; BONE METABOLISM; CARDIOVASCULAR RISK; CHOLESTEROL BLOOD LEVEL; DAIRY PRODUCT; DOSE RESPONSE; GASTROINTESTINAL ABSORPTION; HUMAN; HYPERTENSION; NONHUMAN; OSTEOPROTECTION; PEPTIDE ABSORPTION; PROPHYLAXIS; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN INTAKE; PROTEIN METABOLISM; PROTEIN QUALITY; PROTEIN SECRETION; REVIEW; RISK REDUCTION;

DIET; DIETARY PROTEINS; HEALTH; HUMANS; PEPTIDES;

EID: 84868123294     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S000711451200253X     Document Type: Review

References (95)

1. Korhonen H (2009) Milk-derived bioactive peptides: From science to applications. J Funct Foods 1, 177-187.
2. Kelly D & Coutts APG (1997) Biologically active peptides in colostrum and milk. In Digestive Physiology in Pigs, pp. 163-170 [J-P Laplace, C Février and A Barbeau, editors]. Saint Malo, France: INRA.
3. Meisel H (2005) Biochemical properties of peptides encrypted in bovine milk proteins. Curr Med Chem 12, 1905-1919. (Pubitemid 41015186)
4. Moller NP, Scholz-Ahrens KE, Roos N, et al. (2008) Bioactive peptides and proteins from foods: indication for health effects. Eur J Nutr 47, 171-182.
5. Hu WL, Mazurier J, Sawatzki G, et al. (1988) Lactotransferrin receptor of mouse small-intestinal brush border. Biochem J 249, 435-441.
6. Guesdon B, Pichon L & Tomé D (2006) Opioid Peptides. In Nutraceutical Proteins and Peptides in Health and Disease, pp. 367-376 [Y Mine and F Schahidi, editors]. Boca Raton, Florida: CRC Press.
7. Drescher K, Roos N, Pfeuffer M, et al. (1999) Recovery of 15N-Lactoferrin is higher than that of 15N-Casein in the small intestine of suckling, but not adult miniature pigs. J Nutr 129, 1026-1030.
8. Roos N, Mahe S, Benamouzig R, et al. (1995) 15N-labeled immunoglobulins from bovine colostrum are partially resistant to digestion in human intestine. J Nutr 125, 11238-11244.
9. Korhonen H & Marnila P (2006) Bovine milk antibodies for protection against microbial human disease. In Nutraceutical Proteins and Peptides in Health and Disease, pp. 137-159 [Y Mine and F Shahidi, editors]. Boca Raton, Florida: CRC Press.
10. Korhonen H & Pihlanto A (2007) Technological options for the production of health-promoting proteins and peptides derived from milk and colostrum. Curr Pharm Des 13, 829-843. (Pubitemid 46591100)
11. Baker EN, Baker HM, Koon N, et al. (2002) Lactoferrin: bioactive properties and applications. Bull Int Dairy Fed 375, 54-58.
12. Baveye S, Elass E, Mazurier J, et al. (1999) Lactoferrin: a multifunctional glycoprotein involved in the modulation of the inflammatory process. Clin Chem Lab Med 37, 281-286. (Pubitemid 29209742)
13. Elass E, Baveye S, Fernig D, et al. (2002) Lactoferrin interacts with CD14s and inhibits the expression of endothelial adhesion molecules, induced by the CD14s-lipopolysaccharide complex. Biochem Cell Biol 80, 165.
14. Britton JR, George-Nasscimento C & Koldovsky O (1988) Luminal hydrolysis of recombinant human epidermal growth factor in the rat gastrointestinal tract: segmental and developmental differences. Life Sci 43, 1339-1347.
15. Britton JR, George-Nasscimento C, Udall JN, et al. (1989) Minimal hydrolysis of epidermal growth factor by gastric fluid of preterm infants. Gut 30, 327-332. (Pubitemid 19091158)
16. Read LC, Gale SM & George-Nascimento C (1987) Intestinal absorption of epidermal growth factor in newborn lambs. In Human Lactation 3 The effects of human milk on the recipient infant, pp. 199-204 [AS Goldman, SA Atkinson and LA Hansen, editors]. New York: Plenum Press.
17. Schusdziarra V, Schick A, De La Fuente A, et al. (1983) Effect of β-Casomorphins and analogs on insulin release in dogs. Endocrinology 112, 885-889.
18. Weaver LT (1997) Significance of bioactive substances in milk to the human neonate. Livestock Prod Sci 50, 139-146. (Pubitemid 127396578)
19. Donnet-Hughes A, Duc N, Serrant P, et al. (2000) Bioactive molecules in milk and their role in health and disease: The role of transforming growth factor-β. Immunol Cell Biol 78, 74-79. (Pubitemid 30090992)
20. Beattie RM, Schiffrin EJ, Donnet-Hughes A, et al. (1994) Polymeric nutrition as the primary therapy in children with small bowel Crohn's disease. Aliment Pharmacol Ther 8, 609-615. (Pubitemid 24381361)
21. Fell JM, Paintin M, Arnaud-Battandier F, et al. (2000) Mucosal healing and a fall in mucosal pro-inflammatory cytokine mRNA induced by a specific oral polymeric diet in paediatric Crohn's disease. Aliment Pharmacol Ther 14, 281-289. (Pubitemid 30145315)
22. Ozawa T, Miyata M, Nishimura M, et al. (2009) Transforming growth factor-β activity in commercially available pasteurized cow milk provides protection against inflammation in mice. J Nutr 139, 69-75.
23. Schriffin E, El Yousfi M, Faure M, et al. (2005) Milk caseinbased diet containing TGF-b controls the inflammatory reaction in the HLA-B27 transgenic rat model. J Parent Enteral Nutr 29, S141-S148.
24. Neurath MF, Fuss I, Kelsall BL, et al. (1996) Experimental granulomatous colitis in mice is abrogated by induction of TGF-beta-mediated oral tolerance. J Exp Med 183, 2605-2616. (Pubitemid 26192369)
25. Sanchez de Medina F, Daddaoua A, Requena P, et al. (2010) New insights into the immunological effects of food bioactive peptides in animal models of intestinal inflammation. Proc Nutr Soc 69, 454-462.
26. Pellegrini A (2003) Antimicrobial peptides from food proteins. Curr Pharma Design 9, 1225-1238. (Pubitemid 36592133)
27. Teschemacher H (2003) Opioid receptor ligands derived from food proteins. Curr Pharma Design 9, 1331-1344. (Pubitemid 36592141)
28. Moughan PJ, Fuller MF, Han K-S, et al. (2007) Food-derived bioactive peptides influence gut function. Int J Sport Nutr Exerc Metab 17, S5-S22.
29. Yoshimoto R, Fischl M, Orlowski RC, et al. (1978) Postproline cleaving enzyme and post-proline dipeptidyl amino-peptidase comparison of two peptidases with high specificity for proline residues. J Biol Chem 253, 3708-3716. (Pubitemid 8346568)
30. Mock LW, Green PC & Boyer KD (1990) Specificity and pH dependence for acylproline cleavage by prolidase. J Biol Chem 265, 19600-19605. (Pubitemid 120013905)
31. Naito H & Suzuki H (1974) Further evidence for the formation in vivo of phosphopeptide in the intestinal lumen from dietary b-casein. Agr Biol Chem 38, 1543-1545.
32. Kitts DD, Yuan YV, Nagasawa T, et al. (1992) Effect of casein, casein phosphopeptides and calcium intake on ileal 45Ca disappearance and temporal systolic blood pressure in spontaneously hypertensive rats. Br J Nutr 68, 765-781. (Pubitemid 23027135)
33. Kasai T, Honda T & Kiriyama S (1992) Caseinphosphopeptides (CPP) in feces of rats fed casein diet. Biosci Biotech Biochem 56, 1150-1151.
34. Adibi SA & Morse EL (1971) Intestinal transport of dipeptides in man: relative importance of hydrolysis and intact absorption. J Clin Invest 50, 2266-2275.
35. Hara H, Funabiki R, Iwata M, et al. (1984) Portal absorption of small peptides in rats under unrestrained conditions. J Nutr 114, 1122-1129. (Pubitemid 14124099)
36. Bloch KJ, Wright JA, Bishara SM, et al. (1988) Uptake of polypeptide fragments of proteins by rat intestine in vitro and in vivo. Gastroenterology 95, 1272-1278.
37. Chabance B, Marteau P, Rambaud JC, et al. (1998) Casein peptide release and passage to the blood in humans during digestion of milk or yogurt. Biochimie 80, 155-165. (Pubitemid 28185054)
38. Fosset S, Fromentin G, Gietzen DW, et al. (2002) Peptide fragments released from Phe-caseinmacropeptide in vivo in the rat. Peptides 23, 1773-1781. (Pubitemid 35279836)
39. Nakamura Y, Masuda O & Takano T (1996) Decrease of tissue angiotensin I-converting enzyme activity upon feeding sour milk to spontaneously hypertensive rats. Biosci Biotech Biochem 60, 488-489. (Pubitemid 126460932)
40. Masuda O, Nakamura Y & Takano T (1996) Antihypertensive Peptides Are Present in Aorta after Oral Administration of Sour Milk Containing These Peptides to Spontaneously Hypertensive Rats. J Nutr 126, 3063-3068. (Pubitemid 27023881)
41. Satake M, Enjoh M, Nakamura Y, et al. (2002) Transepithelial Transport of the Bioactive Tripeptide, Val-Pro-Pro, in Human Intestinal Caco-2 Cell Monolayers. Biosci Biotechnol Biochem 66, 378-384. (Pubitemid 39251060)
42. Yokoyama K, Chiba H & Yoshikawa M (1992) Peptide inhibitors for angiotensin I-converting enzyme from thermolysin digest of dried bonito. Biosci Biotech Biochem 56, 1541-1545.
43. Fujita H, Yokoyam K & Yoshikawa M (2000) Classification and antihypertensive activity of angiotensin I-converting enzyme inhibitory peptides derived from food proteins. J Food Sci 65, 564-569. (Pubitemid 30610519)
44. Hata Y, Yamamoto M, Ohni M, et al. (1996) A placebocontrolled study of the effect of sour milk on blood pressure in hypertensive subjects. Am J Clin Nutr 64, 767-771. (Pubitemid 26398281)
45. Yoshikawa M, Fujita H, Matoba N, et al. (2000) Bioactive peptides derived from food proteins preventing lifestylerelated diseases. Biofactors 12, 143-146. (Pubitemid 32107398)
46. Gilani GS, Xiao C & Lee N (2008) Need for accurate and standardized determination of amino acids and bioactive peptides for evaluating protein quality and potential health effects of foods and dietary supplements. JOAC Int 91, 894-900.
47. Carroll KK (1978) The role of dietary protein in hypercholesterolemia and atherosclerosis. Lipids 13, 360-365. (Pubitemid 8346985)
48. Anderson JW, Johnstone BM & Cook-Newell ME (1995) Meta-Analysis of the Effects of Soy Protein Intake on Serum Lipids. N Eng J Med 333, 276-282.
49. Sugano M, Yamada Y, Yoshihida K, et al. (1988) The hypocholesterolemic action of the undigested fraction of soybean protein in rats. Atherosclerosis 72, 115-122.
50. Cho S-J, Juillerat MA & Lee C-H (2007) Cholesterol lowering mechanism of soybean protein hydrolysate. J Agric Food Chem 55, 10599-10604.
51. Morley JE, Levine AS, Yamada T, et al. (1983) Effect of exorphins on gastrointestinal function, hormonal release and appetite. Gastroenterology 84, 1517-1523. (Pubitemid 13092100)
52. Meisel H & Frister H (1989) Chemical characterization of bioactive peptides from in vivo digests of casein. J Dairy Res 56, 343-349.
53. Brantl V, Teschemacher H, Henschen A, et al. (1979) Novel opioid peptides derived from casein (beta-casomorphins). II. Structure of active components from bovine casein peptone. Hoppe-Seyler's Z Physiol Chem 360, 1211-1216. (Pubitemid 10231176)
54. Brantl V (1984) Novel opioid peptides derived from human beta-casein: human beta-casomorphins. Eur J Pharmacol 106, 213-214. (Pubitemid 15189051)
55. Teschemacher H, Koch G & Brantl V (1997) Milk proteinderived opioid receptor ligands. Biopoly 43, 99-117. (Pubitemid 27291389)
56. Brantl V, Gramsch C, Lottspeich F, et al. (1986) Novel opioid peptides derived from hemoglobin: hemorphins. Eur J Pharmacol 125, 309-310. (Pubitemid 16075447)
57. Meisel H & Schlimme E (1990) Milk proteins: precursors of bioactive peptides. Trends Food Sci Technol 1, 41-43.
58. Pihlanto-Leppälä A (2001) Bioactive peptides derived from bovine whey proteins: opioid and ace-inhibitory peptides. Trends Food Sci Technol 11, 347-356. (Pubitemid 32516037)
59. Yoshikawa M, Tani F, Yoshimura T, et al. (1986) Opioid Peptides from Milk Proteins. Agric Biol Chem 50, 2419-2421. (Pubitemid 17189403)
60. Yoshikawa M, Tani F & Chiba H (1988) Structure-activity relationship of opioid antagonist peptides derived from milk proteins. In Peptide Chemistry, pp. 473-476 [T Shiba, editor]. Osaka: Protein Research Foundation.
61. Clare DA & Swaisgood HE (2000) Bioactive milk peptides: A prospectus. J Dairy Sci 83, 1187-1195.
62. Meisel H (1998) Overview on milk protein-derived peptides. Int Dairy J 8, 363-373. (Pubitemid 28504135)
63. Meisel H (1986) Chemical characterization and opioid activity of an exorphin isolated from in vivo digests of casein. FEBS Lett 196, 223-227. (Pubitemid 16047465)
64. Svedberg J, de Haas J, Leimenstoll G, et al. (1985) Demonstration of β-Casomorphin immunoreactive materials in in vitro digests of bovine milk and in small intestine contents after bovine milk ingestion in adult humans. Peptides 6, 825-830. (Pubitemid 16170966)
65. Singh M, Rosen CL, Chang KJ, et al. (1989) Plasma [beta]- casomorphin-7 immunoreactive peptide increases after milk intake in newborn but not in adult dogs. Pediatr Res 26, 34-38.
66. Hamel V, Kielwein G & Teschemacher H (1985) β-Casomorphin immunoreactive materials in cows' milk incubated with various bacterial species. J Dairy Res 52, 139-148.
67. Lin L, Umahara M, York DA, et al. (1998) β-Casomorphins stimulate and enterostatin inhibits the intake of dietary fat in rats. Peptides 19, 325-331. (Pubitemid 28097932)
68. Hedner J & Hedner T (1987) β-Casomorphins induce apnea and irregular breathing in adult rats and newborn rabbits. Life Sci 41, 2303-2312. (Pubitemid 18034054)
69. Pasi A, Mahler H, Lansel N, et al. (1993) Res Commun Chem Pathol Pharmacol 80, 305-322.
70. Fukudome S-I & Yoshikawa M (1992) Opioid peptides derived from wheat gluten: Their isolation and characterization. FEBS Lett 296, 107-111.
71. Fukudome S-I & Yoshikawa M (1993) Gluten exorphin C: A novel opioid peptide derived from wheat gluten. FEBS Lett 316, 17-19. (Pubitemid 23029198)
72. Fukudome S-I, Shimatsu A, Suganuma H, et al. (1995) Effect of gluten exorphins a5 and b5 on the postprandial plasma insulin level in conscious rats. Life Sci 57, 729-734.
73. Glämsta E-L, Marklund A, Hellman U, et al. (1991) Isolation and characterization of a hemoglobin-derived opioid peptide from the human pituitary gland. Regul Pept 34, 169-179.
74. Piot J-M, Zhao Q, Guillochon D, et al. (1992) Isolation and characterization of two opioid peptides from a bovine hemoglobin peptic hydrolysate. Biochem Biophys Res Commun 189, 101-110. (Pubitemid 23030014)
75. Zadina JE, Kastin AJ, Kersh D, et al. (1992) Tyr-MIF-1 and hemorphin can act as opiate agonists as well as antagonists in the guinea pig ileum. Life Sci 51, 869-885.
76. Davis TP, Gillespie TJ & Porreca F (1989) Peptide fragments derived from the b-chain of hemoglobin (hemorphins) are centrally active in vivo. Peptides 10, 747-751. (Pubitemid 19228486)
77. Nyberg F, Sanderson K & Glämsta E-L (1997) The hemorphins: a new class of opioid peptides derived from the blood protein hemoglobin. Biopoly 43, 147-156. (Pubitemid 27291394)
78. Ivanov VT, Karelin AA, Philippova MM, et al. (1997) Hemoglobin as a source of endogenous bioactive peptides: the concept of tissue-specific peptide pool. Biopoly 43, 171-188. (Pubitemid 27291396)
79. Schanbacher FL, Talhouk RS, Murray FA, et al. (1998) Milk- Borne Bioactive Peptides. Int Dairy J 8, 393-403. (Pubitemid 28504138)
80. Shahidi F & Zhong Y (2008) Bioactive peptides. JOAC Int 91, 914-931.
81. Kitts DD (1994) Bioactive substances in food: identification and potential uses. Can J Physiol Pharmacol 72, 423-434. (Pubitemid 24215291)
82. Naito H, Kawakami A & Inamura T (1972) In vivo formation of phosphopeptide with calcium-binding property in the small intestinal tract of the rat fed on casein. Agric Biol Chem 36, 409-415.
83. Sato R, Noguchi T & Naito H (1983) The necessity for the phosphate portion of casein molecules to enhance Ca absorption from the small intestine. Agric Biol Chem 47, 2415-2417.
84. Yuan YV & Kitts DD (1991) Confirmation of calcium absorption and femoral utilization in spontaneously hypertensive rats fed casein phosphopeptide supplemented diets. Nutr Res 11, 1257-1272.
85. Scholz-Ahrens KE, de Vrese M & Barth CA (1991) Influence of casein-derived phosphopeptides on the bioavailability of calcium in vitamin D-deficient miniature pigs. In Gene regulation, structure-function analysis and clinical application, pp. 724-725 [AW Norman, R Bouillon and M Thomasset, editors]. Berlin: W de Gruyter.
86. Hansen M, Sandstöm B, Jensen M, et al. (1997) Casein phosphopeptides improve zinc and calcium absorption from rice-based but not from whole-grain infant cereal. J Pediatr Gastroenterol Nutr 24, 56-62. (Pubitemid 27142875)
87. Narva M, Karkkainen M, Poussa T, et al. (2003) Caseinphosphopeptides in milk and fermented milk do not affect calcium metabolism acutely in postmenopausal women. J Am Coll Nutr 22, 88-93. (Pubitemid 36164462)
88. Uenishi K, Ishida H, Toba Y, et al. (2007) Milk basic protein increases bone mineral density and improves bone metabolism in healthy young women. Osteoporos Int 18, 385-390. (Pubitemid 46233185)
89. Aoe S, Koyama T, Toba Y, et al. (2005) A controlled trial of the effect of milk basic protein (MBP) supplementation on bone metabolism in healthy menopausal women. Osteoporos Int 16, 2123-2128. (Pubitemid 41790935)
90. Toba Y, Takada Y, Yamamura J, et al. (2000) Milk basic protein: a novel protective function of milk against osteoporosis. Bone 27, 403-408. (Pubitemid 30658124)
91. Foltz M, van der Pijl PC & Duchateau GSMJE (2010) Current in vitro testing of bioactive peptides is not valuable. J Nutr 140, 117-118.
92. Fujita H, Yokoyama K & Yoshikawa M (2000) Classification and antihypertensive activity of angiotensin I-converting enzyme inhibitory peptides derived from food proteins. J Food Sci 65, 564-569. (Pubitemid 30610519)
93. Rutherfurd-Markwick KJ & Moughan PJ (2005) Bioactive peptides derived from food. JOAC Int 88, 955-966. (Pubitemid 41066497)
94. Del Mar Contreras M, Lopez-Exposito I, Hernandez-Ledesma B, et al. (2008) Application of mass spectrometry to the characterization and quantification of food-derived bioactive peptides. JOAC Int 91, 981-994.
95. Sato K, Iwai K & Aito-Inoue M (2008) Identification of foodderived bioactive peptides in blood and other biological samples. JOAC Int 91, 995-1001.