메뉴 건너뛰기




Volumn 109, Issue 44, 2012, Pages

PKA and GAB2 play central roles in the FSH signaling pathway to PI3K and AKT in ovarian granulosa cells

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEIN; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FOLLITROPIN; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2; GROWTH FACTOR RECEPTOR BOUND PROTEIN 2 ASSOCIATED BINDING PROTEIN 2; HETERODIMER; INSULIN RECEPTOR SUBSTRATE 1; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; UNCLASSIFIED DRUG;

EID: 84868122919     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1205661109     Document Type: Article
Times cited : (119)

References (56)
  • 2
    • 0025237466 scopus 로고
    • The testicular receptor for follicle stimulating hormone: Structure and functional expression of cloned cDNA
    • Sprengel R, Braun T, Nikolics K, Segaloff DL, Seeburg PH (1990) The testicular receptor for follicle stimulating hormone: Structure and functional expression of cloned cDNA. Mol Endocrinol 4(4):525-530.
    • (1990) Mol Endocrinol , vol.4 , Issue.4 , pp. 525-530
    • Sprengel, R.1    Braun, T.2    Nikolics, K.3    Segaloff, D.L.4    Seeburg, P.H.5
  • 3
    • 0042922520 scopus 로고    scopus 로고
    • Protein kinase B is obligatory for folliclestimulating hormone-induced granulosa cell differentiation
    • Zeleznik AJ, Saxena D, Little-Ihrig L (2003) Protein kinase B is obligatory for folliclestimulating hormone-induced granulosa cell differentiation. Endocrinology 144(9): 3985-3994.
    • (2003) Endocrinology , vol.144 , Issue.9 , pp. 3985-3994
    • Zeleznik, A.J.1    Saxena, D.2    Little-Ihrig, L.3
  • 4
    • 2442485795 scopus 로고    scopus 로고
    • Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follicular differentiation
    • Alam H, et al. (2004) Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of follicular differentiation. J Biol Chem 279(19):19431- 19440.
    • (2004) J Biol Chem , vol.279 , Issue.19 , pp. 19431-19440
    • Alam, H.1
  • 5
    • 20144389096 scopus 로고    scopus 로고
    • Induction of cyclin D2 in rat granulosa cells requires FSHdependent relief from FOXO1 repression coupled with positive signals from Smad
    • Park Y, et al. (2005) Induction of cyclin D2 in rat granulosa cells requires FSHdependent relief from FOXO1 repression coupled with positive signals from Smad. J Biol Chem 280(10):9135-9148.
    • (2005) J Biol Chem , vol.280 , Issue.10 , pp. 9135-9148
    • Park, Y.1
  • 6
    • 0036376131 scopus 로고    scopus 로고
    • Novel signaling pathways that control ovarian follicular development, ovulation, and luteinization
    • Richards JS, et al. (2002) Novel signaling pathways that control ovarian follicular development, ovulation, and luteinization. Recent Prog Horm Res 57:195-220.
    • (2002) Recent Prog Horm Res , vol.57 , pp. 195-220
    • Richards, J.S.1
  • 7
    • 0344825788 scopus 로고    scopus 로고
    • Follicle-stimulating hormone promotes nuclear exclusion of the forkhead transcription factor FoxO1a via phosphatidylinositol 3-kinase in porcine granulosa cells
    • Cunningham MA, Zhu Q, Unterman TG, Hammond JM (2003) Follicle-stimulating hormone promotes nuclear exclusion of the forkhead transcription factor FoxO1a via phosphatidylinositol 3-kinase in porcine granulosa cells. Endocrinology 144(12): 5585-5594.
    • (2003) Endocrinology , vol.144 , Issue.12 , pp. 5585-5594
    • Cunningham, M.A.1    Zhu, Q.2    Unterman, T.G.3    Hammond, J.M.4
  • 8
    • 84858976946 scopus 로고    scopus 로고
    • Follicle-stimulating hormone regulates pro-apoptotic protein Bcl-2-interacting mediator of cell death-extra long (BimEL)-induced porcine granulosa cell apoptosis
    • Wang XL, et al. (2012) Follicle-stimulating hormone regulates pro-apoptotic protein Bcl-2-interacting mediator of cell death-extra long (BimEL)-induced porcine granulosa cell apoptosis. J Biol Chem 287(13):10166-10177.
    • (2012) J Biol Chem , vol.287 , Issue.13 , pp. 10166-10177
    • Wang, X.L.1
  • 9
    • 66649095347 scopus 로고    scopus 로고
    • FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells
    • Liu Z, et al. (2009) FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells. Mol Endocrinol 23(5):649-661.
    • (2009) Mol Endocrinol , vol.23 , Issue.5 , pp. 649-661
    • Liu, Z.1
  • 10
    • 34250788809 scopus 로고    scopus 로고
    • AKT/PKB signaling: Navigating downstream
    • Manning BD, Cantley LC (2007) AKT/PKB signaling: Navigating downstream. Cell 129 (7):1261-1274.
    • (2007) Cell , vol.129 , Issue.7 , pp. 1261-1274
    • Manning, B.D.1    Cantley, L.C.2
  • 11
    • 0034653608 scopus 로고    scopus 로고
    • The PI3K-PDK1 connection: More than just a road to PKB
    • Vanhaesebroeck B, Alessi DR (2000) The PI3K-PDK1 connection: More than just a road to PKB. Biochem J 346(Pt 3):561-576.
    • (2000) Biochem J , vol.346 , Issue.PART 3 , pp. 561-576
    • Vanhaesebroeck, B.1    Alessi, D.R.2
  • 12
    • 0036710280 scopus 로고    scopus 로고
    • IRS proteins and the common path to diabetes
    • White MF (2002) IRS proteins and the common path to diabetes. Am J Physiol Endocrinol Metab 283(3):E413-E422.
    • (2002) Am J Physiol Endocrinol Metab , vol.283 , Issue.3
    • White, M.F.1
  • 13
    • 14844336893 scopus 로고    scopus 로고
    • Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation
    • McGettrick AJ, Feener EP, Kahn CR (2005) Human insulin receptor substrate-1 (IRS-1) polymorphism G972R causes IRS-1 to associate with the insulin receptor and inhibit receptor autophosphorylation. J Biol Chem 280(8):6441-6446.
    • (2005) J Biol Chem , vol.280 , Issue.8 , pp. 6441-6446
    • McGettrick, A.J.1    Feener, E.P.2    Kahn, C.R.3
  • 14
    • 0028909206 scopus 로고
    • Regulation of phosphatidylinositol 3′-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit
    • Rordorf-Nikolic T, Van Horn DJ, Chen D, White MF, Backer JM (1995) Regulation of phosphatidylinositol 3′-kinase by tyrosyl phosphoproteins. Full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit. J Biol Chem 270(8): 3662-3666.
    • (1995) J Biol Chem , vol.270 , Issue.8 , pp. 3662-3666
    • Rordorf-Nikolic, T.1    Van Horn, D.J.2    Chen, D.3    White, M.F.4    Backer, J.M.5
  • 16
    • 0347660479 scopus 로고    scopus 로고
    • The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors
    • Nishida K, Hirano T (2003) The role of Gab family scaffolding adapter proteins in the signal transduction of cytokine and growth factor receptors. Cancer Sci 94(12): 1029-1033.
    • (2003) Cancer Sci , vol.94 , Issue.12 , pp. 1029-1033
    • Nishida, K.1    Hirano, T.2
  • 17
    • 77955599451 scopus 로고    scopus 로고
    • Function, regulation and pathological roles of the Gab/DOS docking proteins
    • Wöhrle FU, Daly RJ, Brummer T (2009) Function, regulation and pathological roles of the Gab/DOS docking proteins. Cell Commun Signal 7:22.
    • (2009) Cell Commun Signal , vol.7 , pp. 22
    • Wöhrle, F.U.1    Daly, R.J.2    Brummer, T.3
  • 20
    • 34047121208 scopus 로고    scopus 로고
    • The p85 regulatory subunit of PI3K mediates TSH-cAMPPKA growth and survival signals
    • De Gregorio G, et al. (2007) The p85 regulatory subunit of PI3K mediates TSH-cAMPPKA growth and survival signals. Oncogene 26(14):2039-2047.
    • (2007) Oncogene , vol.26 , Issue.14 , pp. 2039-2047
    • De Gregorio, G.1
  • 21
    • 72249097487 scopus 로고    scopus 로고
    • Differential regulation of vascular smoothmuscle and endothelial cell proliferation in vitro and in vivo by cAMP/PKA-activated p85alphaPI3K
    • Torella D, et al. (2009) Differential regulation of vascular smoothmuscle and endothelial cell proliferation in vitro and in vivo by cAMP/PKA-activated p85alphaPI3K. AmJ Physiol Heart Circ Physiol 297(6):H2015-H2025.
    • (2009) AmJ Physiol Heart Circ Physiol , vol.297 , Issue.6
    • Torella, D.1
  • 22
    • 0032480888 scopus 로고    scopus 로고
    • Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP
    • de Rooij J, et al. (1998) Epac is a Rap1 guanine-nucleotide-exchange factor directly activated by cyclic AMP. Nature 396(6710):474-477.
    • (1998) Nature , vol.396 , Issue.6710 , pp. 474-477
    • De Rooij, J.1
  • 23
    • 0032545328 scopus 로고    scopus 로고
    • A family of cAMP-binding proteins that directly activate Rap1
    • Kawasaki H, et al. (1998) A family of cAMP-binding proteins that directly activate Rap1. Science 282(5397):2275-2279.
    • (1998) Science , vol.282 , Issue.5397 , pp. 2275-2279
    • Kawasaki, H.1
  • 24
    • 85006314494 scopus 로고    scopus 로고
    • A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK
    • Enserink JM, et al. (2002) A novel Epac-specific cAMP analogue demonstrates independent regulation of Rap1 and ERK. Nat Cell Biol 4(11):901-906.
    • (2002) Nat Cell Biol , vol.4 , Issue.11 , pp. 901-906
    • Enserink, J.M.1
  • 25
    • 0022628244 scopus 로고
    • A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase
    • Cheng HC, et al. (1986) A potent synthetic peptide inhibitor of the cAMP-dependent protein kinase. J Biol Chem 261(3):989-992.
    • (1986) J Biol Chem , vol.261 , Issue.3 , pp. 989-992
    • Cheng, H.C.1
  • 26
    • 36549040859 scopus 로고    scopus 로고
    • The selectivity of protein kinase inhibitors: A further update
    • Bain J, et al. (2007) The selectivity of protein kinase inhibitors: A further update. Biochem J 408(3):297-315.
    • (2007) Biochem J , vol.408 , Issue.3 , pp. 297-315
    • Bain, J.1
  • 27
    • 0023198109 scopus 로고
    • Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene
    • Montminy MR, Bilezikjian LM (1987) Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene. Nature 328(6126):175-178.
    • (1987) Nature , vol.328 , Issue.6126 , pp. 175-178
    • Montminy, M.R.1    Bilezikjian, L.M.2
  • 28
    • 33744810660 scopus 로고    scopus 로고
    • FSH signaling pathways in immature granulosa cells that regulate target gene expression: Branching out from protein kinase A
    • Hunzicker-Dunn M, Maizels ET (2006) FSH signaling pathways in immature granulosa cells that regulate target gene expression: Branching out from protein kinase A. Cell Signal 18(9):1351-1359.
    • (2006) Cell Signal , vol.18 , Issue.9 , pp. 1351-1359
    • Hunzicker-Dunn, M.1    Maizels, E.T.2
  • 29
    • 48249155876 scopus 로고    scopus 로고
    • Constitutively active protein kinase A qualitatively mimics the effects of follicle-stimulating hormone on granulosa cell differentiation
    • Escamilla-Hernandez R, et al. (2008) Constitutively active protein kinase A qualitatively mimics the effects of follicle-stimulating hormone on granulosa cell differentiation. Mol Endocrinol 22(8):1842-1852.
    • (2008) Mol Endocrinol , vol.22 , Issue.8 , pp. 1842-1852
    • Escamilla-Hernandez, R.1
  • 30
    • 0033428925 scopus 로고    scopus 로고
    • Identification of cAMP-dependent protein kinase holoenzymes in preantral- and preovulatory-follicle-enriched ovaries, and their association with A-kinase-anchoring proteins
    • Carr DW, et al. (1999) Identification of cAMP-dependent protein kinase holoenzymes in preantral- and preovulatory-follicle-enriched ovaries, and their association with A-kinase-anchoring proteins. Biochem J 344(Pt 2):613-623.
    • (1999) Biochem J , vol.344 , Issue.PART 2 , pp. 613-623
    • Carr, D.W.1
  • 31
    • 0026770492 scopus 로고
    • Blotting and band-shifting: Techniques for studying proteinprotein interactions
    • Carr DW, Scott JD (1992) Blotting and band-shifting: Techniques for studying proteinprotein interactions. Trends Biochem Sci 17(7):246-249.
    • (1992) Trends Biochem Sci , vol.17 , Issue.7 , pp. 246-249
    • Carr, D.W.1    Scott, J.D.2
  • 32
    • 33746362123 scopus 로고    scopus 로고
    • Delineation of type i protein kinase A-selective signaling events using an RI anchoring disruptor
    • Carlson CR, et al. (2006) Delineation of type I protein kinase A-selective signaling events using an RI anchoring disruptor. J Biol Chem 281(30):21535-21545.
    • (2006) J Biol Chem , vol.281 , Issue.30 , pp. 21535-21545
    • Carlson, C.R.1
  • 34
    • 0034699544 scopus 로고    scopus 로고
    • IRS-2 pathways integrate female reproduction and energy homeostasis
    • Burks DJ, et al. (2000) IRS-2 pathways integrate female reproduction and energy homeostasis. Nature 407(6802):377-382.
    • (2000) Nature , vol.407 , Issue.6802 , pp. 377-382
    • Burks, D.J.1
  • 35
    • 0033826512 scopus 로고    scopus 로고
    • New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway
    • Gu H, et al. (2000) New role for Shc in activation of the phosphatidylinositol 3-kinase/Akt pathway. Mol Cell Biol 20(19):7109-7120.
    • (2000) Mol Cell Biol , vol.20 , Issue.19 , pp. 7109-7120
    • Gu, H.1
  • 36
    • 0033559311 scopus 로고    scopus 로고
    • Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors
    • Nishida K, et al. (1999) Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors. Blood 93(6):1809-1816.
    • (1999) Blood , vol.93 , Issue.6 , pp. 1809-1816
    • Nishida, K.1
  • 37
    • 0033624921 scopus 로고    scopus 로고
    • Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogenactivated protein kinase activation
    • Itoh M, et al. (2000) Role of Gab1 in heart, placenta, and skin development and growth factor- and cytokine-induced extracellular signal-regulated kinase mitogenactivated protein kinase activation. Mol Cell Biol 20(10):3695-3704.
    • (2000) Mol Cell Biol , vol.20 , Issue.10 , pp. 3695-3704
    • Itoh, M.1
  • 38
    • 20244366689 scopus 로고    scopus 로고
    • Requirement of Gab2 for mast cell development and KitL/c-Kit signaling
    • Nishida K, et al. (2002) Requirement of Gab2 for mast cell development and KitL/c-Kit signaling. Blood 99(5):1866-1869.
    • (2002) Blood , vol.99 , Issue.5 , pp. 1866-1869
    • Nishida, K.1
  • 39
    • 0035849822 scopus 로고    scopus 로고
    • Essential role for Gab2 in the allergic response
    • Gu H, et al. (2001) Essential role for Gab2 in the allergic response. Nature 412(6843): 186-190.
    • (2001) Nature , vol.412 , Issue.6843 , pp. 186-190
    • Gu, H.1
  • 40
    • 0028169121 scopus 로고
    • Characterization of recombinant RI beta and evaluation of the presence of RI beta protein in rat brain and testicular extracts
    • DeManno DA, Jackiw V, Brooks EJ, Hunzicker-Dunn M (1994) Characterization of recombinant RI beta and evaluation of the presence of RI beta protein in rat brain and testicular extracts. Biochim Biophys Acta 1222(3):501-510.
    • (1994) Biochim Biophys Acta , vol.1222 , Issue.3 , pp. 501-510
    • Demanno, D.A.1    Jackiw, V.2    Brooks, E.J.3    Hunzicker-Dunn, M.4
  • 41
    • 33947150568 scopus 로고    scopus 로고
    • A-kinase anchoring proteins take shape
    • Beene DL, Scott JD (2007) A-kinase anchoring proteins take shape. Curr Opin Cell Biol 19(2):192-198.
    • (2007) Curr Opin Cell Biol , vol.19 , Issue.2 , pp. 192-198
    • Beene, D.L.1    Scott, J.D.2
  • 42
    • 0026348474 scopus 로고
    • Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif
    • Carr DW, et al. (1991) Interaction of the regulatory subunit (RII) of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif. J Biol Chem 266(22):14188-14192.
    • (1991) J Biol Chem , vol.266 , Issue.22 , pp. 14188-14192
    • Carr, D.W.1
  • 43
    • 75849127506 scopus 로고    scopus 로고
    • Structure of D-AKAP2:PKA RI complex: Insights into AKAP specificity and selectivity
    • Sarma GN, et al. (2010) Structure of D-AKAP2:PKA RI complex: Insights into AKAP specificity and selectivity. Structure 18(2):155-166.
    • (2010) Structure , vol.18 , Issue.2 , pp. 155-166
    • Sarma, G.N.1
  • 44
    • 0032878514 scopus 로고    scopus 로고
    • Single amino acids determine specificity of binding of protein kinase A regulatory subunits by protein kinase A anchoring proteins
    • Miki K, Eddy EM (1999) Single amino acids determine specificity of binding of protein kinase A regulatory subunits by protein kinase A anchoring proteins. J Biol Chem 274 (41):29057-29062.
    • (1999) J Biol Chem , vol.274 , Issue.41 , pp. 29057-29062
    • Miki, K.1    Eddy, E.M.2
  • 45
    • 0026680801 scopus 로고
    • Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein: Cloning and characterization of the RII-binding domain
    • Carr DW, Hausken ZE, Fraser ID, Stofko-Hahn RE, Scott JD (1992) Association of the type II cAMP-dependent protein kinase with a human thyroid RII-anchoring protein. Cloning and characterization of the RII-binding domain. J Biol Chem 267(19): 13376-13382.
    • (1992) J Biol Chem , vol.267 , Issue.19 , pp. 13376-13382
    • Carr, D.W.1    Hausken, Z.E.2    Fraser, I.D.3    Stofko-Hahn, R.E.4    Scott, J.D.5
  • 46
    • 0037080536 scopus 로고    scopus 로고
    • PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2
    • Lynch DK, Daly RJ (2002) PKB-mediated negative feedback tightly regulates mitogenic signalling via Gab2. EMBO J 21(1-2):72-82.
    • (2002) EMBO J , vol.21 , Issue.1-2 , pp. 72-82
    • Lynch, D.K.1    Daly, R.J.2
  • 47
    • 78049470371 scopus 로고    scopus 로고
    • Can endogenous hyperinsulinaemia explain the increased risk of cancer development and mortality in type 2 diabetes: Evidence from mouse models
    • LeRoith D (2010) Can endogenous hyperinsulinaemia explain the increased risk of cancer development and mortality in type 2 diabetes: Evidence from mouse models. Diabetes Metab Res Rev 26(8):599-601.
    • (2010) Diabetes Metab Res Rev , vol.26 , Issue.8 , pp. 599-601
    • Leroith, D.1
  • 48
    • 59649102824 scopus 로고    scopus 로고
    • Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to follicle-stimulating hormone
    • Alam H, et al. (2009) Role of the phosphatidylinositol-3-kinase and extracellular regulated kinase pathways in the induction of hypoxia-inducible factor (HIF)-1 activity and the HIF-1 target vascular endothelial growth factor in ovarian granulosa cells in response to follicle-stimulating hormone. Endocrinology 150(2):915-928.
    • (2009) Endocrinology , vol.150 , Issue.2 , pp. 915-928
    • Alam, H.1
  • 49
    • 33846474121 scopus 로고    scopus 로고
    • G-protein-coupled receptors and cancer
    • Dorsam RT, Gutkind JS (2007) G-protein-coupled receptors and cancer. Nat Rev Cancer 7(2):79-94.
    • (2007) Nat Rev Cancer , vol.7 , Issue.2 , pp. 79-94
    • Dorsam, R.T.1    Gutkind, J.S.2
  • 50
    • 0027452329 scopus 로고
    • Folliclestimulating hormone regulation of A-kinase anchoring proteins in granulosa cells
    • Carr DW, DeManno DA, Atwood A, Hunzicker-Dunn M, Scott JD (1993) Folliclestimulating hormone regulation of A-kinase anchoring proteins in granulosa cells. J Biol Chem 268(28):20729-20732.
    • (1993) J Biol Chem , vol.268 , Issue.28 , pp. 20729-20732
    • Carr, D.W.1    Demanno, D.A.2    Atwood, A.3    Hunzicker-Dunn, M.4    Scott, J.D.5
  • 51
    • 0032941151 scopus 로고    scopus 로고
    • Follicle-stimulating hormone promotes histone H3 phosphorylation on serine-10
    • DeManno DA, et al. (1999) Follicle-stimulating hormone promotes histone H3 phosphorylation on serine-10. Mol Endocrinol 13(1):91-105.
    • (1999) Mol Endocrinol , vol.13 , Issue.1 , pp. 91-105
    • Demanno, D.A.1
  • 52
    • 0019766783 scopus 로고
    • Selective activation of rabbit ovarian protein kinase isozymes in rabbit ovarian follicles and corpora lutea
    • Hunzicker-Dunn M (1981) Selective activation of rabbit ovarian protein kinase isozymes in rabbit ovarian follicles and corpora lutea. J Biol Chem 256(23):12185- 12193.
    • (1981) J Biol Chem , vol.256 , Issue.23 , pp. 12185-12193
    • Hunzicker-Dunn, M.1
  • 53
    • 0035955717 scopus 로고    scopus 로고
    • Follicle-stimulating hormone stimulates protein kinase A-mediated histone H3 phosphorylation and acetylation leading to select gene activation in ovarian granulosa cells
    • Salvador LM, et al. (2001) Follicle-stimulating hormone stimulates protein kinase A-mediated histone H3 phosphorylation and acetylation leading to select gene activation in ovarian granulosa cells. J Biol Chem 276(43):40146-40155.
    • (2001) J Biol Chem , vol.276 , Issue.43 , pp. 40146-40155
    • Salvador, L.M.1
  • 54
    • 53049104223 scopus 로고    scopus 로고
    • Critical role of PDE4D in beta2- adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts
    • Bruss MD, Richter W, Horner K, Jin SL, Conti M (2008) Critical role of PDE4D in beta2- adrenoceptor-dependent cAMP signaling in mouse embryonic fibroblasts. J Biol Chem 283(33):22430-22442.
    • (2008) J Biol Chem , vol.283 , Issue.33 , pp. 22430-22442
    • Bruss, M.D.1    Richter, W.2    Horner, K.3    Jin, S.L.4    Conti, M.5
  • 55
    • 0034602809 scopus 로고    scopus 로고
    • Requirement for nitric oxide activation of p21(ras)/extracellular regulated kinase in neuronal ischemic preconditioning
    • Gonzalez-Zulueta M, et al. (2000) Requirement for nitric oxide activation of p21(ras)/extracellular regulated kinase in neuronal ischemic preconditioning. Proc Natl Acad Sci USA 97(1):436-441.
    • (2000) Proc Natl Acad Sci USA , vol.97 , Issue.1 , pp. 436-441
    • Gonzalez-Zulueta, M.1
  • 56
    • 0034680848 scopus 로고    scopus 로고
    • Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb 2- associated binder 2 as the major mediator in rat hepatocytes
    • Kong M, Mounier C, Wu J, Posner BI (2000) Epidermal growth factor-induced phosphatidylinositol 3-kinase activation and DNA synthesis. Identification of Grb2- associated binder 2 as the major mediator in rat hepatocytes. J Biol Chem 275(46): 36035-36042.
    • (2000) J Biol Chem , vol.275 , Issue.46 , pp. 36035-36042
    • Kong, M.1    Mounier, C.2    Wu, J.3    Posner, B.I.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.