Biochemical characterization of selective inhibitors of human group IIA secreted phospholipase A2 and hyaluronic acid-linked inhibitor conjugates

Biochemistry

Volumn 51, Issue 43, 2012, Pages 8617-8626

  Oslund, Rob C ^a   Gelb, Michael H ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE SITE; BIOCHEMICAL CHARACTERIZATION; CARBOXYLATE GROUPS; ENZYME ACTIVE SITES; HYALURONIC ACIDS; HYDROXYL GROUPS; INHIBITORY EFFECT; LIPID MEMBRANES; LIPID VESICLES; NANOMOLAR AFFINITY; NANOMOLAR RANGE; PEPTIDE COUPLING; PHOSPHOLIPASE A; PROTECTION ASSAY; SELECTIVE INHIBITORS;

AMIDES; CALCIUM; ORGANIC ACIDS;

CARBOXYLATION;

AMIDE; AMINE; CARBOXYLIC ACID DERIVATIVE; HYALURONIC ACID; HYDROXYL GROUP; INDOLE DERIVATIVE; PHOSPHOLIPASE A2 INHIBITOR;

ALKYLATION; ARTICLE; ASSAY; BINDING AFFINITY; CONJUGATE; CONTROLLED STUDY; ENZYME ACTIVE SITE; ENZYME INHIBITION; ENZYME RELEASE; LIPID MEMBRANE; LIPID VESICLE; PRIORITY JOURNAL;

CATALYTIC DOMAIN; DRUG DESIGN; ENZYME INHIBITORS; HUMANS; HYALURONIC ACID; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; PHOSPHOLIPASES A2; PROTEIN BINDING;

EID: 84868121259     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi301140b     Document Type: Article

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