Simplified YM-26734 inhibitors of secreted phospholipase A2 group IIA

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 20, 2008, Pages 5415-5419

  Oslund, Rob C ^a   Cermak, Nathan ^a   Verlinde, Christophe L M J ^b   Gelb, Michael H ^a,b  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Eicosanoids; Inflammation; Lipid mediators; Phospholipases; Structure based drug design

Indexed keywords

DIDODECANOYLPHLOROGLUCINOL; ENZYME INHIBITOR; NATURAL PRODUCT; PHLOROGLUCINOL DERIVATIVE; PHOSPHOLIPASE A2 INHIBITOR; UNCLASSIFIED DRUG; YM 26567 1; YM 26734;

ANIMAL CELL; ARTICLE; CALCIUM BINDING; CELL MEMBRANE PERMEABILITY; CHIRALITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; IC 50; NONHUMAN; RABBIT; STEREOISOMERISM;

ANIMALS; CALCIUM; CATALYTIC DOMAIN; CHEMISTRY, PHARMACEUTICAL; CHROMANS; DRUG DESIGN; GROUP II PHOSPHOLIPASES A2; HUMANS; INDOLES; INHIBITORY CONCENTRATION 50; MICE; MODELS, THEORETICAL; PHENOLS; PROTEIN BINDING; RATS;

EID: 53349164518     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.09.041     Document Type: Article

References (18)

1. Lambeau G., and Gelb M.H. Annu. Rev. Biochem. 77 (2008) 495
2. Valentin E., and Lambeau G. Biochim. Biophys. Acta 1488 (2000) 59
3. Schaloske R.H., and Dennis E.A. Biochim. Biophys. Acta 1761 (2006) 1246
4. Seilhamer J.J., Pruzanski W., Vadas P., Plant S., Miller J.A., Kloss J., and Johnson L.K. J. Biol. Chem. 264 (1989) 5335
5. Henderson W.R., Chi E.Y., Bollinger J.G., Tien Y.T., Ye X., Castelli L., Rubtsov Y.P., Singer A.G., Chiang G.K., Nevalainen T., Rudensky A.Y., and Gelb M.H. J. Exp. Med. 204 (2007) 865
6. Webb N.R. Curr. Opin. Lipidol. 16 (2005) 341
7. Nevalainen T.J., Haapamaki M.M., and Gronroos J.M. Biochim. Biophys. Acta 1488 (2000) 83
8. Reid R.C. Curr. Med. Chem. 12 (2005) 3011
9. Draheim S.E., Bach N.J., Dillard R.D., Berry D.R., Carlson D.G., Chirgadze N.Y., Clawson D.K., Hartley L.W., Johnson L.M., Jones N.D., McKinney E.R., Mihelich E.D., Olkowski J.L., Schevitz R.W., Smith A.C., Snyder D.W., Sommers C.D., and Wery J.P. J. Med. Chem. 39 (1996) 5159
10. Hite, G. A.; Mihelich, E. D.; Tulio, S.; Edmund, W. S. Eur. Patent No. 0846687A1, 1998.
11. Hansford K.A., Reid R.C., Clark C.I., Tyndall J.D.A., Whitehouse M.W., Guthrie T., McGeary R.P., Schafer K., Martin J.L., and Fairlie D.P. Chembiochem 4 (2003) 181
12. Miyake A., Yamamoto H., Kubota E., Hamaguchi K., Kouda A., Honda K., and Kawashima H. Br. J. Pharmacol. 110 (1993) 447
13. Miyake A., Yamamoto H., Takebayashi Y., Harumitsu I., and Honda K. J. Pharm. Exp. Ther. 263 (1992) 1302
14. Hamaguchi, K.; Koda, A.; Yamamoto, H.; Miyake, A.; Isogai, A.; Suzuki, A.; Pei, S.; Li, Y.; Wang, C. WO Patent No. 92/08712, 1992.
15. Hamaguchi K., Kuwata H., Yoshihara K., Masuda S., Shimbara S., Oh-ishi S., Murakami M., and Kudo I. Biochim. Biophys. Acta 1635 (2003) 37
16. Schevitz R.W., Bach N.J., Carlson D.G., Chirgadze N.Y., Clawson D.K., Dillard S.E., Draheim S.E., Hartley L.W., Jones N.D., Mihelich E.D., Olkowski J.L., Snyder D.W., Sommers C., and Wery J.P. Nat. Strut. Biol. 2 (1995) 458
17. Otway D.J., and Rees W.S. Coord. Chem. Rev. 210 (2000) 279
18. Hamaguchi, K.; Koda, A.; Yamamoto, H.; Miyake, S.; Suzuki, A.; Isogai, A.; Pei, S.; Li, Y.; Wang, C. Japanese Patent No. 07002720A, 1995.