Distinct mechanisms of membrane permeation induced by two polymalic acid copolymers

Biomaterials

Volumn 34, Issue 1, 2013, Pages 217-225

  Ding, Hui ^a   Portilla Arias, Jose ^a   Patil, Rameshwar ^a   Black, Keith L ^a   Ljubimova, Julia Y ^a   Holler, Eggehard ^a,b  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Barrel stave model; Carpet model; Endosomolytic drug delivery; Membrane permeation; Polymalic acid

Indexed keywords

ANIONIC POLYMERS; CONCENTRATION-DEPENDENT; CYTOPLASMIC DELIVERY; ETHYL ESTERS; FLUORESCENCE TECHNIQUE; HEALTH SCIENCE; HIGH AFFINITY; HYDROPHOBIC INTERACTIONS; HYDROPHOBIC PATCH; LOW TOXICITY; MEMBRANE LEAKAGES; MEMBRANE PENETRATION; MEMBRANE PERMEATION; NEGATIVE CHARGE; PH-DEPENDENT; PH-DEPENDENT ACTIVITY; POLYMALIC ACID; POLYMERIC DELIVERY SYSTEMS; SECOND-PHASE; SIDE-CHAINS; SINGLE MOLECULE; TRANS-MEMBRANE PORES; TWO-PHASE PROCESS; VALUABLE COMPONENT;

AMINO ACIDS; BIOLOGICAL MEMBRANES; COPOLYMERS; CYTOLOGY; DRUG DELIVERY; HYDROPHOBICITY; MEMBRANES; OLIGOMERS; POLYMERS; TOXICITY;

PERMEATION;

COPOLYMER; LEUCINE; LEUCINE ETHYL ESTER; LIPID; OLIGOMER; POLYMALIC ACID; TRILEUCINE; UNCLASSIFIED DRUG;

ARTICLE; BARREL STAVE MODEL; BINDING AFFINITY; CHANNEL GATING; CHEMICAL ENGINEERING; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; FLUORESCENCE; HYDROPHOBICITY; MEMBRANE MODEL; MEMBRANE PERMEABILITY; PH; PKA; PRIORITY JOURNAL; PROTEIN ASSEMBLY; SURFACE PROPERTY;

ESTERS; FLUORESCENCE RESONANCE ENERGY TRANSFER; HYDRODYNAMICS; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; KINETICS; LIPOSOMES; MALATES; MEMBRANES; MICROSCOPY, CONFOCAL; OLIGOPEPTIDES; PARTICLE SIZE; PERMEABILITY; POLYMERS; RHODAMINES; SOLUTIONS; TEMPERATURE;

EID: 84868115732     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.08.016     Document Type: Article

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