The optimization of polymalic acid peptide copolymers for endosomolytic drug delivery

Biomaterials

Volumn 32, Issue 22, 2011, Pages 5269-5278

  Ding, Hui ^a   Portilla Arias, Jose ^a   Patil, Rameshwar ^a   Black, Keith L ^a   Ljubimova, Julia Y ^a   Holler, Eggehard ^a,b  

^a CEDARS SINAI MEDICAL CENTER   (United States)

^b UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Cytoplasmic delivery; Drug delivery; Endosome escape; Membranolysis; PH dependent copolymer; Polymalic acid

Indexed keywords

CYTOPLASMIC DELIVERY; ENDOSOME ESCAPE; MEMBRANOLYSIS; PH-DEPENDENT; POLYMALIC ACID;

AMINO ACIDS; BIODEGRADABLE POLYMERS; CARBOXYLATION; CELL MEMBRANES; COPOLYMERIZATION; DRUG DELIVERY; PH; PLASTIC PRODUCTS;

COPOLYMERS;

AMINO ACID DERIVATIVE; CARBOXYLIC ACID DERIVATIVE; COPOLYMER; LEUCINE; LEUCINE ETHYL ESTER; LEUCYLLEUCYLLEUCINAMIDE; PEPTIDE DERIVATIVE; PHENYLALANINE; POLYMALIC ACID; TRIPEPTIDE; TRYPTOPHAN; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; BIODEGRADABILITY; CELL MEMBRANE; CYTOTOXICITY; DRUG DELIVERY SYSTEM; ENDOSOME; HUMAN; HUMAN CELL; HYDROPHOBICITY; MACROMOLECULE; MEMBRANE DAMAGE; MOLECULAR WEIGHT; PH; PRIORITY JOURNAL;

CELL MEMBRANE; DRUG CARRIERS; DRUG DELIVERY SYSTEMS; ENDOSOMES; HYDROGEN-ION CONCENTRATION; MALATES; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PEPTIDES; POLYMERS;

EID: 79956071007     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.03.073     Document Type: Article

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