Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse

Journal of Thrombosis and Haemostasis

Volumn 10, Issue 11, 2012, Pages 2344-2353

  Welsh, J D ^a,b   Colace, T V ^a   Muthard, R W ^a   Stalker, T J ^b   Brass, L F ^b   Diamond, S L ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Fibrin; Permeation; Platelet; Shear rate; Thrombin; Tissue factor

Indexed keywords

COLLAGEN; DIMETICONE; FIBRIN; FIBRINOGEN RECEPTOR; PEPTIDE DERIVATIVE; PROTEIN ANTIBODY; THROMBIN; THROMBIN SENSITIVE ANTIBODY; THROMBIN SENSITIVE PEPTIDE; THROMBOPLASTIN; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOLOGICAL MONITORING; BLOOD CLOTTING; CONTROLLED STUDY; FLOW CYTOMETRY; FLUORESCENCE ANALYSIS; MICROFLUIDIC ANALYSIS; MOLECULAR DYNAMICS; MOLECULAR SENSOR; MOUSE; NONHUMAN; PEPTIDE SYNTHESIS; PERFUSION; POLYMERIZATION; PRESSURE GRADIENT; PRIORITY JOURNAL; PROTEIN LOCALIZATION; THROMBOCYTE; THROMBOSIS;

FIBRIN; PERMEATION; PLATELET; SHEAR RATE; THROMBIN; TISSUE FACTOR;

ANIMALS; ANTIBODIES; BLOOD COAGULATION; BLOOD PLATELETS; COLLAGEN; FIBRIN; HEMOSTASIS; HUMANS; KINETICS; LASERS; MICE; MICROFLUIDIC ANALYTICAL TECHNIQUES; MICROFLUIDICS; PEPTIDES; PLATELET MEMBRANE GLYCOPROTEIN IIB; PRESSURE; PROTEIN TRANSPORT; THROMBIN; THROMBOPLASTIN; THROMBOSIS; TIME FACTORS;

EID: 84868108253     PISSN: 15387933     EISSN: 15387836     Source Type: Journal    
DOI: 10.1111/j.1538-7836.2012.04928.x     Document Type: Article

References (26)

1. Leiderman K, Fogelson AL. Grow with the flow: a spatial-temporal model of platelet deposition and blood coagulation under flow. Math Med Biol 2011; 28: 47-84.
2. Diamond SL. Engineering design of optimal strategies for blood clot dissolution. Annu Rev Biomed Eng 1999; 1: 427-62.
3. Okorie UM, Denney WS, Chatterjee MS, Neeves KB, Diamond SL. Determination of surface tissue factor thresholds that trigger coagulation at venous and arterial shear rates: amplification of 100 fM circulating tissue factor requires flow. Blood 2008; 111: 3507-13.
4. Kuharsky AL, Fogelson AL. Surface-mediated control of blood coagulation: the role of binding site densities and platelet deposition. Biophys J 2001; 3: 1050-74.
5. Dormann D, Clemetson KJ, Kehrel BE. The GPIb thrombin-binding site is essential for thrombin-induced platelet procoagulant activity. Blood 2000; 96: 2469-78.
6. Celikel R, McClintock RA, Roberts JR, Mendolicchio GL, Ware J, Varughese KI, Ruggeri ZM. Modulation of α-thrombin function by distinct interactions with platelet glycoprotein Ibα. Science 2003; 301: 218-21.
7. Hathcock JJ, Nemerson Y. Platelet deposition inhibits tissue factor activity: in vitro clots are impermeable to factor Xa. Blood 2004; 1: 123-7.
8. Colace TV, Muthard R, Diamond SL. Thrombus growth and embolism on tissue factor bearing collagen surfaces under flow: role of thrombin with and without fibrin. Arterioscler Thromb Vasc Biol 2012; 32: 1466-76.
9. Gailani D, Broze GJ Jr. Factor XI activation in a revised model of blood coagulation. Science 1991; 23: 909-12.
10. Esmon CT, Fukudome K, Mather T, Bode W, Regan LM, Stearns-Kurosawa DJ, Kurosawa S. Inflammation, sepsis and coagulation. Haematologica 1999; 84: 254-9.
11. Ito Y, Liu LS, Imanishi Y. Interaction of thrombin with synthetic fluorescent substrate immobilized on polymer membrane. Biomaterials 1992; 13: 375-81.
12. Cho H, Baker BR, Wachsmann-Hogiu S, Pagba CV, Laurence TA, Lane SM, Lee LP, Tok JBH. Aptamer-based SERRS sensor for thrombin detection. Nano Lett 2008; 8: 4386-90.
13. Handin RI, Lux SE, Stossel TP. Blood: Principles and Practice of Hematology. Philadelphia, PA: Lippincot Williams and Wilkins, 2003; 1168 pp.
14. Chatterjee MS, Denney WS, Jing H, Diamond SL. Systems biology of coagulation initiation; kinetics of thrombin generation in resting and activated human blood. PLoS Comput Biol 2010; 9: e1000950.
15. Hemker HC, Giesen P, Al Dieri A, Regnault V, de Smedt E, Wagenvoord R, Lecompte T, Beguin S. Calibrated automated thrombin generation measurement in clotting plasma. Pathophysiol Haemost Thromb 2003; 33: 4-15.
16. Guy RD, Fogelson AL, Keener JP. Fibrin gel formation in a shear flow. Math Med Biol 2007; 1: 111-30.
17. Neeves KB, Illing DA, Diamond SL. Thrombin flux and wall shear rate regulate fibrin fiber deposition state during polymerization under flow. Biophys J 2010; 7: 1344-52.
18. Colace TV, Jobson J, Diamond SL. Relipidated tissue factor linked to collagen surfaces potentiates platelet adhesion and fibrin formation in a microfluidic model of vessel injury. Bioconjug Chem 2011; 22: 2104-9.
19. Smith SA, Morrissey JH. Rapid and efficient incorporation of tissue factor into liposomes. J Thromb Haemost 2004; 2: 1155-62.
20. Sudo R, Chung S, Zervantonakis IK, Vickerman V, Toshimitsu Y, Griffith LG, Kamm RD. Transport-mediated angiogenesis in 3D epithelial coculture. FASEB J 2009; 7: 2155-64.
21. Polacheck WJ, Charest JL, Kamm RD. Interstitial flow influences direction of tumor cell migration through competing mechanisms. Proc Natl Acad Sci USA 2011; 27: 11115-20.
22. Stalker TJ, Wu J, Morgans A, Traxler EA, Wang L, Chatterjee MS, Lee D, Quertermous T, Hall RA, Hammer DA, Diamond SL, Brass LF. Endothelial cell specific adhesion molecule (ESAM) localizes to platelet-platelet contacts and regulates thrombus formation in vivo. J Thromb Haemost 2009; 11: 1886-96.
23. Neeves KB, Maloney SF, Fong KP, Schmaier AA, Kahn ML, Brass LF, Diamond SL. Microfluidic focal thrombosis model for measuring murine platelet deposition and stability: PAR4 signaling enhances shear-resistance of platelet aggregates. J Thromb Haemost 2008; 6: 2193-201.
24. Wiig H. Evaluation of methodologies for measurement of interstitial fluid pressure (Pi): physiological implications of recent Pi data. Crit Rev Biomed Eng 1990; 18: 27-54.
25. Parazynski SE, Hargens AR, Tucker B, Aratow M, Styf J, Crenshaw A. Transcapillary fluid shifts in tissues of the head and neck during and after simulated microgravity. J Appl Physiol 1991; 71: 2469-75.
26. Higgins DL, Lewis SD, Shafer JA. Steady state kinetic parameters for the thrombin-catalyzed conversion of human fibrinogen to fibrin. J Biol Chem 1983; 10: 9276-82.