Primary cardiac sarcomas may develop from resident or bone marrow-derived mesenchymal stem cells: Use of immunohistochemistry including CD44 and octamer binding protein 3/4

Histopathology

Volumn 61, Issue 5, 2012, Pages 966-973

  Hegyi, Laszlo ^a   Thway, Khin ^a   Fisher, Cyril ^a   Sheppard, Mary N ^b  

^a ROYAL MARSDEN HOSPITAL   (United Kingdom)

^b ROYAL BROMPTON HOSPITAL   (United Kingdom)

Author keywords

Cardiac tumour; Heart; Immunohistochemistry; Sarcoma; Stem cell

Indexed keywords

HERMES ANTIGEN; OCTAMER TRANSCRIPTION FACTOR 4;

ADOLESCENT; ADULT; ARTICLE; BONE MARROW CELL; CELL DIFFERENTIATION; CHILD; CLINICAL ARTICLE; CYTOPLASM; DISEASE MARKER; FEMALE; HEART SARCOMA; HUMAN; IMMUNOHISTOCHEMISTRY; MALE; MESENCHYMAL STEM CELL; PRIMARY TUMOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; SCHOOL CHILD;

ADOLESCENT; ADULT; ANTIGENS, CD44; CELL DIFFERENTIATION; CHILD; FEMALE; HEART NEOPLASMS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MESENCHYMAL STROMAL CELLS; MIDDLE AGED; NEOPLASTIC STEM CELLS; OCTAMER TRANSCRIPTION FACTOR-3; SARCOMA; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

MYOIDA;

EID: 84868092332     PISSN: 03090167     EISSN: 13652559     Source Type: Journal    
DOI: 10.1111/j.1365-2559.2012.04299.x     Document Type: Article

References (25)

1. Patel J, Sheppard MN. Pathological study of primary cardiac and pericardial tumours in a specialist UK Centre: surgical and autopsy series. Cardiovasc. Pathol. 2010; 19; 343-352.
2. Pasquinelli G, Pacilli A, Alviano F et al. Multidistrict human mesenchymal vascular cells: pluripotency and stemness characteristics. Cytotherapy 2010; 12; 275-287.
3. Charytonowicz E, Cordon-Cardo C, Matushansky I, Ziman M. Alveolar rhabdomyosarcoma: is the cell of origin a mesenchymal stem cell? Cancer Lett. 2009; 279; 126-136.
4. Li N, Yang R, Zhang W, Dorfman H, Rao P, Gorlick R. Genetically transforming human mesenchymal stem cells to sarcomas: changes in cellular phenotype and multilineage differentiation potential. Cancer 2009; 115; 4795-4806.
5. Chen H, Zhang S, Wen JC et al. Several types of soft tissue sarcomas originate from the malignant transformation of adipose tissue-derived stem cells. Mol. Med. Report 2010; 3; 441-448.
6. Barile L, Chimenti I, Gaetani R et al. Cardiac stem cells: isolation, expansion and experimental use for myocardial regeneration. Nat. Clin. Pract. Cardiovasc. Med. 2007; 4(Suppl 1); S9-S14.
7. Crisan M, Chen CW, Corselli M, Andriolo G, Lazzari L, Péault B. Perivascular multipotent progenitor cells in human organs. Ann. N. Y. Acad. Sci. 2009; 1176; 118-123.
8. Firth AL, Yao W, Ogawa A, Madani MM, Lin GY, Yuan JX. Multipotent mesenchymal progenitor cells are present in endarterectomized tissues from patients with chronic thromboembolic pulmonary hypertension. Am. J. Physiol. Cell Physiol. 2010; 298; C1217-C1225.
9. Atlasi Y, Mowla SJ, Ziaee SA, Gokhale PJ, Andrews PW. OCT4 spliced variants are differentially expressed in human pluripotent and nonpluripotent cells. Stem Cells 2008; 26; 3068-3074.
10. Li L, Kwon HJ, Harada H, Ohshima H, Cho SW, Jung HS. Expression patterns of ABCG2, Bmi-1, Oct-3/4, and Yap in the developing mouse incisor. Gene Expr. Patterns 2011; 11; 163-170.
11. Fletcher CDM, Unni KK, Mertens F eds. World Health Organization classification of tumours. Pathology and genetics of tumours of soft tissue and bone. Lyon: IARC Press, 2002.
12. Mohseny AB, Hogendoorn PC. Concise review: mesenchymal tumors: when stem cells go mad. Stem Cells 2011; 29; 397-403.
13. Sheppard MN, Mohiaddin R. Tumors of the heart. Fut. Cardiol. 2010; 6; 181-193.
14. Donsbeck AV, Ranchere D, Coindre JM, Le Gall F, Cordier JF, Loire R. Primary cardiac sarcomas: an immunohistochemical and grading study with long-term follow-up of 24 cases. Histopathology 1999; 34; 295-304.
15. Veinot JP, Burns BF, Commons AS, Thomas J. Cardiac neoplasms at the Canadian Reference Centre for Cancer Pathology. Can. J. Cardiol. 1999; 15; 311-319.
16. Hamidi M, Moody JS, Weigel TL, Kozak KR. Primary cardiac sarcoma. Ann. Thorac. Surg. 2010; 90; 176-181.
17. Schmidt U, Stüben G, Stuschke M, Donhuijsen K. Ultrastructural evidence for divergent and alternating differentiations in spindle cell sarcoma xenografts. J. Submicrosc. Cytol. Pathol. 1997; 29; 187-195.
18. Danielson LS, Menendez S, Attolini CS et al. A differentiation-based microRNA signature identifies leiomyosarcoma as a mesenchymal stem cell-related malignancy. Am. J. Pathol. 2010; 177; 908-917.
19. Rubio R, García-Castro J, Gutiérrez-Aranda I et al. Deficiency in p53 but not retinoblastoma induces the transformation of mesenchymal stem cells in vitro and initiates leiomyosarcoma in vivo. Cancer Res. 2010; 70; 4185-4194.
20. Naka N, Takenaka S, Araki N et al. Synovial sarcoma is a stem cell malignancy. Stem Cells 2010; 28; 1119-1131.
21. Riggi N, Suvà ML, De Vito C et al. EWS-FLI-1 modulates miRNA145 and SOX2 expression to initiate mesenchymal stem cell reprogramming toward Ewing sarcoma cancer stem cells. Genes Dev. 2010; 24; 916-932.
22. Li Q, Hisha H, Takaki T et al. Transformation potential of bone marrow stromal cells into undifferentiated high-grade pleomorphic sarcoma. J. Cancer Res. Clin. Oncol. 2010; 136; 829-838.
23. National Center for Biotechnology Information (NCBI). Entrez Gene, Genes and mapped phenotypes, CD44, CD44 molecule (Indian blood group) [Homo sapiens], Gene ID: 960. 7 December 2010. Available at: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=full_report&list_uids=960.
24. Heyse TJ, Malcherczyk D, Moll R et al. CD44: survival and metastasis in chondrosarcoma. Osteoarthritis Cartilage 2010; 18; 849-856.
25. Pasquinelli G, Tazzari PL, Vaselli C et al. Thoracic aortas from multiorgan donors are suitable for obtaining resident angiogenic mesenchymal stromal cells. Stem Cells 2007; 25; 1627-1634.