Concise review: Mesenchymal tumors: When stem cells go mad

Stem Cells

Volumn 29, Issue 3, 2011, Pages 397-403

  Mohseny, Alexander B ^a   Hogendoorn, Pancras C W ^a  

^a LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Bone marrow; Cancer stem cell; MSC; Multipotential differentiation; Stem cell therapy; Transplantation

Indexed keywords

ACUTE GRANULOCYTIC LEUKEMIA; AUTOIMMUNE DISEASE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BREAST CANCER; CANCER GROWTH; CANCER STEM CELL; CANCER THERAPY; CLEAR CELL SARCOMA; DERMATOFIBROMA; EWING SARCOMA; FIBROSARCOMA; GRAFT VERSUS HOST REACTION; HUMAN; HURLER SYNDROME; KAPOSI SARCOMA; LEUKODYSTROPHY; MESENCHYMAL STEM CELL; MESENCHYMOMA; MESOBLASTIC NEPHROMA; MULTIPOTENT STEM CELL; NONHUMAN; OSTEOGENESIS IMPERFECTA; OSTEOPOROSIS; OSTEOSARCOMA; REVIEW; RHEUMATOID ARTHRITIS; SARCOMA; STEM CELL EXPANSION;

ADOLESCENT; ADULT; ANIMALS; CELL TRANSFORMATION, NEOPLASTIC; CHILD; HUMANS; MESENCHYMAL STEM CELLS; MESODERM; MODELS, BIOLOGICAL; NEOPLASMS; SARCOMA; STEM CELL TRANSPLANTATION;

EID: 79953000341     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.596     Document Type: Review

References (56)

1. Becker AJ, McCulloch EA, Till JE. Cytological demonstration of the clonal nature of spleen colonies derived from transplanted mouse marrow cells. Nature 1963;197:452-454.
2. Bianco P, Gehron RP. Marrow stromal stem cells. J Clin Invest 2000;105:1663-1668. (Pubitemid 30421745)
3. Pittenger MF, Mackay AM, Beck SC et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-147. (Pubitemid 29282067)
4. Fletcher CDM, Unni KK, Mertens F, eds. Pathology and Genetics of Tumours of Soft Tissue and Bone. WHO Classification of Tumours. Lyon: IARC Press, 2002:1-427.
5. Knezevich SR, Garnett MJ, Pysher TJ et al. ETV6-NTRK3 gene fusions and trisomy 11 establish a histogenetic link between mesoblastic nephroma and congenital fibrosarcoma. Cancer Res 1998;58:5046-5048. (Pubitemid 28521157)
6. Tognon C, Knezevich SR, Huntsman D et al. Expression of the ETV6-NTRK3 gene fusion as a primary event in human secretory breast carcinoma. Cancer Cell 2002;2:367-376. (Pubitemid 41039103)
7. Rossi S, Szuhai K, Ijszenga M et al. EWSR1-CREB1 and EWSR1-ATF1 fusion genes in angiomatoid fibrous histiocytoma. Clin Cancer Res 2007;13:7322-7328.
8. Panagopoulos I, Aman P, Fioretos T et al. Fusion of the FUS gene with ERG in acute myeloid leukemia with t(16;21)(p11;q22). Genes Chromosomes Cancer 1994;11:256-262. (Pubitemid 24372150)
9. Hauben EI, Weeden S, Pringle J et al. Does the histological subtype of high-grade central osteosarcoma influence the response to treatment with chemotherapy and does it affect overall survival? A study on 570 patients of two consecutive trials of the European Osteosarcoma Intergroup. Eur J Cancer 2002;38:1218-1225. (Pubitemid 34603483)
10. Tang N, Song WX, Luo J et al. Osteosarcoma development and stem cell differentiation. Clin Orthop Relat Res 2008;466:2114-2130.
11. Boeuf S, Kunz P, Hennig T et al. A chondrogenic gene expression signature in mesenchymal stem cells is a classifier of conventional central chondrosarcoma. J Pathol 2008;216:158-166.
12. Bovee JVMG, Hogendoorn PCW, Wunder JS et al. Cartilage tumours and bone development: Molecular pathology and possible therapeutic targets. Nat Rev Cancer 2010;10:481-488.
13. Danielson LS, Menendez S, Stephan-Otto AC et al. A Differentiation-based MicroRNA signature identifies leiomyosarcoma as a mesenchymal stem cell-related malignancy. Am J Pathol 2010;177:908-917.
14. Matushansky I, Hernando E, Socci ND et al. A developmental model of sarcomagenesis defines a differentiation-based classification for liposarcomas. Am J Pathol 2008;172:1069-1080. (Pubitemid 351520003)
15. Cleton-Jansen AM, Anninga JK, Briaire-de Bruijn IH et al. Profiling of high-grade central osteosarcoma and its putative progenitor cells identifies tumourigenic pathways. Br J Cancer 2009;101:1909-1918.
16. Nielsen TO, West RB, Linn SC et al. Molecular characterisation of soft tissue tumours: A gene expression study. Lancet 2002;359:1301-1307. (Pubitemid 34310636)
17. Webster JA, Beck AH, Sharma M et al. Variations in stromal signatures in breast and colorectal cancer metastases. J Pathol 2010;222:158-165.
18. Li N, Yang R, Zhang W et al. Genetically transforming human mesenchymal stem cells to sarcomas: Changes in cellular phenotype and multilineage differentiation potential. Cancer 2009;115:4795-4806.
19. Cai Y, Mohseny AB, Karperien M et al. Inactive Wnt/beta-catenin pathway in conventional high-grade osteosarcoma. J Pathol 2010;220:24-33.
20. Mohseny AB, Szuhai K, Romeo S et al. Osteosarcoma originates from mesenchymal stem cells in consequence of aneuploidization and genomic loss of Cdkn2. J Pathol 2009;219:294-305.
21. Tolar J, Nauta AJ, Osborn MJ et al. Sarcoma derived from cultured mesenchymal stem cells. Stem Cells 2007;25:371-379. (Pubitemid 46232791)
22. Chanda D, Kumar S, Ponnazhagan S. Therapeutic potential of adult bone marrow-derived mesenchymal stem cells in diseases of the skeleton. J Cell Biochem 2010;111:249-257.
23. Saito T, Nagai M, Ladanyi M. SYT-SSX1 and SYT-SSX2 interfere with repression of E-cadherin by snail and slug: A potential mechanism for aberrant mesenchymal to epithelial transition in human synovial sarcoma. Cancer Res 2006;66:6919-6927. (Pubitemid 44197666)
24. Tirode F, Laud-Duval K, Prieur A et al. Mesenchymal stem cell features of Ewing tumors. Cancer Cell 2007;11:421-429. (Pubitemid 46680428)
25. Rubio D, Garcia-Castro J, Martin MC et al. Spontaneous human adult stem cell transformation. Cancer Res 2005;65:3035-3039. (Pubitemid 40524580)
26. Rubio R, Garcia-Castro J, Gutierrez-Aranda I et al. Deficiency in p53 but not retinoblastoma induces the transformation of mesenchymal stem cells in vitro and initiates leiomyosarcoma in vivo. Cancer Res 2010;70:4185-4194.
27. Li Q, Hisha H, Takaki T et al. Transformation potential of bone marrow stromal cells into undifferentiated high-grade pleomorphic sarcoma. J Cancer Res Clin Oncol 2010;136:829-838.
28. Charytonowicz E, Cordon-Cardo C, Matushansky I et al. Alveolar rhabdomyosarcoma: Is the cell of origin a mesenchymal stem cell? Cancer Lett 2009;279:126-136.
29. Calo E, Quintero-Estades JA, Danielian PS et al. Rb regulates fate choice and lineage commitment in vivo. Nature 2010;466:1110-1114.
30. Helman LJ, Meltzer P. Mechanisms of sarcoma development. Nat Rev Cancer 2003;3:685-694. (Pubitemid 37328823)
31. Riggi N, Suva ML, Suva D et al. EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells. Cancer Res 2008;68:2176-2185. (Pubitemid 351521790)
32. Mohseny AB, Tieken C, Van der Velden PA et al. Small deletions but not methylation underlie CDKN2A/p16 loss of expression in conventional osteosarcoma. Genes Chromosomes Cancer 2010;49:1095-1103.
33. Levings PP, McGarry SV, Currie TP et al. Expression of an exogenous human Oct-4 promoter identifies tumor-initiating cells in osteosarcoma. Cancer Res 2009;69:5648-5655.
34. Simons A, Schepens M, Jeuken J et al. Frequent loss of 9p21 (p16(INK4A)) and other genomic imbalances in human malignant fibrous histiocytoma. Cancer Genet Cytogenet 2000;118:89-98. (Pubitemid 30169209)
35. Van de Rijn M, Fletcher JA. Genetics of soft tissue tumors. Annu Rev Pathol 2006;1:435-466.
36. Marino-Enriquez A, Fletcher CD, Dal CP et al. Dedifferentiated liposarcoma with "homologous" lipoblastic (pleomorphic liposarcoma-like) differentiation: Clinicopathologic and molecular analysis of a series suggesting revised diagnostic criteria. Am J Surg Pathol 2010;34:1122-1131.
37. Matushansky I, Hernando E, Socci ND et al. Derivation of sarcomas from mesenchymal stem cells via inactivation of the Wnt pathway. J Clin Invest 2007;117:3248-3257. (Pubitemid 350096982)
38. Willems SM, Mohseny AB, Balog C et al. Cellular/intramuscular myxoma and grade I myxofibrosarcoma are characterized by distinct genetic alterations and specific composition of their extracellular matrix. J Cell Mol Med 2009;13:1291-1301.
39. Gibbs CP, Kukekov VG, Reith JD et al. Stem-like cells in bone sarcomas: Implications for tumorigenesis. Neoplasia 2005;7:967-976.
40. Suva ML, Riggi N, Stehle JC et al. Identification of cancer stem cells in Ewing's sarcoma. Cancer Res 2009;69:1776-1781.
41. Pardal R, Clarke MF, Morrison SJ. Applying the principles of stem-cell biology to cancer. Nat Rev Cancer 2003;3:895-902. (Pubitemid 37500174)
42. Adhikari AS, Agarwal N, Wood BM et al. CD117 and Stro-1 identify osteosarcoma tumor-initiating cells associated with metastasis and drug resistance. Cancer Res 2010;70:4602-4612.
43. Fujii H, Honoki K, Tsujiuchi T et al. Sphere-forming stem-like cell populations with drug resistance in human sarcoma cell lines. Int J Oncol 2009;34:1381-1386.
44. Reya T, Morrison SJ, Clarke MF et al. Stem cells, cancer, and cancer stem cells. Nature 2001;414:105-111. (Pubitemid 33041634)
45. Honoki K. Do stem-like cells play a role in drug resistance of sarcomas? Expert Rev Anticancer Ther 2010;10:261-270.
46. Henriksen J, Stabell M, Meza-Zepeda LA et al. Identification of target genes for wild type and truncated HMGA2 in mesenchymal stem-like cells. BMC Cancer 2010;10:329.
47. Xie Z. Brain tumor stem cells. Neurochem Res 2009;34:2055-2066.
48. Germano I, Swiss V, Casaccia P. Primary brain tumors, neural stem cell, and brain tumor cancer cells: Where is the link? Neuropharmacology 2010;58:903-910.
49. Fraser CJ, Weigel BJ, Perentesis JP et al. Autologous stem cell transplantation for high-risk Ewing's sarcoma and other pediatric solid tumors. Bone Marrow Transplant 2006;37:175-181. (Pubitemid 43108810)
50. Duan X, Guan H, Cao Y et al. Murine bone marrow-derived mesenchymal stem cells as vehicles for interleukin-12 gene delivery into Ewing sarcoma tumors. Cancer 2009;115:13-22.
51. Khakoo AY, Pati S, Anderson SA et al. Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma. J Exp Med 2006;203:1235-1247. (Pubitemid 43736593)
52. Xu WT, Bian ZY, Fan QM et al. Human mesenchymal stem cells (hMSCs) target osteosarcoma and promote its growth and pulmonary metastasis. Cancer Lett 2009;281:32-41.
53. Karnoub AE, Dash AB, Vo AP et al. Mesenchymal stem cells within tumour stroma promote breast cancer metastasis. Nature 2007;449:557-563. (Pubitemid 47525152)
54. Berger M, Muraro M, Fagioli F et al. Osteosarcoma derived from donor stem cells carrying the Norrie's disease gene. N Engl J Med 2008;359:2502-2504.
55. Perrot P, Rousseau J, Bouffaut AL et al. Safety concern between autologous fat graft, mesenchymal stem cell and osteosarcoma recurrence. PLoS One 2010;5:e10999.
56. Torsvik A, Rosland GV, Svendsen A et al. Spontaneous malignant transformation of human mesenchymal stem cells reflects cross-contamination: Putting the research field on track - letter. Cancer Res 2010;70:6393-6396.