Correction of F508del-CFTR trafficking by the sponge alkaloid latonduine is modulated by interaction with PARP

Chemistry and Biology

Volumn 19, Issue 10, 2012, Pages 1288-1299

  Carlile, Graeme W ^a   Keyzers, Robert A ^b   Teske, Katrina A ^a   Robert, Renaud ^a   Williams, David E ^b   Linington, Roger G ^b   Gray, Christopher A ^b   Centko, Ryan M ^b   Yan, Luping ^b   Anjos, Suzana M ^a   Sampson, Heidi M ^a   Zhang, Donglei ^a   Liao, Jie ^a   Hanrahan, John W ^a   Andersen, Raymond J ^b   Thomas, David Y ^a  

^a MCGILL UNIVERSITY   (Canada)

^b UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALOID DERIVATIVE; LATONDUINE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 1; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 2; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 3; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 4; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 5A; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE 5B; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG TARGETING; GENE DELETION; IN VIVO STUDY; INHIBITION KINETICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN TARGETING; PROTEIN TRANSPORT;

ALKALOIDS; ANIMALS; CELL LINE; CRICETINAE; CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR; ENDOPLASMIC RETICULUM; HETEROCYCLIC COMPOUNDS, 3-RING; HUMANS; MICE; MUTATION; POLY(ADP-RIBOSE) POLYMERASES; PORIFERA; PROTEIN BINDING; PROTEIN FOLDING; PROTEIN TRANSPORT; RNA INTERFERENCE; RNA, SMALL INTERFERING;

EID: 84868012854     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2012.08.014     Document Type: Article

References (41)

1. G.E. Abdelkarim, K. Gertz, C. Harms, J. Katchanov, U. Dirnagl, C. Szabo, and M. Endres Protective effects of PJ34, a novel, potent inhibitor of poly(ADP-ribose) polymerase (PARP) in in vitro and in vivo models of stroke Int. J. Mol. Med. 7 2001 255 260
2. Z.Y.A. Abd Elmageed, A.S. Naura, Y. Errami, and M. Zerfaoui The poly(ADP-ribose) polymerases (PARPs): new roles in intracellular transport Cell. Signal. 24 2012 1 8
3. J.A. Best, and P.M. Quinton Salivary secretion assay for drug efficacy for cystic fibrosis in mice Exp. Physiol. 90 2005 189 193 (Pubitemid 40364797)
4. M.K. Bhangoo, S. Tzankov, A.C. Fan, K. Dejgaard, D.Y. Thomas, and J.C. Young Multiple 40-kDa heat-shock protein chaperones function in Tom70-dependent mitochondrial import Mol. Biol. Cell. 18 2007 3414 3428 (Pubitemid 47378681)
5. G.W. Carlile, R. Robert, D. Zhang, K.A. Teske, Y. Luo, J.W. Hanrahan, and D.Y. Thomas Correctors of protein trafficking defects identified by a novel high-throughput screening assay ChemBioChem 8 2007 1012 1020 (Pubitemid 47189285)
6. S.H. Cheng, R.J. Gregory, J. Marshall, S. Paul, D.W. Souza, G.A. White, C.R. O'Riordan, and A.E. Smith Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis Cell 63 1990 827 834 (Pubitemid 120035055)
7. J.P. Clancy, S.M. Rowe, F.J. Accurso, M.L. Aikten, R.S. Amin, M.A. Ashlock, M. Ballmann, M.P. Boyle, I. Bronsveld, and P.W. Campbell Results of a phase IIa study of VX-809, an investigational CFTR corrector compound, in subjects with cystic fibrosis homozygous for the F508del-CFTR mutation Thorax 67 2012 12 18
8. W. Dalemans, P. Barbry, G. Champigny, S. Jallat, K. Dott, D. Dreyer, R.G. Crystal, A. Pavirani, J.-P. Lecocq, and M. Lazdunski Altered chloride ion channel kinetics associated with the ΔF508 cystic fibrosis mutation Nature 354 1991 526 528 (Pubitemid 21896832)
9. G.M. Denning, L.S. Ostedgaard, S.H. Cheng, A.E. Smith, and M.J. Welsh Localization of cystic fibrosis transmembrane conductance regulator in chloride secretory epithelia J. Clin. Invest. 89 1992 339 349
10. R.L. Dormer, C.M. Harris, Z. Clark, M.M. Pereira, I.J. Doull, C. Norez, F. Becq, and M.A. McPherson Sildenafil (Viagra) corrects ΔF508-CFTR location in nasal epithelial cells from patients with cystic fibrosis Thorax 60 2005 55 59 (Pubitemid 40101019)
11. M.E. Egan, M. Pearson, S.A. Weiner, V. Rajendran, D. Rubin, J. Glöckner-Pagel, S. Canny, K. Du, G.L. Lukacs, and M.J. Caplan Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects Science 304 2004 600 602 (Pubitemid 38541921)
12. - transport and overexpression can generate basolateral CFTR Am. J. Physiol. Lung Cell. Mol. Physiol. 289 2005 L1123 L1130
13. P.J. French, J.H. van Doorninck, R.H. Peters, E. Verbeek, N.A. Ameen, C.R. Marino, H.R. de Jonge, J. Bijman, and B.J. Scholte A Δ F508 mutation in mouse cystic fibrosis transmembrane conductance regulator results in a temperature-sensitive processing defect in vivo J. Clin. Invest. 98 1996 1304 1312 (Pubitemid 26322055)
14. S.E. Gabriel, K.N. Brigman, B.H. Koller, R.C. Boucher, and M.J. Stutts Cystic fibrosis heterozygote resistance to cholera toxin in the cystic fibrosis mouse model Science 266 1994 107 109 (Pubitemid 24345328)
15. T. Huang, Y. You, M.S. Spoor, E.J. Richer, V.V. Kudva, R.C. Paige, M.P. Seiler, J.M. Liebler, J. Zabner, C.G. Plopper, and S.L. Brody Foxj1 is required for apical localization of ezrin in airway epithelial cells J. Cell. Sci. 116 2003 4935 4945 (Pubitemid 38016700)
16. D.M. Hutt, D. Herman, A.P. Rodrigues, S. Noel, J.M. Pilewski, J. Matteson, B. Hoch, W. Kellner, J.W. Kelly, and A. Schmidt Reduced histone deacetylase 7 activity restores function to misfolded CFTR in cystic fibrosis Nat. Chem. Biol. 6 2010 25 33
17. - channel by ATP-driven nucleotide-binding domain dimerisation J. Physiol. 587 2009 2151 2161
18. M. Isabelle, X. Moreel, J.P. Gagne, M. Rouleau, C. Ethier, P. Gagne, M.J. Hendzel, and G.G. Poirier Investigation of PARP-1, PARP-2 and PARG interactomes by affinity-purification mass spectrometry Proteome Sci. 8 2010 22
19. G. Jansen, A.Y. Lee, E. Epp, A. Fredette, J. Surprenant, D. Harcus, M. Scott, E. Tan, T. Nishimura, and M. Whiteway Chemogenomic profiling predicts antifungal synergies Mol. Syst. Biol. 5 2009 338
20. H. Jiang, J.H. Kim, K.M. Frizzell, W.L. Krauss, and H. Lin Clickable NAD analogues for labeling substrate proteins of poly(ADP-ribose) polymerases J. Am. Chem. Soc. 132 2010 9363 9372
21. R.G. Linington, D.E. Williams, A. Tahir, R. van Soest, and R.J. Andersen Latonduines A and B, new alkaloids isolated from the marine sponge Stylissa carteri: structure elucidation, synthesis, and biogenetic implications Org. Lett. 5 2003 2735 2738 (Pubitemid 37140853)
22. S.K. Liu, C. Coackley, M. Krause, F. Jalali, N. Chan, and R.G. Bristow A novel poly(ADP-ribose) polymerase inhibitor, ABT-888, radiosensitizes malignant human cell lines under hypoxia Radioother. Oncol. 88 2008 258 268
23. T.W. Loo, M.C. Bartlett, and D.M. Clarke Rescue of ΔF508 and other misprocessed CFTR mutants by a novel quinazoline compound Mol. Pharm. 2 2005 407 413 (Pubitemid 41503681)
24. O. Loseva, A.S. Jemth, H.E. Bryant, H. Schüler, L. Lehtiö, T. Karlberg, and T. Helleday PARP-3 is a mono-ADP-ribosylase that activates PARP-1 in the absence of DNA J. Biol. Chem. 285 2010 8054 8060
25. G.L. Lukacs, X.B. Chang, C. Bear, N. Kartner, A. Mohamed, J.R. Riordan, and S. Grinstein The ΔF508 mutation decreases the stability of cystic fibrosis transmembrane conductance regulator in the plasma membrane. Determination of functional half-lives on transfected cells J. Biol. Chem. 268 1993 21592 21598 (Pubitemid 23320650)
26. A.W. Maresso, M.R. Baldwin, and J.T. Barbieri Ezrin/radixin/moesin proteins are high affinity targets for ADP-ribosylation by Pseudomonas aeruginosa ExoS J. Biol. Chem. 279 2004 38402 38408 (Pubitemid 39295990)
27. C. Norez, S. Noel, M. Wilke, M. Bijvelds, H. Jorna, P. Melin, H. DeJonge, and F. Becq Rescue of functional delF508-CFTR channels in cystic fibrosis epithelial cells by the α-glucosidase inhibitor miglustat FEBS Lett. 580 2006 2081 2086
28. L.T.S. Paleari, S. Trombino, C. Falugi, L. Gallus, S. Carlone, C. Angelini, K. Sepcic, T. Turk, M. Faimali, D.M. Noonan, and A. Albini Marine sponge-derived polymeric alkylpyridinium salts as a novel tumor chemotherapeutic targeting the cholinergic system in lung tumors Int. J. Oncol. 29 2006 1381 1388
29. W.M. Rabeh, F. Bossard, H. Xu, T. Okiyoneda, M. Bagdany, C.M. Mulvihill, K. Du, S. di Bernardo, Y. Liu, and L. Konermann Correction of both NBD1 energetics and domain interface is required to restore ΔF508 CFTR folding and function Cell 148 2012 150 163
30. J.R. Riordan, J.M. Rommens, B. Kerem, N. Alon, R. Rozmahel, Z. Grzelczak, J. Zielenski, S. Lok, N. Plavsic, and J.L. Chou Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA Science 245 1989 1066 1073 (Pubitemid 19231814)
31. R. Robert, G.W. Carlile, C. Pavel, N. Liu, S.M. Anjos, J. Liao, Y. Luo, D. Zhang, D.Y. Thomas, and J.W. Hanrahan Structural analog of sildenafil identified as a novel corrector of the F508del-CFTR trafficking defect Mol. Pharmacol. 73 2008 478 489 (Pubitemid 351159218)
32. R. Robert, G.W. Carlile, J. Liao, H. Balghi, P. Lesimple, N. Liu, B. Kus, D. Rotin, M. Wilke, and H.R. de Jonge Correction of the ΔPhe508 cystic fibrosis transmembrane conductance regulator trafficking defect by the bioavailable compound glafenine Mol. Pharmacol. 77 2010 922 930
33. R.C. Rubenstein, M.E. Egan, and P.L. Zeitlin In vitro pharmacologic restoration of CFTR-mediated chloride transport with sodium 4-phenylbutyrate in cystic fibrosis epithelial cells containing Δ F508-CFTR J. Clin. Invest. 100 1997 2457 2465 (Pubitemid 27514885)
34. H.M. Sampson, R. Robert, J. Liao, E. Matthes, G.W. Carlile, J.W. Hanrahan, and D.Y. Thomas Identification of a NBD1-binding pharmacological chaperone that corrects the trafficking defect of F508del-CFTR Chem. Biol. 18 2011 231 242
35. S. Sato, C.L. Ward, M.E. Krouse, J.J. Wine, and R.R. Kopito Glycerol reverses the misfolding phenotype of the most common cystic fibrosis mutation J. Biol. Chem. 271 1996 635 638 (Pubitemid 26034907)
36. G.S. Scott, C. Szabo, and D.C. Hooper Poly(ADP-ribose) polymerase activity contributes to peroxynitrite-induced spinal cord neuronal cell death in vitro J. Neurotrauma 21 2004 1255 1263 (Pubitemid 39280851)
37. D. Sipkema, M.C.R. Franssen, R. Osinga, J. Tramper, and R.H. Wijffels Marine sponges as pharmacy Mar. Biotechnol. 7 2005 142 162 (Pubitemid 41187741)
38. M. Tantama, W.-C. Lin, and S. Licht An activity-based protein profiling probe for the nicotinic acetylcholine receptor J. Am. Chem. Soc. 130 2008 15766 15767
39. F. Van Goor, S. Hadida, P.D. Grootenhuis, B. Burton, J.H. Stack, K.S. Straley, C.J. Decker, M. Miller, J. McCartney, and E.R. Olsen Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809 Proc. Natl. Acad. Sci. USA 108 2011 18843 18848
40. X. Wang, J. Venable, P. LaPointe, D.M. Hutt, A.V. Koulov, J. Coppinger, C. Gurkan, W. Kellner, J. Matteson, and H. Plutner Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis Cell 127 2006 803 815 (Pubitemid 44716255)
41. L. Zhang, B. Button, S.E. Gabriel, S. Burkett, Y. Yan, M.H. Skiadopoulos, Y.L. Dang, L.N. Vogel, T. McKay, and A. Mengos CFTR delivery to 25% of surface epithelial cells restores normal rates of mucus transport to human cystic fibrosis airway epithelium PLoS Biol. 7 2009 e1000155