18α-glycyrrhetinic acid down-regulates expression of type i and iii collagen via tgf-β1/smad signaling pathway in human and rat hepatic stellate cells

International Journal of Medical Sciences

Volumn 9, Issue 5, 2012, Pages 370-379

  Lu, Lun gen ^a   Zong, Lei ^a,b   Qu, Ying ^a   Xu, Ming yi ^a   Dong, Yu wei ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b WEIFANG PEOPLE'S HOSPITAL   (China)

Author keywords

18 glycyrrhetinic acid; Hepatic stellate cell; Tgf 1 smad; Transcription factor

Indexed keywords

18ALPHA GLYCYRRHETINIC ACID; COLLAGEN TYPE 1; COLLAGEN TYPE 3; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MESSENGER RNA; PREGNANCY SPECIFIC BETA1 GLYCOPROTEIN; SMAD PROTEIN; SMAD2 PROTEIN; SMAD3 PROTEIN; SMAD4 PROTEIN; SMAD7 PROTEIN; TRANSCRIPTION FACTOR AP 1; TRANSFORMING GROWTH FACTOR BETA1; 18ALPHA-GLYCYRRHETINIC ACID; ACTA2 PROTEIN, HUMAN; ACTIN; DRUG DERIVATIVE; GLYCYRRHETINIC ACID; SMOOTH MUSCLE ACTIN, RAT;

ANIMAL CELL; ARTICLE; CELL GROWTH; CELL VIABILITY; COL1A2 GENE; COL3A1 GENE; CONCENTRATION RESPONSE; CONTROLLED STUDY; GEL MOBILITY SHIFT ASSAY; GENE; GENE EXPRESSION REGULATION; GENE TARGETING; IMMUNOCYTOCHEMISTRY; INTRACELLULAR SIGNALING; NONHUMAN; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REAL TIME POLYMERASE CHAIN REACTION; SMAD2 GENE; SMAD3 GENE; SMAD4 GENE; SMAD7 GENE; STELLATE CELL; TBETAR 2 GENE; WESTERN BLOTTING; ANIMAL; CELL LINE; DRUG EFFECT; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; METABOLISM; SIGNAL TRANSDUCTION;

ACTINS; ANIMALS; BLOTTING, WESTERN; CELL LINE; COLLAGEN TYPE I; COLLAGEN TYPE III; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GLYCYRRHETINIC ACID; HUMANS; IMMUNOHISTOCHEMISTRY; RATS; REAL-TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84868005326     PISSN: 14491907     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijms.4395     Document Type: Article

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