Melanocortin 4 receptor antagonists attenuates morphine antinociceptive tolerance, astroglial activation and cytokines expression in the spinal cord of rat

Neuroscience Letters

Volumn 529, Issue 2, 2012, Pages 112-117

  Niu, ZeJun ^a   Ma, JiaGui ^b   Chu, HaiChen ^a   Zhao, Yang ^a   Feng, Wei ^a   Cheng, YongWei ^a  

^a QINGDAO UNIVERSITY   (China)

^b Aviation General Hospital   (China)

Author keywords

Astrocyte; Cytokines; HS014; Melanocortin 4 receptor (MC4R); Morphine tolerance

Indexed keywords

BETA INTERMEDIN[11-22][11 (N ACETYLCYSTEINE) 14 [3 (2 NAPHTHYL) DEXTRO ALANINE] 18 CYSTEINE 22 ASPARTIC ACID AMIDE] 11,18 CYCLIC DISULFIDE; CYTOKINE; GLIAL FIBRILLARY ACIDIC PROTEIN; INTERLEUKIN 10; INTERLEUKIN 1BETA; INTERLEUKIN 6; MELANOCORTIN 4 RECEPTOR; MELANOCORTIN 4 RECEPTOR ANTAGONIST; MORPHINE; OPIATE; RECEPTOR BLOCKING AGENT; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTINOCICEPTION; ARTICLE; ASTROCYTE; CONTROLLED STUDY; CYTOKINE RELEASE; DRUG POTENCY; DRUG TOLERANCE; HOT PLATE TEST; IMMUNE SYSTEM; IMMUNOHISTOCHEMISTRY; INFLAMMATION; MACROGLIA; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; REPEATED DRUG DOSE; SINGLE DRUG DOSE; SPINAL CORD;

ANALGESICS, OPIOID; ANIMALS; ASTROCYTES; CYTOKINES; DRUG TOLERANCE; HOT TEMPERATURE; HYPERALGESIA; INJECTIONS, SPINAL; MALE; MORPHINE; NOCICEPTION; PEPTIDES, CYCLIC; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MELANOCORTIN, TYPE 4; SPINAL CORD;

EID: 84867998179     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.09.034     Document Type: Article

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