-
1
-
-
0035722282
-
Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura
-
Ruggenenti, P., Noris, M. & Remuzzi, G. Thrombotic microangiopathy, hemolytic uremic syndrome, and thrombotic thrombocytopenic purpura. Kidney Int. 60, 831-846 (2001
-
(2001)
Kidney Int
, vol.60
, pp. 831-846
-
-
Ruggenenti, P.1
Noris, M.2
Remuzzi, G.3
-
2
-
-
0036683408
-
Von Willebrand factor cleaving protease (ADAMTS13) is deficient in recurrent and familial thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
-
Remuzzi, G. et al. von Willebrand factor cleaving protease (ADAMTS13) is deficient in recurrent and familial thrombotic thrombocytopenic purpura and hemolytic uremic syndrome. Blood 100, 778-785 (2002
-
(2002)
Blood
, vol.100
, pp. 778-785
-
-
Remuzzi, G.1
-
3
-
-
0023278579
-
HUS and TTP: Variable expression of a single entity
-
Remuzzi, G. HUS and TTP: variable expression of a single entity. Kidney Int. 32, 292-308 (1987
-
(1987)
Kidney Int
, vol.32
, pp. 292-308
-
-
Remuzzi, G.1
-
4
-
-
15244348050
-
Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome
-
Tarr, P. I., Gordon, C. A. & Chandler, W. L. Shiga-toxin-producing Escherichia coli and haemolytic uraemic syndrome. Lancet 365, 1073-1086 (2005
-
(2005)
Lancet
, vol.365
, pp. 1073-1086
-
-
Tarr, P.I.1
Gordon, C.A.2
Chandler, W.L.3
-
5
-
-
70350279315
-
Atypical hemolytic-uremic syndrome
-
Noris, M. & Remuzzi, G. Atypical hemolytic-uremic syndrome. N. Engl. J. Med. 361, 1676-1687 (2009
-
(2009)
N. Engl. J. Med
, vol.361
, pp. 1676-1687
-
-
Noris, M.1
Remuzzi, G.2
-
6
-
-
78449293078
-
Genetics and complement in atypical HUS
-
Kavanagh, D. & Goodship, T. Genetics and complement in atypical HUS. Pediatr. Nephrol. 25, 2431-2442 (2010
-
(2010)
Pediatr. Nephrol
, vol.25
, pp. 2431-2442
-
-
Kavanagh, D.1
Goodship, T.2
-
7
-
-
0032569884
-
Von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome
-
Furlan, M. et al. von Willebrand factor-cleaving protease in thrombotic thrombocytopenic purpura and the hemolytic-uremic syndrome. N. Engl. J. Med. 339, 1578-1584 (1998
-
(1998)
N. Engl. J. Med
, vol.339
, pp. 1578-1584
-
-
Furlan, M.1
-
8
-
-
0032569840
-
Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura
-
Tsai, H. M. & Lian, E. C. Antibodies to von Willebrand factor-cleaving protease in acute thrombotic thrombocytopenic purpura. N. Engl. J. Med. 339, 1585-1594 (1998
-
(1998)
N. Engl. J. Med
, vol.339
, pp. 1585-1594
-
-
Tsai, H.M.1
Lian, E.C.2
-
9
-
-
73349123465
-
Pathophysiology of thrombotic thrombocytopenic purpura
-
Tsai, H. M. Pathophysiology of thrombotic thrombocytopenic purpura. Int. J. Hematol. 91, 1-19 (2010
-
(2010)
Int. J. Hematol
, vol.91
, pp. 1-19
-
-
Tsai, H.M.1
-
10
-
-
0141832540
-
Is severe deficiency of ADAMTS-13 specific for thrombotic thrombocytopenic purpura? Yes
-
Tsai, H. M. Is severe deficiency of ADAMTS-13 specific for thrombotic thrombocytopenic purpura? Yes. J. Thromb. Haemost. 1, 625-631 (2003
-
(2003)
J. Thromb. Haemost
, vol.1
, pp. 625-631
-
-
Tsai, H.M.1
-
11
-
-
79151475628
-
The complement system
-
Sarma, J. V. & Ward, P. A. The complement system. Cell Tissue Res. 343, 227-235 (2011
-
(2011)
Cell Tissue Res
, vol.343
, pp. 227-235
-
-
Sarma, J.V.1
Ward, P.A.2
-
12
-
-
77955883153
-
Complement: A key system for immune surveillance and homeostasis
-
Ricklin, D., Hajishengallis, G., Yang, K. & Lambris, J. D. Complement: A key system for immune surveillance and homeostasis. Nat. Immunol. 11, 785-797 (2010
-
(2010)
Nat. Immunol
, vol.11
, pp. 785-797
-
-
Ricklin, D.1
Hajishengallis, G.2
Yang, K.3
Lambris, J.D.4
-
13
-
-
79960435714
-
Alternative pathway activation of complement by Shiga toxin promotes exuberant C3a formation that triggers microvascular thrombosis
-
Morigi, M. et al. Alternative pathway activation of complement by Shiga toxin promotes exuberant C3a formation that triggers microvascular thrombosis. J. Immunol. 187, 172-180 (2011
-
(2011)
J. Immunol
, vol.187
, pp. 172-180
-
-
Morigi, M.1
-
14
-
-
0031045303
-
C5a induces tissue factor activity on endothelial cells
-
Ikeda, K. et al. C5a induces tissue factor activity on endothelial cells. Thromb. Haemost. 77, 394-398 (1997
-
(1997)
Thromb. Haemost
, vol.77
, pp. 394-398
-
-
Ikeda, K.1
-
15
-
-
0031010642
-
The cytolytically inactive terminal complement complex activates endothelial cells to express adhesion molecules and tissue factor procoagulant activity
-
Tedesco, F. et al. The cytolytically inactive terminal complement complex activates endothelial cells to express adhesion molecules and tissue factor procoagulant activity. J. Exp. Med. 185, 1619-1627 (1997
-
(1997)
J. Exp. Med
, vol.185
, pp. 1619-1627
-
-
Tedesco, F.1
-
16
-
-
0025349483
-
Release of heparan sulfate from endothelial cells Implications for pathogenesis of hyperacute rejection
-
Platt, J. L. et al. Release of heparan sulfate from endothelial cells. Implications for pathogenesis of hyperacute rejection. J. Exp. Med. 171, 1363-1368 (1990
-
(1990)
J. Exp. Med
, vol.171
, pp. 1363-1368
-
-
Platt, J.L.1
-
17
-
-
0028938634
-
Transient perturbation of endothelial integrity induced by natural antibodies and complement
-
Saadi, S. & Platt, J. L. Transient perturbation of endothelial integrity induced by natural antibodies and complement. J. Exp. Med. 181, 21-31 (1995
-
(1995)
J. Exp. Med
, vol.181
, pp. 21-31
-
-
Saadi, S.1
Platt, J.L.2
-
18
-
-
0031758037
-
Neutrophil adhesion to human endothelial cells is induced by the membrane attack complex: The roles of P-selectin and platelet activating factor
-
Kilgore, K. S., Ward, P. A. & Warren, J. S. Neutrophil adhesion to human endothelial cells is induced by the membrane attack complex: The roles of P-selectin and platelet activating factor. Inflammation 22, 583-598 (1998
-
(1998)
Inflammation
, vol.22
, pp. 583-598
-
-
Kilgore, K.S.1
Ward, P.A.2
Warren, J.S.3
-
19
-
-
1242293775
-
C5a-induced gene expression in human umbilical vein endothelial cells
-
Albrecht, E. A. et al. C5a-induced gene expression in human umbilical vein endothelial cells. Am. J. Pathol. 164, 849-859 (2004
-
(2004)
Am. J. Pathol
, vol.164
, pp. 849-859
-
-
Albrecht, E.A.1
-
20
-
-
0036092972
-
Cytolytically inactive terminal complement complex causes transendothelial migration of polymorphonuclear leukocytes in vitro and in vivo
-
Dobrina, A. et al. Cytolytically inactive terminal complement complex causes transendothelial migration of polymorphonuclear leukocytes in vitro and in vivo. Blood 99, 185-192 (2002
-
(2002)
Blood
, vol.99
, pp. 185-192
-
-
Dobrina, A.1
-
21
-
-
0034838024
-
Mechanisms of signal transduction activated by sublytic assembly of terminal complement complexes on nucleated cells
-
Niculescu, F. & Rus, H. Mechanisms of signal transduction activated by sublytic assembly of terminal complement complexes on nucleated cells. Immunol. Res. 24, 191-199 (2001
-
(2001)
Immunol. Res
, vol.24
, pp. 191-199
-
-
Niculescu, F.1
Rus, H.2
-
22
-
-
68049129555
-
The role of the anaphylatoxins in health and disease
-
Klos, A. et al. The role of the anaphylatoxins in health and disease. Mol. Immunol. 46, 2753-2766 (2009
-
(2009)
Mol. Immunol
, vol.46
, pp. 2753-2766
-
-
Klos, A.1
-
23
-
-
0018101590
-
The human complement system in thrombin-mediated platelet function
-
Polley, M. J. & Nachman, R. The human complement system in thrombin-mediated platelet function. J. Exp. Med. 147, 1713-1726 (1978
-
(1978)
J. Exp. Med
, vol.147
, pp. 1713-1726
-
-
Polley, M.J.1
Nachman, R.2
-
24
-
-
0020613041
-
Human platelet activation by C3a and C3a des-Arg
-
Polley, M. J. & Nachman, R. L. Human platelet activation by C3a and C3a des-Arg. J. Exp. Med. 158, 603-615 (1983
-
(1983)
J. Exp. Med
, vol.158
, pp. 603-615
-
-
Polley, M.J.1
Nachman, R.L.2
-
25
-
-
0021931355
-
Effect of complement proteins C5b-9 on blood platelets Evidence for reversible depolarization of membrane potential
-
Wiedmer, T. & Sims, P. J. Effect of complement proteins C5b-9 on blood platelets. Evidence for reversible depolarization of membrane potential. J. Biol. Chem. 260, 8014-8019 (1985
-
(1985)
J. Biol. Chem
, vol.260
, pp. 8014-8019
-
-
Wiedmer, T.1
Sims, P.J.2
-
26
-
-
0023696448
-
Complement proteins C5b-9 initiate secretion of platelet storage granules without increased binding of fibrinogen or von Willebrand factor to newly expressed cell surface GPIIb-IIIa
-
Ando, B., Wiedmer, T., Hamilton, K. K. & Sims, P. J. Complement proteins C5b-9 initiate secretion of platelet storage granules without increased binding of fibrinogen or von Willebrand factor to newly expressed cell surface GPIIb-IIIa. J. Biol. Chem. 263, 11907-11914 (1988
-
(1988)
J. Biol. Chem
, vol.263
, pp. 11907-11914
-
-
Ando, B.1
Wiedmer, T.2
Hamilton, K.K.3
Sims, P.J.4
-
27
-
-
0022826152
-
On the mechanism by which complement proteins C5b-9 increase platelet prothrombinase activity
-
Wiedmer, T., Esmon, C. T. & Sims, P. J. On the mechanism by which complement proteins C5b-9 increase platelet prothrombinase activity. J. Biol. Chem. 261, 14587-14592 (1986
-
(1986)
J. Biol. Chem
, vol.261
, pp. 14587-14592
-
-
Wiedmer, T.1
Esmon, C.T.2
Sims, P.J.3
-
28
-
-
0024253430
-
Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity
-
Sims, P. J., Faioni, E. M., Wiedmer, T. & Shattil, S. J. Complement proteins C5b-9 cause release of membrane vesicles from the platelet surface that are enriched in the membrane receptor for coagulation factor Va and express prothrombinase activity. J. Biol. Chem. 263, 18205-18212 (1988
-
(1988)
J. Biol. Chem
, vol.263
, pp. 18205-18212
-
-
Sims, P.J.1
Faioni, E.M.2
Wiedmer, T.3
Shattil, S.J.4
-
29
-
-
45949108983
-
Factor H dysfunction in patients with atypical hemolytic uremic syndrome contributes to complement deposition on platelets and their activation
-
Ståhl, A. L. et al. Factor H dysfunction in patients with atypical hemolytic uremic syndrome contributes to complement deposition on platelets and their activation. Blood 111, 5307-5315 (2008
-
(2008)
Blood
, vol.111
, pp. 5307-5315
-
-
Ståhl, A.L.1
-
30
-
-
65349135436
-
Abnormal platelet function in C3-deficient mice
-
Gushiken, F. C., Han, H., Li, J., Rumbaut, R. E. & Afshar-Kharghan, V. Abnormal platelet function in C3-deficient mice. J. Thromb. Haemost. 7, 865-870 (2009
-
(2009)
J. Thromb. Haemost
, vol.7
, pp. 865-870
-
-
Gushiken, F.C.1
Han, H.2
Li, J.3
Rumbaut, R.E.4
Afshar-Kharghan, V.5
-
31
-
-
0029035237
-
Human polymorphonuclear leukocytes store large amounts of terminal complement components C7 and C6, which may be released on stimulation
-
Høgåsen, A. K., Würzner, R., Abrahamsen, T. G. & Dierich, M. P. Human polymorphonuclear leukocytes store large amounts of terminal complement components C7 and C6, which may be released on stimulation. J. Immunol. 154, 4734-4740 (1995
-
(1995)
J. Immunol
, vol.154
, pp. 4734-4740
-
-
Høgåsen, A.K.1
Würzner, R.2
Abrahamsen, T.G.3
Dierich, M.P.4
-
32
-
-
0026763203
-
Biosynthesis and secretion of complement component C3) by activated human polymorphonuclear leukocytes
-
Botto, M., Lissandrini, D., Sorio, C. & Walport, M. J. Biosynthesis and secretion of complement component (C3) by activated human polymorphonuclear leukocytes. J. Immunol. 149, 1348-1355 (1992
-
(1992)
J. Immunol
, vol.149
, pp. 1348-1355
-
-
Botto, M.1
Lissandrini, D.2
Sorio, C.3
Walport, M.J.4
-
33
-
-
0029793161
-
Complement activation by myeloperoxidase products released from stimulated human polymorphonuclear leukocytes
-
Vogt, W. Complement activation by myeloperoxidase products released from stimulated human polymorphonuclear leukocytes. Immunobiology 195, 334-346 (1996
-
(1996)
Immunobiology
, vol.195
, pp. 334-346
-
-
Vogt, W.1
-
34
-
-
79251544880
-
Complement alternative pathway acts as a positive feedback amplification of neutrophil activation
-
Camous, L. et al. Complement alternative pathway acts as a positive feedback amplification of neutrophil activation. Blood 117, 1340-1349 (2011
-
(2011)
Blood
, vol.117
, pp. 1340-1349
-
-
Camous, L.1
-
35
-
-
77954313737
-
Complement activation on platelets: Implications for vascular inflammation and thrombosis
-
Peerschke, E. I., Yin, W. & Ghebrehiwet, B. Complement activation on platelets: Implications for vascular inflammation and thrombosis. Mol. Immunol. 47, 2170-2175 (2010
-
(2010)
Mol. Immunol
, vol.47
, pp. 2170-2175
-
-
Peerschke, E.I.1
Yin, W.2
Ghebrehiwet, B.3
-
36
-
-
78149477844
-
Molecular intercommunication between the complement and coagulation systems
-
Amara, U. et al. Molecular intercommunication between the complement and coagulation systems. J. Immunol. 185, 5628-5636 (2010
-
(2010)
J. Immunol
, vol.185
, pp. 5628-5636
-
-
Amara, U.1
-
37
-
-
80955168000
-
For the hus investigation team epidemic profile of shiga-toxin-producing escherichia coli o104:h4 outbreak in germany
-
Frank, C. et al. for the HUS Investigation Team. Epidemic profile of Shiga-toxin-producing Escherichia coli O104:H4 outbreak in Germany. N. Engl. J. Med. 365, 1771-1780 (2011
-
(2011)
N. Engl. J. Med
, vol.365
, pp. 1771-1780
-
-
Frank, C.1
-
38
-
-
80052150179
-
Origins of the E coli strain causing an outbreak of hemolytic-uremic syndrome in Germany
-
Rasko, D. A. et al. Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in Germany. N. Engl. J. Med. 365, 709-717 (2011
-
(2011)
N. Engl. J. Med
, vol.365
, pp. 709-717
-
-
Rasko, D.A.1
-
39
-
-
0027185787
-
Endothelial heterogeneity in Shiga toxin receptors and responses
-
Obrig, T. G. et al. Endothelial heterogeneity in Shiga toxin receptors and responses. J. Biol. Chem. 268, 15484-15488 (1993
-
(1993)
J. Biol. Chem
, vol.268
, pp. 15484-15488
-
-
Obrig, T.G.1
-
40
-
-
75749125021
-
Shiga toxins from cell biology to biomedical applications
-
Johannes, L. & Römer, W. Shiga toxins - from cell biology to biomedical applications. Nat. Rev. Microbiol. 8, 105-116 (2010
-
(2010)
Nat. Rev. Microbiol
, vol.8
, pp. 105-116
-
-
Johannes, L.1
Römer, W.2
-
41
-
-
18744414483
-
Shiga toxin-2 triggers endothelial leukocyte adhesion and transmigration via NF-κB dependent up-regulation of IL-8 and MCP-1
-
Zoja, C. et al. Shiga toxin-2 triggers endothelial leukocyte adhesion and transmigration via NF-κB dependent up-regulation of IL-8 and MCP-1. Kidney Int. 62, 846-856 (2002
-
(2002)
Kidney Int
, vol.62
, pp. 846-856
-
-
Zoja, C.1
-
42
-
-
84863012126
-
The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-Associated hemolytic uremic syndrome in humans and mice
-
Petruzziello-Pellegrini, T. N. et al. The CXCR4/CXCR7/SDF-1 pathway contributes to the pathogenesis of Shiga toxin-Associated hemolytic uremic syndrome in humans and mice. J. Clin. Invest. 122, 759-776 (2012
-
(2012)
J. Clin. Invest
, vol.122
, pp. 759-776
-
-
Petruzziello-Pellegrini, T.N.1
-
43
-
-
0028850520
-
Verotoxin-1 promotes leukocyte adhesion to cultured endothelial cells under physiologic flow conditions
-
Morigi, M. et al. Verotoxin-1 promotes leukocyte adhesion to cultured endothelial cells under physiologic flow conditions. Blood 86, 4553-4558 (1995
-
(1995)
Blood
, vol.86
, pp. 4553-4558
-
-
Morigi, M.1
-
44
-
-
0035885951
-
Verotoxin-1-induced up-regulation of adhesive molecules renders microvascular endothelial cells thrombogenic at high shear stress
-
Morigi, M. et al. Verotoxin-1-induced up-regulation of adhesive molecules renders microvascular endothelial cells thrombogenic at high shear stress. Blood 98, 1828-1835 (2001
-
(2001)
Blood
, vol.98
, pp. 1828-1835
-
-
Morigi, M.1
-
45
-
-
23044459579
-
Shiga toxin enhances functional tissue factor on human glomerular endothelial cells: Implications for the pathophysiology of hemolytic uremic syndrome
-
Nestoridi, E., Tsukurov, O., Kushak, R. I., Ingelfinger, J. R. & Grabowski, E. F. Shiga toxin enhances functional tissue factor on human glomerular endothelial cells: Implications for the pathophysiology of hemolytic uremic syndrome. J. Thromb. Haemost. 3, 752-762 (2005
-
(2005)
J. Thromb. Haemost
, vol.3
, pp. 752-762
-
-
Nestoridi, E.1
Tsukurov, O.2
Kushak, R.I.3
Ingelfinger, J.R.4
Grabowski, E.F.5
-
46
-
-
0035874529
-
Platelet activation by Shiga toxin and circulatory factors as a pathogenetic mechanism in the hemolytic uremic syndrome
-
Karpman, D. et al. Platelet activation by Shiga toxin and circulatory factors as a pathogenetic mechanism in the hemolytic uremic syndrome. Blood 97, 3100-3108 (2001
-
(2001)
Blood
, vol.97
, pp. 3100-3108
-
-
Karpman, D.1
-
47
-
-
0029957125
-
Effects of verocytotoxin-1 on nonadherent human monocytes: Binding characteristics protein syn thesis and induction of cytokine release
-
van Setten, P. A., Monnens, L. A., Verstraten, R. G., van den Heuvel, L. P. & van Hinsbergh, V. W. Effects of verocytotoxin-1 on nonadherent human monocytes: binding characteristics, protein synthesis, and induction of cytokine release. Blood 88, 174-183 (1996
-
(1996)
Blood
, vol.88
, pp. 174-183
-
-
Van Setten, P.A.1
Monnens, L.A.2
Verstraten, R.G.3
Van Den Heuvel, L.P.4
Van Hinsbergh, V.W.5
-
48
-
-
0015937612
-
Letter Plasma-C3 in haemolytic-uraemic syndrome and thrombotic thrombocytopenic purpura
-
Cameron, J. S. & Vick, R. Letter: Plasma-C3 in haemolytic-uraemic syndrome and thrombotic thrombocytopenic purpura. Lancet 2, 975 (1973
-
(1973)
Lancet
, vol.2
, pp. 975
-
-
Cameron, J.S.1
Vick, R.2
-
49
-
-
0015939385
-
Letter: Serum-complement levels in haemolytic-uraemic syndrome
-
Kaplan, B. S., Thomson, P. D. & MacNab, G. M. Letter: Serum-complement levels in haemolytic-uraemic syndrome. Lancet 2, 1505-1506 (1973
-
(1973)
Lancet
, vol.2
, pp. 1505-1506
-
-
Kaplan, B.S.1
Thomson, P.D.2
MacNab, G.M.3
-
50
-
-
0016383779
-
Letter Serum-complement levels in haemolytic-uraemic syndrome
-
Monnens, L., Hendrickx, G., van Wieringen, P. & van Munster, P. Letter: Serum-complement levels in haemolytic-uraemic syndrome. Lancet 2, 294 (1974
-
(1974)
Lancet
, vol.2
, pp. 294
-
-
Monnens, L.1
Hendrickx, G.2
Van Wieringen, P.3
Van Munster, P.4
-
51
-
-
0026666338
-
Hypocomplementemia and leukocytosis in diarrhea-Associated hemolytic uremic syndrome
-
Robson, W. L., Leung, A. K., Fick, G. H. & McKenna, A. I. Hypocomplementemia and leukocytosis in diarrhea-Associated hemolytic uremic syndrome. Nephron 62, 296-299 (1992
-
(1992)
Nephron
, vol.62
, pp. 296-299
-
-
Robson, W.L.1
Leung, A.K.2
Fick, G.H.3
McKenna, A.I.4
-
52
-
-
79959776422
-
Eculizumab in severe Shiga-toxin-associated HUS
-
Lapeyraque, A. L. et al. Eculizumab in severe Shiga-toxin-associated HUS. N. Engl. J. Med. 364, 2561-2563 (2011
-
(2011)
N. Engl. J. Med
, vol.364
, pp. 2561-2563
-
-
Lapeyraque, A.L.1
-
53
-
-
0018851755
-
The complement system in hemolytic-uremic syndrome in childhood
-
Monnens, L., Molenaar, J., Lambert, P. H., Proesmans, W. & van Munster, P. The complement system in hemolytic-uremic syndrome in childhood. Clin. Nephrol. 13, 168-171 (1980
-
(1980)
Clin. Nephrol
, vol.13
, pp. 168-171
-
-
Monnens, L.1
Molenaar, J.2
Lambert, P.H.3
Proesmans, W.4
Van Munster, P.5
-
54
-
-
73649122762
-
Alternative pathway of complement in children with diarrhea-Associated hemolytic uremic syndrome
-
Thurman, J. M. et al. Alternative pathway of complement in children with diarrhea-Associated hemolytic uremic syndrome. Clin. J. Am. Soc. Nephrol. 4, 1920-1924 (2009
-
(2009)
Clin. J. Am. Soc. Nephrol
, vol.4
, pp. 1920-1924
-
-
Thurman, J.M.1
-
55
-
-
79956293593
-
Complement activation on platelet-leukocyte complexes and microparticles in enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome
-
Ståhl, A. L., Sartz, L. & Karpman, D. Complement activation on platelet-leukocyte complexes and microparticles in enterohemorrhagic Escherichia coli-induced hemolytic uremic syndrome. Blood 117, 5503-5513 (2011
-
(2011)
Blood
, vol.117
, pp. 5503-5513
-
-
Ståhl, A.L.1
Sartz, L.2
Karpman, D.3
-
56
-
-
17144418992
-
Platelet activation leads to activation and propagation of the complement system
-
Del Conde, I., Crúz, M. A., Zhang, H., López, J. A. & Afshar-Kharghan, V. Platelet activation leads to activation and propagation of the complement system. J. Exp. Med. 201, 871-879 (2005
-
(2005)
J. Exp. Med
, vol.201
, pp. 871-879
-
-
Del Conde, I.1
Crúz, M.A.2
Zhang, H.3
López, J.A.4
Afshar-Kharghan, V.5
-
57
-
-
70350693665
-
Shiga toxin activates complement and binds factor H: Evidence for an active role of complement in hemolytic uremic syndrome
-
Orth, D. et al. Shiga toxin activates complement and binds factor H: Evidence for an active role of complement in hemolytic uremic syndrome. J. Immunol. 182, 6394-6400 (2009
-
(2009)
J. Immunol
, vol.182
, pp. 6394-6400
-
-
Orth, D.1
-
58
-
-
0021946215
-
The association between idiopathic hemolytic uremic syndrome and infection by verotoxin-producing Escherichia coli
-
Karmali, M. A. et al. The association between idiopathic hemolytic uremic syndrome and infection by verotoxin-producing Escherichia coli. J. Infect. Dis. 151, 775-782 (1985
-
(1985)
J. Infect. Dis
, vol.151
, pp. 775-782
-
-
Karmali, M.A.1
-
59
-
-
0026773074
-
Hemolytic-uremic syndrome and Vero cytotoxin-producing Escherichia coli infection in Italy
-
The HUS Italian Study Group
-
Caprioli, A. et al. Hemolytic-uremic syndrome and Vero cytotoxin-producing Escherichia coli infection in Italy. The HUS Italian Study Group. J. Infect. Dis. 166, 154-158 (1992
-
(1992)
J. Infect. Dis
, vol.166
, pp. 154-158
-
-
Caprioli, A.1
-
60
-
-
0016403925
-
Letter: Haemolytic-uraemic syndrome: Evidence for intravascular C3 activation
-
Stühlinger, W., Kourilsky, O., Kanfer, A. & Sraer, J. D. Letter: Haemolytic-uraemic syndrome: Evidence for intravascular C3 activation. Lancet 2, 788-789 (1974
-
(1974)
Lancet
, vol.2
, pp. 788-789
-
-
Stühlinger, W.1
Kourilsky, O.2
Kanfer, A.3
Sraer, J.D.4
-
61
-
-
84945700670
-
Familial hypocomplementemic hemolytic uremic syndrome with HLA-A3,B7 haplotype
-
Carreras, L. et al. Familial hypocomplementemic hemolytic uremic syndrome with HLA-A3,B7 haplotype. JAMA 245, 602-604 (1981
-
(1981)
JAMA
, vol.245
, pp. 602-604
-
-
Carreras, L.1
-
62
-
-
0031970553
-
Genetic studies into inherited and sporadic hemolytic uremic syndrome
-
Warwicker, P. et al. Genetic studies into inherited and sporadic hemolytic uremic syndrome. Kidney Int. 53, 836-844 (1998
-
(1998)
Kidney Int
, vol.53
, pp. 836-844
-
-
Warwicker, P.1
-
63
-
-
81455159919
-
-
NCBI Bookshelf [online
-
Noris, M., Bresin, E., Mele, C., Remuzzi, G. & Caprioli, J. Atypical hemolytic-uremic syndrome. NCBI Bookshelf [online], http://www.ncbi.nlm.nih.gov/ books/NBK1367/?report=printable (2011
-
(2011)
Atypical Hemolytic-uremic Syndrome
-
-
Noris, M.1
Bresin, E.2
Mele, C.3
Remuzzi, G.4
Caprioli, J.5
-
64
-
-
0042329931
-
Haemolytic uraemic syndrome and mutations of the factor H gene: A registry-based study of German speaking countries
-
Neumann, H. P. et al. Haemolytic uraemic syndrome and mutations of the factor H gene: A registry-based study of German speaking countries. J. Med. Genet. 40, 676-681 (2003
-
(2003)
J. Med. Genet
, vol.40
, pp. 676-681
-
-
Neumann, H.P.1
-
65
-
-
33747159590
-
Genetics of HUS: The impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome
-
Caprioli, J. et al. Genetics of HUS: The impact of MCP, CFH, and IF mutations on clinical presentation, response to treatment, and outcome. Blood 108, 1267-1279 (2006
-
(2006)
Blood
, vol.108
, pp. 1267-1279
-
-
Caprioli, J.1
-
66
-
-
0035128326
-
Factor H mutations in hemolytic uremic syndrome cluster in exons 18-20, a domain important for host cell recognition
-
Richards, A. et al. Factor H mutations in hemolytic uremic syndrome cluster in exons 18-20, a domain important for host cell recognition. Am. J. Hum. Genet. 68, 485-490 (2001
-
(2001)
Am. J. Hum. Genet
, vol.68
, pp. 485-490
-
-
Richards, A.1
-
67
-
-
0242570482
-
Familial haemolytic uraemic syndrome and an MCP mutation
-
Noris, M. et al. Familial haemolytic uraemic syndrome and an MCP mutation. Lancet 362, 1542-1547 (2003
-
(2003)
Lancet
, vol.362
, pp. 1542-1547
-
-
Noris, M.1
-
68
-
-
0242331610
-
Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome
-
Richards, A. et al. Mutations in human complement regulator, membrane cofactor protein (CD46), predispose to development of familial hemolytic uremic syndrome. Proc. Natl Acad. Sci. USA 100, 12966-12971 (2003
-
(2003)
Proc. Natl Acad. Sci. USA
, vol.100
, pp. 12966-12971
-
-
Richards, A.1
-
69
-
-
19444369542
-
Complement factor I: A susceptibility gene for atypical haemolytic uraemic syndrome
-
Fremeaux-Bacchi, V. et al. Complement factor I: A susceptibility gene for atypical haemolytic uraemic syndrome. J. Med. Genet. 41, e84 (2004
-
(2004)
J. Med. Genet
, vol.41
-
-
Fremeaux-Bacchi, V.1
-
70
-
-
27744452766
-
Mutations in complement factor I predispose to development of atypical hemolytic uremic syndrome
-
Kavanagh, D. et al. Mutations in complement factor I predispose to development of atypical hemolytic uremic syndrome. J. Am. Soc. Nephrol. 16, 2150-2155 (2005
-
(2005)
J. Am. Soc. Nephrol
, vol.16
, pp. 2150-2155
-
-
Kavanagh, D.1
-
71
-
-
75749153964
-
Mutations in components of complement influence the outcome of factor I-Associated atypical hemolytic uremic syndrome
-
Bienaime, F. et al. Mutations in components of complement influence the outcome of factor I-Associated atypical hemolytic uremic syndrome. Kidney Int. 77, 339-349 (2010
-
(2010)
Kidney Int
, vol.77
, pp. 339-349
-
-
Bienaime, F.1
-
72
-
-
67651166873
-
Thrombomodulin mutations in atypical hemolytic-uremic syndrome
-
Delvaeye, M. et al. Thrombomodulin mutations in atypical hemolytic-uremic syndrome. N. Engl. J. Med. 361, 345-357 (2009
-
(2009)
N. Engl. J. Med
, vol.361
, pp. 345-357
-
-
Delvaeye, M.1
-
73
-
-
54049137505
-
Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome
-
Frémeaux-Bacchi, V. et al. Mutations in complement C3 predispose to development of atypical hemolytic uremic syndrome. Blood 112, 4948-4952 (2008
-
(2008)
Blood
, vol.112
, pp. 4948-4952
-
-
Frémeaux-Bacchi, V.1
-
74
-
-
33846094404
-
Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome
-
Goicoechea de Jorge, E. et al. Gain-of-function mutations in complement factor B are associated with atypical hemolytic uremic syndrome. Proc. Natl Acad. Sci. USA 104, 240-245 (2007
-
(2007)
Proc. Natl Acad. Sci. USA
, vol.104
, pp. 240-245
-
-
Goicoechea De Jorge, E.1
-
75
-
-
20544437666
-
Anti-factor H autoantibodies associated with atypical hemolytic uremic syndrome
-
Dragon-Durey, M. A. et al. Anti-factor H autoantibodies associated with atypical hemolytic uremic syndrome. J. Am. Soc. Nephrol. 16, 555-563 (2005
-
(2005)
J. Am. Soc. Nephrol
, vol.16
, pp. 555-563
-
-
Dragon-Durey, M.A.1
-
76
-
-
78649863686
-
Clinical features of anti-factor H autoantibody-Associated hemolytic uremic syndrome
-
Dragon-Durey, M. A. et al. Clinical features of anti-factor H autoantibody-Associated hemolytic uremic syndrome. J. Am. Soc. Nephrol. 21, 2180-2187 (2010
-
(2010)
J. Am. Soc. Nephrol
, vol.21
, pp. 2180-2187
-
-
Dragon-Durey, M.A.1
-
77
-
-
67449119124
-
The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome
-
Ferreira, V. P. et al. The binding of factor H to a complex of physiological polyanions and C3b on cells is impaired in atypical hemolytic uremic syndrome. J. Immunol. 182, 7009-7018 (2009
-
(2009)
J. Immunol
, vol.182
, pp. 7009-7018
-
-
Ferreira, V.P.1
-
78
-
-
0037396993
-
Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome
-
Manuelian, T. et al. Mutations in factor H reduce binding affinity to C3b and heparin and surface attachment to endothelial cells in hemolytic uremic syndrome. J. Clin. Invest. 111, 1181-1190 (2003
-
(2003)
J. Clin. Invest
, vol.111
, pp. 1181-1190
-
-
Manuelian, T.1
-
79
-
-
33846668749
-
Hemolytic uremic syndrome: A factor H mutation (E1172Stop) causes defective complement control at the surface of endothelial cells
-
Heinen, S. et al. Hemolytic uremic syndrome: A factor H mutation (E1172Stop) causes defective complement control at the surface of endothelial cells. J. Am. Soc. Nephrol. 18, 506-514 (2007
-
(2007)
J. Am. Soc. Nephrol
, vol.18
, pp. 506-514
-
-
Heinen, S.1
-
80
-
-
72949096309
-
Functional analyses indicate a pathogenic role of factor H autoantibodies in atypical haemolytic uraemic syndrome
-
Strobel, S. et al. Functional analyses indicate a pathogenic role of factor H autoantibodies in atypical haemolytic uraemic syndrome. Nephrol. Dial. Transplant. 25, 136-144 (2010
-
(2010)
Nephrol. Dial. Transplant
, vol.25
, pp. 136-144
-
-
Strobel, S.1
-
81
-
-
34548853385
-
Anti factor H autoantibodies block C-Terminal recognition function of factor H in hemolytic uremic syndrome
-
Józsi, M. et al. Anti factor H autoantibodies block C-Terminal recognition function of factor H in hemolytic uremic syndrome. Blood 110, 1516-1518 (2007
-
(2007)
Blood
, vol.110
, pp. 1516-1518
-
-
Józsi, M.1
-
82
-
-
33745812440
-
Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome
-
Fremeaux-Bacchi, V. et al. Genetic and functional analyses of membrane cofactor protein (CD46) mutations in atypical hemolytic uremic syndrome. J. Am. Soc. Nephrol. 17, 2017-2025 (2006
-
(2006)
J. Am. Soc. Nephrol
, vol.17
, pp. 2017-2025
-
-
Fremeaux-Bacchi, V.1
-
83
-
-
34548309310
-
Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome
-
Kavanagh, D. et al. Characterization of mutations in complement factor I (CFI) associated with hemolytic uremic syndrome. Mol. Immunol. 45, 95-105 (2008
-
(2008)
Mol. Immunol
, vol.45
, pp. 95-105
-
-
Kavanagh, D.1
-
84
-
-
70350475255
-
Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome
-
Roumenina, L. T. et al. Hyperfunctional C3 convertase leads to complement deposition on endothelial cells and contributes to atypical hemolytic uremic syndrome. Blood 114, 2837-2845 (2009
-
(2009)
Blood
, vol.114
, pp. 2837-2845
-
-
Roumenina, L.T.1
-
85
-
-
0032950690
-
Hypocomplementemia discloses genetic predisposition to hemolytic uremic syndrome and thrombotic thrombocytopenic purpura: Role of factor h abnormalities italian registry of familial and recurrent hemolytic uremic syndrome/thrombotic thrombocytopenic purpura
-
Noris, M. et al. Hypocomplementemia discloses genetic predisposition to hemolytic uremic syndrome and thrombotic thrombocytopenic purpura: Role of factor H abnormalities. Italian Registry of Familial and Recurrent Hemolytic Uremic Syndrome/Thrombotic Thrombocytopenic Purpura. J. Am. Soc. Nephrol. 10, 281-293 (1999
-
(1999)
J. Am. Soc. Nephrol
, vol.10
, pp. 281-293
-
-
Noris, M.1
-
86
-
-
0035089983
-
Familial hemolytic uremic syndrome associated with complement factor H deficiency
-
Landau, D. et al. Familial hemolytic uremic syndrome associated with complement factor H deficiency. J. Pediatr. 138, 412-417 (2001
-
(2001)
J. Pediatr
, vol.138
, pp. 412-417
-
-
Landau, D.1
-
87
-
-
0031693194
-
Hypocomplementemic autosomal recessive hemolytic uremic syndrome with decreased factor H
-
Ohali, M. et al. Hypocomplementemic autosomal recessive hemolytic uremic syndrome with decreased factor H. Pediatr. Nephrol. 12, 619-624 (1998
-
(1998)
Pediatr. Nephrol
, vol.12
, pp. 619-624
-
-
Ohali, M.1
-
88
-
-
0026560219
-
Familial recurrent haemolytic-uraemic syndrome with hypocomplementaemia
-
Zachwieja, J., Strzykala, K., Golda, W. & Maciejewski, J. Familial, recurrent haemolytic-uraemic syndrome with hypocomplementaemia. Pediatr. Nephrol. 6, 221-222 (1992
-
(1992)
Pediatr. Nephrol
, vol.6
, pp. 221-222
-
-
Zachwieja, J.1
Strzykala, K.2
Golda, W.3
Maciejewski, J.4
-
89
-
-
33644870779
-
Phenotypic expression of factor H mutations in patients with atypical hemolytic uremic syndrome
-
Vaziri-Sani, F. et al. Phenotypic expression of factor H mutations in patients with atypical hemolytic uremic syndrome. Kidney Int. 69, 981-988 (2006
-
(2006)
Kidney Int
, vol.69
, pp. 981-988
-
-
Vaziri-Sani, F.1
-
90
-
-
84883553701
-
Glomerular endothelial microvascular heterogeneity and response to cytokines predispose to development of atypical hus [abstract
-
Richards, A. Glomerular endothelial microvascular heterogeneity and response to cytokines predispose to development of atypical HUS [abstract]. Mol. Immunol. 48, 1732 (2011
-
(2011)
Mol. Immunol
, vol.48
, Issue.1732
-
-
Richards, A.1
-
91
-
-
77958587405
-
Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype
-
Noris, M. et al. Relative role of genetic complement abnormalities in sporadic and familial aHUS and their impact on clinical phenotype. Clin. J. Am. Soc. Nephrol. 5, 1844-1859 (2010
-
(2010)
Clin. J. Am. Soc. Nephrol
, vol.5
, pp. 1844-1859
-
-
Noris, M.1
-
92
-
-
75649133611
-
Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome
-
Moore, I. et al. Association of factor H autoantibodies with deletions of CFHR1, CFHR3, CFHR4, and with mutations in CFH, CFI, CD46, and C3 in patients with atypical hemolytic uremic syndrome. Blood 115, 379-387 (2010
-
(2010)
Blood
, vol.115
, pp. 379-387
-
-
Moore, I.1
-
93
-
-
33644964155
-
Insights into hemolytic uremic syndrome: Segregation of three independent predisposition factors in a large, multiple affected pedigree
-
Esparza-Gordillo, J. et al. Insights into hemolytic uremic syndrome: Segregation of three independent predisposition factors in a large, multiple affected pedigree. Mol. Immunol. 43, 1769-1775 (2006
-
(2006)
Mol. Immunol
, vol.43
, pp. 1769-1775
-
-
Esparza-Gordillo, J.1
-
94
-
-
14644424005
-
Predisposition to atypical hemolytic uremic syndrome involves the concurrence of different susceptibility alleles in the regulators of complement activation gene cluster in 1q32
-
Esparza-Gordillo, J. et al. Predisposition to atypical hemolytic uremic syndrome involves the concurrence of different susceptibility alleles in the regulators of complement activation gene cluster in 1q32. Hum. Mol. Genet. 14, 703-712 (2005
-
(2005)
Hum. Mol. Genet
, vol.14
, pp. 703-712
-
-
Esparza-Gordillo, J.1
-
95
-
-
34250329129
-
Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains
-
Pickering, M. C. et al. Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains. J. Exp. Med. 204, 1249-1256 (2007
-
(2007)
J. Exp. Med
, vol.204
, pp. 1249-1256
-
-
Pickering, M.C.1
-
96
-
-
77952556624
-
Pregnancy-Associated hemolytic uremic syndrome revisited in the era of complement gene mutations
-
Fakhouri, F. et al. Pregnancy-Associated hemolytic uremic syndrome revisited in the era of complement gene mutations. J. Am. Soc. Nephrol. 21, 859-867 (2010
-
(2010)
J. Am. Soc. Nephrol
, vol.21
, pp. 859-867
-
-
Fakhouri, F.1
-
97
-
-
84876071858
-
In patients with atypical hemolytic uremic syndrome C5 activation causes loss of endothelial thromboresistance [abstract
-
Galbusera, M. et al. In patients with atypical hemolytic uremic syndrome C5 activation causes loss of endothelial thromboresistance [abstract]. Mol. Immunol. 48, 1680 (2011
-
(2011)
Mol. Immunol
, vol.48
, pp. 1680
-
-
Galbusera, M.1
-
98
-
-
38349172121
-
Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome
-
Fang, C. J. et al. Membrane cofactor protein mutations in atypical hemolytic uremic syndrome (aHUS), fatal Stx-HUS, C3 glomerulonephritis, and the HELLP syndrome. Blood 111, 624-632 (2008
-
(2008)
Blood
, vol.111
, pp. 624-632
-
-
Fang, C.J.1
-
99
-
-
47249144803
-
Von willebrand factor ADAMTS13, and thrombotic thrombocytopenic purpura
-
Sadler, J. E. Von Willebrand factor, ADAMTS13, and thrombotic thrombocytopenic purpura. Blood 112, 11-18 (2008
-
(2008)
Blood
, vol.112
, pp. 11-18
-
-
Sadler, J.E.1
-
100
-
-
0037111571
-
Cloning, expression, and functional characterization of the von willebrand factor-cleaving protease (ADAMTS13
-
Plaimauer, B. et al. Cloning, expression, and functional characterization of the von Willebrand factor-cleaving protease (ADAMTS13). Blood 100, 3626-3632 (2002
-
(2002)
Blood
, vol.100
, pp. 3626-3632
-
-
Plaimauer, B.1
-
101
-
-
0035807348
-
Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura
-
Levy, G. G. et al. Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura. Nature 413, 488-494 (2001
-
(2001)
Nature
, vol.413
, pp. 488-494
-
-
Levy, G.G.1
-
102
-
-
33749872079
-
In-vitro and in-vivo consequences of mutations in the von Willebrand factor cleaving protease ADAMTS13 in thrombotic thrombocytopenic purpura
-
Donadelli, R. et al. In-vitro and in-vivo consequences of mutations in the von Willebrand factor cleaving protease ADAMTS13 in thrombotic thrombocytopenic purpura. Thromb. Haemost. 96, 454-464 (2006
-
(2006)
Thromb. Haemost
, vol.96
, pp. 454-464
-
-
Donadelli, R.1
-
103
-
-
0037968640
-
ADAMTS13 activity in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: Relation to presenting features and clinical outcomes in a prospective cohort of 142 patients
-
Vesely, S. K. et al. ADAMTS13 activity in thrombotic thrombocytopenic purpura-hemolytic uremic syndrome: Relation to presenting features and clinical outcomes in a prospective cohort of 142 patients. Blood 102, 60-68 (2003
-
(2003)
Blood
, vol.102
, pp. 60-68
-
-
Vesely, S.K.1
-
104
-
-
0035885927
-
Specific von Willebrand factor-cleaving protease in thrombotic microangiopathies: A study of 111 cases
-
Veyradier, A., Obert, B., Houllier, A., Meyer, D. & Girma, J. P. Specific von Willebrand factor-cleaving protease in thrombotic microangiopathies: A study of 111 cases. Blood 98, 1765-1772 (2001
-
(2001)
Blood
, vol.98
, pp. 1765-1772
-
-
Veyradier, A.1
Obert, B.2
Houllier, A.3
Meyer, D.4
Girma, J.P.5
-
105
-
-
0017603160
-
Thrombotic thrombocytopenic purpura with C3 vascular deposits: Report of a case
-
Weisenburger, D. D., O'Conner, M. L. & Hart, M. N. Thrombotic thrombocytopenic purpura with C3 vascular deposits: Report of a case. Am. J. Clin. Pathol. 67, 61-63 (1977
-
(1977)
Am. J. Clin. Pathol
, vol.67
, pp. 61-63
-
-
Weisenburger, D.D.1
O'Conner, M.L.2
Hart, M.N.3
-
106
-
-
0032755412
-
Characterization of platelet glycoproteins and platelet/endothelial cell antibodies in patients with thrombotic thrombocytopenic purpura
-
Wright, J. F. et al. Characterization of platelet glycoproteins and platelet/endothelial cell antibodies in patients with thrombotic thrombocytopenic purpura. Br. J. Haematol. 107, 546-555 (1999
-
(1999)
Br. J. Haematol
, vol.107
, pp. 546-555
-
-
Wright, J.F.1
-
107
-
-
20144365269
-
Complement activation: The missing link between ADAMTS-13 deficiency and microvascular thrombosis of thrombotic microangiopathies
-
Ruiz-Torres, M. P. et al. Complement activation: The missing link between ADAMTS-13 deficiency and microvascular thrombosis of thrombotic microangiopathies. Thromb. Haemost. 93, 443-452 (2005
-
(2005)
Thromb. Haemost
, vol.93
, pp. 443-452
-
-
Ruiz-Torres, M.P.1
-
108
-
-
84860474599
-
Complement activation in thrombotic thrombocytopenic purpura
-
Réti, M. et al. Complement activation in thrombotic thrombocytopenic purpura. J. Thromb. Haemost. 10, 791-798 (2012
-
(2012)
J. Thromb. Haemost
, vol.10
, pp. 791-798
-
-
Réti, M.1
-
109
-
-
84861526957
-
Eculizumab in the treatment of refractory idiopathic thrombotic thrombocytopenic purpura
-
Chapin, J., Weksler, B., Magro, C. & Laurence, J. Eculizumab in the treatment of refractory idiopathic thrombotic thrombocytopenic purpura. Br. J. Haematol. 157, 772-774 (2012
-
(2012)
Br. J. Haematol
, vol.157
, pp. 772-774
-
-
Chapin, J.1
Weksler, B.2
Magro, C.3
Laurence, J.4
-
110
-
-
33744987414
-
Generation of C5a in the absence of C3: A new complement activation pathway
-
Huber-Lang, M. et al. Generation of C5a in the absence of C3: A new complement activation pathway. Nat. Med. 12, 682-687 (2006
-
(2006)
Nat. Med
, vol.12
, pp. 682-687
-
-
Huber-Lang, M.1
-
113
-
-
84867985179
-
-
US National Library Of Medicine
-
US National Library of Medicine. ClinicalTrials.gov [online], http://clinicaltrials.gov/ct2/show/NCT01410916?term=NCT01410916&rank=1 (2012
-
(2012)
ClinicalTrials.gov [Online
-
-
-
114
-
-
84876094054
-
Best supportive care and therapeutic plasma exchange [abstract SAP179
-
Kielstein, J. et al. Best supportive care and therapeutic plasma exchange [abstract SAP179]. Nephrol. Dial. Transplant. 27 (SUPPL. 2), ii373-ii374 (2012
-
(2012)
Nephrol. Dial. Transplant
, vol.27
, Issue.SUPPL. 2
-
-
Kielstein, J.1
-
115
-
-
59449088846
-
Eculizumab for congenital atypical hemolytic-uremic syndrome
-
Gruppo, R. A. & Rother, R. P. Eculizumab for congenital atypical hemolytic-uremic syndrome. N. Engl. J. Med. 360, 544-546 (2009
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 544-546
-
-
Gruppo, R.A.1
Rother, R.P.2
-
116
-
-
84859798441
-
Eculizumab in the treatment of atypical hemolytic uremic syndrome in infants
-
Ariceta, G., Arrizabalaga, B., Aguirre, M., Morteruel, E. & Lopez-Trascasa, M. Eculizumab in the treatment of atypical hemolytic uremic syndrome in infants. Am. J. Kidney Dis. 59, 707-710 (2012
-
(2012)
Am. J. Kidney Dis
, vol.59
, pp. 707-710
-
-
Ariceta, G.1
Arrizabalaga, B.2
Aguirre, M.3
Morteruel, E.4
Lopez-Trascasa, M.5
-
117
-
-
59449107473
-
Eculizumab for atypical hemolytic-uremic syndrome
-
Nürnberger, J. et al. Eculizumab for atypical hemolytic-uremic syndrome. N. Engl. J. Med. 360, 542-544 (2009
-
(2009)
N. Engl. J. Med
, vol.360
, pp. 542-544
-
-
Nürnberger, J.1
-
118
-
-
78650507665
-
Eculizumab: Safety and efficacy after 17 months of treatment in a renal transplant patient with recurrent atypical hemolytic-uremic syndrome: Case report
-
Châtelet, V. et al. Eculizumab: Safety and efficacy after 17 months of treatment in a renal transplant patient with recurrent atypical hemolytic-uremic syndrome: Case report. Transplant. Proc. 42, 4353-4355 (2010
-
(2010)
Transplant. Proc
, vol.42
, pp. 4353-4355
-
-
Châtelet, V.1
-
119
-
-
77951876953
-
Prophylactic eculizumab after renal transplantation in atypical hemolytic-uremic syndrome
-
Zimmerhackl, L. B. et al. Prophylactic eculizumab after renal transplantation in atypical hemolytic-uremic syndrome. N. Engl. J. Med. 362, 1746-1748 (2010
-
(2010)
N. Engl. J. Med
, vol.362
, pp. 1746-1748
-
-
Zimmerhackl, L.B.1
-
120
-
-
80052473232
-
Prophylactic eculizumab prior to kidney transplantation for atypical hemolytic uremic syndrome
-
Weitz, M., Amon, O., Bassler, D., Koenigsrainer, A. & Nadalin, S. Prophylactic eculizumab prior to kidney transplantation for atypical hemolytic uremic syndrome. Pediatr. Nephrol. 26, 1325-1329 (2011
-
(2011)
Pediatr. Nephrol
, vol.26
, pp. 1325-1329
-
-
Weitz, M.1
Amon, O.2
Bassler, D.3
Koenigsrainer, A.4
Nadalin, S.5
-
121
-
-
84863981968
-
Ph II study of eculizumab (ECU) in patients (PTS) with atypical hemolytic uremic syndrome (aHUS) receiving chronic plasma exchange/infusion (PE/PI) [abstract TH-PO366
-
Licht, C. et al. Ph II study of eculizumab (ECU) in patients (PTS) with atypical hemolytic uremic syndrome (aHUS) receiving chronic plasma exchange/infusion (PE/PI) [abstract TH-PO366]. J. Am. Soc. Nephrol. 22, 197A (2011
-
(2011)
J. Am. Soc. Nephrol
, vol.22
-
-
Licht, C.1
-
122
-
-
84863981968
-
Continued improvements in renal function with sustained eculizumab (ECU) in patients (PTS) with atypical hemolytic uremic syndrome (aHUS) resistant to plasma exchange/infusion (PE/PI) [abstract TH-PO367
-
Greenbaum, L. A. et al. Continued improvements in renal function with sustained eculizumab (ECU) in patients (PTS) with atypical hemolytic uremic syndrome (aHUS) resistant to plasma exchange/infusion (PE/PI) [abstract TH-PO367]. J. Am. Soc. Nephrol. 22, 197A (2011
-
(2011)
J. Am. Soc. Nephrol
, vol.22
-
-
Greenbaum, L.A.1
-
123
-
-
79960465027
-
Inhibiting the C5-C5a receptor axis
-
Woodruff, T. M., Nandakumar, K. S. & Tedesco, F. Inhibiting the C5-C5a receptor axis. Mol. Immunol. 48, 1631-1642 (2011
-
(2011)
Mol. Immunol
, vol.48
, pp. 1631-1642
-
-
Woodruff, T.M.1
Nandakumar, K.S.2
Tedesco, F.3
-
124
-
-
84856633285
-
Therapeutic targeting of the complement system in age-related macular degeneration: A review
-
Troutbeck, R., Al-Qureshi, S. & Guymer, R. H. Therapeutic targeting of the complement system in age-related macular degeneration: A review. Clin. Experiment. Ophthalmol. 40, 18-26 (2012
-
(2012)
Clin. Experiment. Ophthalmol
, vol.40
, pp. 18-26
-
-
Troutbeck, R.1
Al-Qureshi, S.2
Guymer, R.H.3
-
125
-
-
65449188713
-
Complement fraction 3 binding on erythrocytes as additional mechanism of disease in paroxysmal nocturnal hemoglobinuria patients treated by eculizumab
-
Risitano, A. M. et al. Complement fraction 3 binding on erythrocytes as additional mechanism of disease in paroxysmal nocturnal hemoglobinuria patients treated by eculizumab. Blood 113, 4094-4100 (2009
-
(2009)
Blood
, vol.113
, pp. 4094-4100
-
-
Risitano, A.M.1
-
126
-
-
77956135186
-
Genetics and genetic testing in hemolytic uremic syndrome/thrombotic thrombocytopenic purpura
-
Noris, M. & Remuzzi, G. Genetics and genetic testing in hemolytic uremic syndrome/thrombotic thrombocytopenic purpura. Semin. Nephrol. 30, 395-408 (2010
-
(2010)
Semin. Nephrol
, vol.30
, pp. 395-408
-
-
Noris, M.1
Remuzzi, G.2
-
127
-
-
79953691827
-
Mutations in complement regulatory proteins predispose to preeclampsia: A genetic analysis of the PROMISSE cohort
-
Salmon, J. E. et al. Mutations in complement regulatory proteins predispose to preeclampsia: A genetic analysis of the PROMISSE cohort. Plos Med. 8, e1001013 (2011
-
(2011)
Plos Med
, vol.8
-
-
Salmon, J.E.1
-
128
-
-
48349086641
-
Complement mutation-Associated de novo thrombotic microangiopathy following kidney transplantation
-
Le Quintrec, M. et al. Complement mutation-Associated de novo thrombotic microangiopathy following kidney transplantation. Am. J. Transplant. 8, 1694-1701 (2008
-
(2008)
Am. J. Transplant
, vol.8
, pp. 1694-1701
-
-
Le Quintrec, M.1
-
129
-
-
77951853702
-
Eculizumab and renal transplantation in a patient with CAPS
-
Lonze, B. E., Singer, A. L. & Montgomery, R. A. Eculizumab and renal transplantation in a patient with CAPS. N. Engl. J. Med. 362, 1744-1745 (2010
-
(2010)
N. Engl. J. Med
, vol.362
, pp. 1744-1745
-
-
Lonze, B.E.1
Singer, A.L.2
Montgomery, R.A.3
-
130
-
-
4644237694
-
Soluble human complement receptor 1 limits ischemic damage in cardiac surgery patients at high risk requiring cardiopulmonary bypass
-
Lazar, H. L. et al. Soluble human complement receptor 1 limits ischemic damage in cardiac surgery patients at high risk requiring cardiopulmonary bypass. Circulation 110, II274-II279 (2004
-
(2004)
Circulation
, vol.110
-
-
Lazar, H.L.1
-
131
-
-
54149107444
-
Pexelizumab in ischemic heart disease: A systematic review and meta-Analysis on 15,196 patients
-
Testa, L. et al. Pexelizumab in ischemic heart disease: A systematic review and meta-Analysis on 15,196 patients. J. Thorac. Cardiovasc. Surg. 136, 884-893 (2008
-
(2008)
J. Thorac. Cardiovasc. Surg
, vol.136
, pp. 884-893
-
-
Testa, L.1
-
132
-
-
36448982862
-
Blocking the receptor for C5a in patients with rheumatoid arthritis does not reduce synovial inflammation
-
Vergunst, C. E. et al. Blocking the receptor for C5a in patients with rheumatoid arthritis does not reduce synovial inflammation. Rheumatology (Oxford) 46, 1773-1778 (2007
-
(2007)
Rheumatology (Oxford
, vol.46
, pp. 1773-1778
-
-
Vergunst, C.E.1
|