The cytolytically inactive terminal complement complex activates endothelial cells to express adhesion molecules and tissue factor procoagulant activity

Journal of Experimental Medicine

Volumn 185, Issue 9, 1997, Pages 1619-1627

  Tedesco, Francesco ^a   Pausa, Mario ^a   Nardon, Ermanno ^a   Introna, Martino ^b   Mantovani, Alberto ^b,c   Dobrina, Aldo ^a  

^a UNIVERSITY OF TRIESTE   (Italy)

^b MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^c UNIVERSITY OF BRESCIA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

COBROTOXIN; PROCOAGULANT; THROMBOPLASTIN;

ANTIGEN EXPRESSION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; CELL MIGRATION; COMPLEMENT ACTIVATION; COMPLEX FORMATION; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; FAST PROTEIN LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LIGAND BINDING; LUNG INJURY; PRIORITY JOURNAL; RECEPTOR UPREGULATION;

CELL ADHESION MOLECULES; CELLS, CULTURED; COMPLEMENT MEMBRANE ATTACK COMPLEX; E-SELECTIN; ENDOTHELIUM, VASCULAR; HUMANS; INTERCELLULAR ADHESION MOLECULE-1; RNA, MESSENGER; THROMBOPLASTIN; VASCULAR CELL ADHESION MOLECULE-1;

EID: 0031010642     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.185.9.1619     Document Type: Article

References (39)

1. Foreman, K.E., M.M. Glovsky, R.L. Warner, S.J. Horvath, and P.A. Ward. 1996. Comparative effect of C3a and C5a on adhesion molecule expression on neutrophils and endothelial cells. Inflammation. 20:1-9.
2. Vaporciyan, A.A., M.S. Mulligan, J.S. Warren, P.A. Barton, M. Miyasaka, and P.A. Ward. 1995. Up-regulation of lung vascular ICAM-1 in rats is complement dependent. J. Immunol. 155:1442-1449.
3. Lozada, C., R.I. Levin, M. Huie, R. Hirschhorn, D. Naime, M. Whitlow, P.A. Recht, B. Golden, and B.N. Cronstein. 1995. Identification of C1q as the heat-labile serum cofactor required for immune complexes to stimulate endothelial expression of the adhesion molecules E-selectin and intercellular and vascular cell adhesion molecule 1. Prof. Natl. Acad. Sci. USA. 92:8378-8382.
4. Foreman, K.E., A.A. Vaporciyan, B.K. Bonish, M.L. Jones, K.J. Johnson, M.M. Glovski, S.M. Eddy, and P.A. Ward. 1994. C5a-induced expression of P-selectin in endothelial cells. J. Clin. Invest. 94:1147-1155.
5. Marks, R.M., R.F. Todd III, and P.A. Ward. 1989. Rapid induction of neutrophil-endothelial adhesion by endothelial complement fixation. Nature (Lond.). 339:314-317.
6. Suttorp, N., W. Seeger, S. Zinsky., and S. Bhakdi. 1987. Complement complex C5b-8 induces PGI2 formation in cultured endothelial cells. Am. J. Physiol. 253:13-21.
7. Hattori, R., K.K. Hamilton, R.P. McEver, and P.J. Sims. 1989. Complement proteins C5b-9 induce secretion of high molecular weight multimers of endothelial von Willebrand factor and translocation of granule membrane protein GMP-140 to the cell surface. J. Biol. Chem. 264:9053-9060.
8. Benzaquen, L.R., A. Nicholson-Weller, and J.A. Halperin. 1994. Terminal complement proteins C5b-9 release basic fibroblast growth factor and platelet-derived growth factor from endothelial cells. J. Exp. Med. 179:985-992.
9. Kilgore, K.S., C.M. Flory, B.F. Miller, V.M. Evans, and J.S. Warren. 1996. The membrane attack complex of complement induces interleukin-8 and monocyte chemoattractant protein-1 secretion from human umbilical vein endothelial cells. Am. J. Pathol. 149:953-961.
10. Kilgore, K.S., J.P. Shen, B.F. Miller, P.A. Ward, and J.S. Warren. 1995. Enhancement by the complement membrane attack complex of tumor necrosis factor-α-induced endothelial cell expression of E-selectin and ICAM-1. J. Immunol. 155: 1434-1441.
11. Podack, E.R., W.P. Kolb, and H.J. Müller-Eberhard. 1978. The C5b-9 complex: formation, isolation, and inhibition of its activity by lipoprotein and the S-protein of human serum. J. Immunol. 120:1841-1848.
12. Murphy, B., L. Kirzbaum, I.D. Walker, A.J.F. d'Apice. 1988. SP-40,40, a newly identified normal human serum protein found in the SC5b-9 complex of complement and in the immune deposits in glomerulonephritis. J. Clin. Invest. 81: 1848-1864.
13. Lachmann, P.J., and R.A. Thompson. 1970. Reactive lysis: the complement-mediated lysis of unsensitized cells. II. The characterization of activated reactor as C56 and the participation of C8 and C9. J. Exp. Med. 131:643-657.
14. Wang, C., S. Barbashov, R.M. Jack, T. Barrett, P.F. Weller, and A. Nicholson-Weller. 1995. Hemolytically inactive C5b67 complex: an agonist of polymorphonuclear leukocytes. Blood. 85:2570-2578.
15. Lachmann, P.J., A.B. Kay, and R.A. Thompson. 1970. The chemotactic activity for neutrophil and eosinophil leukocytes of the trimolecular complex of the fifth, sixth and seventh components of human complement (C567) prepared in free solution by the "reactive lysis" procedure. Immunology. 19: 895-899.
16. Mollnes, T.E., T. Lea, M. Harboe, and J. Tschopp. 1985. Monoclonal antibodies recognizing a neoantigen of poly(C9) detect the human terminal complement complex in tissue and plasma. Scand. J. Immunol. 22:183-195.
17. Dustin, M.L., R. Rothlein, A.K. Bhan, C.A. Dinarello, and T.A. Springer. 1986. Induction by IL-1α and interferon-γ: tissue distribution, biochemistry, and function of a natural adherence molecule (ICAM-1). J. Immunol. 137:245-254.
18. Carlos, T., B.R. Schwartz, N.L. Kovach, E. Yee, M. Rosso, L. Osborn, G. Ghi-Rosso, B. Newman, R. Lobb, and J.M. Harlan. 1990. Vascular cell adhesion molecule-1 mediates lymphocyte adherence to cytokine-activated cultured human endothelial cells. Blood. 76:965-970.
19. Tedesco, F., L. Roncelli, B.H. Petersen, V. Agnello, and J. Sodetz. 1990. Two distinct abnormalities in patients with C8α-γ deficiency. Low level of C8β chain and presence of dysfunctional C8α-γ subunit. J. Clin. Invest. 86:884-888.
20. Harrison, R.A., and P.J. Lachmann. 1986. Complement technology. In Handbook of Experimental Immunology. D.M. Weir, L.A. Herzenberg, C. Blackwell, L.A. Herzenberg, editors. Blackwell, Oxford. 1-49.
21. Schneider, C., R.A. Newman, R.D. Sutherland , U. Asser, and M.F. Greaves. 1982. A one-step purification of membrane proteins using a high efficiency immunomatrix. J. Biol. Chem. 257:10766-10769.
22. Jaffe, E.A., R.L. Nachman, C.G. Becker, and C.R. Minick. 1973. Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J. Clin. Invest. 52:2745-2756.
23. Dobrina, A., E. Nardon, E. Vecile, M. Cinco, and P. Patriarca. 1995. Leptospira icterohemorrhagiae and Leptospire peptidolgycans induce endothelial cell adhesiveness for polymorphonuclear leukocytes. Infect. Immun. 63:2995-2999.
24. Mulder, A.B., K.S.M. Hegge-Paping, C.P.E. Magielse, N.R. Blom, J.W. Smit, J. van der Meer, M.R. Halie, and V.J.J. Bom. 1994. Tumor necrosis factor α-induced endothelial tissue factor is located on the cell surface rather than in the endothelial matrix. Blood. 84:1559-1566.
25. Golay, J., F. Passerini, and M. Introna. 1991. A simple and rapid method to analyse specific mRNA from few cells in a semi-quantitative way using the polymerase chain reaction. PCR Methods and Applications. 1:144-145.
26. Osborn, L., C. Hession, R. Tizard, C. Vassallo, L. Luhowskji, G. Chi-Rosso, and R. Lobb. 1989. Direct expression cloning of vascular cell adhesion molecule-1, a cytokine induced endothelial protein that binds to lymphocytes. Cell. 59:1203-1211.
27. Bevilacqua, M.P., S. Stengelin, M.A. Gimbrone, and B. Seed. 1989. Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science (Wash. DC). 243: 1160-1165.
28. - B lymphocytes and in Burkitt's lymphoma cell lines. J. Immunol. 153:543-553.
29. Jonijc, N., I. Martin-Padura, T. Pollicino, S. Bernasconi, P. Jilek, A. Bigotti, R. Mortarini, A. Anichini, G. Parmiani, F. Colotta, et al. 1992. Regulated expression of vascular cell adhesion molecule-1 in human malignant melanoma. Am. J. Pathol. 141:1323-1330.
30. Silversmith, R.E., and G.L. Nelsestuen. 1986. Fluid-phase assembly of the membrane attack complex of complement. Biochemistry. 25:841-851.
31. Pober, J.S., M.A. Gimbrone, L.A. Lapierre, D.L. Mendrick, W. Fiers, R. Rothlein, and T.A. Springer. 1986. Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J. Immunol. 137:1893-1886.
32. Saadi, S., R.A. Holzknecht, C.P. Patte, D.M. Stern, and J.L. Platt. 1995. Complement-mediated regulation of tissue factor activity in endothelium. J. Exp. Med. 182:1807-1814.
33. Hamilton, K.K., Z. Ji, S. Rollins, B.H. Stewart, and P.J. Sims. 1990. Regulatory control of the terminal complement proteins at the surface of human endothelial cells: neutralization of a C5b-9 inhibitor by antibody to CD59. Blood. 76: 2572-2577.
34. Falk, R.J., A.P. Dalmasso, Y. Kim, S. Lam, and A. Michael. 1985. Radioimmunoassay of the attack complex of complement in serum from patients with systemic lupus erythematosus. N. Engl. J. Med. 312:1594-1599.
35. Sanders, M.E., E.L. Alexander, C.L. Koski, M.M. Frank, and K.A. Joiner. 1987. Detection of activated terminal complement (C5b-9) in cerebrospinal fluid from patients with central nervous system involvement of primary syndrome or systemic lupus erythematosus. J. Immunol. 138:2095-2099.
36. Gawryl, M.S., D.S. Chudwin, P.F. Langlois, and T.F. Lint. 1988. The terminal complement complex, C5b-9, a marker of disease activity in patients with systemic lupus erythematosus. Arthritis Rheum. 31:188-195.
37. Greenstein, J.D., P.W. Peake, and J.A. Charlesworth. 1995. The kinetics and distribution of C9 and SC5b-9 in vivo: effects of complement activation. Clin. Exp. Immunol. 100:40-46.
38. Tedesco, F., W. Nürnberger, and S. Perissutti. 1993. Inherited deficiencies of the terminal complement components. Int. Rev. Immunol. 10:51-64.
39. Platonov, A.E., V.B. Beloborodov, and I.V. Vershinina. 1993. Meningococcal disease in patients with late complement component deficiency: studies in the USSR. Medicine (Baltimore). 72:374-392.