Targeting the microbiota-gut-brain axis to modulate behavior: Which bacterial strain will translate best to humans?

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 4, 2012, Pages

  McLean, Peter G ^a   Bergonzelli, Gabriella E ^a   Collins, Stephen M ^a   Bercik, Premysl ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANXIOLYTIC AGENT; NCC 4007; PROBIOTIC AGENT; UNCLASSIFIED DRUG;

ANXIETY DISORDER; BACTERIAL STRAIN; BEHAVIOR; BIFIDOBACTERIUM LONGUM; CENTRAL NERVOUS SYSTEM; COLITIS; DRUG EFFICACY; FEAR; HUMAN; HYPERTHERMIA; IRRITABLE COLON; LACTOBACILLUS RHAMNOSUS; LETTER; MAZE TEST; MICROBIOTA GUT BRAIN AXIS; MOOD; NERVE CELL EXCITABILITY; NEUROMODULATION; NONHUMAN; PRIORITY JOURNAL; TRANQUILIZING ACTIVITY; VAGUS NERVE;

ANIMALS; EMOTIONS; LACTOBACILLUS; MALE; RECEPTORS, GABA; VAGUS NERVE;

BACTERIA (MICROORGANISMS);

EID: 84856377281     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1118626109     Document Type: Letter

References (5)

1. Bravo JA, et al. (2011) Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve. Proc Natl Acad Sci USA 108:16050-16055.
2. Bercik P, et al. (2010) Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice. Gastroenterology 139:2102-2112, e1.
3. Bercik P, et al. (2011) The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication. Neurogastroenterol Motil 23:1132-1139.
4. Park AJ, et al. (2011) The anxiolytic effect of Bifidobacterium longum NCC3001 requires vagal integrity for gut-brain communication. Gastroenterology 140:S18-S19.
5. Kunze WA, et al. (2009) Lactobacillus reuteri enhances excitability of colonic AH neurons by inhibiting calcium-dependent potassium channel opening. J Cell Mol Med 13(8B):2261-2270.