The TLR7/8 agonist CL097 primes N-formyl-methionyl-leucyl-phenylalanine- stimulated NADPH oxidase activation in human neutrophils: Critical role of p47phox phosphorylation and the proline isomerase Pin1

Journal of Immunology

Volumn 189, Issue 9, 2012, Pages 4657-4665

  Makni Maalej, Karama ^a,b   Boussetta, Tarek ^a,b   Hurtado Nedelec, Margarita ^a,b,c   Belambri, Sahra Amel ^a,b   Gougerot Pocidalo, Marie Anne ^a,b,c   El Benna, Jamel ^a,b  

^a INSERM   (France)

^b UNIVERSITÉ PARIS DESCARTES   (France)

^c BICHAT HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CELL PROTEIN; CL 097; CYTOCHROME B558; FORMYLMETHIONYLLEUCYLPHENYLALANINE; GENISTEIN; JUGLONE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; PEPTIDYLPROLYL ISOMERASE PIN1; PROTEIN KINASE C; PROTEIN KINASE C INHIBITOR; PROTEIN P47PHOX; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SERINE; SUPEROXIDE; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR AGONIST; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; CYTOSOL; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; HUMAN; HUMAN CELL; INHIBITION KINETICS; INTRACELLULAR TRANSPORT; LEUKOCYTE ACTIVATION; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION;

DRUG SYNERGISM; ENZYME ACTIVATION; HUMANS; IMIDAZOLES; INFLAMMATION; MOLECULAR TARGETED THERAPY; N-FORMYLMETHIONINE LEUCYL-PHENYLALANINE; NADPH OXIDASE; NEUTROPHILS; PEPTIDYLPROLYL ISOMERASE; PHOSPHORYLATION; QUINOLINES; REACTIVE OXYGEN SPECIES; TOLL-LIKE RECEPTOR 7; TOLL-LIKE RECEPTOR 8;

EID: 84867908884     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1201007     Document Type: Article

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