Apolipoprotein A-I inhibits CD40 proinflammatory signaling via ATP-binding cassette transporter A1-mediated modulation of lipid raft in macrophages

Journal of Atherosclerosis and Thrombosis

Volumn 19, Issue 9, 2012, Pages 823-836

  Yin, Kai ^a   Chen, Wu Jun ^a   Zhou, Zhi Gang ^a   Zhao, Guo Jun ^a   Lv, Yun Chen ^a   Ouyang, Xin Pin ^a   Yu, Xiao Hua ^a   Fu, Yuchang ^b   Jiang, Zhi Sheng ^a   Tang, Chao Ke ^a  

^a UNIVERSITY OF SOUTH CHINA   (China)

^b UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

Author keywords

Apolipoprotein A I; ATP binding cassette transporter A1; CD40; Lipid raft

Indexed keywords

ABC TRANSPORTER A1; APOLIPOPROTEIN A1; BETA CYCLODEXTRIN; CD40 LIGAND; CHOLESTEROL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; SOLUBLE CD40 LIGAND; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; UNCLASSIFIED DRUG;

ARTICLE; CHOLESTEROL TRANSPORT; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FOAM CELL; HUMAN; HUMAN CELL; INFLAMMATION; LIPID RAFT; LIQUID SCINTILLATION COUNTING; MACROPHAGE; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANTIGENS, CD40; APOLIPOPROTEIN A-I; ATP-BINDING CASSETTE TRANSPORTERS; BLOTTING, WESTERN; CD40 LIGAND; CELLS, CULTURED; ENZYME-LINKED IMMUNOSORBENT ASSAY; FOAM CELLS; HUMANS; IMMUNOENZYME TECHNIQUES; IMMUNOPRECIPITATION; INFLAMMATION MEDIATORS; MACROPHAGES; MEMBRANE MICRODOMAINS; NF-KAPPA B; PROTEIN TRANSPORT; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, SMALL INTERFERING; TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PEPTIDES AND PROTEINS;

EID: 84867907667     PISSN: 13403478     EISSN: 18803873     Source Type: Journal    
DOI: 10.5551/jat.12823     Document Type: Article

References (52)

1. Williams KJ, Tabas I: Atherosclerosis and inflammation. Science, 2002; 297: 521-522
2. Libby P: Inflammation in atherosclerosis. Nature, 2002; 420: 868-874
3. Blake GJ, Ridker PM: Inflammatory bio-markers and cardiovascular risk prediction. J Intern Med, 2002; 252: 283-294
4. Hansson GK: Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med, 2005; 352: 1685-1695
5. Lievens D, Eijgelaar WJ, Biessen EA, Daemen MJ, Lutgens E: The multi-functionality of CD40L and its receptor CD40 in atherosclerosis. Thromb Haemost, 2009; 102: 206-214
6. Szabolcs MJ, Cannon PJ, Thienel U, Chen R, Michler RE, Chess L, Yellin MJ: Analysis of CD154 and CD40 expression in native coronary atherosclerosis and transplant associated coronary artery disease. Virchows Arch, 2000; 437: 149-159
7. Mach F, Schonbeck U, Sukhova GK, Atkinson E, Libby P: Reduction of atherosclerosis in mice by inhibition of CD40 signalling. Nature, 1998; 394: 200-203
8. Schonbeck U, Sukhova GK, Shimizu K, Mach F, Libby P: Inhibition of CD40 signaling limits evolution of established atherosclerosis in mice. Proc Natl Acad Sci U S A, 2000; 97: 7458-7463
9. Sierra-Johnson J, Fisher RM, Romero-Corral A, Somers VK, Lopez-Jimenez F, Ohrvik J, Walldius G, Hellenius ML, Hamsten A: Concentration of apolipoprotein B is comparable with the apolipoprotein B/apolipoprotein A-I ratio and better than routine clinical lipid measurements in predicting coronary heart disease mortality: findings from a multi-ethnic US population. Eur Heart J, 2009; 30: 710-717
10. van der Steeg WA, Holme I, Boekholdt SM, Larsen ML, Lindahl C, Stroes ES, Tikkanen MJ, Wareham NJ, Faergeman O, Olsson AG, Pedersen TR, Khaw KT, Kastelein JJ: High-density lipoprotein cholesterol, highdensity lipoprotein particle size, and apolipoprotein A-I: significance for cardiovascular risk: the IDEAL and EPICNorfolk studies. J Am Coll Cardiol, 2008; 51: 634-642
11. Alexander ET, Vedhachalam C, Sankaranarayanan S, de la Llera-Moya M, Rothblat GH, Rader DJ, Phillips MC: Influence of apolipoprotein A-I domain structure on macrophage reverse cholesterol transport in mice. Arterioscler Thromb Vasc Biol, 2011; 31: 320-327
12. Moore RE, Navab M, Millar JS, Zimetti F, Hama S, Rothblat GH, Rader DJ: Increased atherosclerosis in mice lacking apolipoprotein A-I attributable to both impaired reverse cholesterol transport and increased inflammation. Circ Res, 2005; 97: 763-771
13. Murphy AJ, Woollard KJ, Suhartoyo A, Stirzaker RA, Shaw J, Sviridov D, Chin-Dusting JP: Neutrophil activation is attenuated by high-density lipoprotein and apolipoprotein A-I in in vitro and in vivo models of inflammation. Arterioscler Thromb Vasc Biol, 2011; 31: 1333-1341
14. Nobecourt E, Tabet F, Lambert G, Puranik R, Bao S, Yan L, Davies MJ, Brown BE, Jenkins AJ, Dusting GJ, Bonnet DJ, Curtiss LK, Barter PJ, Rye KA: Nonenzymatic glycation impairs the antiinflammatory properties of apolipoprotein A-I. Arterioscler Thromb Vasc Biol, 2010; 30: 766-772
15. Yin K, Deng X, Mo ZC, Zhao GJ, Jiang J, Cui LB, Tan CZ, Wen GB, Fu Y, Tang CK: Tristetraprolin-dependent Post-transcriptional Regulation of Inflammatory Cytokine mRNA Expression by Apolipoprotein A-I: role of ATPbinding membrane cassette transporter A1 and signal transducer and activator of transcription 3. J Biol Chem, 2011; 286: 13834-13845
16. Murphy AJ, Woollard KJ, Hoang A, Mukhamedova N, Stirzaker RA, McCormick SP, Remaley AT, Sviridov D, Chin-Dusting J: High-density lipoprotein reduces the human monocyte inflammatory response. Arterioscler Thromb Vasc Biol, 2008; 28: 2071-2077
17. Davi G, Tuttolomondo A, Santilli F, Basili S, Ferrante E, Di Raimondo D, Pinto A, Licata G: CD40 ligand and MCP-1 as predictors of cardiovascular events in diabetic patients with stroke. J Atheroscler Thromb, 2009; 16: 707-713
18. Fotin-Mleczek M, Henkler F, Hausser A, Glauner H, Samel D, Graness A, Scheurich P, Mauri D, Wajant H: Tumor necrosis factor receptor-associated factor (TRAF) 1 regulates CD40-induced TRAF2-mediated NF-kappaB activation. J Biol Chem, 2004; 279: 677-685
19. Andrade RM, Wessendarp M, Portillo JA, Yang JQ, Gomez FJ, Durbin JE, Bishop GA, Subauste CS: TNF receptor-associated factor 6-dependent CD40 signaling primes macrophages to acquire antimicrobial activity in response to TNF-alpha. J Immunol, 2005; 175: 6014-6021
20. Mukundan L, Bishop GA, Head KZ, Zhang L, Wahl LM, Suttles J: TNF receptor-associated factor 6 is an essential mediator of CD40-activated proinflammatory pathways in monocytes and macrophages. J Immunol, 2005; 174: 1081-1090
21. Noels H, van Loo G, Hagens S, Broeckx V, Beyaert R, Marynen P, Baens M: A Novel TRAF6 binding site in MALT1 defines distinct mechanisms of NF-kappaB activation by API2middle dotMALT1 fusions. J Biol Chem, 2007; 282: 10180-10189
22. Ha H, Kwak HB, Lee SK, Na DS, Rudd CE, Lee ZH, Kim HH: Membrane rafts play a crucial role in receptor activator of nuclear factor kappaB signaling and osteoclast function. J Biol Chem, 2003; 278: 18573-18580
23. Yin K, Liao D, Tang C: ABCA1: A Possible Link Between Inflammation And Reverse Cholesterol Transport. Mol Med, 2010; 16: 438-449
24. Zhu X, Lee JY, Timmins JM, Brown JM, Boudyguina E, Mulya A, Gebre AK, Willingham MC, Hiltbold EM, Mishra N, Maeda N, Parks JS: Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages. J Biol Chem, 2008; 283: 22930-22941
25. Hao XR, Cao DL, Hu YW, Li XX, Liu XH, Xiao J, Liao DF, Xiang J, Tang CK: IFN-gamma down-regulates ABCA1 expression by inhibiting LXRalpha in a JAK/STAT signaling pathway-dependent manner. Atherosclerosis, 2009; 203: 417-428
26. Zuhorn IS, Kalicharan R, Hoekstra D: Lipoplex-mediated transfection of mammalian cells occurs through the cholesterol-dependent clathrin-mediated pathway of endocytosis. J Biol Chem, 2002; 277: 18021-18028
27. Hu YW, Ma X, Li XX, Liu XH, Xiao J, Mo ZC, Xiang J, Liao DF, Tang CK: Eicosapentaenoic acid reduces ABCA1 serine phosphorylation and impairs ABCA1-dependent cholesterol efflux through cyclic AMP/protein kinase A signaling pathway in THP-1 macrophage-derived foam cells. Atherosclerosis, 2009; 204: e35-43
28. Yang W, Di Vizio D, Kirchner M, Steen H, Freeman MR: Proteome scale characterization of human S-acylated proteins in lipid raft-enriched and non-raft membranes. Mol Cell Proteomics, 2010; 9: 54-70
29. Adam RM, Yang W, Di Vizio D, Mukhopadhyay NK, Steen H: Rapid preparation of nuclei-depleted detergentresistant membrane fractions suitable for proteomics analysis. BMC Cell Biol, 2008; 9: 30
30. Secchiero P, Milani D, Gonelli A, Melloni E, Campioni D, Gibellini D, Capitani S, Zauli G: Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) and TNF-alpha promote the NF-kappaB-dependent maturation of normal and leukemic myeloid cells. J Leukoc Biol, 2003; 74: 223-232
31. Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L: SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell, 2007; 28: 91-106
32. Brady K, Fitzgerald S, Moynagh PN: Tumour-necrosisfactor-receptor-associated factor 6, NF-kappaB-inducing kinase and IkappaB kinases mediate IgE isotype switching in response to CD40. Biochem J, 2000; 350 Pt 3: 735-740
33. Cuaz-Perolin C, Billiet L, Bauge E, Copin C, Scott-Algara D, Genze F, Buchele B, Syrovets T, Simmet T, Rouis M: Antiinflammatory and antiatherogenic effects of the NFkappaB inhibitor acetyl-11-keto-beta-boswellic acid in LPS-challenged ApoE-/-mice. Arterioscler Thromb Vasc Biol, 2008; 28: 272-277
34. Xia M, Ling W, Zhu H, Wang Q, Ma J, Hou M, Tang Z, Li L, Ye Q: Anthocyanin prevents CD40-activated proinflammatory signaling in endothelial cells by regulating cholesterol distribution. Arterioscler Thromb Vasc Biol, 2007; 27: 519-524
35. Li C, Norris PS, Ni CZ, Havert ML, Chiong EM, Tran BR, Cabezas E, Reed JC, Satterthwait AC, Ware CF, Ely KR: Structurally distinct recognition motifs in lymphotoxin-beta receptor and CD40 for tumor necrosis factor receptor-associated factor (TRAF)-mediated signaling. J Biol Chem, 2003; 278: 50523-50529
36. Zhu X, Owen JS, Wilson MD, Li H, Griffiths GL, Thomas MJ, Hiltbold EM, Fessler MB, Parks JS: Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol. J Lipid Res, 2010; 51: 3196-3206
37. Tellier E, Canault M, Poggi M, Bonardo B, Nicolay A, Alessi MC, Nalbone G, Peiretti F: HDLs activate ADAM17-dependent shedding. J Cell Physiol, 2008; 214: 687-693
38. Lutgens E, Lievens D, Beckers L, Wijnands E, Soehnlein O, Zernecke A, Seijkens T, Engel D, Cleutjens J, Keller AM, Naik SH, Boon L, Oufella HA, Mallat Z, Ahonen CL, Noelle RJ, de Winther MP, Daemen MJ, Biessen EA, Weber C: Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile. J Exp Med, 2010; 207: 391-404
39. Antoniades C, Bakogiannis C, Tousoulis D, Antonopoulos AS, Stefanadis C: The CD40/CD40 ligand system: linking inflammation with atherothrombosis. J Am Coll Cardiol, 2009; 54: 669-677
40. Chen J, Chen L, Wang G, Tang H: Cholesterol-dependent and-independent CD40 internalization and signaling activation in cardiovascular endothelial cells. Arterioscler Thromb Vasc Biol, 2007; 27: 2005-2013
41. Suttles J, Stout RD: Macrophage CD40 signaling: a pivotal regulator of disease protection and pathogenesis. Semin Immunol, 2009; 21: 257-264
42. Lum HD, Buhtoiarov IN, Schmidt BE, Berke G, Paulnock DM, Sondel PM, Rakhmilevich AL: In vivo CD40 ligation can induce T-cell-independent antitumor effects that involve macrophages. J Leukoc Biol, 2006; 79: 1181-1192
43. Wang L, Chen WZ, Wu MP: Apolipoprotein A-I inhibits chemotaxis, adhesion, activation of THP-1 cells and improves the plasma HDL inflammatory index. Cytokine, 2010; 49: 194-200
44. Fischer WH, Jagels MA, Hugli TE: Regulation of IL-6 synthesis in human peripheral blood mononuclear cells by C3a and C3a (desArg). J Immunol, 1999; 162: 453-459
45. Pullen SS, Dang TT, Crute JJ, Kehry MR: CD40 signaling through tumor necrosis factor receptor-associated factors (TRAFs). Binding site specificity and activation of downstream pathways by distinct TRAFs. J Biol Chem, 1999; 274: 14246-14254
46. Rub A, Dey R, Jadhav M, Kamat R, Chakkaramakkil S, Majumdar S, Mukhopadhyaya R, Saha B: Cholesterol depletion associated with Leishmania major infection alters macrophage CD40 signalosome composition and effector function. Nat Immunol, 2009; 10: 273-280
47. Pearson LL, Castle BE, Kehry MR: CD40-mediated signaling in monocytic cells: up-regulation of tumor necrosis factor receptor-associated factor mRNAs and activation of mitogen-activated protein kinase signaling pathways. Int Immunol, 2001; 13: 273-283
48. Nadiri A, Polyak MJ, Jundi M, Alturaihi H, Reyes-Moreno C, Hassan GS, Mourad W: CD40 translocation to lipid rafts: signaling requirements and downstream biological events. Eur J Immunol, 2011; 41: 2358-2367
49. Gaus K, Kritharides L, Schmitz G, Boettcher A, Drobnik W, Langmann T, Quinn CM, Death A, Dean RT, Jessup W: Apolipoprotein A-1 interaction with plasma membrane lipid rafts controls cholesterol export from macrophages. FASEB J, 2004; 18: 574-576
50. Koseki M, Hirano K, Masuda D, Ikegami C, Tanaka M, Ota A, Sandoval JC, Nakagawa-Toyama Y, Sato SB, Kobayashi T, Shimada Y, Ohno-Iwashita Y, Matsuura F, Shimomura I, Yamashita S: Increased lipid rafts and accelerated lipopolysaccharide-induced tumor necrosis factoralpha secretion in Abca1-deficient macrophages. J Lipid Res, 2007; 48: 299-306
51. Sanchez SA, Tricerri MA, Gratton E: Interaction of high density lipoprotein particles with membranes containing cholesterol. J Lipid Res, 2007; 48: 1689-1700
52. Higashi N, Matsumura Y, Mizuno F, Kasahara K, Sugiura S, Mikasa K, Kita E: Enhanced expression of ATP-binding cassette transporter A1 in non-rafts decreases the sensitivity of vascular endothelial cells to Shiga toxin. Microb Pathog, 2010; 49: 141-152