Target protein interactions of indole-3-carbinol and the highly potent derivative 1-benzyl-I3C with the C-terminal domain of human elastase uncouples cell cycle arrest from apoptotic signaling

Molecular Carcinogenesis

Volumn 51, Issue 11, 2012, Pages 881-894

  Aronchik, Ida ^a   Chen, Tony ^a   Durkin, Kathleen A ^a   Horwitz, Marshall S ^b   Preobrazhenskaya, Maria N ^c   Bjeldanes, Leonard F ^a   Firestone, Gary L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c GAUSE INSTITUTE OF NEW ANTIBIOTICS   (Russian Federation)

Author keywords

1 benzyl indole 3 carbinol (1 benzyl I3C); 3,3 diindolylmethane (DIM); Anti proliferative signaling; Breast cancer; Cell cycle; In silico analysis; Indole 3 carbinol (I3C); Phytochemical

Indexed keywords

1 BENZYL INDOLE 3 CARBINOL; 3 INDOLEMETHANOL; ANTINEOPLASTIC AGENT; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDOLE DERIVATIVE; LEUKOCYTE ELASTASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; BREAST CANCER; CANCER CELL; CATALYSIS; COMPUTER SIMULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING AND TRANSPORT; DRUG BINDING SITE; DRUG STRUCTURE; DRUG TARGETING; ENZYMATIC ASSAY; ENZYME ACTIVITY; ENZYME BINDING; ENZYME STRUCTURE; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; NUCLEAR LOCALIZATION SIGNAL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

APOPTOSIS; BREAST NEOPLASMS; CELL CYCLE; CELL LINE, TUMOR; ENZYME INHIBITORS; FEMALE; HUMANS; INDOLES; LEUKOCYTE ELASTASE; MODELS, MOLECULAR; MUTATION; NF-KAPPA B; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION; VEGETABLES;

BRASSICA OLERACEA VAR. CAPITATA; BRASSICA OLERACEA VAR. GEMMIFERA; BRASSICA OLERACEA VAR. ITALICA;

EID: 84867902533     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20857     Document Type: Article

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