Poorly differentiated synovial sarcoma is associated with high expression of enhancer of zeste homologue 2 (EZH2)

Journal of Translational Medicine

Volumn 10, Issue 1, 2012, Pages

  Changchien, Yi Che ^a   Tátrai, Péter ^b   Papp, Gergo ^a   Sápi, Johanna ^c   Fónyad, László ^a   Szendroi, Miklós ^a   Pápai, Zsuzsanna ^d   Sápi, Zoltán ^a  

^a SEMMELWEIS UNIVERSITY   (Hungary)

^b INSTITUTE OF EXPERIMENTAL MEDICINE   (Hungary)

^c BUDAPEST UNIVERSITY OF TECHNOLOGY AND ECONOMICS   (Hungary)

^d Military Hospital State Health Centre Department of Oncology   (Hungary)

Author keywords

EZH2; H3K27me3; Histone methyltransferase; Polycomb group; Synovial sarcoma

Indexed keywords

HISTONE; HISTONE 3 LYSINE 27; KI 67 ANTIGEN; MESSENGER RNA; TRANSCRIPTION FACTOR EZH2; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CANCER PROGNOSIS; DISTANT METASTASIS; FEMALE; FUSION GENE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MALE; PROTEIN EXPRESSION; SYNOVIAL SARCOMA; TISSUE MICROARRAY; TUMOR GROWTH; TUMOR LOCALIZATION; TUMOR VOLUME;

CELL DIFFERENTIATION; HISTONES; HUMANS; IMMUNOHISTOCHEMISTRY; KI-67 ANTIGEN; POLYCOMB REPRESSIVE COMPLEX 2; PROGNOSIS; RNA, MESSENGER; SARCOMA, SYNOVIAL; TISSUE ARRAY ANALYSIS;

EID: 84867894995     PISSN: None     EISSN: 14795876     Source Type: Journal    
DOI: 10.1186/1479-5876-10-216     Document Type: Article

References (38)

1. Naka N, Takenaka S, Araki N, Miwa T, Hashimoto N, Yoshioka K, Joyama S, Hamada KI, Tsukamoto Y, Tomita Y, et al. Synovial Sarcoma Is a Stem Cell Malignancy. Stem Cells 2010, 28:1119-1131.
2. Fisher C, Geurts DBD, van Kessel A. Synovial sarcoma 2002, IARC Press, Lyon.
3. Enzinger FM, Weiss SW. Soft Tissue Tumors 2008, Mosby, St. Louis.
4. Sauvageau M, Sauvageau G. Polycomb Group Proteins: Multi-Faceted Regulators of Somatic Stem Cells and Cancer. Cell Stem Cell 2010, 7:299-313. 10.1016/j.stem.2010.08.002, 20804967.
5. Surface LE, Thornton SR, Boyer LA. Polycomb Group Proteins Set the Stage for Early Lineage Commitment. Cell Stem Cell 2010, 7:288-298. 10.1016/j.stem.2010.08.004, 20804966.
6. Chang CJ, Hung MC. The role of EZH2 in tumour progression. Br J Cancer 2012, 106:243-247. 10.1038/bjc.2011.551, 22187039.
7. Chase A, Cross NC. Aberrations of EZH2 in cancer. Clin Cancer Res 2011, 17:2613-2618. 10.1158/1078-0432.CCR-10-2156, 21367748.
8. Sun B, Sun Y, Wang J, Zhao X, Zhang S, Liu Y, Li X, Feng Y, Zhou H, Hao X. The diagnostic value of SYT-SSX detected by reverse transcriptase-polymerase chain reaction (RT-PCR) and fluorescence in situ hybridization (FISH) for synovial sarcoma: a review and prospective study of 255 cases. Cancer Sci 2008, 99:1355-1361. 10.1111/j.1349-7006.2008.00830.x, 18460022.
9. Ladanyi M. Fusions of the SYT and SSX genes in synovial sarcoma. Oncogene 2001, 20:5755-5762. 10.1038/sj.onc.1204601, 11607825.
10. Lubieniecka JM, de Bruijn DRH, Su L, van Dijk AHA, Subramanian S, van de Rijn M, Poulin N, van Kessel AG, Nielsen TO. Histone deacetylase inhibitors reverse SS18-SSX-mediated polycomb silencing of the tumor suppressor early growth response 1 in synovial sarcoma. Cancer Res 2008, 68:4303-4310. 10.1158/0008-5472.CAN-08-0092, 18519690.
11. de Bruijn DRH, Nap JP, van Kessel AG. The (epi)genetics of human synovial sarcoma. Gene Chromosome Canc 2007, 46:107-117.
12. Su L, Sampaio AV, Jones KB, Pacheco M, Goytain A, Lin SJ, Poulin N, Yi L, Rossi FM, Kast J, et al. Deconstruction of the SS18-SSX Fusion Oncoprotein Complex: Insights into Disease Etiology and Therapeutics. Cancer Cell 2012, 21:333-347. 10.1016/j.ccr.2012.01.010, 22439931.
13. Yamaga K, Osaki M, Kidani K, Shomori K, Yoshida H, Ito H. High expression of enhancer of zeste homologue 2 indicates poor prognosis in patients with soft tissue sarcomas. Mol Med Rep 2008, 1:633-639.
14. Bergh P, Meis-Kindblom JM, Gherlinzoni F, Berlin O, Bacchini P, Bertoni F, Gunterberg B, Kindblom LG. Synovial sarcoma: identification of low and high risk groups. Cancer 1999, 85:2596-2607. 10.1002/(SICI)1097-0142(19990615)85:12<2596::AID-CNCR16>3.0.CO;2-K, 10375108.
15. Ladanyi M, Antonescu CR, Leung DH, Woodruff JM, Kawai A, Healey JH, Brennan MF, Bridge JA, Neff JR, Barr FG, et al. Impact of SYT-SSX fusion type on the clinical behavior of synovial sarcoma: a multi-institutional retrospective study of 243 patients. Cancer Res 2002, 62:135-140.
16. Nakayama R, Mitani S, Nakagawa T, Hasegawa T, Kawai A, Morioka H, Yabe H, Toyama Y, Ogose A, Toguchida J, et al. Gene Expression Profiling of Synovial Sarcoma: Distinct Signature of Poorly Differentiated Type. Am J Surg Pathol 2010, 34:1599-1607.
17. Koh CM, Iwata T, Zheng QZ, Bethel C, Yegnasubramanian S, De Marzo AM. Myc Enforces Overexpression of EZH2 in Early Prostatic Neoplasia via Transcriptional and Post-transcriptional Mechanisms. Oncotarget 2011, 2:669-683. 3248223, 21941025.
18. Chang CJ, Yang JY, Xia W, Chen CT, Xie X, Chao CH, Woodward WA, Hsu JM, Hortobagyi GN, Hung MC. EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-β-catenin signaling. Cancer Cell 2011, 19:86-100. 10.1016/j.ccr.2010.10.035, 3041516, 21215703.
19. Richter GHS, Plehm S, Fasan A, Rossler S, Unland R, Bennani-Baiti IM, Hotfilder M, Lowel D, von Luettichau I, Mossbrugger I, et al. EZH2 is a mediator of EWS/FLI1 driven tumor growth and metastasis blocking endothelial and neuro-ectodermal differentiation. Proc Natl Acad Sci U S A 2009, 106:5324-5329. 10.1073/pnas.0810759106, 2656557, 19289832.
20. Ciarapica R, Russo G, Verginelli F, Raimondi L, Donfrancesco A, Rota R, Giordano A. Deregulated expression of miR-26a and Ezh2 in rhabdomyosarcoma. Cell Cycle 2009, 8:172-175. 10.4161/cc.8.1.7292, 19106613.
21. van der Vlag J, Otte AP. Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation. Nat Genet 1999, 23:474-478. 10.1038/70602, 10581039.
22. Vire E, Brenner C, Deplus R, Blanchon L, Fraga M, Didelot C, Morey L, Van Eynde A, Bernard D, Vanderwinden JM, et al. The polycomb group protein EZH2 directly controls DNA methylation (vol 439, pg 871, 2006). Nature 2007, 446:871-874. 10.1038/nature05677, 17443179.
23. Shao Z, Raible F, Mollaaghababa R, Guyon JR, Wu CT, Bender W, Kingston RE. Stabilization of chromatin structure by PRC1, a Polycomb complex. Cell 1999, 98:37-46. 10.1016/S0092-8674(00)80604-2, 10412979.
24. Yu J, Rhodes DR, Tomlins SA, Cao X, Chen G, Mehra R, Wang X, Ghosh D, Shah RB, Varambally S, et al. A polycomb repression signature in metastatic prostate cancer predicts cancer outcome. Cancer Res 2007, 67:10657-10663. 10.1158/0008-5472.CAN-07-2498, 18006806.
25. Ciarapica R, Miele L, Giordano A, Locatelli F, Rota R. Enhancer of zeste homolog 2 (EZH2) in pediatric soft tissue sarcomas: first implications. BMC Med 2011, 9:36. 10.1186/1741-7015-9-36, 3094236, 21481281.
26. Bracken AP, Pasini D, Capra M, Prosperini E, Colli E, Helin K. EZH2 is downstream of the pRB-E2F pathway, essential for proliferation and amplified in cancer. EMBO J 2003, 22:5323-5335. 10.1093/emboj/cdg542, 213796, 14532106.
27. Wu ZL, Zheng SS, Li ZM, Qiao YY, Aau MY, Yu Q. Polycomb protein EZH2 regulates E2F1-dependent apoptosis through epigenetically modulating Bim expression. Cell Death Differ 2010, 17:801-810. 10.1038/cdd.2009.162, 19893569.
28. Yap DB, Chu J, Berg T, Schapira M, Cheng SW, Moradian A, Morin RD, Mungall AJ, Meissner B, Boyle M, et al. Somatic mutations at EZH2 Y641 act dominantly through a mechanism of selectively altered PRC2 catalytic activity, to increase H3K27 trimethylation. Blood 2011, 117:2451-2459. 10.1182/blood-2010-11-321208, 3062411, 21190999.
29. Bödör C, O'Riain C, Wrench D, Matthews J, Iyengar S, Tayyib H, Calaminici M, Clear A, Iqbal S, Quentmeier H, et al. EZH2 Y641 mutations in follicular lymphoma. Leukemia 2011, 25:726-729. 10.1038/leu.2010.311, 21233829.
30. Cai MY, Hou JH, Rao HL, Luo RZ, Li M, Pei XQ, Lin MC, Guan XY, Kung HF, Zeng YX, Xie D. High expression of H3K27me3 in human hepatocellular carcinomas correlates closely with vascular invasion and predicts worse prognosis in patients. Mol Med 2011, 17:12-20. 3022987, 20844838.
31. He LR, Liu MZ, Li BK, Rao HL, Liao YJ, Guan XY, Zeng YX, Xie D. Prognostic impact of H3K27me3 expression on locoregional progression after chemoradiotherapy in esophageal squamous cell carcinoma. BMC Cancer 2009, 9:461. 10.1186/1471-2407-9-461, 2804715, 20028503.
32. Wei Y, Xia W, Zhang Z, Liu J, Wang H, Adsay NV, Albarracin C, Yu D, Abbruzzese JL, Mills GB, et al. Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers. Mol Carcinog 2008, 47:701-706. 10.1002/mc.20413, 2580832, 18176935.
33. Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC. Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science 2005, 310:306-310. 10.1126/science.1118947, 16224021.
34. Kuzmichev A, Margueron R, Vaquero A, Preissner TS, Scher M, Kirmizis A, Ougang XS, Brockdorff N, Abate-Shen C, Farnham P, Reinberg D. Composition and histone substrates of polycomb repressive group complexes change during cellular differentiation. Proc Natl Acad Sci U S A 2005, 102:1859-1864. 10.1073/pnas.0409875102, 548563, 15684044.
35. Hasegawa T, Yamamoto S, Yokoyama R, Umeda T, Matsuno Y, Hirohashi S. Prognostic significance of grading and staging systems using MIB-1 score in adult patients with soft tissue sarcoma of the extremities and trunk. Cancer 2002, 95:843-851. 10.1002/cncr.10728, 12209729.
36. Balogh Z, Szemlaky Z, Szendroi M, Antal I, Pápai Z, Fónyad L, Papp G, Changchien YC, Sápi Z. Correlation between DNA ploidy, metaphase high-resolution comparative genomic hybridization results and clinical outcome of synovial sarcoma. Diagn Pathol 2011, 6:107. 10.1186/1746-1596-6-107, 3214833, 22053830.
37. Ito T, Ouchida M, Morimoto Y, Yoshida A, Jitsumori Y, Ozaki T, Sonobe H, Inoue H, Shimizu K. Significant growth suppression of synovial sarcomas by the histone deacetylase inhibitor FK228 in vitro and in vivo. Cancer Lett 2005, 224:311-319. 10.1016/j.canlet.2004.10.030, 15914281.
38. Wang C, Liu Z, Woo CW, Li Z, Wang L, Wei JS, Marquez VE, Bates SE, Jin Q, Khan J, et al. EZH2 mediates epigenetic silencing of neuroblastoma suppressor genes CASZ1, CLU, RUNX3, and NGFR. Cancer Res 2012, 72:315-324. 10.1158/0008-5472.CAN-11-0961, 22068036.